Cold pressor testing and sympathetic nervous system contribution to ischemia with no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Project
Cold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT s...
Saved in:
| Published in | American heart journal plus Vol. 13; p. 100080 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2022
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2666-6022 2666-6022 |
| DOI | 10.1016/j.ahjo.2021.100080 |
Cover
| Abstract | Cold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT stress cardiac magnetic resonance (CMR) imaging between women with suspected INOCA and reference subjects.
Prospective cohort.
Academic hospital.
107 women with suspected INOCA and 21-age-matched reference women.
CPT stress CMR was performed with measurement of myocardial perfusion reserve index (MPRI), adjusted for rate pressure product (MPRIRPP). Invasive coronary function testing in a subset of INOCA women (n = 42) evaluated for endothelial dysfunction in response to acetylcholine, including impaired coronary diameter response ≤0% and coronary blood flow response (ΔCBF) <50%.
MPRIRPP.
Compared to reference women, the INOCA group demonstrated higher resting RPP (p = 0.005) and CPT MPRIRPP (1.09 ± 0.36 vs 0.83 ± 0.18, p = 0.002). Furthermore, INOCA women with impaired ΔCBF (n = 23) had higher CPT MPRIRPP (p = 0.044) compared to reference women despite lower left ventricular ejection fraction (64 ± 7% vs 69 ± 2%, p = 0.005) and higher mass-to-volume ratio (0.79 ± 0.15 vs 0.62 ± 0.09, p < 0.0001). These differences in CPT MPRIRPP did not persist after adjusting for age, body mass index, and history of hypertension. CPT MPRIRPP among INOCA women did not differ based on defined acetylcholine responses.
Myocardial perfusion reserve to CPT stress is greater among women with INOCA compared to reference subjects. This CPT response was also noted in women with coronary endothelial dysfunction, suggesting a greater contribution of the SNS to coronary flow than endothelial dysfunction. Therapies to modulate sympathetic activity should be studied in this population.
•Ischemia with no obstructive coronary arteries (INOCA) is increasingly recognized.•Women with INOCA often have dysregulation of myocardial blood flow.•Myocardial blood flow is influenced by sympathetic activity and the endothelium.•Sympathetic activity may predominate over endothelial dysfunction in INOCA women. |
|---|---|
| AbstractList | Cold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT stress cardiac magnetic resonance (CMR) imaging between women with suspected INOCA and reference subjects.
Prospective cohort.
Academic hospital.
107 women with suspected INOCA and 21-age-matched reference women.
CPT stress CMR was performed with measurement of myocardial perfusion reserve index (MPRI), adjusted for rate pressure product (MPRIRPP). Invasive coronary function testing in a subset of INOCA women (n = 42) evaluated for endothelial dysfunction in response to acetylcholine, including impaired coronary diameter response ≤0% and coronary blood flow response (ΔCBF) <50%.
MPRIRPP.
Compared to reference women, the INOCA group demonstrated higher resting RPP (p = 0.005) and CPT MPRIRPP (1.09 ± 0.36 vs 0.83 ± 0.18, p = 0.002). Furthermore, INOCA women with impaired ΔCBF (n = 23) had higher CPT MPRIRPP (p = 0.044) compared to reference women despite lower left ventricular ejection fraction (64 ± 7% vs 69 ± 2%, p = 0.005) and higher mass-to-volume ratio (0.79 ± 0.15 vs 0.62 ± 0.09, p < 0.0001). These differences in CPT MPRIRPP did not persist after adjusting for age, body mass index, and history of hypertension. CPT MPRIRPP among INOCA women did not differ based on defined acetylcholine responses.
Myocardial perfusion reserve to CPT stress is greater among women with INOCA compared to reference subjects. This CPT response was also noted in women with coronary endothelial dysfunction, suggesting a greater contribution of the SNS to coronary flow than endothelial dysfunction. Therapies to modulate sympathetic activity should be studied in this population.
