Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation
Although an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role of EAT inflammation in AF is unclear. We investigated the association between AF and inflammation of the EAT around the LA. We retrospectively identifi...
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| Published in | Journal of cardiology Vol. 68; no. 5; pp. 406 - 411 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.11.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0914-5087 1876-4738 |
| DOI | 10.1016/j.jjcc.2015.11.005 |
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| Abstract | Although an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role of EAT inflammation in AF is unclear. We investigated the association between AF and inflammation of the EAT around the LA.
We retrospectively identified regions of EAT around the LA and measured the density of these areas using computed tomography (CT).
A total of 32 patients who underwent their first catheter ablation for paroxysmal AF (PAF) were enrolled (mean age 62.5±11.1 years). Patients without a history of AF (n=32), but who underwent cardiac CT and were matched by age, sex, and metabolic risk factors, were enrolled in the control group (62.2±12.1 years). The mean EAT density around the LA was significantly higher in the PAF group than in the control group (−108.1±6.7 vs. −111.6±5.5 Hounsfield units; p=0.02), while the densities of subcutaneous adipose tissue (SAT) in the abdomen and thorax did not differ between the two groups. In a multiple logistic regression analysis, a higher EAT density was significantly associated with the presence of PAF after adjusting for other risk factors (odds ratio: 1.25; 95% confidence interval: 1.08–1.45, p=0.003).
This study supports the hypothesis that inflammation of EAT around the LA, but not SAT, is related to the presence of PAF. |
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| AbstractList | Although an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role of EAT inflammation in AF is unclear. We investigated the association between AF and inflammation of the EAT around the LA.
We retrospectively identified regions of EAT around the LA and measured the density of these areas using computed tomography (CT).
A total of 32 patients who underwent their first catheter ablation for paroxysmal AF (PAF) were enrolled (mean age 62.5±11.1 years). Patients without a history of AF (n=32), but who underwent cardiac CT and were matched by age, sex, and metabolic risk factors, were enrolled in the control group (62.2±12.1 years). The mean EAT density around the LA was significantly higher in the PAF group than in the control group (-108.1±6.7 vs. -111.6±5.5 Hounsfield units; p=0.02), while the densities of subcutaneous adipose tissue (SAT) in the abdomen and thorax did not differ between the two groups. In a multiple logistic regression analysis, a higher EAT density was significantly associated with the presence of PAF after adjusting for other risk factors (odds ratio: 1.25; 95% confidence interval: 1.08-1.45, p=0.003).
This study supports the hypothesis that inflammation of EAT around the LA, but not SAT, is related to the presence of PAF. BACKGROUNDAlthough an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role of EAT inflammation in AF is unclear. We investigated the association between AF and inflammation of the EAT around the LA.METHODSWe retrospectively identified regions of EAT around the LA and measured the density of these areas using computed tomography (CT).RESULTSA total of 32 patients who underwent their first catheter ablation for paroxysmal AF (PAF) were enrolled (mean age 62.5±11.1 years). Patients without a history of AF (n=32), but who underwent cardiac CT and were matched by age, sex, and metabolic risk factors, were enrolled in the control group (62.2±12.1 years). The mean EAT density around the LA was significantly higher in the PAF group than in the control group (-108.1±6.7 vs. -111.6±5.5 Hounsfield units; p=0.02), while the densities of subcutaneous adipose tissue (SAT) in the abdomen and thorax did not differ between the two groups. In a multiple logistic regression analysis, a higher EAT density was significantly associated with the presence of PAF after adjusting for other risk factors (odds ratio: 1.25; 95% confidence interval: 1.08-1.45, p=0.003).CONCLUSIONSThis study supports the hypothesis that inflammation of EAT around the LA, but not SAT, is related to the presence of PAF. Abstract Background Although an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role of EAT inflammation in AF is unclear. We investigated the association between AF and inflammation of the EAT around the LA. Methods We retrospectively identified regions of EAT around the LA and measured the density of these areas using computed tomography (CT). Results A total of 32 patients who underwent their first catheter ablation for paroxysmal AF (PAF) were enrolled (mean age 62.5 ± 11.1 years). Patients without a history of AF ( n = 32), but who underwent cardiac CT and were matched by age, sex, and metabolic risk factors, were enrolled in the control group (62.2 ± 12.1 years). The mean EAT density around the LA was significantly higher in the PAF group than in the control group (−108.1 ± 6.7 vs. −111.6 ± 5.5 Hounsfield units; p = 0.02), while the densities of subcutaneous adipose tissue (SAT) in the abdomen and thorax did not differ between the two groups. In a multiple logistic regression analysis, a higher EAT density was significantly associated with the presence of PAF after adjusting for other risk factors (odds ratio: 1.25; 95% confidence interval: 1.08–1.45, p = 0.003). Conclusions This study supports the hypothesis that inflammation of EAT around the LA, but not SAT, is related to the presence of PAF. Although an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role of EAT inflammation in AF is unclear. We investigated the association between AF and inflammation of the EAT around the LA. We retrospectively identified regions of EAT around the LA and measured the density of these areas using computed tomography (CT). A total of 32 patients who underwent their first catheter ablation for paroxysmal AF (PAF) were enrolled (mean age 62.5±11.1 years). Patients without a history of AF (n=32), but who underwent cardiac CT and were matched by age, sex, and metabolic risk factors, were enrolled in the control group (62.2±12.1 years). The mean EAT density around the LA was significantly higher in the PAF group than in the control group (−108.1±6.7 vs. −111.6±5.5 Hounsfield units; p=0.02), while the densities of subcutaneous adipose tissue (SAT) in the abdomen and thorax did not differ between the two groups. In a multiple logistic regression analysis, a higher EAT density was significantly associated with the presence of PAF after adjusting for other risk factors (odds ratio: 1.25; 95% confidence interval: 1.08–1.45, p=0.003). This study supports the hypothesis that inflammation of EAT around the LA, but not SAT, is related to the presence of PAF. |
| Author | Kato, Takeshi Takamura, Masayuki Furusho, Hiroshi Usui, Soichiro Murai, Hisayoshi Kaneko, Shuichi Kusayama, Takashi Kashiwagi, Haruka |
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| Keywords | Inflammation Left atrium Computed tomography Paroxysmal atrial fibrillation Epicardial adipose tissue |
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| Snippet | Although an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role of EAT... Abstract Background Although an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden,... BACKGROUNDAlthough an increased epicardial adipose tissue (EAT) volume around the left atrium (LA) is related to the atrial fibrillation (AF) burden, the role... |
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| SubjectTerms | Adipose Tissue - diagnostic imaging Atrial Fibrillation - surgery Cardiovascular Case-Control Studies Catheter Ablation Computed tomography Epicardial adipose tissue Female Heart Atria - diagnostic imaging Humans Inflammation Inflammation - diagnostic imaging Left atrium Male Middle Aged Paroxysmal atrial fibrillation Pericardium - diagnostic imaging Retrospective Studies Tomography, X-Ray Computed |
| Title | Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation |
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