神经肽Y基因多态性和精神分裂症的关联研究

目的·探讨中国汉族人群神经肽Y（NPY）基因多态性与精神分裂症的相关性。方法·采用Taq Man探针基因分型技术对678例精神分裂症患者（病例组）及685例正常对照者（对照组）的NPY基因多态性（rs16148、rs1859290、rs16147、rs16478）进行分型。应用SHEsis在线软件比较各组间的等位基因频率、基因型频率、单倍型频率分布有无差异。结果·rs16478位点基因型频率分布在成年起病精神分裂症（AOS）组和对照组间存在边缘统计学差异（χ^2=6.66,P=0.036,P（校正）=0.144）。在隐性模式下,rs1859290位点CC基因型的频率分布在男性病例组和对照组间差...

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Published in上海交通大学学报（医学版） Vol. 37; no. 12; pp. 1581 - 1587
Main Author 赵静;吕钦谕;陆颖;胡国芹;鲍晨曦;朱明环;贾思;程小燕;耿瑞杰;姜雅琴;禹顺英;易正辉
Format Journal Article
LanguageChinese
Published 上海交通大学 医学院附属精神卫生中心,上海,200030%上海市虹口区精神卫生中心,上海,200083 2017
Subjects
关联分析
单核苷酸多态性
神经肽Y
精神分裂症
精神分裂症
single nucleotide polymorphism
单核苷酸多态性
neuropeptide Y
association study
关联分析
神经肽Y
schizophrenia
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ISSN1674-8115
DOI10.3969/j.issn.1674-8115.2017.12.001

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Summary:目的·探讨中国汉族人群神经肽Y（NPY）基因多态性与精神分裂症的相关性。方法·采用Taq Man探针基因分型技术对678例精神分裂症患者（病例组）及685例正常对照者（对照组）的NPY基因多态性（rs16148、rs1859290、rs16147、rs16478）进行分型。应用SHEsis在线软件比较各组间的等位基因频率、基因型频率、单倍型频率分布有无差异。结果·rs16478位点基因型频率分布在成年起病精神分裂症（AOS）组和对照组间存在边缘统计学差异（χ^2=6.66,P=0.036,P（校正）=0.144）。在隐性模式下,rs1859290位点CC基因型的频率分布在男性病例组和对照组间差异有统计学意义（P=0.012,OR=0.97,95%CI为0.94-0.99,P（校正）=0.048）。单倍型CCTA（由rs16148、rs1859290、rs16147、rs16478构成）的频率分布在男性AOS组和对照组间的差异有统计学意义（8.1%vs 13.2%,OR=0.57,P=0.010,P校正=0.040）。结论·在中国汉族人群中,NPY基因可能是精神分裂症的易感基因。
Bibliography:31-2045/R
ZHAO Jing1, LU Qin-yu1, LU Ying1, HU Guo-qin1, BAO Chen-xi1, ZHU Ming-huan1, JIA Si1, CHENG Xiao-yan1, GENG Rui-jie1, JIANG Ya-qin2, YU Shun-ying1, YI Zheng-hui1（1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Hongkou District Mental Health Center, Shanghai 200083, China）
neuropeptide Y; schizophrenia; association study; single nucleotide polymorphism
Objective·To explore the association between neuropeptide Y （NPY） gene polymorphism and schizophrenia in Chinese Han population. Methods·Four single nucleotide polymorphism （SNP） loci （rs16148, rs1859290, rs16147, and rs16478 in NPY gene） were selected and genotyped by TaqMan genotyping assay in a case-control study with 678 schizophrenia cases （case group） and 685 healthy controls （control group）. The allele, genotype and haplotype frequencies distribution of the SNPs between the groups were compared with SHEsis online software. Results·The distribution of genotype frequency of locus
ISSN:1674-8115
DOI:10.3969/j.issn.1674-8115.2017.12.001