Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer - Grinde, Maria T.; Hilmarsdottir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads H.; Rye, Morten Beck; Mælandsmo, Gunhild M.; Moestue, Siver A. (Breast cancer research : BCR, 2019)
Keywords: 13C MRS; Addictions; Alanine; Aldehyde dehydrogenase 18 family member A1 (ALDH18A1); Amino acids; Analysis; Animals; Biological markers; Biomarkers; Biomedical and Life Sciences; Biomedicine; Biosynthesis; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer cells; Cancer prevention; Cancer Research; Cancer treatment; CB-839; Cell Line, Tumor; Clinical medical disciplines: 750; Clinical trials; Computational Biology; Disease Models, Animal; DNA microarrays; Enzyme Inhibitors - pharmacology; Enzymes; Female; Gene expression; Gene expression analysis; Gene Expression Profiling; Genes; Genetic aspects; Genetic research; Glutamate; Glutaminase; Glutaminase - antagonists & inhibitors; Glutaminase - metabolism; Glutaminase inhibitor; Glutamine; Glutamine - metabolism; Glutathione; High-resolution magic angle spinning MR spectroscopy (HR MAS MRS); Humans; Immunohistochemistry; Kinases; Klinisk medisinske fag: 750; Lactates; Lactic acid; Magnetic Resonance Spectroscopy; Mammals; Medical disciplines: 700; Medical research; Medisinske Fag: 700; Metabolism; Metabolites; Metabolomics - methods; Mice; Models, Biological; Oncology; Oncology: 762; Onkologi: 762; Patient-derived xenograft (PDX); Patients; Proline; Proline - metabolism; Protein expression; Proteins; Research Article; Spectrum analysis; Surgical Oncology; Tumors; VDP; Xenograft Model Antitumor Assays; Xenografts; Immunohistochemistry; Glutaminase inhibitor; Gene expression analysis; High-resolution magic angle spinning MR spectroscopy (HR MAS MRS); Cancer treatment; Patient-derived xenograft (PDX); Aldehyde dehydrogenase 18 family member A1 (ALDH18A1); CB-839; C MRS; Glutaminase; 13C MRS