Integrated exposure assessment of sewage workers to genotoxicants: an urinary biomarker approach and oxidative stress evaluation
Background Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays...
Saved in:
| Published in | Environmental health Vol. 10; no. 1; p. 23 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
24.03.2011
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1476-069X 1476-069X |
| DOI | 10.1186/1476-069X-10-23 |
Cover
| Abstract | Background
Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by
in vitro
comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine.
Methods
During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels.
Results
Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m
-3
for fluoranthene) and volatile organic compounds (e.g. 19.1 ± 2.9 [standard error] μ.m
-3
for benzene) were elevated in sewage compared to office workplaces (
P
< 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (
P
< 0.001) than office workers.
Conclusions
The integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. |
|---|---|
| AbstractList | BACKGROUND: Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2' deoxyguanosine. METHODS: During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2' deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels. RESULTS: Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m-3 for fluoranthene) and volatile organic compounds (e.g. 19.1+/-2.9 [standard error] u.m-3 for benzene) were elevated in sewage compared to office workplaces (P<0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (P<0.001) than office workers. CONCLUSIONS: The integrated and non specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine. During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels. Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m.sup.-3 .sup.for fluoranthene) and volatile organic compounds (e.g. 19.1 [+ -] 2.9 [standard error] [mu].m.sup.-3 .sup.for benzene) were elevated in sewage compared to office workplaces (P [less than] 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (P [less than] 0.001) than office workers. The integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. Abstract Background: Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine. Methods: During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels. Results: Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m-3 for fluoranthene) and volatile organic compounds (e.g. 19.1 ± 2.9 [standard error] μ.m-3 for benzene) were elevated in sewage compared to office workplaces (P < 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (P < 0.001) than office workers. Conclusions: The integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine.BACKGROUNDSewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine.During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels.METHODSDuring three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels.Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m-3 for fluoranthene) and volatile organic compounds (e.g. 19.1 ± 2.9 [standard error] μ.m-3 for benzene) were elevated in sewage compared to office workplaces (P < 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (P < 0.001) than office workers.RESULTSWorkplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m-3 for fluoranthene) and volatile organic compounds (e.g. 19.1 ± 2.9 [standard error] μ.m-3 for benzene) were elevated in sewage compared to office workplaces (P < 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (P < 0.001) than office workers.The integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace.CONCLUSIONSThe integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine. During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels. Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m-3 for fluoranthene) and volatile organic compounds (e.g. 19.1 ± 2.9 [standard error] μ.m-3 for benzene) were elevated in sewage compared to office workplaces (P < 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (P < 0.001) than office workers. The integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. Background Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine. Methods During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels. Results Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m.sup.-3 .sup.for fluoranthene) and volatile organic compounds (e.g. 19.1 [+ -] 2.9 [standard error] [mu].m.sup.