Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder
Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 ( ADGRL3 ; formerly latrophilin 3, LPHN3 ) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of ADGRL...
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| Published in | Scientific reports Vol. 11; no. 1; pp. 2373 - 12 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
27.01.2021
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-021-81915-z |
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| Abstract | Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (
ADGRL3
; formerly
latrophilin 3, LPHN3
) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of
ADGRL3
risk variants. We examined here whether individuals with different
ADGRL3
haplotypes, including both patients with ADHD and healthy controls, showed differences in brain anatomy and function. We recruited and genotyped adult patients with combined type ADHD and healthy controls to achieve a sample balanced for age, sex, premorbid IQ, and three
ADGRL3
haplotype groups (risk, protective, and others). The final sample (n = 128) underwent structural and functional brain imaging (voxel-based morphometry and n-back working memory fMRI). We analyzed the brain structural and functional effects of ADHD, haplotypes, and their interaction, covarying for age, sex, and medication. Individuals (patients or controls) with the protective haplotype showed strong, widespread hypo-activation in the frontal cortex extending to inferior temporal and fusiform gyri. Individuals (patients or controls) with the risk haplotype also showed hypo-activation, more focused in the right temporal cortex. Patients showed parietal hyper-activation. Disorder-haplotype interactions, as well as structural findings, were not statistically significant. To sum up, both protective and risk
ADGRL3
haplotypes are associated with substantial brain hypo-activation during working memory tasks, stressing this gene’s relevance in cognitive brain function. Conversely, we did not find brain effects of the interactions between adult ADHD and
ADGRL3
haplotypes. |
|---|---|
| AbstractList | Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (
ADGRL3
; formerly
latrophilin 3, LPHN3
) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of
ADGRL3
risk variants. We examined here whether individuals with different
ADGRL3
haplotypes, including both patients with ADHD and healthy controls, showed differences in brain anatomy and function. We recruited and genotyped adult patients with combined type ADHD and healthy controls to achieve a sample balanced for age, sex, premorbid IQ, and three
ADGRL3
haplotype groups (risk, protective, and others). The final sample (n = 128) underwent structural and functional brain imaging (voxel-based morphometry and n-back working memory fMRI). We analyzed the brain structural and functional effects of ADHD, haplotypes, and their interaction, covarying for age, sex, and medication. Individuals (patients or controls) with the protective haplotype showed strong, widespread hypo-activation in the frontal cortex extending to inferior temporal and fusiform gyri. Individuals (patients or controls) with the risk haplotype also showed hypo-activation, more focused in the right temporal cortex. Patients showed parietal hyper-activation. Disorder-haplotype interactions, as well as structural findings, were not statistically significant. To sum up, both protective and risk
ADGRL3
haplotypes are associated with substantial brain hypo-activation during working memory tasks, stressing this gene’s relevance in cognitive brain function. Conversely, we did not find brain effects of the interactions between adult ADHD and
ADGRL3
haplotypes. Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of ADGRL3 risk variants. We examined here whether individuals with different ADGRL3 haplotypes, including both patients with ADHD and healthy controls, showed differences in brain anatomy and function. We recruited and genotyped adult patients with combined type ADHD and healthy controls to achieve a sample balanced for age, sex, premorbid IQ, and three ADGRL3 haplotype groups (risk, protective, and others). The final sample (n = 128) underwent structural and functional brain imaging (voxel-based morphometry and n-back working memory fMRI). We analyzed the brain structural and functional effects of ADHD, haplotypes, and their interaction, covarying for age, sex, and medication. Individuals (patients or controls) with the protective haplotype showed strong, widespread hypo-activation in the frontal cortex extending to