Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

The authors find that optogenetic stimulation of melanin-concentrating hormone (MCH)-expressing neurons in the lateral hypothalamus selectively extends the duration of paradoxical sleep episodes in mice. Activation of MCH fibers in the tuberomammillary nucleus leads to the release of GABA and a simi...

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Published inNature neuroscience Vol. 16; no. 11; pp. 1637 - 1643
Main Authors Jego, Sonia, Glasgow, Stephen D, Herrera, Carolina Gutierrez, Ekstrand, Mats, Reed, Sean J, Boyce, Richard, Friedman, Jeffrey, Burdakov, Denis, Adamantidis, Antoine R
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.11.2013
Nature Publishing Group
Subjects
6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
631/378/1385/1817
631/378/1385/2641
631/378/1385/519
631/378/1697/1691
Animal Genetics and Genomics
Animals
Animals, Newborn
Artificial chromosomes
Behavioral Sciences
Bicuculline - pharmacology
Biological Techniques
Biomedicine
Channelrhodopsins
Excitatory Amino Acid Antagonists - pharmacology
Eye movements
GABA-A Receptor Antagonists - pharmacology
Gene Expression Regulation
Genetic aspects
Hypothalamic Hormones - genetics
Hypothalamus
Hypothalamus - cytology
Hypothalamus - drug effects
Hypothalamus - physiology
Light
Melanins - genetics
Membrane Potentials - drug effects
Membrane Potentials - physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Net - drug effects
Nerve Net - physiology
Neural Pathways - drug effects
Neural Pathways - physiology
Neurobiology
Neurons
Neurons - drug effects
Neurons - physiology
Neurosciences
Optogenetics
Peptides
Physiological aspects
Pituitary Hormones - genetics
Sleep
Sleep, REM - physiology
Theta Rhythm - drug effects
Theta Rhythm - genetics
Transduction, Genetic
Valine - analogs & derivatives
Valine - pharmacology
United Kingdom
New York
United States > US
Online AccessGet full text
ISSN1097-6256
1546-1726
1546-1726
DOI10.1038/nn.3522

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Abstract The authors find that optogenetic stimulation of melanin-concentrating hormone (MCH)-expressing neurons in the lateral hypothalamus selectively extends the duration of paradoxical sleep episodes in mice. Activation of MCH fibers in the tuberomammillary nucleus leads to the release of GABA and a similar increase in paradoxical sleep stability. Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg( Pmch - cre ) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, their acute silencing (eNpHR3.0, archaerhodopsin) reduced the frequency and amplitude of hippocampal theta rhythm without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced GABA A -mediated inhibitory postsynaptic currents in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), and in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.
AbstractList Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, their acute silencing (eNpHR3.0, archaerhodopsin) reduced the frequency and amplitude of hippocampal theta rhythm without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced GABAA-mediated inhibitory postsynaptic currents in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), and in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, their acute silencing (eNpHR3.0, archaerhodopsin) reduced the frequency and amplitude of hippocampal theta rhythm without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced GABAA-mediated inhibitory postsynaptic currents in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), and in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.
The authors find that optogenetic stimulation of melanin-concentrating hormone (MCH)-expressing neurons in the lateral hypothalamus selectively extends the duration of paradoxical sleep episodes in mice. Activation of MCH fibers in the tuberomammillary nucleus leads to the release of GABA and a similar increase in paradoxical sleep stability. Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg( Pmch - cre ) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, their acute silencing (eNpHR3.0, archaerhodopsin) reduced the frequency and amplitude of hippocampal theta rhythm without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced GABA A -mediated inhibitory postsynaptic currents in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), and in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, their acute silencing (eNpHR3.0, archaerhodopsin) reduced the frequency and amplitude of hippocampal theta rhythm without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced [GABA.sub.A]-mediated inhibitory postsynaptic currents in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), and in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, their acute silencing (eNpHR3.0, archaerhodopsin) reduced the frequency and amplitude of hippocampal theta rhythm without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced GABAA-mediated inhibitory postsynaptic currents in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), and in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.
Rapid-Eye Movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus (LH). LH melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, however, their action on REM sleep remains unclear. Using optogenetic tools in newly-generated Tg( Pmch - Cre ) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM sleep episode. In contrast, their acute silencing (eNpHR3.0, ArchT) reduced the frequency and amplitude of hippocampal theta rhythm, without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced GABA A -mediated inhibitory post-synaptic currents (IPSCs) in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), while in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.