•Ischemia with no obstructive coronary arteries (INOCA) is increasingly recognized.•Women with INOCA often have dysregulation of myocardial blood flow.•Myocardial blood flow is influenced by sympathetic activity and the endothelium.•Sympathetic activity may predominate over endothelial dysfunction in INOCA women. Cold Pressor Testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT stress cardiac magnetic resonance (CMR) imaging between women with suspected INOCA and reference subjects.Study ObjectiveCold Pressor Testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT stress cardiac magnetic resonance (CMR) imaging between women with suspected INOCA and reference subjects.Prospective cohort.DesignProspective cohort.Academic hospital.SettingAcademic hospital.107 women with suspected INOCA and 21-age-matched reference women.Participants107 women with suspected INOCA and 21-age-matched reference women.CPT stress CMR was performed with measurement of myocardial perfusion reserve index (MPRI), adjusted for rate pressure product (MPRIRPP). Invasive coronary function testing in a subset of INOCA women (n=42) evaluated for endothelial dysfunction in response to acetylcholine, including impaired coronary diameter response ≤0% and coronary blood flow response (ΔCBF) <50%.InterventionsCPT stress CMR was performed with measurement of myocardial perfusion reserve index (MPRI), adjusted for rate pressure product (MPRIRPP). Invasive coronary function testing in a subset of INOCA women (n=42) evaluated for endothelial dysfunction in response to acetylcholine, including impaired coronary diameter response ≤0% and coronary blood flow response (ΔCBF) <50%.MPRIRPP.Main Outcome MeasureMPRIRPP.Compared to reference women, the INOCA group demonstrated higher resting RPP (p=0.005) and CPT MPRIRPP (1.09±0.36 vs 0.83±0.18, p=0.002). Furthermore, INOCA women with impaired ΔCBF (n=23) had higher CPT MPRIRPP (p=0.044) compared to reference women despite lower left ventricular ejection fraction (64±7 % vs 69±2 %, p=0.005) and mass-to-volume ratio (0.79±0.15 vs 0.62±0.09, p<0.0001). These differences in CPT MPRIRPP did not persist after adjusting for age, body mass index, and history of hypertension. CPT MPRIRPP among INOCA women did not differ based on defined acetylcholine responses.ResultsCompared to reference women, the INOCA group demonstrated higher resting RPP (p=0.005) and CPT MPRIRPP (1.09±0.36 vs 0.83±0.18, p=0.002). Furthermore, INOCA women with impaired ΔCBF (n=23) had higher CPT MPRIRPP (p=0.044) compared to reference women despite lower left ventricular ejection fraction (64±7 % vs 69±2 %, p=0.005) and mass-to-volume ratio (0.79±0.15 vs 0.62±0.09, p<0.0001). These differences in CPT MPRIRPP did not persist after adjusting for age, body mass index, and history of hypertension. CPT MPRIRPP among INOCA women did not differ based on defined acetylcholine responses.Myocardial perfusion reserve to CPT stress is greater among women with INOCA compared to reference subjects. CPT induced a higher MPRIRPP also in women with coronary endothelial dysfunction, suggesting a greater contribution of the SNS to coronary flow than endothelial dysfunction. Further investigation in a larger cohort is needed.ConclusionsMyocardial perfusion reserve to CPT stress is greater among women with INOCA compared to reference subjects. CPT induced a higher MPRIRPP also in women with coronary endothelial dysfunction, suggesting a greater contribution of the SNS to coronary flow than endothelial dysfunction. Further investigation in a larger cohort is needed. AbstractStudy objectiveCold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT stress cardiac magnetic resonance (CMR) imaging between women with suspected INOCA and reference subjects. DesignProspective cohort. SettingAcademic hospital. Participants107 women with suspected INOCA and 21-age-matched reference