-3 .sup.for benzene) were elevated in sewage compared to office workplaces (P [less than] 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity (P [less than] 0.001) than office workers. Conclusions The integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. Background Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We aimed to explore integrated urinary biomarkers, assessing the overall urine genotoxicity by in vitro comet and micronucleus assays and measuring urinary 8-oxo-2'-deoxyguanosine. Methods During three consecutive working days, polycyclic aromatic hydrocarbons and volatile organic compounds were sampled in workplace air of 34 sewage and 30 office workers, as indicators of airborne exposure. The last day, subjects collected their 24 hours urine. Genotoxicity of urinary extracts was assessed by comet and micronucleus assays on a HepG2 cell line. Using competitive enzymatic immunoassay we evaluated the 24 hours urinary 8-oxo-2'-deoxyguanosine excretion. Benzo(a)pyrene toxicity equivalent factors and inhalation unit risk for Benzo(a)pyrene and benzene were used to give an estimate of cancer risk levels. Results Workplace air concentrations of polycyclic aromatic hydrocarbons (e.g. 23.7 [range 2.4-104.6] ng.m -3 for fluoranthene) and volatile organic compounds (e.g. 19.1 ± 2.9 [standard error] μ.m -3 for benzene) were elevated in sewage compared to office workplaces ( P < 0.01) and corresponded to an increased lifetime cancer risk. The urinary extracts of sewage workers showed higher genotoxicity ( P < 0.001) than office workers. Conclusions The integrated and non-specific urinary biomarkers of exposure showed that sewage workers experience exposure to mixtures of genotoxicants in the workplace. |
| ArticleNumber | 23 |
| Audience | Academic |
| Author | Zmirou-Navier, Denis Ferrari, Luc Sari-Minodier, Irène Paris, Christophe Al Zabadi, Hamzeh Tiberguent, Aziz Kerautret, Marie-Aude |
| AuthorAffiliation | 5 Aix-Marseille University School of Medicine, EA 1784, 13005 Marseille, France 7 Occupational medicine service of the City of Paris, France 3 Nancy University Faculty of Pharmacy, 54000 Nancy, France 2 INSERM U954, School of Medicine, 54505 Vandœuvre-lès-Nancy, France 1 An-Najah National University, School of Medicine-Public Health Department, Nablus, Palestine 8 EHESP School of Public Health-IRSET, 35000 Rennes, France 6 Paris City Hygiene laboratory, Paris, France 4 Nancy University School of Medicine, 54505 Vandœuvre-lès-Nancy, France |
| AuthorAffiliation_xml | – name: 2 INSERM U954, School of Medicine, 54505 Vandœuvre-lès-Nancy, France – name: 8 EHESP School of Public Health-IRSET, 35000 Rennes, France – name: 1 An-Najah National University, School of Medicine-Public Health Department, Nablus, Palestine – name: 4 Nancy University School of Medicine, 54505 Vandœuvre-lès-Nancy, France – name: 3 Nancy University Faculty of Pharmacy, 54000 Nancy, France – name: 5 Aix-Marseille University School of Medicine, EA 1784, 13005 Marseille, France – name: 7 Occupational medicine service of the City of Paris, France – name: 6 Paris City Hygiene laboratory, Paris, France |
| Author_xml | – sequence: 1 givenname: Hamzeh surname: Al Zabadi fullname: Al Zabadi, Hamzeh email: halzabadi@gmail.com organization: An-Najah National University, School of Medicine-Public Health Department, INSERM U954, School of Medicine, 54505 Vandœuvre-lès-Nancy, Nancy University School of Medicine – sequence: 2 givenname: Luc surname: Ferrari fullname: Ferrari, Luc organization: INSERM U954, School of Medicine, 54505 Vandœuvre-lès-Nancy, Nancy University Faculty of Pharmacy – sequence: 3 givenname: Irène surname: Sari-Minodier fullname: Sari-Minodier, Irène organization: Aix-Marseille University School of Medicine – sequence: 4 givenname: Marie-Aude surname: Kerautret fullname: Kerautret, Marie-Aude organization: Paris City Hygiene laboratory – sequence: 5 givenname: Aziz surname: Tiberguent fullname: Tiberguent, Aziz organization: Occupational medicine service of the City of Paris – sequence: 6 givenname: Christophe surname: Paris fullname: Paris, Christophe organization: INSERM U954, School of Medicine, 54505 Vandœuvre-lès-Nancy, Nancy University School of Medicine – sequence: 7 givenname: Denis surname: Zmirou-Navier fullname: Zmirou-Navier, Denis organization: INSERM U954, School of Medicine, 54505 Vandœuvre-lès-Nancy, Nancy University School of Medicine, EHESP School of Public Health-IRSET |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21435260$$D View this record in MEDLINE/PubMed https://inserm.hal.science/inserm-00583422$$DView record in HAL |
| BookMark | eNp9ks1v1DAQxSNURD_gzA1ZcODCtv6O3QNSVQFdaSUuIHGzvM4kdcnai51s2xt_Ok63lLYClIOj8e89z4zefrUTYoCqeknwISFKHhFeyxmW-tuM4BllT6q9u8rOvf_daj_nC4xJraR4Vu1SwpmgEu9VP-dhgC7ZARoEV-uYxwTI5gw5ryAMKLYow6XtAF3G9B1SRkNEHYQ4xCvvbBjyMbIBjckHm67R0seVnThk1-sUrTsvtw0qbGMHvwGUh1SsEWxsP5ZKDM-rp63tM7y4PQ-qrx8_fDk9my0-f5qfnixmTjI8zDSWTdvWSi9ZyzC4tuUgtFsyITjYVuqGNg2XjSyTac0cr5lTQlPrQHBuLTuo5lvfJtoLs06-9HltovXmphBTZ2wavOvBOMo150LoGtecSKkEawglSkkOVIIqXu-3XutxuYLGlUUl2z8wfXgT_Lnp4sYwXBOGdTF4tzU4fyQ7O1kYHzKklcFYKMYp3ZCCv719L8UfI-TBrHx20Pc2QByzURIrRQSrC_n6EXkRxxTKYo3GlCnFiCzQmy3U2TKtD20sTbrJ0pxQwTjWQk1DHv6FKl8DK-9KDFtf6g8Er-5v5W6u32ErwNEWcCnmnKC9Qwg2U5zNFFgzBXaqUFYU4pHC-eEmNqUX3_9Hh7e6XF4IHaQ_a_iX5BcnNggD |