Audience Academic
Author Jego, Sonia
Friedman, Jeffrey
Adamantidis, Antoine R
Herrera, Carolina Gutierrez
Glasgow, Stephen D
Burdakov, Denis
Ekstrand, Mats
Boyce, Richard
Reed, Sean J
AuthorAffiliation 1 Douglas Institute, Department of Psychiatry, McGill University, Montreal
2 Rockefeller University, New York, USA
3 MRC National Institute for Medical Research and King’s College London, London, United Kingdom
AuthorAffiliation_xml – name: 2 Rockefeller University, New York, USA
– name: 3 MRC National Institute for Medical Research and King’s College London, London, United Kingdom
– name: 1 Douglas Institute, Department of Psychiatry, McGill University, Montreal
Author_xml – sequence: 1
  givenname: Sonia
  surname: Jego
  fullname: Jego, Sonia
  organization: Department of Psychiatry, Douglas Institute, McGill University
– sequence: 2
  givenname: Stephen D
  surname: Glasgow
  fullname: Glasgow, Stephen D
  organization: Department of Psychiatry, Douglas Institute, McGill University
– sequence: 3
  givenname: Carolina Gutierrez
  surname: Herrera
  fullname: Herrera, Carolina Gutierrez
  organization: Department of Psychiatry, Douglas Institute, McGill University
– sequence: 4
  givenname: Mats
  surname: Ekstrand
  fullname: Ekstrand, Mats
  organization: Howard Hughes Medical Institute, Laboratory of Molecular Genetics, Rockefeller University
– sequence: 5
  givenname: Sean J
  surname: Reed
  fullname: Reed, Sean J
  organization: Department of Psychiatry, Douglas Institute, McGill University
– sequence: 6
  givenname: Richard
  surname: Boyce
  fullname: Boyce, Richard
  organization: Department of Psychiatry, Douglas Institute, McGill University
– sequence: 7
  givenname: Jeffrey
  surname: Friedman
  fullname: Friedman, Jeffrey
  organization: Howard Hughes Medical Institute, Laboratory of Molecular Genetics, Rockefeller University
– sequence: 8
  givenname: Denis
  surname: Burdakov
  fullname: Burdakov, Denis
  organization: MRC National Institute for Medical Research and King's College London
– sequence: 9
  givenname: Antoine R
  surname: Adamantidis
  fullname: Adamantidis, Antoine R
  email: antoine.adamantidis@mcgill.ca
  organization: Department of Psychiatry, Douglas Institute, McGill University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24056699$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1093/nar/gni035
10.1111/j.1460-9568.2005.04104.x
10.1186/1471-2202-4-19
10.1128/JVI.00254-08
10.1523/JNEUROSCI.1887-05.2005
10.1111/j.1460-9568.2005.04100.x
10.1016/j.smrv.2012.10.002
10.1038/nrn895
10.1523/JNEUROSCI.1225-13.2013
10.1038/nature05744
10.1523/JNEUROSCI.1885-12.2012
10.1111/j.1460-9568.2008.06129.x
10.1006/geno.2002.6771
10.1016/j.neuron.2012.09.014
10.1371/journal.pone.0004272
10.1126/science.1168878
10.1002/cne.21482
10.1523/JNEUROSCI.0706-12.2012
10.1073/pnas.0908200106
10.1002/cne.20891
10.1523/JNEUROSCI.21-08-02610.2001
10.1002/cne.1085
10.1152/jn.01052.2009
10.1038/nn.2247
10.1016/j.peptides.2013.03.015
10.1016/j.cell.2010.02.037
10.1038/nature06310
10.1523/JNEUROSCI.22-11-04568.2002
10.1038/nature04767