inferior temporal and fusiform gyri. Individuals (patients or controls) with the risk haplotype also showed hypo-activation, more focused in the right temporal cortex. Patients showed parietal hyper-activation. Disorder-haplotype interactions, as well as structural findings, were not statistically significant. To sum up, both protective and risk ADGRL3 haplotypes are associated with substantial brain hypo-activation during working memory tasks, stressing this gene’s relevance in cognitive brain function. Conversely, we did not find brain effects of the interactions between adult ADHD and ADGRL3 haplotypes. Abstract Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of ADGRL3 risk variants. We examined here whether individuals with different ADGRL3 haplotypes, including both patients with ADHD and healthy controls, showed differences in brain anatomy and function. We recruited and genotyped adult patients with combined type ADHD and healthy controls to achieve a sample balanced for age, sex, premorbid IQ, and three ADGRL3 haplotype groups (risk, protective, and others). The final sample (n = 128) underwent structural and functional brain imaging (voxel-based morphometry and n-back working memory fMRI). We analyzed the brain structural and functional effects of ADHD, haplotypes, and their interaction, covarying for age, sex, and medication. Individuals (patients or controls) with the protective haplotype showed strong, widespread hypo-activation in the frontal cortex extending to inferior temporal and fusiform gyri. Individuals (patients or controls) with the risk haplotype also showed hypo-activation, more focused in the right temporal cortex. Patients showed parietal hyper-activation. Disorder-haplotype interactions, as well as structural findings, were not statistically significant. To sum up, both protective and risk ADGRL3 haplotypes are associated with substantial brain hypo-activation during working memory tasks, stressing this gene’s relevance in cognitive brain function. Conversely, we did not find brain effects of the interactions between adult ADHD and ADGRL3 haplotypes. Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of ADGRL3 risk variants. We examined here whether individuals with different ADGRL3 haplotypes, including both patients with ADHD and healthy controls, showed differences in brain anatomy and function. We recruited and genotyped adult patients with combined type ADHD and healthy controls to achieve a sample balanced for age, sex, premorbid IQ, and three ADGRL3 haplotype groups (risk, protective, and others). The final sample (n = 128) underwent structural and functional brain imaging (voxel-based morphometry and n-back working memory fMRI). We analyzed the brain structural and functional effects of ADHD, haplotypes, and their interaction, covarying for age, sex, and medication. Individuals (patients or controls) with the protective haplotype showed strong, widespread hypo-activation in the frontal cortex extending to inferior temporal and fusiform gyri. Individuals (patients or controls) with the risk haplotype also showed hypo-activation, more focused in the right temporal cortex. Patients showed parietal hyper-activation. Disorder-haplotype interactions, as well as structural findings, were not statistically significant. To sum up, both protective and risk ADGRL3 haplotypes are associated with substantial brain hypo-activation during working memory tasks, stressing this gene's relevance in cognitive brain function. Conversely, we did not find brain effects of the interactions between adult ADHD and ADGRL3 haplotypes.Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomical or functional brain substrates of ADGRL3 risk variants. We examined here whether individuals with different ADGRL3 haplotypes, including both patients with ADHD and healthy controls, showed differences in brain anatomy and function. We recruited and genotyped adult patients with combined type ADHD and healthy controls to achieve a sample balanced for age, sex, premorbid IQ, and three ADGRL3 haplotype groups (risk, protective, and others). The final sample (n = 128) underwent structural and functional brain imaging (voxel-based morphometry and n-back working memory fMRI). We analyzed the brain structural and functional effects of ADHD, haplotypes, and their interaction, covarying for age, sex, and medication. Individuals (patients or controls) with the protective haplotype showed strong, widespread hypo-activation in the frontal cortex extending to inferior temporal and fusiform gyri. Individuals (patients or controls) with the risk haplotype also showed hypo-activation, more focused in the right temporal cortex. Patients showed parietal hyper-activation. Disorder-haplotype interactions, as well as structural findings, were not statistically significant. To sum up, both protective and risk ADGRL3 haplotypes are associated with substantial brain hypo-activation during working memory tasks, stressing this gene's relevance in cognitive brain function. Conversely, we did not find brain effects of the interactions between adult ADHD and ADGRL3 haplotypes. |