| CitedBy_id | crossref_primary_10_1016_j_heliyon_2023_e22516 crossref_primary_10_1007_s11356_017_1045_4 crossref_primary_10_1016_j_toxlet_2011_11_011 crossref_primary_10_1016_j_molliq_2023_122506 crossref_primary_10_1016_j_scitotenv_2022_154233 crossref_primary_10_1007_s10661_021_08878_6 crossref_primary_10_1080_10937404_2019_1692744 crossref_primary_10_17795_jhealthscope_16440 crossref_primary_10_3390_ijerph14040389 crossref_primary_10_1016_j_envres_2016_10_012 crossref_primary_10_1016_j_mrgentox_2023_503598 crossref_primary_10_3390_cancers14205164 crossref_primary_10_1080_10937404_2014_976893 crossref_primary_10_3390_ijms20081908 crossref_primary_10_1016_j_biochi_2023_02_006 crossref_primary_10_4236_abb_2012_327118 crossref_primary_10_47470_0016_9900_2022_101_11_1328_1333 crossref_primary_10_3390_toxics12040270 |
| Cites_doi | 10.1186/1471-2407-8-67 10.1016/j.ecoenv.2004.12.010 10.1196/annals.1454.013 10.1080/03602530601093489 10.1093/carcin/23.2.273 10.1016/S1383-5718(99)00034-0 10.1016/j.watres.2004.04.036 10.1016/j.scitotenv.2008.08.015 10.1136/oem.56.10.672 10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J 10.1016/0273-2300(92)90009-X 10.1093/mutage/geg031 10.1002/(SICI)1098-2280(2000)35:3<167::AID-EM3>3.0.CO;2-G 10.1289/ehp.9334 10.1016/j.chemosphere.2004.10.040 10.1093/oxfordjournals.aje.a114478 10.1289/ehp.9330 10.1016/j.mrfmmm.2005.01.022 10.1016/j.toxlet.2006.08.011 10.1016/S0021-9258(18)65610-8 10.1038/nprot.2007.77 10.1002/1098-2280(2000)36:1<52::AID-EM8>3.0.CO;2-9 10.1136/oem.2005.022954 10.1136/oem.60.8.595 10.1080/10715760500190115 10.1006/rtph.1998.1235 10.1136/oem.54.7.494 10.1080/15287399209531687 10.1002/em.20384 10.1016/S0045-6535(98)00186-6 10.1158/1055-9965.EPI-04-0899 10.1136/oem.57.9.577 10.1017/S1462399409001197 10.1016/S0048-9697(99)00192-8 10.1016/S0048-9697(03)00054-8 10.1089/ars.2006.8.1011 10.1007/s11745-001-0844-z 10.1289/ehp.8562 10.1016/0014-4827(88)90265-0 10.1016/S1383-5718(00)00051-6 10.2134/jeq1999.00472425002800010021x |
| ContentType | Journal Article |
| Copyright | Al Zabadi et al; licensee BioMed Central Ltd. 2011 COPYRIGHT 2011 BioMed Central Ltd. 2011 Al Zabadi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Distributed under a Creative Commons Attribution 4.0 International License Copyright ©2011 Al Zabadi et al; licensee BioMed Central Ltd. 2011 Al Zabadi et al; licensee BioMed Central Ltd. |
| Copyright_xml | – notice: Al Zabadi et al; licensee BioMed Central Ltd. 2011 – notice: COPYRIGHT 2011 BioMed Central Ltd. – notice: 2011 Al Zabadi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. – notice: Distributed under a Creative Commons Attribution 4.0 International License – notice: Copyright ©2011 Al Zabadi et al; licensee BioMed Central Ltd. 2011 Al Zabadi et al; licensee BioMed Central Ltd. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T2 7U7 7X7 7XB 88E 8C1 8FE 8FG 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ATCPS AZQEC BENPR BGLVJ BHPHI C1K CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. L6V M0S M1P M7S PATMY PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY 7X8 1XC VOOES 5PM DOA |
| DOI | 10.1186/1476-069X-10-23 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health and Safety Science Abstracts (Full archive) Toxicology Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Public Health Database ProQuest SciTech Collection ProQuest Technology Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Agricultural & Environmental Science Collection ProQuest Central Essentials ProQuest Central Technology Collection ProQuest Natural Science Collection (Hollins) Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Engineering Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Engineering Database Environmental Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering collection Environmental Science Collection MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Technology Collection ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection ProQuest Engineering Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Agricultural & Environmental Science Collection Health & Safety Science Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Engineering Database ProQuest Public Health Toxicology Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Environmental Science Collection ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Materials Science & Engineering Collection Environmental Science Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Public Health |
| EISSN | 1476-069X |
| EndPage | 23 |
| ExternalDocumentID | oai_doaj_org_article_c249445597074166853d1218864e26e8 PMC3071309 oai_HAL_inserm_00583422v1 2504416251 A253409588 21435260 10_1186_1476_069X_10_23 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | France |
| GeographicLocations_xml | – name: France |