10.1523/JNEUROSCI.2341-06.2006
10.1016/j.brainres.2010.11.027
10.1371/journal.pone.0000299
10.1016/j.neuron.2005.04.035
10.1016/0006-8993(76)90480-7
10.1523/JNEUROSCI.1954-08.2008
10.1046/j.1460-9568.2003.02861.x
10.1016/j.neuron.2010.11.032
10.1126/science.1094539
10.1016/j.neuroscience.2008.08.048
10.1038/nn.2495
10.1126/science.1135627
10.1016/j.neuroscience.2008.05.035
10.1016/j.neuroscience.2012.07.072
10.1523/JNEUROSCI.01-08-00876.1981
10.1073/pnas.0811400106
10.1016/S0896-6273(04)00251-X
10.1002/cne.903190204
10.1002/cne.1191
10.1371/journal.pone.0011766
10.1523/JNEUROSCI.4925-04.2005
10.1002/cne.23273
10.1016/j.conb.2013.02.006
10.1016/j.jneumeth.2010.06.020
10.1038/nature08652
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References Tan (CR38) 2002; 79
Mileykovskiy, Kiyashchenko, Siegel (CR46) 2005; 46
Lagos, Torterolo, Jantos, Monti (CR42) 2011; 1369
Pachoud (CR50) 2010; 104
Chee, Pissios, Maratos-Flier (CR44) 2013; 521
Adamantidis (CR23) 2008; 27
Saito, Cheng, Leslie, Civelli (CR43) 2001; 435
Verret (CR15) 2003; 4
van den Pol (CR41) 2012; 76
Lu (CR13) 2002; 22
Schöne (CR40) 2012; 32
Chow (CR34) 2010; 463
Boissard, Fort, Gervasoni, Barbagli, Luppi (CR9) 2003; 18
Willie, Sinton, Maratos-Flier, Yanagisawa (CR22) 2008; 156
Han, Boyden (CR33) 2007; 2
Lee, Hassani, Jones (CR45) 2005; 25
Franken, Chollet, Tafti (CR54) 2001; 21
Del Cid-Pellitero, Jones (CR36) 2012; 223
Konadhode (CR18) 2013; 33
Adamantidis (CR49) 2005; 21
Hanriot (CR20) 2007; 505
Hassani, Lee, Jones (CR21) 2009; 106
Gunaydin (CR26) 2010; 13
Sapin (CR8) 2009; 4
Lu, Sherman, Devor, Saper (CR11) 2006; 441
Fort (CR37) 2008; 155
Clément (CR14) 2012; 32
Gradinaru (CR32) 2010; 141
Zhang (CR31) 2007; 446
Jouvet (CR1) 1962; 100
McGinty, Harper (CR3) 1976; 101
Schöne (CR56) 2012; 32
Elias (CR35) 2001; 432
CR12
Verret, Fort, Gervasoni, Leger, Luppi (CR10) 2006; 495
Bittencourt (CR27) 1992; 319
McCarley, Hobson (CR5) 1975; 189
Saper, Fuller, Pedersen, Lu, Scammell (CR2) 2010; 68
Grimm (CR52) 2008; 82
Takahashi, Lin, Sakai (CR39) 2006; 26
Pace-Schott, Hobson (CR7) 2002; 3
Wu, Dumalska, Morozova, van den Pol, Alreja (CR48) 2009; 106
Modirrousta, Mainville, Jones (CR19) 2005; 21
Tsai (CR24) 2009; 324
Adamantidis, Zhang, Aravanis, Deisseroth, de Lecea (CR53) 2007; 450
Monti, Torterolo, Lagos (CR17) 2013; 17
Lu (CR47) 2013; 44
Hobson, McCarley, Wyzinski (CR6) 1975; 189
van den Pol, Acuna-Goycolea, Clark, Ghosh (CR28) 2004; 42
Atasoy, Aponte, Su, Sternson (CR25) 2008; 28
Warming, Costantino, Court, Jenkins, Copeland (CR51) 2005; 33
Aston-Jones, Bloom (CR4) 1981; 1
Burdakov, Gerasimenko, Verkhratsky (CR29) 2005; 25
Sapin (CR16) 2010; 5
Berndt, Yizhar, Gunaydin, Hegemann, Deisseroth (CR30) 2009; 12
Bokil, Andrews, Kulkarni, Mehta, Mitra (CR55) 2010; 192
R Boissard (BFnn3522_CR9) 2003; 18
BY Mileykovskiy (BFnn3522_CR46) 2005; 46
M Wu (BFnn3522_CR48) 2009; 106
L Verret (BFnn3522_CR15) 2003; 4
F Zhang (BFnn3522_CR31) 2007; 446
RR Konadhode (BFnn3522_CR18) 2013; 33
LA Gunaydin (BFnn3522_CR26) 2010; 13
DJ McGinty (BFnn3522_CR3) 1976; 101
A Berndt (BFnn3522_CR30) 2009; 12