| ArticleNumber | 2373 |
| Author | Palomar, Gloria Monté-Rubio, Gemma C. Ribases, Marta Castellanos, F. Xavier Sánchez-Mora, Cristina Ramos-Quiroga, Josep A. Pomarol-Clotet, Edith Casas, Miquel Moreno-Alcázar, Ana Fortea, Lydia Salavert, Josep Bosch, Rosa Radua, Joaquim Canales-Rodríguez, Erick J. Milham, Michael P. |
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Rosselló, Institute of Neurosciences, University of Barcelona – sequence: 9 givenname: Gemma C. surname: Monté-Rubio fullname: Monté-Rubio, Gemma C. organization: FIDMAG Research Foundation, Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Institute of Neurosciences, University of Barcelona – sequence: 10 givenname: Erick J. surname: Canales-Rodríguez fullname: Canales-Rodríguez, Erick J. organization: FIDMAG Research Foundation, Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne (EPFL) – sequence: 11 givenname: Michael P. surname: Milham fullname: Milham, Michael P. organization: Nathan Kline Institute for Psychiatric Research, Center for the Developing Brain, Child Mind Institute – sequence: 12 givenname: F. Xavier surname: Castellanos fullname: Castellanos, F. Xavier organization: Nathan Kline Institute for Psychiatric Research, Department of Child and Adolescent Psychiatry, Hassenfeld Children’s Hospital at NYU Langone – sequence: 13 givenname: Miquel surname: Casas fullname: Casas, Miquel organization: Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Vall D’Hebron Barcelona Hospital Campus – sequence: 14 givenname: Edith surname: Pomarol-Clotet fullname: Pomarol-Clotet, Edith email: epomarol-clotet@fidmag.com organization: FIDMAG Research Foundation, Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III – sequence: 15 givenname: Joaquim surname: Radua fullname: Radua, Joaquim email: radua@clinic.cat organization: FIDMAG Research Foundation, Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/. Rosselló, Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London |
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| Cites_doi | 10.1007/s00787-015-0755-8 10.1016/j.schres.2010.11.016 10.1006/nimg.2001.0931 10.1212/01.wnl.0000103169.80910.8b 10.1017/S0033291720000574 10.1016/j.biopsych.2004.11.024 10.1002/hbm.10062 10.1016/0013-4694(93)90119-G 10.1016/j.neuroimage.2003.12.023 10.1037/a0032371 10.1176/appi.ajp.2011.11020281 10.1016/j.neuroimage.2008.03.061 10.1016/s1361-8415(01)00036-6 10.1017/S0033291713001037 10.1176/appi.ajp.2019.18091033 10.1016/j.biopsych.2008.10.005 10.1016/j.neuroimage.2010.09.088 10.1038/s41386-020-0664-5 10.1016/j.biopsych.2013.10.016 10.1086/319501 10.1016/j.pscychresns.2016.06.002 10.3389/fnhum.2019.00180 10.1111/j.1601-183X.2010.00649.x 10.1038/mp.2010.6 10.1016/j.neuroimage.2020.116683 10.1038/s41380-020-0673-0 10.1093/nar/16.3.1215 10.1001/jamapsychiatry.2013.277 10.1111/gbb.12224 10.1016/j.neuroimage.2004.07.051 10.1038/s41588-018-0269-7 10.1016/j.neuroimage.2013.07.072 10.1177/1087054715611492 10.1109/42.906424 10.3390/cells8080907 10.1016/j.neuroimage.2013.07.084 10.1016/s1053-8119(02)91132-8 10.1016/j.rpsm.2012.05.004 10.1016/j.neubiorev.2019.02.011 10.1038/mp.2016.74 10.1503/jpn.190179 10.1016/j.biopsych.2004.10.020 10.1006/nimg.2001.0961 10.1016/S1053-8119(03)00435-X 10.1001/jamapsychiatry.2016.0700 10.1176/ajp.150.6.885 |
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| References | Beckmann, Jenkinson, Smith (CR55) 2003; 20 First, Spitzer, Gibbon, William (CR33) 2002 Norman (CR15) 2016; 73 Smith (CR41) 2002; 17 McCarthy, Skokauskas, Frodl (CR24) 2014; 44 Smith (CR48) 2004; 23 Nakao, Radua, Rubia, Mataix-Cols (CR13) 2011; 168 Nelson (CR36) 1982 Bonvicini, Faraone, Scassellati (CR8) 2016; 21 Rubia (CR25) 2014; 76 McGurn (CR37) 2004; 62 Emch, von Bastian, Koch (CR23) 2019; 13 Durnez, Moerkerke, Nichols (CR54) 2014; 84 Ramos-Quiroga (CR29) 2012; 5 Lamichhane, Westbrook, Cole, Braver (CR22) 2020; 212 Rovira (CR7) 2020 Smith, Nichols (CR52) 2009; 44 Moreno-Alcazar (CR14) 2016; 254 First, Gibbon, Spitzer, William, Benjamin (CR34) 1997 CR3 Epstein, Johnson (CR28) 1999 Stephens, Smith, Donnelly (CR39) 2001; 68 