women. InterventionsCPT stress CMR was performed with measurement of myocardial perfusion reserve index (MPRI), adjusted for rate pressure product (MPRI RPP). Invasive coronary function testing in a subset of INOCA women (n = 42) evaluated for endothelial dysfunction in response to acetylcholine, including impaired coronary diameter response ≤0% and coronary blood flow response (ΔCBF) <50%. Main outcome measureMPRI RPP. ResultsCompared to reference women, the INOCA group demonstrated higher resting RPP (p = 0.005) and CPT MPRI RPP (1.09 ± 0.36 vs 0.83 ± 0.18, p = 0.002). Furthermore, INOCA women with impaired ΔCBF (n = 23) had higher CPT MPRI RPP (p = 0.044) compared to reference women despite lower left ventricular ejection fraction (64 ± 7% vs 69 ± 2%, p = 0.005) and higher mass-to-volume ratio (0.79 ± 0.15 vs 0.62 ± 0.09, p < 0.0001). These differences in CPT MPRI RPP did not persist after adjusting for age, body mass index, and history of hypertension. CPT MPRI RPP among INOCA women did not differ based on defined acetylcholine responses. ConclusionsMyocardial perfusion reserve to CPT stress is greater among women with INOCA compared to reference subjects. This CPT response was also noted in women with coronary endothelial dysfunction, suggesting a greater contribution of the SNS to coronary flow than endothelial dysfunction. Therapies to modulate sympathetic activity should be studied in this population. Study objective: Cold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT stress cardiac magnetic resonance (CMR) imaging between women with suspected INOCA and reference subjects. Design: Prospective cohort. Setting: Academic hospital. Participants: 107 women with suspected INOCA and 21-age-matched reference women. Interventions: CPT stress CMR was performed with measurement of myocardial perfusion reserve index (MPRI), adjusted for rate pressure product (MPRIRPP). Invasive coronary function testing in a subset of INOCA women (n = 42) evaluated for endothelial dysfunction in response to acetylcholine, including impaired coronary diameter response ≤0% and coronary blood flow response (ΔCBF) <50%. Main outcome measure: MPRIRPP. Results: Compared to reference women, the INOCA group demonstrated higher resting RPP (p = 0.005) and CPT MPRIRPP (1.09 ± 0.36 vs 0.83 ± 0.18, p = 0.002). Furthermore, INOCA women with impaired ΔCBF (n = 23) had higher CPT MPRIRPP (p = 0.044) compared to reference women despite lower left ventricular ejection fraction (64 ± 7% vs 69 ± 2%, p = 0.005) and higher mass-to-volume ratio (0.79 ± 0.15 vs 0.62 ± 0.09, p < 0.0001). These differences in CPT MPRIRPP did not persist after adjusting for age, body mass index, and history of hypertension. CPT MPRIRPP among INOCA women did not differ based on defined acetylcholine responses. Conclusions: Myocardial perfusion reserve to CPT stress is greater among women with INOCA compared to reference subjects. This CPT response was also noted in women with coronary endothelial dysfunction, suggesting a greater contribution of the SNS to coronary flow than endothelial dysfunction. Therapies to modulate sympathetic activity should be studied in this population. Cold Pressor Testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow regulation in women with suspected ischemia and no obstructive coronary arteries (INOCA), we compared myocardial perfusion reserve during CPT stress cardiac magnetic resonance (CMR) imaging between women with suspected INOCA and reference subjects. Prospective cohort. Academic hospital. 