M Modirrousta (BFnn3522_CR19) 2005; 21
D Atasoy (BFnn3522_CR25) 2008; 28
JC Bittencourt (BFnn3522_CR27) 1992; 319
CF Elias (BFnn3522_CR35) 2001; 432
JA Hobson (BFnn3522_CR6) 1975; 189
MJS Chee (BFnn3522_CR44) 2013; 521
X Han (BFnn3522_CR33) 2007; 2
CB Saper (BFnn3522_CR2) 2010; 68
E Sapin (BFnn3522_CR16) 2010; 5
JM Monti (BFnn3522_CR17) 2013; 17
EF Pace-Schott (BFnn3522_CR7) 2002; 3
E Sapin (BFnn3522_CR8) 2009; 4
J Lu (BFnn3522_CR11) 2006; 441
CP Tan (BFnn3522_CR38) 2002; 79
H-C Tsai (BFnn3522_CR24) 2009; 324
RW McCarley (BFnn3522_CR5) 1975; 189
K Takahashi (BFnn3522_CR39) 2006; 26
A Adamantidis (BFnn3522_CR49) 2005; 21
C Schöne (BFnn3522_CR40) 2012; 32
JT Willie (BFnn3522_CR22) 2008; 156
BY Chow (BFnn3522_CR34) 2010; 463
B Pachoud (BFnn3522_CR50) 2010; 104
H Bokil (BFnn3522_CR55) 2010; 192
L Hanriot (BFnn3522_CR20) 2007; 505
Z-H Lu (BFnn3522_CR47) 2013; 44
D Burdakov (BFnn3522_CR29) 2005; 25
D Grimm (BFnn3522_CR52) 2008; 82
AR Adamantidis (BFnn3522_CR53) 2007; 450
L Verret (BFnn3522_CR10) 2006; 495
V Gradinaru (BFnn3522_CR32) 2010; 141
S Warming (BFnn3522_CR51) 2005; 33
P Lagos (BFnn3522_CR42) 2011; 1369
M Jouvet (BFnn3522_CR1) 1962; 100
C Schöne (BFnn3522_CR56) 2012; 32
P Fort (BFnn3522_CR37) 2008; 155
BFnn3522_CR12
AN van den Pol (BFnn3522_CR28) 2004; 42
E Del Cid-Pellitero (BFnn3522_CR36) 2012; 223
P Franken (BFnn3522_CR54) 2001; 21
O Clément (BFnn3522_CR14) 2012; 32
G Aston-Jones (BFnn3522_CR4) 1981; 1
A Adamantidis (BFnn3522_CR23) 2008; 27
J Lu (BFnn3522_CR13) 2002; 22
AN van den Pol (BFnn3522_CR41) 2012; 76
Y Saito (BFnn3522_CR43) 2001; 435
MG Lee (BFnn3522_CR45) 2005; 25
OK Hassani (BFnn3522_CR21) 2009; 106
References_xml – volume: 33
  start-page: e36
  year: 2005
  ident: CR51
  article-title: Simple and highly efficient BAC recombineering using galK selection
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gni035
– volume: 21
  start-page: 2807
  year: 2005
  end-page: 2816
  ident: CR19
  article-title: Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2005.04104.x
– volume: 4
  start-page: 19
  year: 2003
  ident: CR15
  article-title: A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-4-19
– volume: 463
  start-page: 98
  year: 2010
  end-page: 102
  ident: CR34
  article-title: High-performance genetically targetable optical neural silencing by light-driven proton pumps
  publication-title: Nature
– volume: 82
  start-page: 5887
  year: 2008
  end-page: 5911
  ident: CR52
  article-title: and gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses
  publication-title: J. Virol.
  doi: 10.1128/JVI.00254-08
– volume: 25
  start-page: 6716
  year: 2005
  end-page: 6720
  ident: CR45
  article-title: Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1887-05.2005
– ident: CR12
– volume: 21
  start-page: 2837
  year: 2005
  end-page: 2844
  ident: CR49
  article-title: Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2005.04100.x
– volume: 17
  start-page: 293
  year: 2013
  end-page: 298
  ident: CR17
  article-title: Melanin-concentrating hormone control of sleep-wake behavior
  publication-title: Sleep Med. Rev.