| GroupedDBID | --- 0R~ 29G 2VQ 2WC 2XV 4.4 4P2 53G 5GY 5VS 6PF 7X7 7XC 88E 8C1 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAJSJ AASML AAWTL ABDBF ABJCF ABUWG ACGFO ACGFS ACIHN ACIWK ACPRK ACUHS ADBBV ADFRT ADRAZ ADUKV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS ATCPS BAPOH BAWUL BCNDV BENPR BFQNJ BGLVJ BHPHI BMC BPHCQ BVXVI C1A C6C CCPQU CS3 DIK E3Z EAD EAP EAS EBD EBLON EBS ECGQY EJD EMB EMK EMOBN ESTFP ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HCIFZ HMCUK HYE IAO IEP IHR INH INR IPNFZ ITC ITG ITH KQ8 L6V L7B M1P M48 M7S M~E O5R O5S OK1 OVT PATMY PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PUEGO PYCSY RBZ RIG RNS ROL RPM RSV SEV SOJ SV3 TR2 TUS U2A UKHRP WOQ WOW XSB AAYXX ALIPV CITATION -5A -5G -A0 -BR 3V. ACRMQ ADINQ C24 CGR CUY CVF ECM EIF FRP NPM PMFND 7T2 7U7 7XB 8FK AZQEC C1K DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 1XC VOOES 5PM |
| ID | FETCH-LOGICAL-c630t-906dff789b3f30ecff4e59cb3554eaf69d2dd46d6143993c473c8592ace544aa3 |
| IEDL.DBID | M48 |
| ISSN | 1476-069X |
| IngestDate | Wed Aug 27 00:32:12 EDT 2025 Thu Aug 21 13:45:39 EDT 2025 Fri Sep 12 12:51:29 EDT 2025 Mon Sep 08 04:10:17 EDT 2025 Fri Jul 25 10:39:34 EDT 2025 Tue Jun 17 21:48:03 EDT 2025 Tue Jun 10 20:09:14 EDT 2025 Wed Feb 19 01:53:50 EST 2025 Tue Jul 01 02:00:17 EDT 2025 Thu Apr 24 23:03:12 EDT 2025 Sat Sep 06 07:32:10 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Lifetime Cancer Risk Micronucleus Assay Office Worker Comet Assay HepG2 Cell |
| Language | English |
| License | http://www.springer.com/tdm Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c630t-906dff789b3f30ecff4e59cb3554eaf69d2dd46d6143993c473c8592ace544aa3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0001-6417-4980 0000-0002-3159-6826 0000-0001-6923-2545 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1186/1476-069X-10-23 |
| PMID | 21435260 |
| PQID | 902388316 |
| PQPubID | 44372 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c249445597074166853d1218864e26e8 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3071309 hal_primary_oai_HAL_inserm_00583422v1 proquest_miscellaneous_860881537 proquest_journals_902388316 gale_infotracmisc_A253409588 gale_infotracacademiconefile_A253409588 pubmed_primary_21435260 crossref_primary_10_1186_1476_069X_10_23 crossref_citationtrail_10_1186_1476_069X_10_23 springer_journals_10_1186_1476_069X_10_23 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2011-03-24 |
| PublicationDateYYYYMMDD | 2011-03-24 |
| PublicationDate_xml | – month: 03 year: 2011 text: 2011-03-24 day: 24 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Environmental health |
| PublicationTitleAbbrev | Environ Health |
| PublicationTitleAlternate | Environ Health |
| PublicationYear | 2011 |
| Publisher | BioMed Central BioMed Central Ltd BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: BMC |
| References | M Fenech (398_CR25) 2007; 2 J Gasperi (398_CR18) 2008; 407 NJ Hewitt (398_CR53) 2007; 39 S Loft (398_CR27) 1999; 441 RG Faragher (398_CR49) 2009; 11 WJ Walker (398_CR16) 1999; 38 E Manoli (398_CR2) 1999; 28 MS Cooke (398_CR14) 2005; 574 FJ Bris (398_CR1) 1999; 235 398_CR33 398_CR34 E Atasoy (398_CR17) 2004; 38 R Olinski (398_CR13) 2006; 8 M Sørensen (398_CR28) 2005; 14 M Kirsch-Volders (398_CR26) 2000; 35 HH Taussky (398_CR29) 1954; 208 C Paz-y-Miño (398_CR38) 2008; 1140 JF Collins (398_CR32) 1998; 28 MA Callahan (398_CR10) 2007; 115 RA Lyons (398_CR5) 2000; 57 M Harri (398_CR39) 2005; 39 L Friis (398_CR36) 1997; 54 398_CR41 398_CR43 398_CR44 398_CR45 B Marczynski (398_CR47) 2002; 23 A Karaman (398_CR37) 2009; 14 P Pierucci (398_CR19) 2005; 59 SPSS Institute Inc (398_CR30) 2008 H Al Zabadi (398_CR21) 2008; 8 V Muller-Pillet (398_CR24) 2000; 36 AL Liu (398_CR40) 2006; 114 KB Mulloy (398_CR4) 2001; 16 398_CR48 ES Hansen (398_CR3) 2003; 60 PB Ryan (398_CR11) 2007; 115 I Mantis (398_CR20) 2005; 62 JM Scarlett-Kranz (398_CR35) 1986; 124 NP Singh (398_CR23) 1988; 175 A Aouadene (398_CR46) 2008; 49 P Wild (398_CR9) 2006; 63 K Krishnamurthi (398_CR6) 2003; 16 R Yoshida (398_CR15) 2003; 18 RJ Jandacek (398_CR50) 2001; 36 RR Tice (398_CR42) 2000; 35 SY Park (398_CR51) 2006; 167 398_CR22 IC Nisbet (398_CR31) 1992; 16 M Uhl (398_CR52) 2000; 468 XF Ma (398_CR12) 1992; 37 L Friis (398_CR8) 1999; 56 M Sorensen (398_CR7) 2003; 309 9282126 - Occup Environ Med. 1997 Jul;54(7):494-8 16675419 - Environ Health Perspect. 2006 May;114(5):673-7 11872632 - Carcinogenesis. 2002 Feb;23(2):273-81 17546000 - Nat Protoc. 2007;2(5):1084-104 17520075 - Environ Health Perspect. 2007 May;115(5):833-40 10224318 - Mutat Res. 1999 Apr 26;441(1):11-9 12798093 - Sci Total Environ. 2003 Jun 20;309(1-3):69-80 15894700 - Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1340-3 18814902 - Sci Total Environ. 2008 Dec 15;407(1):263-72 16216634 - Ecotoxicol Environ Saf. 2005 Nov;62(3):397-407 18366096 - Environ Mol Mutagen. 2008 May;49(4):283-99 3345800 - Exp Cell Res. 1988 Mar;175(1):184-91 1464904 - J Toxicol Environ Health. 1992 Dec;37(4):483-94 13174594 - J Biol Chem. 1954 Jun;208(2):853-61 16497857 - Occup Environ Med. 2006 Mar;63(3):168-72 16087477 - Free Radic Res. 2005 Sep;39(9):963-72 10535121 - Sci Total Environ. 1999 Sep 1;235(1-3):211-20 11834080 - Lipids. 