107 women with suspected INOCA and 21-age-matched reference women. CPT stress CMR was performed with measurement of myocardial perfusion reserve index (MPRI), adjusted for rate pressure product (MPRI ). Invasive coronary function testing in a subset of INOCA women (n=42) evaluated for endothelial dysfunction in response to acetylcholine, including impaired coronary diameter response ≤0% and coronary blood flow response (ΔCBF) <50%. MPRI . Compared to reference women, the INOCA group demonstrated higher resting RPP (p=0.005) and CPT MPRI (1.09±0.36 vs 0.83±0.18, p=0.002). Furthermore, INOCA women with impaired ΔCBF (n=23) had higher CPT MPRI (p=0.044) compared to reference women despite lower left ventricular ejection fraction (64±7 % vs 69±2 %, p=0.005) and mass-to-volume ratio (0.79±0.15 vs 0.62±0.09, p<0.0001). These differences in CPT MPRI did not persist after adjusting for age, body mass index, and history of hypertension. CPT MPRI among INOCA women did not differ based on defined acetylcholine responses. Myocardial perfusion reserve to CPT stress is greater among women with INOCA compared to reference subjects. CPT induced a higher MPRI also in women with coronary endothelial dysfunction, suggesting a greater contribution of the SNS to coronary flow than endothelial dysfunction. Further investigation in a larger cohort is needed. |
| ArticleNumber | 100080 |
| Author | Wei, J. Mehta, P.K. Jalnapurkar, S. AlBadri, A. Handberg, E.M. Sharif, B. Berman, D.S. Shufelt, C. Anderson, R.D. Petersen, J.W. Zarrini, P. Barsky, L.L. Pepine, C.J. Thomson, L.E.J. Cook-Wiens, G. Nelson, M.D. Bairey Merz, C.N. |
| AuthorAffiliation | 3 University of Texas, Arlington, TX 2 Emory University, Atlanta, GA 4 Division of Cardiology, University of Florida, Gainesville, FL 1 Barbra Streisand Women’s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA |
| AuthorAffiliation_xml | – name: 3 University of Texas, Arlington, TX – name: 1 Barbra Streisand Women’s Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA – name: 2 Emory University, Atlanta, GA – name: 4 Division of Cardiology, University of Florida, Gainesville, FL |
| Author_xml | – sequence: 1 givenname: J. surname: Wei fullname: Wei, J. email: janet.wei@cshs.org organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 2 givenname: L.L. surname: Barsky fullname: Barsky, L.L. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 3 givenname: S. surname: Jalnapurkar fullname: Jalnapurkar, S. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 4 givenname: P. surname: Zarrini fullname: Zarrini, P. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 5 givenname: G. surname: Cook-Wiens fullname: Cook-Wiens, G. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 6 givenname: A. surname: AlBadri fullname: AlBadri, A. organization: Emory University, Atlanta, GA, United States of America – sequence: 7 givenname: M.D. surname: Nelson fullname: Nelson, M.D. organization: University of Texas, Arlington, TX, United States of America – sequence: 8 givenname: C. surname: Shufelt fullname: Shufelt, C. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 9 givenname: B. surname: Sharif fullname: Sharif, B. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 10 givenname: D.S. surname: Berman fullname: Berman, D.S. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 11 givenname: L.E.J. surname: Thomson fullname: Thomson, L.E.J. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 12 givenname: E.M. surname: Handberg fullname: Handberg, E.M. organization: Division of Cardiology, University of Florida, Gainesville, FL, United States of America – sequence: 13 givenname: J.W. surname: Petersen fullname: Petersen, J.W. organization: Division of Cardiology, University of Florida, Gainesville, FL, United States of America – sequence: 14 givenname: R.D. surname: Anderson fullname: Anderson, R.D. organization: Division of Cardiology, University of Florida, Gainesville, FL, United States of America – sequence: 15 givenname: C.J. surname: Pepine fullname: Pepine, C.J. organization: Division of Cardiology, University of Florida, Gainesville, FL, United States of America – sequence: 16 givenname: C.N. surname: Bairey Merz fullname: Bairey