妊娠期高血压疾病患者血浆D-二聚体与亮氨酸氨基肽酶的关系

目的：探讨妊娠期高血压疾病（hypertensive disorders complicating pregnancy,HDCP）患者血浆D-二聚体与亮氨酸氨基肽酶（leucine aminopeptidase,LAP）的关系以及临床上的应用价值。方法：选取2015年8月—2016年12月在南平市第一医院产检正常的妊娠妇女404例,经体检未孕健康妇女101例。选取同期在南平市第一医院收治的HDCP妇女116例。检测受试者LAP、碱性磷酸酶（ALP）、D-二聚体﹑尿总蛋白、尿肌酐等,计算尿总蛋白肌酐比（UTPCR）。采用单因素方差分析、Pearson相关分析和趋势图分析D-二聚体与LAP、UTP...

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Published in国际妇产科学杂志 Vol. 44; no. 5; pp. 565 - 568
Main Author 叶桂云 池细俤 朱家瑞 黄远茂 陈莉青 李文燕
Format Journal Article
LanguageChinese
Published 福建医科大学附属南平第一医院检验科, 福建省南平市,353000 2017
Subjects
D-二聚体
亮氨酸氨基肽酶
尿总蛋白肌酐比
高血压,妊娠性
Leucine aminopeptidase
D-二聚体
亮氨酸氨基肽酶
Hypertension,pregnancy-induced
D-dimer
Urinary total protein/creatinine ratio
尿总蛋白肌酐比
高血压,妊娠性
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ISSN1674-1870

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Summary:目的：探讨妊娠期高血压疾病（hypertensive disorders complicating pregnancy,HDCP）患者血浆D-二聚体与亮氨酸氨基肽酶（leucine aminopeptidase,LAP）的关系以及临床上的应用价值。方法：选取2015年8月—2016年12月在南平市第一医院产检正常的妊娠妇女404例,经体检未孕健康妇女101例。选取同期在南平市第一医院收治的HDCP妇女116例。检测受试者LAP、碱性磷酸酶（ALP）、D-二聚体﹑尿总蛋白、尿肌酐等,计算尿总蛋白肌酐比（UTPCR）。采用单因素方差分析、Pearson相关分析和趋势图分析D-二聚体与LAP、UTPCR等的关系。结果：HDCP组患者收缩压、D-二聚体浓度和UTPCR高于非妊娠期组和正常妊娠各期组,差异有统计学意义（均P〈0.05）,LAP浓度低于妊娠晚期组（P〈0.05）。妊娠晚期组的D-二聚体浓度仅与UTPCR值呈正相关（r=0.190,P=0.011）。HDCP组患者D-二聚体浓度与孕周和LAP浓度呈负相关（r=-0.505,P=0.000;r=-0.443,P=0.001）,与UTPCR值呈正相关（r=0.372,P=0.004）。趋势图显示HDCP组患者血浆D-二聚体浓度高于正常妊娠晚期妇女,血浆LAP浓度低于正常妊娠晚期妇女。结论：HDCP患者血浆D-二聚体与LAP相关性较好,联合检测D-二聚体和LAP,结合UTPCR对HDCP早期发现、治疗及预防有重要临床价值。
Bibliography:YE Gui-yun,CHI Xi-di,ZHU Jia-rui,HUANG Yuan-mao,CHEN Li-qing,LI Wen-yan（Department of Laboratery Medical,Fujian Medical University Affiliated Nanping First Hospital, Nanping 353000, Fujian Province, China）
12-1399/R
Hypertension, pregnancy-induced; D-dirner; Leucine aminopeptidase; Urinary total proteirdcreatinine ratio
Objective：To investigate the relationship and the application value of plasma D-dimer and leucine aminopeptidase（LAP） in the hypertensive disorders complicating pregnancy（HDCP）.Methods：A number of 404 healthy pregnant women and 101 healthy non-pregnant women were enrolled from the obstetrical examination department of Fujian Medical University Affiliated Nanping First Hospital from August 2015 to December 2016,and a total of 116 HDCP were enrolled from the Obstetrics and Gynecology Department of Nanping First Hospital from August 2015 to December 2016.LAP,alkaline phosphatase（ALP）,plasma D-dimer,urine total protein and urine creatinine of all the subjects were detected,and value of urinary total
ISSN:1674-1870