2001 Dec;36(12):1289-305 11107222 - Occup Med. 2001 Jan-Mar;16(1):23-38 10737956 - Environ Mol Mutagen. 2000;35(3):206-21 10882898 - Mutat Res. 2000 Jul 10;468(2):213-25 14614189 - Mutagenesis. 2003 Nov;18(6):533-7 15914207 - Mutat Res. 2005 Jul 1;574(1-2):58-66 17364884 - Drug Metab Rev. 2007;39(1):159-234 18991910 - Ann N Y Acad Sci. 2008 Oct;1140:121-8 10935937 - Occup Environ Med. 2000 Sep;57(9):577-81 17029827 - Toxicol Lett. 2006 Nov 1;167(1):27-33 18325085 - BMC Cancer. 2008;8:67 19365775 - Clin Toxicol (Phila). 2009 Apr;47(4):321-6 1293646 - Regul Toxicol Pharmacol. 1992 Dec;16(3):290-300 19732491 - Expert Rev Mol Med. 2009;11:e27 10658545 - Occup Environ Med. 1999 Oct;56(10):672-3 10901661 - Chemosphere. 1999 Jan;38(2):363-77 3776971 - Am J Epidemiol. 1986 Dec;124(6):884-93 10737951 - Environ Mol Mutagen. 2000;35(3):167-72 16771691 - Antioxid Redox Signal. 2006 May-Jun;8(5-6):1011-9 10918360 - Environ Mol Mutagen. 2000;36(1):52-8 12747010 - Biomed Environ Sci. 2003 Mar;16(1):68-82 15763095 - Chemosphere. 2005 Apr;59(3):423-30 17520071 - Environ Health Perspect. 2007 May;115(5):799-806 12883021 - Occup Environ Med. 2003 Aug;60(8):595-8 9784432 - Regul Toxicol Pharmacol. 1998 Aug;28(1):45-54 15276743 - Water Res. 2004 Aug-Sep;38(14-15):3265-74 |
| References_xml | – volume: 8 start-page: 67 year: 2008 ident: 398_CR21 publication-title: BMC Cancer doi: 10.1186/1471-2407-8-67 – volume: 62 start-page: 397 year: 2005 ident: 398_CR20 publication-title: Ecotoxicol Environ Saf doi: 10.1016/j.ecoenv.2004.12.010 – ident: 398_CR41 – ident: 398_CR48 – volume: 1140 start-page: 121 year: 2008 ident: 398_CR38 publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1454.013 – volume: 39 start-page: 159 year: 2007 ident: 398_CR53 publication-title: Drug Metab Rev doi: 10.1080/03602530601093489 – volume: 23 start-page: 273 year: 2002 ident: 398_CR47 publication-title: Carcinogenesis doi: 10.1093/carcin/23.2.273 – ident: 398_CR44 – volume: 441 start-page: 11 year: 1999 ident: 398_CR27 publication-title: Mutat Res doi: 10.1016/S1383-5718(99)00034-0 – volume: 38 start-page: 3265 year: 2004 ident: 398_CR17 publication-title: Water Res doi: 10.1016/j.watres.2004.04.036 – volume: 407 start-page: 263 year: 2008 ident: 398_CR18 publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2008.08.015 – volume: 56 start-page: 672 year: 1999 ident: 398_CR8 publication-title: Occup Environ Med doi: 10.1136/oem.56.10.672 – volume: 16 start-page: 23 year: 2001 ident: 398_CR4 publication-title: Occup Med – volume: 16 start-page: 68 year: 2003 ident: 398_CR6 publication-title: Biomed Environ Sci – volume: 35 start-page: 206 year: 2000 ident: 398_CR42 publication-title: Environ Mol Mutagen doi: 10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J – ident: 398_CR34 – volume: 16 start-page: 290 year: 1992 ident: 398_CR31 publication-title: Regul Toxicol Pharmacol doi: 10.1016/0273-2300(92)90009-X – volume: 18 start-page: 533 year: 2003 ident: 398_CR15 publication-title: Mutagenesis doi: 10.1093/mutage/geg031 – volume-title: SPSS for window-statistical package for the social sciences, version 16 year: 2008 ident: 398_CR30 – ident: 398_CR45 – volume: 35 start-page: 167 year: 2000 ident: 398_CR26 publication-title: Environ Mol Mutagen doi: 10.1002/(SICI)1098-2280(2000)35:3<167::AID-EM3>3.0.CO;2-G – volume: 115 start-page: 833 year: 2007 ident: 398_CR11 publication-title: Environ Health Perspect doi: 10.1289/ehp.9334 – volume: 59 start-page: 423 year: 2005 ident: 398_CR19 publication-title: Chemosphere doi: 10.1016/j.chemosphere.2004.10.040 – volume: 124 start-page: 884 year: 1986 ident: 398_CR35 publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a114478 – ident: 398_CR33 – volume: 14 start-page: 1 year: 2009 ident: 398_CR37 publication-title: Clin Toxicol (Phila) – volume: 115 start-page: 799 year: 2007 ident: 398_CR10 publication-title: Environ Health Perspect doi: 10.1289/ehp.9330 – volume: 574 start-page: 58 year: 2005 ident: 398_CR14 publication-title: Mutat Res doi: 10.1016/j.mrfmmm.2005.01.022 – volume: 167 start-page: 27 year: 2006 ident: 398_CR51 publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2006.08.011 – volume: 208 start-page: 853 year: 1954 ident: 398_CR29 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)65610-8 – volume: 2 start-page: 1084 year: 2007 ident: 398_CR25 publication-title: Nat Protoc doi: 10.1038/nprot.2007.77 – volume: 36 start-page: 52 year: 2000 ident: 398_CR24 publication-title: Environ Mol Mutagen doi: 10.1002/1098-2280(2000)36:1<52::AID-EM8>3.0.CO;2-9 – ident: 398_CR43 – volume: 63 start-page: 168 year: 2006 ident: 398_CR9 publication-title: Occup Environ Med doi: 10.1136/oem.2005.022954 – volume: 60 start-page: 595 year: 2003 ident: 398_CR3 publication-title: Occup Environ Med doi: 10.1136/oem.60.8.595 – volume: 39 start-page: 963 year: 2005 ident: 398_CR39 publication-title: Free Radic Res doi: 10.1080/10715760500190115 – volume: 28 start-page: 45 year: 1998 ident: 