Alderson, Kasper, Hudec, Patros (CR46) 2013; 27 Ashburner, Friston (CR44) 2001; 14 Ribases (CR40) 2011; 10 Bruxel (CR9) 2020 Green, Swets (CR47) 1966 Biederman (CR4) 2005; 57 Faraone (CR5) 2005; 57 Arcos-Burgos (CR10) 2010; 15 Gomar (CR35) 2011; 128 Demontis (CR6) 2019; 51 Ward, Wender, Reimherr (CR30) 1993; 150 Zhang, Brady, Smith (CR42) 2001; 20 Salimi-Khorshidi, Smith, Nichols (CR53) 2011; 54 Bruxel (CR11) 2015; 14 Lara (CR1) 2009; 65 Roman-Urrestarazu (CR16) 2016; 25 CR57 Hoogman (CR27) 2019; 176 Gevins, Cutillo (CR45) 1993; 87 Samea (CR19) 2019; 100 Salavert (CR18) 2015 (CR2) 2000 Woolrich, Behrens, Beckmann, Jenkinson, Smith (CR56) 2004; 21 DuPaul (CR31) 1998 Miller, Dykes, Polesky (CR38) 1988; 16 Lukito (CR20) 2020; 50 Conners (CR32) 1999 Jenkinson, Smith (CR51) 2001; 5 Puentes-Rozo (CR12) 2019; 8 Hart, Radua, Nakao, Mataix-Cols, Rubia (CR17) 2013; 70 Moreno-Alcazar (CR26) 2016; 254 Woolrich, Ripley, Brady, Smith (CR50) 2001; 14 Jenkinson, Bannister, Brady, Smith (CR49) 2002; 17 Westwood, Radua, Rubia (CR21) 2020; 45 Radua, Canales-Rodriguez, Pomarol-Clotet, Salvador (CR43) 2014; 86 J Ashburner (81915_CR44) 2001; 14 EM Bruxel (81915_CR9) 2020 81915_CR57 EM Bruxel (81915_CR11) 2015; 14 A Roman-Urrestarazu (81915_CR16) 2016; 25 A Moreno-Alcazar (81915_CR26) 2016; 254 K Rubia (81915_CR25) 2014; 76 P Rovira (81915_CR7) 2020 J Epstein (81915_CR28) 1999 SA Miller (81915_CR38) 1988; 16 JJ Gomar (81915_CR35) 2011; 128 J Biederman (81915_CR4) 2005; 57 SJ Westwood (81915_CR21) 2020; 45 C Lara (81915_CR1) 2009; 65 B McGurn (81915_CR37) 2004; 62 D Demontis (81915_CR6) 2019; 51 B Lamichhane (81915_CR22) 2020; 212 M Ribases (81915_CR40) 2011; 10 A Gevins (81915_CR45) 1993; 87 J Salavert (81915_CR18) 2015 M First (81915_CR33) 2002 H Hart (81915_CR17) 2013; 70 PJ Puentes-Rozo (81915_CR12) 2019; 8 J Radua (81915_CR43) 2014; 86 C Bonvicini (81915_CR8) 2016; 21 RM Alderson (81915_CR46) 2013; 27 CF Beckmann (81915_CR55) 2003; 20 MW Woolrich (81915_CR56) 2004; 21 SM Smith (81915_CR48) 2004; 23 SV Faraone (81915_CR5) 2005; 57 M First (81915_CR34) 1997 HE Nelson (81915_CR36) 1982 CK Conners (81915_CR32) 1999 H McCarthy (81915_CR24) 2014; 44 SM Smith (81915_CR41) 2002; 17 M Jenkinson (81915_CR51) 2001; 5 SM Smith (81915_CR52) 2009; 44 MF Ward (81915_CR30) 1993; 150 81915_CR3 A Moreno-Alcazar (81915_CR14) 2016; 254 LJ Norman (81915_CR15) 2016; 73 Y Zhang (81915_CR42) 2001; 20 JA Ramos-Quiroga (81915_CR29) 2012; 5 M Arcos-Burgos (81915_CR10) 2010; 15 M Jenkinson (81915_CR49) 2002; 17 F Samea (81915_CR19) 2019; 100 MW Woolrich (81915_CR50) 2001; 14 M Emch (81915_CR23) 2019; 13 M Hoogman (81915_CR27) 2019; 176 American Psychiatric Association (81915_CR2) 2000 J Durnez (81915_CR54) 2014; 84 M Stephens (81915_CR39) 2001; 68 GJ DuPaul (81915_CR31) 1998 T Nakao (81915_CR13) 2011; 168 G Salimi-Khorshidi (81915_CR53) 2011; 54 S Lukito (81915_CR20) 2020; 50 DM Green (81915_CR47) 1966 |
| References_xml | – volume: 25 start-page: 529 year: 2016 end-page: 538 ident: CR16 article-title: Brain structural deficits and working memory fMRI dysfunction in young adults who were diagnosed with ADHD in adolescence publication-title: Eur. Child Adolesc. Psychiatry doi: 10.1007/s00787-015-0755-8 – volume: 128 start-page: 175 year: 2011 end-page: 176 ident: CR35 article-title: Validation of the Word Accentuation Test (TAP) as a means of estimating premorbid IQ in Spanish speakers publication-title: Schizophr. Res. doi: 10.1016/j.schres.2010.11.016 – volume: 14 start-page: 1370 year: 2001 end-page: 1386 ident: CR50 article-title: Temporal autocorrelation in univariate linear modeling of FMRI data publication-title: Neuroimage doi: 10.1006/nimg.2001.0931 – year: 2002 ident: CR33 publication-title: Structured Clinical Interview for DSM-IV Axis I Disorders: Research version, Patient Edition – volume: 62 start-page: 1184 year: 2004 end-page: 1186 ident: CR37 article-title: Pronunciation of irregular words is preserved in dementia, validating premorbid IQ estimation publication-title: Neurology doi: 10.1212/01.wnl.0000103169.80910.8b – volume: 50 start-page: 894 year: 2020 end-page: 919 ident: CR20 article-title: Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder publication-title: Psychol. Med. doi: 10.1017/S0033291720000574 – volume: 57 start-page: 1313 year: 2005 end-page: 1323 ident: CR5 article-title: Molecular genetics of attention-deficit/hyperactivity disorder publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2004.11.024 – volume: 17 start-page: 143 year: 2002 end-page: 155 ident: CR41 article-title: Fast robust automated brain extraction publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.10062 – volume: 87 start-page: 128 year: 1993 end-page: 143 ident: CR45 article-title: Spatiotemporal dynamics of component processes in human working memory publication-title: Electroencephalogr. Clin. Neurophysiol. doi: 10.1016/0013-4694(93)90119-G – volume: 21 start-page: 1732 year: 2004 end-page: 1747 ident: CR56 article-title: Multilevel linear modelling for FMRI group analysis using Bayesian inference publication-title: Neuroimage doi: 10.1016/j.neuroimage.2003.12.023 – volume: 27 start-page: 287 year: 2013 end-page: 302 ident: CR46 article-title: Attention-deficit/hyperactivity disorder (ADHD) and working memory in adults: a meta-analytic review publication-title: Neuropsychology doi: 10.1037/a0032371 – year: 1966 ident: CR47 publication-title: Signal Detection Theory and Psychophysics – volume: 168 start-page: 1154 year: 2011 end-page: 1163 ident: CR13 article-title: Gray matter volume abnormalities in ADHD: Voxel-based meta-analysis exploring the effects of age and stimulant medication publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2011.11020281 – year: 1997 ident: CR34 publication-title: Interview for DSM-IV Axis II Personality Disorders SCID-II – volume: 44 start-page: 83 year: 2009 end-page: 98 ident: CR52 article-title: Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.03.061 – volume: 5 start-page: 143 year: 2001 end-page: 156 ident: CR51 article-title: A global optimisation method for robust affine registration of brain images publication-title: Med. Image Anal. doi: 10.1016/s1361-8415(01)00036-6 – volume: 44 start-page: 869 year: 2014 end-page: 880 ident: CR24 article-title: Identifying a consistent pattern of neural function in attention deficit hyperactivity disorder: A meta-analysis publication-title: Psychol. Med. doi: 10.1017/S0033291713001037 – volume: 176 start-page: 531 year: 2019 end-page: 542 ident: CR27 article-title: Brain imaging of the cortex in ADHD: A coordinated analysis of large-scale clinical and population-based samples publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2019.18091033 – volume: 65 start-page: 46 year: 2009 end-page: 54 ident: CR1 article-title: Childhood predictors of adult attention-deficit/hyperactivity disorder: Results from the World Health Organization World Mental Health Survey Initiative publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2008.10.005 – volume: 150 start-page: 885 year: 1993 end-page: 890 ident: CR30 article-title: The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder publication-title: Am. J. Psychiatry – volume: 54 start-page: 2006 year: 2011 end-page: 2019 ident: CR53 article-title: Adjusting the effect of nonstationarity in cluster-based and TFCE inference publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.09.088 – year: 2020 ident: CR7 article-title: Shared genetic background between children and adults with attention deficit/hyperactivity disorder publication-title: Neuropsychopharmacology doi: 10.1038/s41386-020-0664-5 – ident: CR57 – volume: 76 start-page: 616 year: 2014 end-page: 628 ident: CR25 article-title: Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: A systematic review and meta-analysis publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2013.10.016 – volume: 68 start-page: 978 year: 2001 end-page: 989 ident: CR39 article-title: A new statistical method for haplotype reconstruction from population data publication-title: Am. J. Hum. Genet. doi: 10.1086/319501 – volume: 254 start-page: 41 year: 2016 end-page: 47 ident: CR14 article-title: Brain abnormalities in adults with Attention Deficit Hyperactivity Disorder revealed by voxel-based morphometry publication-title: Psychiatry Res. doi: 10.1016/j.pscychresns.2016.06.002 – volume: 254 start-page: 41 year: 2016 end-page: 47 ident: CR26 article-title: Brain abnormalities in adults with attention deficit hyperactivity disorder revealed by voxel-based morphometry publication-title: Psychiatry Res. Neuroimag. doi: 10.1016/j.pscychresns.2016.06.002 – volume: 13 start-page: 180 year: 2019 ident: CR23 article-title: Neural correlates of verbal working memory: An fMRI meta-analysis publication-title: Front. Human Neurosci. doi: 10.3389/fnhum.2019.00180 – volume: 10 start-page: 149 year: 2011 end-page: 157 ident: CR40 article-title: Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study publication-title: Genes Brain Behav. doi: 10.1111/j.1601-183X.2010.00649.x – volume: 15 start-page: 1053 year: 2010 end-page: 1066 ident: CR10 article-title: A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication publication-title: Mol. Psychiatry doi: 