  doi: 10.1016/j.smrv.2012.10.002
– volume: 3
  start-page: 591
  year: 2002
  end-page: 605
  ident: CR7
  article-title: The neurobiology of sleep: genetics, cellular physiology and subcortical networks
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn895
– volume: 33
  start-page: 10257
  year: 2013
  end-page: 10263
  ident: CR18
  article-title: Optogenetic stimulation of MCH neurons increases sleep
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1225-13.2013
– volume: 446
  start-page: 633
  year: 2007
  end-page: 639
  ident: CR31
  article-title: Multimodal fast optical interrogation of neural circuitry
  publication-title: Nature
  doi: 10.1038/nature05744
– volume: 32
  start-page: 16763
  year: 2012
  end-page: 16774
  ident: CR14
  article-title: The lateral hypothalamic area controls paradoxical (REM) sleep by means of descending projections to brainstem GABAergic neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1885-12.2012
– volume: 27
  start-page: 1793
  year: 2008
  end-page: 1800
  ident: CR23
  article-title: Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2008.06129.x
– volume: 79
  start-page: 785
  year: 2002
  end-page: 792
  ident: CR38
  article-title: Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression
  publication-title: Genomics
  doi: 10.1006/geno.2002.6771
– volume: 76
  start-page: 98
  year: 2012
  end-page: 115
  ident: CR41
  article-title: Neuropeptide transmission in brain circuits
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.09.014
– volume: 4
  start-page: e4272
  year: 2009
  ident: CR8
  article-title: Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0004272
– volume: 324
  start-page: 1080
  year: 2009
  end-page: 1084
  ident: CR24
  article-title: Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning
  publication-title: Science
  doi: 10.1126/science.1168878
– volume: 505
  start-page: 147
  year: 2007
  end-page: 157
  ident: CR20
  article-title: Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.21482
– volume: 32
  start-page: 12437
  year: 2012
  end-page: 12443
  ident: CR40
  article-title: Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0706-12.2012
– volume: 106
  start-page: 17217
  year: 2009
  end-page: 17222
  ident: CR48
  article-title: Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0908200106
– volume: 495
  start-page: 573
  year: 2006
  end-page: 586
  ident: CR10
  article-title: Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.20891
– volume: 21
  start-page: 2610
  year: 2001
  end-page: 2621
  ident: CR54
  article-title: The homeostatic regulation of sleep need is under genetic control
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.21-08-02610.2001
– volume: 32
  start-page: 12437
  year: 2012
  end-page: 12443
  ident: CR56
  article-title: Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0706-12.2012
– volume: 432
  start-page: 1
  year: 2001
  end-page: 19
  ident: CR35
  article-title: Characterization of CART neurons in the rat and human hypothalamus
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.1085
– volume: 104
  start-page: 1417
  year: 2010
  end-page: 1425
  ident: CR50
  article-title: Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.01052.2009
– volume: 12
  start-page: 229
  year: 2009
  end-page: 234
  ident: CR30
  article-title: Bi-stable neural state switches
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2247
– volume: 44
  start-page: 32
  year: 2013
  end-page: 39
  ident: CR47
  article-title: Melanin concentrating hormone induces hippocampal acetylcholine release via the medial septum in rats
  publication-title: Peptides
  doi: 10.1016/j.peptides.2013.03.015
– volume: 141
  start-page: 154
  year: 2010
  end-page: 165
  ident: CR32
  article-title: Molecular and cellular approaches for diversifying and extending optogenetics
  publication-title: Cell
  doi: 10.1016/j.cell.2010.02.037
– volume: 450
  start-page: 420
  year: 2007
  end-page: 424
  ident: CR53
  article-title: Neural substrates of awakening probed with optogenetic control of hypocretin neurons
  publication-title: Nature
  doi: 10.1038/nature06310
– volume: 22
  start-page: 4568
  year: 2002
  end-page: 4576
  ident: CR13
  article-title: Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.22-11-04568.2002
– volume: 441
  start-page: 589
  year: 2006
  end-page: 594
  ident: CR11
  article-title: A putative flip-flop switch for control of REM sleep
  publication-title: Nature
  doi: 10.1038/nature04767
– volume: 26
  start-page: 10292
  year: 2006
  end-page: 10298
  ident: CR39
  article-title: Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2341-06.2006
– volume: 1369
  start-page: 112
  year: 2011
  end-page: 118
  ident: CR42
  article-title: Immunoneutralization of melanin-concentrating hormone (MCH) in the dorsal raphe nucleus: effects on sleep and wakefulness
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2010.11.027
– volume: 192
  start-page: 146
  year: 2010
  end-page: 151
  ident: CR55
  article-title: Chronux: a platform for analyzing neural signals
  publication-title: J. Neurosci. Methods
– volume: 2
  start-page: e299
  year: 2007
  ident: CR33
  article-title: Multiple-color optical activation, silencing and desynchronization of neural activity, with single-spike temporal resolution
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000299
– volume: 46
  start-page: 787
  year: 2005
  end-page: 798
  ident: CR46
  article-title: Behavioral correlates of activity in identified hypocretin/orexin neurons
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.04.035
– volume: 100
  start-page: 125
  year: 1962
  end-page: 206
  ident: CR1
  article-title: Research on the neural structures and responsible mechanisms in different phases of physiological sleep
  publication-title: Arch. Ital. Biol.