398_CR32 publication-title: Regul Toxicol Pharmacol doi: 10.1006/rtph.1998.1235 – volume: 54 start-page: 494 year: 1997 ident: 398_CR36 publication-title: Occup Environ Med doi: 10.1136/oem.54.7.494 – volume: 37 start-page: 483 year: 1992 ident: 398_CR12 publication-title: J Toxicol Environ Health doi: 10.1080/15287399209531687 – volume: 49 start-page: 283 year: 2008 ident: 398_CR46 publication-title: Environ Mol Mutagen doi: 10.1002/em.20384 – volume: 38 start-page: 363 year: 1999 ident: 398_CR16 publication-title: Chemosphere doi: 10.1016/S0045-6535(98)00186-6 – volume: 14 start-page: 1340 year: 2005 ident: 398_CR28 publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-04-0899 – volume: 57 start-page: 577 year: 2000 ident: 398_CR5 publication-title: Occup Environ Med doi: 10.1136/oem.57.9.577 – volume: 11 start-page: e27 year: 2009 ident: 398_CR49 publication-title: Expert Rev Mol Med doi: 10.1017/S1462399409001197 – volume: 235 start-page: 211 year: 1999 ident: 398_CR1 publication-title: Sci Total Environ doi: 10.1016/S0048-9697(99)00192-8 – ident: 398_CR22 – volume: 309 start-page: 69 year: 2003 ident: 398_CR7 publication-title: Sci Total Environ doi: 10.1016/S0048-9697(03)00054-8 – volume: 8 start-page: 1011 year: 2006 ident: 398_CR13 publication-title: Antioxid Redox Signal doi: 10.1089/ars.2006.8.1011 – volume: 36 start-page: 1289 year: 2001 ident: 398_CR50 publication-title: Lipids doi: 10.1007/s11745-001-0844-z – volume: 114 start-page: 673 year: 2006 ident: 398_CR40 publication-title: Environ Health Perspect doi: 10.1289/ehp.8562 – volume: 175 start-page: 184 year: 1988 ident: 398_CR23 publication-title: Exp Cell Res doi: 10.1016/0014-4827(88)90265-0 – volume: 468 start-page: 213 year: 2000 ident: 398_CR52 publication-title: Mutat Res doi: 10.1016/S1383-5718(00)00051-6 – volume: 28 start-page: 176 year: 1999 ident: 398_CR2 publication-title: J Environ Qual doi: 10.2134/jeq1999.00472425002800010021x – reference: 12883021 - Occup Environ Med. 2003 Aug;60(8):595-8 – reference: 18366096 - Environ Mol Mutagen. 2008 May;49(4):283-99 – reference: 10935937 - Occup Environ Med. 2000 Sep;57(9):577-81 – reference: 19365775 - Clin Toxicol (Phila). 2009 Apr;47(4):321-6 – reference: 19732491 - Expert Rev Mol Med. 2009;11:e27 – reference: 1293646 - Regul Toxicol Pharmacol. 1992 Dec;16(3):290-300 – reference: 17520075 - Environ Health Perspect. 2007 May;115(5):833-40 – reference: 12747010 - Biomed Environ Sci. 2003 Mar;16(1):68-82 – reference: 14614189 - Mutagenesis. 2003 Nov;18(6):533-7 – reference: 1464904 - J Toxicol Environ Health. 1992 Dec;37(4):483-94 – reference: 16216634 - Ecotoxicol Environ Saf. 2005 Nov;62(3):397-407 – reference: 3776971 - Am J Epidemiol. 1986 Dec;124(6):884-93 – reference: 10535121 - Sci Total Environ. 1999 Sep 1;235(1-3):211-20 – reference: 10224318 - Mutat Res. 1999 Apr 26;441(1):11-9 – reference: 16087477 - Free Radic Res. 2005 Sep;39(9):963-72 – reference: 18325085 - BMC Cancer. 2008;8:67 – reference: 16771691 - Antioxid Redox Signal. 2006 May-Jun;8(5-6):1011-9 – reference: 12798093 - Sci Total Environ. 2003 Jun 20;309(1-3):69-80 – reference: 18991910 - Ann N Y Acad Sci. 2008 Oct;1140:121-8 – reference: 10918360 - Environ Mol Mutagen. 2000;36(1):52-8 – reference: 10901661 - Chemosphere. 1999 Jan;38(2):363-77 – reference: 16675419 - Environ Health Perspect. 2006 May;114(5):673-7 – reference: 15763095 - Chemosphere. 2005 Apr;59(3):423-30 – reference: 10658545 - Occup Environ Med. 1999 Oct;56(10):672-3 – reference: 11872632 - Carcinogenesis. 2002 Feb;23(2):273-81 – reference: 17364884 - Drug Metab Rev. 2007;39(1):159-234 – reference: 17546000 - Nat Protoc. 2007;2(5):1084-104 – reference: 16497857 - Occup Environ Med. 2006 Mar;63(3):168-72 – reference: 3345800 - Exp Cell Res. 1988 Mar;175(1):184-91 – reference: 15276743 - Water Res. 2004 Aug-Sep;38(14-15):3265-74 – reference: 9784432 - Regul Toxicol Pharmacol. 1998 Aug;28(1):45-54 – reference: 10737951 - Environ Mol Mutagen. 2000;35(3):167-72 – reference: 15914207 - Mutat Res. 2005 Jul 1;574(1-2):58-66 – reference: 11107222 - Occup Med. 2001 Jan-Mar;16(1):23-38 – reference: 17520071 - Environ Health Perspect. 2007 May;115(5):799-806 – reference: 11834080 - Lipids. 2001 Dec;36(12):1289-305 – reference: 15894700 - Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1340-3 – reference: 10737956 - Environ Mol Mutagen. 2000;35(3):206-21 – reference: 10882898 - Mutat Res. 2000 Jul 10;468(2):213-25 – reference: 13174594 - J Biol Chem. 1954 Jun;208(2):853-61 – reference: 18814902 - Sci Total Environ. 2008 Dec 15;407(1):263-72 – reference: 9282126 - Occup Environ Med. 1997 Jul;54(7):494-8 – reference: 17029827 - Toxicol Lett. 2006 Nov 1;167(1):27-33 |
| SSID | ssj0017865 |
| Score | 2.0119426 |
| Snippet | Background
Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative... Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative stress. We... Background Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative... Abstract Background: Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and... BACKGROUND: Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and oxidative... Abstract Background Sewage workers are exposed to multiple chemicals among which many are suspected genotoxicants. Therefore, they might incur DNA damage and... |
| SourceID | doaj pubmedcentral hal proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 23 |
| SubjectTerms | Adult Air Pollution, Indoor Analysis Benzene Benzene - analysis Benzo(a)pyrene - analysis Biological markers Biomarkers Biomarkers, Tumor - metabolism Cancer Comet Assay Demographic aspects Deoxyguanosine - analogs & derivatives Deoxyguanosine - urine Deoxyribonucleic acid Diagnosis DNA Earth and Environmental Science Environment Environmental Health Environmental Monitoring - methods Genotoxicity Health aspects Health care Health risks Hep G2 Cells Humans Identification and classification Inhalation Inhalation Exposure Integrated approach Life Sciences Male Medicine Metabolism Metabolites Micronucleus Tests Middle Aged Mutagens - toxicity Occupational Exposure Occupational health and safety Occupational Medicine/Industrial Medicine Organic compounds Oxidative Stress Paris PCB Polychlorinated biphenyls Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - analysis Preventive medicine Public Health Pyrene Sanitary Engineering Sanitation workers Santé publique et épidémiologie Sewage Standard deviation Statistical analysis Studies Urine VOCs Volatile hydrocarbons Volatile organic compounds Volatile Organic Compounds - analysis Workers Young Adult |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagB8QF8Sa0RT6AgENoEjuO3duCqBZEOVFpb5bjh1qpTardFMqNn86M8yihqrhwtSeyY49nvrHHnwl5aXjmnFB1KiWDACUolxrweqkLucuCQEo3PNE9_CqWR_zzqlz98dQX5oT19MD9wO1ZiA84R9wbwYMA9-Jy8EtScF8IH6_5ghsbg6nh_KCS8RHJnEOzmVCrgdQnl2JvKkMLVLCZP4q0_ZNxvn2MuZHXgef1_Mm_DlGjbzq4T-4NoJIu-p95QG755iG5czgcmz8ivz6NpBCO-svzFncFqZk4OWkb6Mb_AMtCMU0LACHtWorsrV17iWay2-xT01DcmDfrnxSv7GNWz5qOjORQ6yjIukgjTvsLKPSKSfwxOTr4-O3DMh2eXkitYFmXqky4ECqpahZY5m0I3JfK1ohOvAlCucI5Lhw4d0Q4llfMylIVxvqSc2PYE7LVtI1_Rmhl6qwyAcJGGzgEg3XOTC2Dz0tfh-BMQt6NE6DtwEuOz2Oc6hifSKFxxjTOGJYULCFvpg_Oe0qOm0Xf44xOYsilHQtAw_SgYfpfGpaQ16gPGlc8dMya4eIC_B5yZ-lFUTKIkksJkjszSVipdlb9CjRq1pnl4gtIg7E50_jAI-NF8T1PyPaoc3qwKButEFzBehIJoVMtNoBJco1vLzZaCnAZ4MGqhDztFXRqq0BYDKFrQqqZ6s46M69pTo4j2zjDfYxMJeTtqORXnbph2J__j2HfJnf7_XuWFnyHbHXrC78LALCrX8S1_hvOOFNv priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZokRBShaA8GlqQDyDgEJrYjuNwQQtiWRDlRKW9WY4fLRIky24K5cZPZyavKlTlGk8SJzOel8ffEPLEiMQ5WZSxUhwClFC42IDVi11IXRIkQrrhju7RZ7k4Fh-X2bKvzdn0ZZWDTmwVtast5sgPCzQu8Dz5evUjxqZRuLnad9DYItdTBoKEB8Xn78dNhFzJrEfzSZU8TAXMIZHFElUP4xND1OL1j1p56xSLIi97nJcLJ__ZPW2N0vw2udV7k3TWsf8OuearXXLjqN8v3yU7XVaOdoeN7pI_HwZ0CEf9-arG9CA1IzgnrQPd-F-gYijWa4FnSJuaIoxrU5-jvmw2r6ipKGbozfo3xbP7WN6zpgM0OYw6CrSuxROn3UkUegEpfo8cz999ebuI-x4MsZU8aeIikS6EXBUlDzzxNgThs8KW6KZ4E2ThmHNCOrDy6OpYkXOrsoIZ6zMhjOH3yXZVV36P0NyUSW4CxI82CIgKy5SbUgWfZr4MwZmIvBwYom0PUI59Mr7pNlBRUiMHNXIQrzAekefjDasOm-Nq0jfI4ZEMQbXbC_X6RPdrVFsIRYXAEKv1UyV4Mi4FF0hJ4Zn0KiLPUD40Ln2YmDX9CQb4PATR0jOWcQiXMwWUBxNKWLJ2MvwUJGwymcXsE1CD1vmusdMjF4z9TCOyP8ig7lXLRo8LISJ0HMUXYLVc5euzjVYSbAeYsjwiDzqBHd_F0D-GGDYi-USUJ5OZjlRfT1vYcY4JjaSIyItB6C8mdcVvf_jfD9gnN7sMPY-ZOCDbzfrMPwIXrykftwv5LxCsUDI priority: 102 providerName: ProQuest – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB7RIiGkCkF5NLQgH0DAITSJHcfhtqyoFkQ5UWlvluOHigRJtZtCufHTmUmyKaH0wDUeK048nvnGnvkM8MyIxDlZVrFSHAOUULrYoNeLXUhdEiRRutGJ7vEnuTgRH5b5ciBJolqYP8_vUyUPU4EdE1kuyV5kfAtu5mh1KXdvLufjcUGhZD7w9vyj08TldMz8o_3dOqX0x6vY8mqK5F_npJ37OboLdwbcyGb9RN-DG77ehVvHw8n4Luz0-2-sLyu6D7_eb3ggHPMXZw1tBDIz0nCyJrC1_4HGhFFmFmJA1jaMCFvb5oIsY7t-w0zNaC_erH4yqtKnRJ4V25CQY6tjKOs65nDW15ywS_LwB3By9O7zfBEPty3EVvKkjctEuhAKVVY88MTbEITPS1sRIPEmyNJlzgnp0J8TqLGi4FblZWasz4Uwhj-E7bqp_R6wwlRJYQJGijYIjP-qlJtKBZ_mvgrBmQhebyZE24GKnG7E-Kq7kERJTTOoaQbpScYjeDl2OOtZOK4XfUszPIoRfXb3ALVKD6tRWww6haBgqkOkEjGLSxHsKCl8Jr2K4AXph6ZFjgOzZqhVwM8juiw9y3KOgXGuUPJgIomL006an6OGTQazmH1EabQv3zTd6chFln1PI9jf6KAejMhal4SncAnJCNjYSi-gvLjaN-drrSR6CXRaRQSPeoUd35UREsZoNYJiosqTwUxb6i-nHcE4p62LpIzg1UbpLwd1zW9__B-y-3C735nncSYOYLtdnfsnCO3a6mm3rH8Dr-lICA priority: 102 providerName: Springer Nature |
| Title | Integrated exposure assessment of sewage workers to genotoxicants: an urinary biomarker approach and oxidative stress evaluation |
| URI | https://link.springer.com/article/10.1186/1476-069X-10-23 https://www.ncbi.nlm.nih.gov/pubmed/21435260 https://www.proquest.com/docview/902388316 https://www.proquest.com/docview/860881537 https://inserm.hal.science/inserm-00583422 https://pubmed.ncbi.nlm.nih.gov/PMC3071309 https://doaj.org/article/c249445597074166853d1218864e26e8 |