Merz, C.N. organization: Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States of America – sequence: 17 givenname: P.K. surname: Mehta fullname: Mehta, P.K. organization: Emory University, Atlanta, GA, United States of America |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36262746$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNU01v1DAQjVARLaV_gAPyDS5bbCexkwohoaVApUogysfRcpxJ18GxF9vZan8o_wdnt121SEBPtmbmvTfjN36c7VlnIcueEnxMMGEv-2O56N0xxZSkAMYVfpAdUMbYjGFK927d97OjEPpUQkuSE1Y9yvZzRhnlBTvIfs2dadHSQwjOowghanuJpG1RWA9LGRcQtUIW_MqNIcVChAEpZ6PXzRi1syg6pINawKAlutJxgaxDrgnRjyrqFaRi76z0ayR9hHS0OoAMcII-QxhNDKjzbkBJCH13A9jnAZ3d0F2sbZuSgE5X0oxykpvNb-i-yaBGIz16uw7daNWmmU_e9aDik-xhJ02Ao-vzMPv67vTL_MPs_OP7s_mb85lK48cZ5x1UBZG4YUUn2xpYA6zDVclIRQkQ2lDV1Y1kJbAcWlx1OeOSyoIQRlWp8sPsbMvbOtmLpddD6kw4qcUm4PylSFNrZUB0PD1_3XCc16ooeVErRRIzhaYDJTlLXPmWa7RLub6SxuwICRaT56IXk-di8lxsPU-o11vUcmwGaBUkZ6S508rdjNULcelWoi55xdlE8OKawLufY_JfDMlOMEZaSJYLyimracF4mUqf3dbaidxsUyqotgXKuxA8dELpuLEtSWvz7znoH9B7Df9qC4Lk8UqDF0FpsApa7dMWJBP0vd5uB1dGW62k-QFrCL0bvU3bI4gIVGBxMf2o6UPRCc8rkghO_k7wP_XfTqI2FQ |
| CitedBy_id | crossref_primary_10_31083_j_rcm2403090 |
| Cites_doi | 10.1016/j.ahj.2019.11.017 10.1186/s12968-015-0166-5 10.1016/S0002-9149(96)00357-8 10.1161/01.CIR.83.2.391 10.1161/CIRCIMAGING.114.002481 10.1007/s11357-018-0048-5 10.1002/clc.22660 10.1046/j.1440-1681.1999.03126.x 10.1016/j.jacc.2018.11.040 10.1161/CIRCOUTCOMES.116.003863 10.1016/j.jcin.2012.01.023 10.1016/S0735-1097(03)00166-9 10.1161/CIRCIMAGING.114.001714 10.1161/01.RES.79.3.455 10.1007/s00259-002-0818-1 10.1161/CIRCULATIONAHA.116.024534 10.14336/AD.2013.0400320 10.1161/01.CIR.96.3.821 10.1371/journal.pone.0169818 10.1046/j.1365-2796.1999.00449.x 10.1161/CIRCULATIONAHA.117.031999 10.1056/NEJM199704243361703 10.33549/physiolres.931360 10.1152/ajpregu.00562.2010 10.1155/2019/7169275 10.1002/j.2040-4603.2015.tb00658.x 10.1161/01.CIR.77.1.43 10.1371/journal.pone.0172538 10.1093/eurheartj/ehv647 |
| ContentType | Journal Article |
| Copyright | 2021 |
| Copyright_xml | – notice: 2021 |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1016/j.ahjo.2021.100080 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2666-6022 |
| EndPage | 100080 |
| ExternalDocumentID | oai_doaj_org_article_f72519b7039c45749cc1ba62ebfeca76 10.1016/j.ahjo.2021.100080 PMC9578760 36262746 10_1016_j_ahjo_2021_100080 S2666602221000781 1_s2_0_S2666602221000781 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL090957 – fundername: NHLBI NIH HHS grantid: K23 HL125941 – fundername: NHLBI NIH HHS grantid: R01 HL153430 – fundername: NHLBI NIH HHS grantid: K23 HL105787 |
| GroupedDBID | .1- .FO AAEDW AALRI AAXUO AAYWO ACVFH ADCNI ADVLN AEUPX AFJKZ AFPUW AFRHN AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP EBS FDB GROUPED_DOAJ M~E OK1 RPM Z5R 6I. AAFTH AAYXX CITATION NPM 7X8 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c627t-77fe841a0b64fad9e6be6f08561821e12b2cf9ba65e63ed08f367a2a41162c5c3 |
| IEDL.DBID | DOA |
| ISSN | 2666-6022 |
| IngestDate | Wed Aug 27 01:13:53 EDT 2025 Wed Aug 20 00:15:07 EDT 2025 Thu Aug 21 18:39:55 EDT 2025 Thu Jul 10 17:17:31 EDT 2025 Thu Apr 03 07:00:20 EDT 2025 Wed Oct 01 05:59:17 EDT 2025 Thu Apr 24 23:05:34 EDT 2025 Sat Jun 28 18:17:56 EDT 2025 Tue Feb 25 20:09:51 EST 2025 Tue Aug 26 16:33:50 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | NTG EF INOCA ACH CBF CPT CAD CMR LV WISE Sympathetic nervous system CFR CVD Microcirculation RPP NHLBI Magnetic resonance imaging Perfusion SNS MPRI coronary artery disease ejection fraction cardiac magnetic resonance imaging left ventricle National Heart, Lung, and Blood Institute myocardial perfusion reserve index nitroglycerin cold pressor testing rate pressure product sympathetic nervous system coronary flow reserve acetylcholine coronary blood flow coronary vascular dysfunction Women's Ischemia Syndrome Evaluation ischemia and no obstructive coronary arteries |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. cc-by-nc-nd |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c627t-77fe841a0b64fad9e6be6f08561821e12b2cf9ba65e63ed08f367a2a41162c5c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/f72519b7039c45749cc1ba62ebfeca76 |