– volume: 101
  start-page: 569
  year: 1976
  end-page: 575
  ident: CR3
  article-title: Dorsal raphe neurons: depression of firing during sleep in cats
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(76)90480-7
– volume: 28
  start-page: 7025
  year: 2008
  end-page: 7030
  ident: CR25
  article-title: FLEX switch targets channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1954-08.2008
– volume: 18
  start-page: 1627
  year: 2003
  end-page: 1639
  ident: CR9
  article-title: Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset
  publication-title: Eur. J. Neurosci.
  doi: 10.1046/j.1460-9568.2003.02861.x
– volume: 68
  start-page: 1023
  year: 2010
  end-page: 1042
  ident: CR2
  article-title: Sleep state switching
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.11.032
– volume: 189
  start-page: 55
  year: 1975
  end-page: 58
  ident: CR6
  article-title: Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups
  publication-title: Science
  doi: 10.1126/science.1094539
– volume: 156
  start-page: 819
  year: 2008
  end-page: 829
  ident: CR22
  article-title: Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2008.08.048
– volume: 13
  start-page: 387
  year: 2010
  end-page: 392
  ident: CR26
  article-title: Ultrafast optogenetic control
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2495
– volume: 189
  start-page: 58
  year: 1975
  end-page: 60
  ident: CR5
  article-title: Neuronal excitability modulation over the sleep cycle: a structural and mathematical model
  publication-title: Science
  doi: 10.1126/science.1135627
– volume: 155
  start-page: 174
  year: 2008
  end-page: 181
  ident: CR37
  article-title: The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2008.05.035
– volume: 223
  start-page: 269
  year: 2012
  end-page: 276
  ident: CR36
  article-title: Immunohistochemical evidence for synaptic release of GABA from melanin-concentrating hormone containing varicosities in the locus coeruleus
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2012.07.072
– volume: 1
  start-page: 876
  year: 1981
  end-page: 886
  ident: CR4
  article-title: Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.01-08-00876.1981
– volume: 106
  start-page: 2418
  year: 2009
  end-page: 2422
  ident: CR21
  article-title: Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0811400106
– volume: 42
  start-page: 635
  year: 2004
  end-page: 652
  ident: CR28
  article-title: Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
  publication-title: Neuron
  doi: 10.1016/S0896-6273(04)00251-X
– volume: 319
  start-page: 218
  year: 1992
  end-page: 245
  ident: CR27
  article-title: The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.903190204
– volume: 435
  start-page: 26
  year: 2001
  end-page: 40
  ident: CR43
  article-title: Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.1191
– volume: 5
  start-page: e11766
  year: 2010
  ident: CR16
  article-title: A very large number of GABAergic neurons are activated in the tuberal hypothalamus during paradoxical (REM) sleep hypersomnia
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0011766
– volume: 25
  start-page: 2429
  year: 2005
  end-page: 2433
  ident: CR29
  article-title: Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4925-04.2005
– volume: 521
  start-page: 2208
  year: 2013
  end-page: 2234
  ident: CR44
  article-title: Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.23273
– volume: 21
  start-page: 2807
  year: 2005
  ident: BFnn3522_CR19
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2005.04104.x
– volume: 22
  start-page: 4568
  year: 2002
  ident: BFnn3522_CR13
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.22-11-04568.2002
– volume: 324
  start-page: 1080
  year: 2009
  ident: BFnn3522_CR24
  publication-title: Science
  doi: 10.1126/science.1168878
– volume: 101
  start-page: 569
  year: 1976
  ident: BFnn3522_CR3
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(76)90480-7
– volume: 432
  start-page: 1
  year: 2001
  ident: BFnn3522_CR35
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.1085
– volume: 25
  start-page: 2429
  year: 2005
  ident: BFnn3522_CR29
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4925-04.2005
– volume: 319
  start-page: 218
  year: 1992
  ident: BFnn3522_CR27
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.903190204
– volume: 82
  start-page: 5887
  year: 2008
  ident: BFnn3522_CR52
  publication-title: J. Virol.