| Volume | 10 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: RBZ dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: KQ8 dateStart: 20020701 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: KQ8 dateStart: 20020101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: DOA dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: ABDBF dateStart: 20020101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: DIK dateStart: 20020101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: GX1 dateStart: 20020101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: M~E dateStart: 20020101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: RPM dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: 8FG dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: 8C1 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1476-069X dateEnd: 20250131 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: M48 dateStart: 20020701 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal – providerCode: PRVAVX databaseName: Springer Nature HAS Fully OA customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: AAJSJ dateStart: 20021201 isFulltext: true titleUrlDefault: https://www.springernature.com providerName: Springer Nature – providerCode: PRVAVX databaseName: Springer Nature OA Free Journals customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: C6C dateStart: 20021201 isFulltext: true titleUrlDefault: http://www.springeropen.com/ providerName: Springer Nature – providerCode: PRVAVX databaseName: SpringerLink Journals (ICM) customDbUrl: eissn: 1476-069X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0017865 issn: 1476-069X databaseCode: U2A dateStart: 20021201 isFulltext: true titleUrlDefault: http://www.springerlink.com/journals/ providerName: Springer Nature |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELfoJiFeEN-EjcoPIOAhI4kdx0FCKKtWSkUnBFTqW-TENkMayWgz6N7407lLk1Rhm8RLKtnXxInvfL_zx-8Ieaa4p7WIM1dKBgGKjbWrwOu52vraswIp3XBFd3YsJnM-XYSLbTqg5gOurgztMJ_UfHl6sP558Q4M_m1t8FK89jnc3BPxAseUgA3ILrilAFV8xrdLCpGs80p2wg3PzxU36Lmomsm_G68HJ7hd8jIWvbyl8p911dpdje-Q2w3OpMlGMe6SG6a4R27OmpX0--TPh5YnQlOzPitxopCqjqaTlpauzG8YbCju3AKMSKuSIqFrVa5x5KxWb6gqKM7Vq-UFxVP8uNFnSVuScqjVFGR1zSxON2dS6JZc_AGZj4--jiZuk43BzQXzKjf2hLY2knHGLPNMbi03YZxnCFiMsiLWgdZcaPD3CHpyHrFchnGgchNyrhR7SHaKsjCPCY1U5kXKQiSZWw7xYeYzlUlr_NBk1mrlkIO2A9K8oSrHjBmnaR2ySJFij6XYY1gSMIe87P5wtmHpuF70EHu0E0N67bqgXH5LG2tNcwhKOcdgq0asAjCN9gEMScFNIIx0yAvUhxTVEhqWq-YsA7we0mmlSRAyCJxDCZL7PUkw3rxX_Rw0qteYSfIRpGH8-ZFizkfGg-CX75C9VufS1kbSGPEWmJhwCO1q8QG4b64w5fkqlQK8CDi1yCGPNgraPStApAzRrEOinur2GtOvKb6f1ATkDKc2vNghr1ol3zbqms_-5P97aI_c2kzcMzfg-2SnWp6bp4D8qmxIBtEigqsc-Xgdvx-S3SSZfpnC7-HR8afPUDoSo2E9szKs7R-u8yD5C6LGW7Y |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbaIgESQlBeoQV8oAIOoUnsOA4SQsuj2qXbnlppb8aJbYoEybKb0vbGH-I_MpNXFapy6zWeJHZmMg_P-BtCnmseGCPSzJeSQYDiUuNrsHq-caEJnEBIN8zo7u2L8SH_PItnK-RPdxYGyyo7nVgralPmuEe-naJxgeeJd_OfPjaNwuRq10GjkYpde3YCEdvy7eQjsHcrinY-HXwY-21TAT8XLKj8NBDGuUSmGXMssLlz3MZpnqHdtdqJ1ETGcGHAbKHtznnCchmnkc5tzLnWDJ67Sq5xFnCE6k9mfXwXJlLELXpQKMV2yGHNgUhnqOoiNjB8dX-A3gqsHmER5kUP92Kh5j_Z2toI7twht1vvlY4acbtLVmyxTq7vtfn5dXKr2QWkzeGme-T3pEOjMNSezkvcjqS6BwOlpaNLewIqjWJ9GHiitCopwsZW5Snq52r5huqCYkZAL84oYgVgOdGCdlDoMGoo0Joav5w2J1_oOYT5fXJ4Jex5QNaKsrCPCE10FiTaQbyaOw5RaBYynUlnw9hmzhntkdcdQ1TeAqJjX47vqg6MpFDIQYUcxCsR88jL_oZ5gwVyOel75HBPhiDe9YVy8VW1OkHlEPpyjiFd7RcL8JxMCC6XFNxGwkqPvED5UKhqYGK5bk9MwPIQtEuNophBeB5LoNwcUIKKyAfDWyBhg8mMR1OgBi33Q2FnScaj6FfokY1OBlWrypaq__E8QvtRfAFW5xW2PF4qKcBWgelMPPKwEdj-XRH64xAzeyQZiPJgMsOR4ttRDXPOcAMlSD3yqhP680ld8tkf_3cBz8iN8cHeVE0n-7sb5GaTHWB-xDfJWrU4tk_Avayyp_VPTcmXq9YifwGFeY3Q |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZoK1VICEF5hRbwAQQcQpPYcRxuy2O1XdoKCSrtzXL8oEiQrHZTKDd-OjN5VaH0wDWeJE48j2_s8WdCnmoeWSvyIpSSQYLicxtqiHqh9bGNvEBKN1zRPToWsxM-X6SLrjZn3Ve790uS7Z4GZGkq6_2l9a2JS7Efc3hcJPIFepGEbZAtmeYCcq-tyWT-aT4sI2RSpB2fzz9uG4WihrF_8Msbp1gWeRlzXi6d_Gv9tAlL01vkZocn6aRVgNvkmit3yPZRt2K-Q26083K03W50h_w-6PkhLHXnywonCKke6Dlp5ena_QQnQ7FiC7AhrSuKRK51dY4es16_prqkOEevV78o7t7HAp8V7cnJodVSkLUNozht96LQC1Lxu-Rk-v7z21nYncIQGsGiOswjYb3PZF4wzyJnvOcuzU2BQMVpL3KbWMuFhTiPYMfwjBkYjUQbl3KuNbtHNsuqdA8IzXQRZdpDBmk8h7ywiJkupHdx6grvrQ7Iq35AlOkoyvGkjG-qSVWkUDiCCkcQryQsIC-GG5YtO8fVom9whAcxpNVuLlSrL6qzUmUgGeUck6wGqQrAMjYGECQFd4lwMiDPUT8UGj90zOhuDwN8HtJoqUmSMkiYUwmSeyNJMFozan4GGjbqzGxyCNLgd74rPOuR8ST5EQdkt9dB1TmXtcoRZ4FpiYDQoRVfgPVypavO1koKiB4QzLKA3G8VdnhXgggZstiAZCNVHnVm3FJ-PW2IxxlOaUR5QF72Sn_RqSt--8P_kH1Ctj--m6rDg-MPu-R6O3nPwoTvkc16deYeAfqri8edjf8BrK9Usw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Integrated+exposure+assessment+of+sewage+workers+to+genotoxicants%3A+an+urinary+biomarker+approach+and+oxidative+stress+evaluation&rft.jtitle=Environmental+health&rft.au=Al+Zabadi%2C+Hamzeh&rft.au=Ferrari%2C+Luc&rft.au=Sari-Minodier%2C+Ir%C3%A8ne&rft.au=Kerautret%2C+Marie-Aude&rft.date=2011-03-24&rft.issn=1476-069X&rft.eissn=1476-069X&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1186%2F1476-069X-10-23&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_1476_069X_10_23 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1476-069X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1476-069X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1476-069X&client=summon |