| PMID | 36262746 |
| PQID | 2726924675 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_f72519b7039c45749cc1ba62ebfeca76 unpaywall_primary_10_1016_j_ahjo_2021_100080 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9578760 proquest_miscellaneous_2726924675 pubmed_primary_36262746 crossref_citationtrail_10_1016_j_ahjo_2021_100080 crossref_primary_10_1016_j_ahjo_2021_100080 elsevier_sciencedirect_doi_10_1016_j_ahjo_2021_100080 elsevier_clinicalkeyesjournals_1_s2_0_S2666602221000781 elsevier_clinicalkey_doi_10_1016_j_ahjo_2021_100080 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-01-01 |
| PublicationDateYYYYMMDD | 2022-01-01 |
| PublicationDate_xml | – month: 01 year: 2022 text: 2022-01-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | American heart journal plus |
| PublicationTitleAlternate | Am Heart J Plus |
| PublicationYear | 2022 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Quesada, AlBadri, Wei, Shufelt, Mehta, Maughan (bb0055) 2020; 220 Bairey Merz, Handberg, Shufelt, Mehta, Minissian, Wei (bb0065) 2016; 37 Jones, Spraul, Matt, Seals, Skinner, Ravussin (bb0140) 1996; 270 Richardson, Clarke, Quinn, Holmes (bb0145) 2015; 5 Britten, Zeiher, Schachinger (bb0050) 1999; 245 Thomson, Wei, Agarwal, Haft-Baradaran, Shufelt, Mehta (bb0015) 2015; 8 AlBadri, Wei, Mehta, Landes, Petersen, Anderson (bb0025) 2017; 12 Landes, Dela Cruz, Wei, AlBadri, Shufelt, Mehta (bb0060) 2017; 12 AlBadri, Bairey Merz, Johnson, Wei, Mehta, Cook-Wiens (bb0020) 2019; 73 Di Carli, Janisse, Grunberger, Ager (bb0120) 2003; 41 Mourot, Bouhaddi, Regnard (bb0150) 2009; 58 Sheng, Zhu (bb0105) 2018; 10 Kenkre, Malhotra, Johnson, Handberg, Thompson, Marroquin (bb0005) 2017; 10 Iwado, Yoshinaga, Furuyama, Ito, Noriyasu, Katoh (bb0115) 2002; 29 Bairey Merz, Pepine, Walsh, Fleg (bb0040) 2017; 135 Pasini, Capecchi, Colafati, Randisi, Puccetti, Di Perri (bb0125) 1999; 26 Di Carli, Tobes, Mangner, Levine, Muzik, Chakroborty (bb0095) 1997; 336 Nelson, Sharif, Shaw, Cook-Wiens, Wei, Shufelt (bb0090) 2017; 40 Meeder, Peels, Blanksma, Tan, Pruim, van der Wall (bb0155) 1996; 78 Balasubramanian, Hall, Subramanian (bb0160) 2019; 41 Zeiher, Drexler (bb0030) 1991; 86 Zeiher, Drexler, Wollschlager, Just (bb0035) 1991; 83 Anderson, Petersen, Mehta, Wei, Johnson, Handberg (bb0010) 2019; 2019 Souza, Tezini (bb0130) 2013; 4 Parnham, Gleadle, Leong, Grover, Bradbrook, Woodman (bb0070) 2015; 17 Wei, Bakir, Darounian, Li, Landes, Mehta (bb0075) 2018; 137 Wei, Mehta, Johnson, Samuels, Kar, Anderson (bb0080) 2012; 5 Lanza, Giordano, Pristipino, Calcagni, Meduri, Trani (bb0045) 1997; 96 Jarvis, VanGundy, Galbreath, Shibata, Okazaki, Reelick (bb0135) 2011; 301 Nelson, Szczepaniak, Wei, Haftabaradaren, Bharadwaj, Sharif (bb0085) 2014; 7 Ungerer, Kessebohm, Kronsbein, Lohse, Richardt (bb0100) 1996; 79 Nabel, Ganz, Gordon, Alexander, Selwyn (bb0110) 1988; 77 Mourot (10.1016/j.ahjo.2021.100080_bb0150) 2009; 58 Iwado (10.1016/j.ahjo.2021.100080_bb0115) 2002; 29 Di Carli (10.1016/j.ahjo.2021.100080_bb0120) 2003; 41 Bairey Merz (10.1016/j.ahjo.2021.100080_bb0040) 2017; 135 Nelson (10.1016/j.ahjo.2021.100080_bb0090) 2017; 40 Landes (10.1016/j.ahjo.2021.100080_bb0060) 2017; 12 Jones (10.1016/j.ahjo.2021.100080_bb0140) 1996; 270 Sheng (10.1016/j.ahjo.2021.100080_bb0105) 2018; 10 AlBadri (10.1016/j.ahjo.2021.100080_bb0020) 2019; 73 Britten (10.1016/j.ahjo.2021.100080_bb0050) 1999; 245 Nelson (10.1016/j.ahjo.2021.100080_bb0085) 2014; 7 Bairey Merz (10.1016/j.ahjo.2021.100080_bb0065) 2016; 37 Zeiher (10.1016/j.ahjo.2021.100080_bb0035) 1991; 83 Balasubramanian (10.1016/j.ahjo.2021.100080_bb0160) 2019; 41 Anderson (10.1016/j.ahjo.2021.100080_bb0010) 2019; 2019 Di Carli (10.1016/j.ahjo.2021.100080_bb0095) 1997; 336 Kenkre (10.1016/j.ahjo.2021.100080_bb0005) 2017; 10 Parnham (10.1016/j.ahjo.2021.100080_bb0070) 2015; 17 Souza (10.1016/j.ahjo.2021.100080_bb0130) 2013; 4 Richardson (10.1016/j.ahjo.2021.100080_bb0145) 2015; 5 Zeiher (10.1016/j.ahjo.2021.100080_bb0030) 1991; 86 Thomson (10.1016/j.ahjo.2021.100080_bb0015) 2015; 8 Meeder (10.1016/j.ahjo.2021.100080_bb0155) 1996; 78 Quesada (10.1016/j.ahjo.2021.100080_bb0055) 2020; 220 Wei (10.1016/j.ahjo.2021.100080_bb0080) 2012; 5 Nabel (10.1016/j.ahjo.2021.100080_bb0110) 1988; 77 Lanza (10.1016/j.ahjo.2021.100080_bb0045) 1997; 96 Jarvis (10.1016/j.ahjo.2021.100080_bb0135) 2011; 301 Wei (10.1016/j.ahjo.2021.100080_bb0075) 2018; 137 AlBadri (10.1016/j.ahjo.2021.100080_bb0025) 2017; 12 Ungerer (10.1016/j.ahjo.2021.100080_bb0100) 1996; 79 Pasini (10.1016/j.ahjo.2021.100080_bb0125) 1999; 26 |
| References_xml | – volume: 41 start-page: 13 year: 2019 end-page: 24 ident: bb0160 article-title: Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases publication-title: Geroscience – volume: 79 start-page: 455 year: 1996 end-page: 460 ident: bb0100 article-title: Activation of beta-adrenergic receptor kinase during myocardial ischemia publication-title: Circ. Res. – volume: 301 start-page: R193 year: 2011 end-page: R200 ident: bb0135 article-title: Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. – volume: 29 start-page: 984 year: 2002 end-page: 990 ident: bb0115 article-title: Decreased endothelium-dependent coronary vasomotion in healthy young smokers publication-title: Eur. J. Nucl. Med. Mol. Imaging – volume: 7 start-page: 510 year: 2014 end-page: 516 ident: bb0085 article-title: Diastolic dysfunction in women with signs and symptoms of ischemia in the absence of obstructive coronary artery disease: a hypothesis-generating study publication-title: Circ. Cardiovasc. Imaging – volume: 4 start-page: 320 year: 2013 end-page: 328 ident: bb0130 article-title: Autonomic cardiovascular damage during post-menopause: the role of physical training publication-title: Aging Dis. – volume: 58 start-page: 83 year: 2009 end-page: 91 ident: bb0150 article-title: Effects of the cold pressor test on cardiac autonomic control in normal subjects publication-title: Physiol. Res. – volume: 10 start-page: 17 year: 2018 end-page: 28 ident: bb0105 article-title: The crosstalk between autonomic nervous system and blood vessels publication-title: Int. J. Physiol. Pathophysiol. Pharmacol. – volume: 41 start-page: 1387 year: 2003 end-page: 1393 ident: bb0120 article-title: Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes publication-title: J. Am. Coll. Cardiol. – volume: 135 start-page: 1075 year: 2017 end-page: 1092 ident: bb0040 article-title: Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade publication-title: Circulation – volume: 73 start-page: 684 year: 2019 end-page: 693 ident: bb0020 article-title: Impact of abnormal coronary reactivity on long-term clinical outcomes in women publication-title: J. Am. Coll. Cardiol. – volume: 12 year: 2017 ident: bb0025 article-title: Acetylcholine versus cold pressor testing for evaluation of coronary endothelial function publication-title: PLoS One – volume: 2019 start-page: 8 year: 2019 ident: bb0010 article-title: Prevalence of coronary endothelial and microvascular dysfunction in women with symptoms of ischemia and no obstructive coronary artery disease is confirmed by a new cohort: the NHLBI-sponsored Women’s ischemia syndrome Evaluation–Coronary vascular dysfunction (WISE-CVD) publication-title: J. Interv. Cardiol. – volume: 5 start-page: 1877 year: 2015 end-page: 1909 ident: bb0145 article-title: Physiological implications of myocardial scar structure publication-title: Compr. Physiol. – volume: 86 start-page: 203 year: 