  doi: 10.1128/JVI.00254-08
– volume: 1
  start-page: 876
  year: 1981
  ident: BFnn3522_CR4
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.01-08-00876.1981
– volume: 12
  start-page: 229
  year: 2009
  ident: BFnn3522_CR30
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2247
– volume: 3
  start-page: 591
  year: 2002
  ident: BFnn3522_CR7
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn895
– volume: 76
  start-page: 98
  year: 2012
  ident: BFnn3522_CR41
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.09.014
– volume: 223
  start-page: 269
  year: 2012
  ident: BFnn3522_CR36
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2012.07.072
– volume: 17
  start-page: 293
  year: 2013
  ident: BFnn3522_CR17
  publication-title: Sleep Med. Rev.
  doi: 10.1016/j.smrv.2012.10.002
– volume: 450
  start-page: 420
  year: 2007
  ident: BFnn3522_CR53
  publication-title: Nature
  doi: 10.1038/nature06310
– volume: 46
  start-page: 787
  year: 2005
  ident: BFnn3522_CR46
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.04.035
– ident: BFnn3522_CR12
  doi: 10.1016/j.conb.2013.02.006
– volume: 32
  start-page: 12437
  year: 2012
  ident: BFnn3522_CR40
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0706-12.2012
– volume: 495
  start-page: 573
  year: 2006
  ident: BFnn3522_CR10
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.20891
– volume: 155
  start-page: 174
  year: 2008
  ident: BFnn3522_CR37
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2008.05.035
– volume: 192
  start-page: 146
  year: 2010
  ident: BFnn3522_CR55
  publication-title: J. Neurosci. Methods
  doi: 10.1016/j.jneumeth.2010.06.020
– volume: 27
  start-page: 1793
  year: 2008
  ident: BFnn3522_CR23
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2008.06129.x
– volume: 21
  start-page: 2610
  year: 2001
  ident: BFnn3522_CR54
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.21-08-02610.2001
– volume: 463
  start-page: 98
  year: 2010
  ident: BFnn3522_CR34
  publication-title: Nature
  doi: 10.1038/nature08652
– volume: 104
  start-page: 1417
  year: 2010
  ident: BFnn3522_CR50
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.01052.2009
– volume: 32
  start-page: 12437
  year: 2012
  ident: BFnn3522_CR56
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0706-12.2012
– volume: 13
  start-page: 387
  year: 2010
  ident: BFnn3522_CR26
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2495
– volume: 106
  start-page: 17217
  year: 2009
  ident: BFnn3522_CR48
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0908200106
– volume: 1369
  start-page: 112
  year: 2011
  ident: BFnn3522_CR42
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2010.11.027
– volume: 505
  start-page: 147
  year: 2007
  ident: BFnn3522_CR20
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.21482
– volume: 2
  start-page: e299
  year: 2007
  ident: BFnn3522_CR33
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000299
– volume: 435
  start-page: 26
  year: 2001
  ident: BFnn3522_CR43
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.1191
– volume: 68
  start-page: 1023
  year: 2010
  ident: BFnn3522_CR2
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.11.032
– volume: 32
  start-page: 16763
  year: 2012
  ident: BFnn3522_CR14
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1885-12.2012
– volume: 106
  start-page: 2418
  year: 2009
  ident: BFnn3522_CR21
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0811400106
– volume: 33
  start-page: e36
  year: 2005
  ident: BFnn3522_CR51
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gni035
– volume: 141
  start-page: 154
  year: 2010
  ident: BFnn3522_CR32
  publication-title: Cell
  doi: 10.1016/j.cell.2010.02.037
– volume: 4
  start-page: 19
  year: 2003
  ident: BFnn3522_CR15
  publication-title: BMC Neurosci.