10.1038/mp.2010.6 – year: 1998 ident: CR31 publication-title: ADHD Rating Scale-IV: Checlist, Norms and Clinical Interpretation – volume: 212 start-page: 116683 year: 2020 ident: CR22 article-title: Exploring brain-behavior relationships in the N-back task publication-title: Neuroimage doi: 10.1016/j.neuroimage.2020.116683 – year: 2020 ident: CR9 article-title: Meta-analysis and systematic review of ADGRL3 (LPHN3) polymorphisms in ADHD susceptibility publication-title: Mol. Psychiatry doi: 10.1038/s41380-020-0673-0 – volume: 16 start-page: 1215 year: 1988 ident: CR38 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res doi: 10.1093/nar/16.3.1215 – year: 1982 ident: CR36 publication-title: National Adult Reading Test (NART): For the Assessment of Premorbid Intelligence in Patients with Dementia: Test Manual – year: 1999 ident: CR32 publication-title: Conners’ Adult ADHD Rating Scale (CAARS): Technical manual – volume: 70 start-page: 185 year: 2013 end-page: 198 ident: CR17 article-title: Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: Exploring task-specific, stimulant medication, and age effects publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2013.277 – year: 2000 ident: CR2 publication-title: Diagnostic and Statistical Manual of Mental Disorders – volume: 14 start-page: 419 year: 2015 end-page: 427 ident: CR11 article-title: LPHN3 and attention-deficit/hyperactivity disorder: A susceptibility and pharmacogenetic study publication-title: Genes Brain Behav doi: 10.1111/gbb.12224 – volume: 23 start-page: S208 issue: Suppl 1 year: 2004 end-page: 219 ident: CR48 article-title: Advances in functional and structural MR image analysis and implementation as FSL publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.07.051 – volume: 51 start-page: 63 year: 2019 end-page: 75 ident: CR6 article-title: Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder publication-title: Nat. Genet. doi: 10.1038/s41588-018-0269-7 – year: 1999 ident: CR28 publication-title: Conners Adult ADHD Diagnostic Interview for DSM-IV – ident: CR3 – volume: 84 start-page: 45 year: 2014 end-page: 64 ident: CR54 article-title: Post-hoc power estimation for topological inference in fMRI publication-title: Neuroimage doi: 10.1016/j.neuroimage.2013.07.072 – year: 2015 ident: CR18 article-title: functional imaging changes in the medial prefrontal cortex in adult ADHD publication-title: J. Attent. Disord. doi: 10.1177/1087054715611492 – volume: 20 start-page: 45 year: 2001 end-page: 57 ident: CR42 article-title: Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm publication-title: IEEE Trans. Med. Imaging doi: 10.1109/42.906424 – volume: 8 start-page: 907 year: 2019 ident: CR12 article-title: Genetic variation underpinning ADHD risk in a Caribbean community publication-title: Cells doi: 10.3390/cells8080907 – volume: 86 start-page: 81 year: 2014 end-page: 90 ident: CR43 article-title: Validity of modulation and optimal settings for advanced voxel-based morphometry publication-title: Neuroimage doi: 10.1016/j.neuroimage.2013.07.084 – volume: 17 start-page: 825 year: 2002 end-page: 841 ident: CR49 article-title: Improved optimization for the robust and accurate linear registration and motion correction of brain images publication-title: Neuroimage doi: 10.1016/s1053-8119(02)91132-8 – volume: 5 start-page: 229 year: 2012 end-page: 235 ident: CR29 article-title: Validez de criterio y concurrente versión española de la Conners Adult ADHD Diagnostic Interview for DSM-IV publication-title: Rev. Psiquiatr. Salud Ment. doi: 10.1016/j.rpsm.2012.05.004 – volume: 100 start-page: 1 year: 2019 end-page: 8 ident: CR19 article-title: Brain alterations in children/adolescents with ADHD revisited: A neuroimaging meta-analysis of 96 structural and functional studies publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2019.02.011 – volume: 21 start-page: 872 year: 2016 end-page: 884 ident: CR8 article-title: Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies publication-title: Mol. Psychiatry doi: 10.1038/mp.2016.74 – volume: 45 start-page: 190179 year: 2020 ident: CR21 article-title: Non-invasive brain stimulation in children and adults with attention-deficit/hyperactivity disorder: A systematic review and meta-analysis publication-title: J. Psychiatry Neurosci. doi: 10.1503/jpn.190179 – volume: 57 start-page: 1215 year: 2005 end-page: 1220 ident: CR4 article-title: Attention-deficit/hyperactivity disorder: A selective overview publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2004.10.020 – volume: 14 start-page: 1238 year: 2001 end-page: 1243 ident: CR44 article-title: Why voxel-based morphometry should be used publication-title: Neuroimage doi: 10.1006/nimg.2001.0961 – volume: 20 start-page: 1052 year: 2003 end-page: 1063 ident: CR55 article-title: General multilevel linear modeling for group analysis in FMRI publication-title: Neuroimage doi: 10.1016/S1053-8119(03)00435-X – volume: 73 start-page: 815 year: 2016 end-page: 825 ident: CR15 article-title: Structural and functional brain abnormalities in attention-deficit/hyperactivity disorder and obsessive-compulsive disorder: A comparative meta-analysis publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2016.0700 – volume-title: Structured Clinical Interview for DSM-IV Axis I Disorders: Research version, Patient Edition year: 2002 ident: 81915_CR33 – volume: 23 start-page: S208 issue: Suppl 1 year: 2004 ident: 81915_CR48 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.07.051 – volume: 57 start-page: 1215 year: 2005 ident: 81915_CR4 publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2004.10.020 – volume: 76 start-page: 616 year: 2014 ident: 81915_CR25 publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2013.10.016 – volume: 176 start-page: 531 year: 2019 ident: 81915_CR27 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2019.18091033 – volume: 14 start-page: 1238 year: 2001 ident: 81915_CR44 publication-title: Neuroimage doi: 10.1006/nimg.2001.0961 – volume: 73 start-page: 815 year: 2016 ident: 81915_CR15 publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2016.0700 – volume: 57 start-page: 1313 year: 2005 ident: 81915_CR5 publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2004.11.024 – volume: 54 start-page: 2006 year: 2011 ident: 81915_CR53 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.09.088 – volume: 5 start-page: 229 year: 2012 ident: 81915_CR29 publication-title: Rev. Psiquiatr. Salud Ment. doi: 10.1016/j.rpsm.2012.05.004 – volume: 62 start-page: 1184 year: 2004 ident: 81915_CR37 publication-title: Neurology doi: 10.1212/01.wnl.0000103169.80910.8b – volume-title: Signal Detection Theory and Psychophysics year: 1966 ident: 81915_CR47 – volume: 84 start-page: 45 year: 2014 ident: 81915_CR54 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2013.07.072 – volume: 21 start-page: 1732 year: 2004 ident: 81915_CR56 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2003.12.023 – volume: 5 start-page: 143 year: 2001 ident: 81915_CR51 publication-title: Med. Image Anal. doi: 10.1016/s1361-8415(01)00036-6 – year: 2020 ident: 81915_CR9 publication-title: Mol. Psychiatry doi: 10.1038/s41380-020-0673-0 – volume: 70 start-page: 185 year: 2013 ident: 81915_CR17 publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2013.277 – volume: 17 start-page: 825 year: 2002 ident: 81915_CR49 publication-title: Neuroimage doi: 10.1016/s1053-8119(02)91132-8 – year: 2015 ident: 81915_CR18 publication-title: J. Attent. Disord. doi: 10.1177/1087054715611492 – volume-title: Conners Adult ADHD Diagnostic Interview for DSM-IV year: 1999 ident: 81915_CR28 – volume: 14 start-page: 419 year: 2015 ident: 81915_CR11 publication-title: Genes Brain Behav doi: 10.1111/gbb.12224 – volume: 16 start-page: 1215 year: 1988 ident: 81915_CR38 publication-title: Nucleic Acids Res doi: 10.1093/nar/16.3.1215 – year: 2020 ident: 81915_CR7 publication-title: Neuropsychopharmacology doi: 10.1038/s41386-020-0664-5 – volume: 212 start-page: 116683 year: 2020 ident: 81915_CR22 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2020.116683 – volume: 21 start-page: 872 year: 2016 ident: 81915_CR8 publication-title: Mol. Psychiatry doi: 10.1038/mp.2016.74 – volume: 15 start-page: 1053 year: 2010 ident: 81915_CR10 publication-title: Mol. Psychiatry doi: 10.1038/mp.2010.6 – volume: 27 start-page: 287 year: 2013 ident: 81915_CR46 publication-title: Neuropsychology doi: 10.1037/a0032371 – volume: 8 start-page: 907 year: 2019 ident: 81915_CR12 publication-title: Cells doi: 10.3390/cells8080907 – volume: 20 start-page: 1052 year: 2003 ident: 81915_CR55 publication-title: Neuroimage doi: 10.1016/S1053-8119(03)00435-X – ident: 81915_CR57 – volume-title: Diagnostic and Statistical Manual of Mental Disorders year: 2000 ident: 81915_CR2 – volume: 44 start-page: 869 year: 2014 ident: 81915_CR24 publication-title: Psychol. Med. doi: 10.1017/S0033291713001037 – volume: 254 start-page: 41 year: 2016 ident: 81915_CR14 publication-title: Psychiatry Res. doi: 10.1016/j.pscychresns.2016.06.002 – volume-title: Interview for DSM-IV Axis II Personality Disorders SCID-II year: 1997 ident: 81915_CR34 – volume: 10 start-page: 149 year: 2011 ident: 81915_CR40 publication-title: Genes