线粒体融合基因2在肝细胞癌中的杂合性缺失及意义
R730.231; 目的:探讨线粒体融合基因2(Mfn2)在肝癌患者中的杂合性缺失(LOH)特点及其临床意义.方法:选用位于Mfn2附近的4个多态性微卫星标记,对29例肝癌患者进行LOH分析.结果:微卫星D1S2667、D1S2740、D1S434和D1S228的LOH发生率分别为21%、23%、21%和22%.Mfn2基因LOH患者的HBV感染,与患者年龄、肿瘤大小、包膜的完整性及分化程度存在一定的相关性(P<0.05);与患者性别、HCV感染、有无癌栓、肝内肿瘤的多发性、有无肝硬化以及AFP值高低无明显相关(P>0.05).结论:肝癌患者Mfn2基因发生LOH与临床病理参数有一...
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| Published in | 浙江大学学报（医学版） Vol. 39; no. 5; pp. 506 - 510 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
浙江大学医学院附属第一医院肝胆外科,浙江,杭州,310003
2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-9292 |
| DOI | 10.3785/j.issn.1008-9292.2010.05.011 |
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| Abstract | R730.231; 目的:探讨线粒体融合基因2(Mfn2)在肝癌患者中的杂合性缺失(LOH)特点及其临床意义.方法:选用位于Mfn2附近的4个多态性微卫星标记,对29例肝癌患者进行LOH分析.结果:微卫星D1S2667、D1S2740、D1S434和D1S228的LOH发生率分别为21%、23%、21%和22%.Mfn2基因LOH患者的HBV感染,与患者年龄、肿瘤大小、包膜的完整性及分化程度存在一定的相关性(P<0.05);与患者性别、HCV感染、有无癌栓、肝内肿瘤的多发性、有无肝硬化以及AFP值高低无明显相关(P>0.05).结论:肝癌患者Mfn2基因发生LOH与临床病理参数有一定的相关性,其在肝癌的发生和发展过程中起到一定作用. |
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| AbstractList | R730.231; 目的:探讨线粒体融合基因2(Mfn2)在肝癌患者中的杂合性缺失(LOH)特点及其临床意义.方法:选用位于Mfn2附近的4个多态性微卫星标记,对29例肝癌患者进行LOH分析.结果:微卫星D1S2667、D1S2740、D1S434和D1S228的LOH发生率分别为21%、23%、21%和22%.Mfn2基因LOH患者的HBV感染,与患者年龄、肿瘤大小、包膜的完整性及分化程度存在一定的相关性(P<0.05);与患者性别、HCV感染、有无癌栓、肝内肿瘤的多发性、有无肝硬化以及AFP值高低无明显相关(P>0.05).结论:肝癌患者Mfn2基因发生LOH与临床病理参数有一定的相关性,其在肝癌的发生和发展过程中起到一定作用. |
| Author | 瞿丽 王伟林 郑树森 周武华 尉建锋 |
| AuthorAffiliation | 浙江大学医学院附属第一医院肝胆外科,浙江,杭州,310003 |
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| Author_FL | ZHENG Shu-sen WEI Jian-feng QU Li ZHOU Wu-hua WANG Wei-ling |
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| Author_xml | – sequence: 1 fullname: 瞿丽 – sequence: 2 fullname: 王伟林 – sequence: 3 fullname: 尉建锋 – sequence: 4 fullname: 周武华 – sequence: 5 fullname: 郑树森 |
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| Keywords | 线粒体蛋白质类 杂合子丢失 癌,肝细胞 基因缺失 |
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| Title | 线粒体融合基因2在肝细胞癌中的杂合性缺失及意义 |
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