  doi: 10.1186/1471-2202-4-19
– volume: 5
  start-page: e11766
  year: 2010
  ident: BFnn3522_CR16
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0011766
– volume: 446
  start-page: 633
  year: 2007
  ident: BFnn3522_CR31
  publication-title: Nature
  doi: 10.1038/nature05744
– volume: 189
  start-page: 55
  year: 1975
  ident: BFnn3522_CR6
  publication-title: Science
  doi: 10.1126/science.1094539
– volume: 44
  start-page: 32
  year: 2013
  ident: BFnn3522_CR47
  publication-title: Peptides
  doi: 10.1016/j.peptides.2013.03.015
– volume: 156
  start-page: 819
  year: 2008
  ident: BFnn3522_CR22
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2008.08.048
– volume: 26
  start-page: 10292
  year: 2006
  ident: BFnn3522_CR39
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2341-06.2006
– volume: 441
  start-page: 589
  year: 2006
  ident: BFnn3522_CR11
  publication-title: Nature
  doi: 10.1038/nature04767
– volume: 521
  start-page: 2208
  year: 2013
  ident: BFnn3522_CR44
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.23273
– volume: 100
  start-page: 125
  year: 1962
  ident: BFnn3522_CR1
  publication-title: Arch. Ital. Biol.
– volume: 42
  start-page: 635
  year: 2004
  ident: BFnn3522_CR28
  publication-title: Neuron
  doi: 10.1016/S0896-6273(04)00251-X
– volume: 189
  start-page: 58
  year: 1975
  ident: BFnn3522_CR5
  publication-title: Science
  doi: 10.1126/science.1135627
– volume: 79
  start-page: 785
  year: 2002
  ident: BFnn3522_CR38
  publication-title: Genomics
  doi: 10.1006/geno.2002.6771
– volume: 21
  start-page: 2837
  year: 2005
  ident: BFnn3522_CR49
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2005.04100.x
– volume: 4
  start-page: e4272
  year: 2009
  ident: BFnn3522_CR8
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0004272
– volume: 18
  start-page: 1627
  year: 2003
  ident: BFnn3522_CR9
  publication-title: Eur. J. Neurosci.
  doi: 10.1046/j.1460-9568.2003.02861.x
– volume: 28
  start-page: 7025
  year: 2008
  ident: BFnn3522_CR25
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1954-08.2008
– volume: 33
  start-page: 10257
  year: 2013
  ident: BFnn3522_CR18
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1225-13.2013
– volume: 25
  start-page: 6716
  year: 2005
  ident: BFnn3522_CR45
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1887-05.2005
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Snippet The authors find that optogenetic stimulation of melanin-concentrating hormone (MCH)-expressing neurons in the lateral hypothalamus selectively extends the...
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus...
Rapid-Eye Movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus (LH). LH melanin-concentrating...
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StartPage 1637
SubjectTerms 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
631/378/1385/1817
631/378/1385/2641
631/378/1385/519
631/378/1697/1691
Animal Genetics and Genomics
Animals
Animals, Newborn
Artificial chromosomes
Behavioral Sciences
Bicuculline - pharmacology
Biological Techniques
Biomedicine
Channelrhodopsins
Excitatory Amino Acid Antagonists - pharmacology
Eye movements
GABA-A Receptor Antagonists - pharmacology
Gene Expression Regulation
Genetic aspects
Hypothalamic Hormones - genetics
Hypothalamus
Hypothalamus - cytology
Hypothalamus - drug effects
Hypothalamus - physiology
Light
Melanins - genetics
Membrane Potentials - drug effects
Membrane Potentials - physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Net - drug effects
Nerve Net - physiology
Neural Pathways - drug effects
Neural Pathways - physiology
Neurobiology
Neurons
Neurons - drug effects
Neurons - physiology
Neurosciences
Optogenetics
Peptides
Physiological aspects
Pituitary Hormones - genetics
Sleep
Sleep, REM - physiology
Theta Rhythm - drug effects
Theta Rhythm - genetics
Transduction, Genetic
Valine - analogs & derivatives
Valine - pharmacology
Title Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus
URI https://link.springer.com/article/10.1038/nn.3522
https://www.ncbi.nlm.nih.gov/pubmed/24056699
https://www.proquest.com/docview/1459206484
https://www.proquest.com/docview/1447106249
https://www.proquest.com/docview/1554945064
https://pubmed.ncbi.nlm.nih.gov/PMC4974078
Volume 16
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