Brain Behav. doi: 10.1111/j.1601-183X.2010.00649.x – volume: 25 start-page: 529 year: 2016 ident: 81915_CR16 publication-title: Eur. Child Adolesc. Psychiatry doi: 10.1007/s00787-015-0755-8 – volume: 254 start-page: 41 year: 2016 ident: 81915_CR26 publication-title: Psychiatry Res. Neuroimag. doi: 10.1016/j.pscychresns.2016.06.002 – volume-title: Conners’ Adult ADHD Rating Scale (CAARS): Technical manual year: 1999 ident: 81915_CR32 – volume: 100 start-page: 1 year: 2019 ident: 81915_CR19 publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2019.02.011 – volume: 44 start-page: 83 year: 2009 ident: 81915_CR52 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.03.061 – volume-title: ADHD Rating Scale-IV: Checlist, Norms and Clinical Interpretation year: 1998 ident: 81915_CR31 – volume: 150 start-page: 885 year: 1993 ident: 81915_CR30 publication-title: Am. J. Psychiatry doi: 10.1176/ajp.150.6.885 – volume-title: National Adult Reading Test (NART): For the Assessment of Premorbid Intelligence in Patients with Dementia: Test Manual year: 1982 ident: 81915_CR36 – volume: 86 start-page: 81 year: 2014 ident: 81915_CR43 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2013.07.084 – volume: 17 start-page: 143 year: 2002 ident: 81915_CR41 publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.10062 – volume: 87 start-page: 128 year: 1993 ident: 81915_CR45 publication-title: Electroencephalogr. Clin. Neurophysiol. doi: 10.1016/0013-4694(93)90119-G – volume: 45 start-page: 190179 year: 2020 ident: 81915_CR21 publication-title: J. Psychiatry Neurosci. doi: 10.1503/jpn.190179 – volume: 168 start-page: 1154 year: 2011 ident: 81915_CR13 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2011.11020281 – volume: 13 start-page: 180 year: 2019 ident: 81915_CR23 publication-title: Front. Human Neurosci. doi: 10.3389/fnhum.2019.00180 – volume: 51 start-page: 63 year: 2019 ident: 81915_CR6 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0269-7 – volume: 14 start-page: 1370 year: 2001 ident: 81915_CR50 publication-title: Neuroimage doi: 10.1006/nimg.2001.0931 – ident: 81915_CR3 – volume: 68 start-page: 978 year: 2001 ident: 81915_CR39 publication-title: Am. J. Hum. Genet. doi: 10.1086/319501 – volume: 65 start-page: 46 year: 2009 ident: 81915_CR1 publication-title: Biol. Psychiat. doi: 10.1016/j.biopsych.2008.10.005 – volume: 128 start-page: 175 year: 2011 ident: 81915_CR35 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2010.11.016 – volume: 50 start-page: 894 year: 2020 ident: 81915_CR20 publication-title: Psychol. Med. doi: 10.1017/S0033291720000574 – volume: 20 start-page: 45 year: 2001 ident: 81915_CR42 publication-title: IEEE Trans. Med. Imaging doi: 10.1109/42.906424 |
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| Score | 2.3224964 |
| Snippet | Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (
ADGRL3
; formerly
latrophilin 3, LPHN3
) is associated with... Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with... Abstract Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated... |
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| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
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| SubjectTerms | 631/1647/1513/2192 631/1647/245/1627 631/1647/245/1628 692/617/375/366/1311 Adult Attention Deficit Disorder with Hyperactivity - diagnosis Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Brain Brain - metabolism Brain - physiopathology Brain mapping Case-Control Studies Cognitive ability Cortex (frontal) Cortex (parietal) Female Functional magnetic resonance imaging Functional Neuroimaging Genetic Association Studies Genetic Predisposition to Disease Genotype Haplotypes Humanities and Social Sciences Humans Hyperactivity Image Processing, Computer-Assisted Male Memory Middle Aged Morphometry multidisciplinary Neuroimaging Receptors, G-Protein-Coupled - genetics Receptors, Peptide - genetics Science Science (multidisciplinary) Short term memory Statistical analysis Structure-function relationships Temporal lobe Young Adult |
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| Title | Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder |
| URI | https://link.springer.com/article/10.1038/s41598-021-81915-z https://www.ncbi.nlm.nih.gov/pubmed/33504901 https://www.proquest.com/docview/2481000816 https://www.proquest.com/docview/2482662780 https://pubmed.ncbi.nlm.nih.gov/PMC7840726 http://kipublications.ki.se/Default.aspx?queryparsed=id:147073726 https://doaj.org/article/d6a7a4f2ed7241499062980a6f50f247 |
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