1991 end-page: 213 ident: bb0030 article-title: Coronary hemodynamic determinants of epicardial artery vasomotor responses during sympathetic stimulation in humans publication-title: Basic Res. Cardiol. – volume: 83 start-page: 391 year: 1991 end-page: 401 ident: bb0035 article-title: Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis publication-title: Circulation – volume: 245 start-page: 315 year: 1999 end-page: 327 ident: bb0050 article-title: Clinical importance of coronary endothelial vasodilator dysfunction and therapeutic options publication-title: J. Intern. Med. – volume: 96 start-page: 821 year: 1997 end-page: 826 ident: bb0045 article-title: Abnormal cardiac adrenergic nerve function in patients with syndrome X detected by [123I]metaiodobenzylguanidine myocardial scintigraphy publication-title: Circulation – volume: 40 start-page: 300 year: 2017 end-page: 306 ident: bb0090 article-title: Myocardial tissue deformation is reduced in subjects with coronary microvascular dysfunction but not rescued by treatment with ranolazine publication-title: Clin. Cardiol. – volume: 77 start-page: 43 year: 1988 end-page: 52 ident: bb0110 article-title: Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test publication-title: Circulation – volume: 26 start-page: 774 year: 1999 end-page: 778 ident: bb0125 article-title: Systemic adenosine increase during cold pressor test is dependent on sympathetic activation publication-title: Clin. Exp. Pharmacol. Physiol. – volume: 78 start-page: 526 year: 1996 end-page: 531 ident: bb0155 article-title: Comparison between positron emission tomography myocardial perfusion imaging and intracoronary doppler flow velocity measurements at rest and during cold pressor testing in angiographically normal coronary arteries in patients with one-vessel coronary artery disease publication-title: Am. J. Cardiol. – volume: 10 year: 2017 ident: bb0005 article-title: Ten-year mortality in the WISE study (Women's ischemia syndrome Evaluation) publication-title: Circ. Cardiovasc. Qual. Outcomes – volume: 336 start-page: 1208 year: 1997 end-page: 1215 ident: bb0095 article-title: Effects of cardiac sympathetic innervation on coronary blood flow publication-title: N. Engl. J. Med. – volume: 220 start-page: 224 year: 2020 end-page: 236 ident: bb0055 article-title: Design, methodology and baseline characteristics of the Women's ischemia syndrome evaluation-coronary vascular dysfunction (WISE-CVD) publication-title: Am. Heart J. – volume: 8 year: 2015 ident: bb0015 article-title: Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction. A National Heart, Lung, and Blood Institute-sponsored study from the Women's ischemia syndrome evaluation publication-title: Circ. Cardiovasc. Imaging – volume: 12 year: 2017 ident: bb0060 article-title: Cold pressor stress cardiac magnetic resonance myocardial flow reserve is not useful for detection of coronary endothelial dysfunction in women with signs and symptoms of ischemia and no obstructive CAD publication-title: PLoS One – volume: 137 start-page: 874 year: 2018 end-page: 876 ident: bb0075 article-title: Myocardial scar is prevalent and associated with subclinical myocardial dysfunction in women with suspected ischemia but no obstructive coronary artery disease: from the Women's ischemia syndrome evaluation-coronary vascular dysfunction study publication-title: Circulation – volume: 37 start-page: 1504 year: 2016 end-page: 1513 ident: bb0065 article-title: A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve publication-title: Eur. Heart J. – volume: 17 start-page: 56 year: 2015 ident: bb0070 article-title: Myocardial perfusion is impaired in asymptomatic renal and liver transplant recipients: a cardiovascular magnetic resonance study publication-title: J Cardiovasc. Magn. Reson. – volume: 270 start-page: H350 year: 1996 end-page: H357 ident: bb0140 article-title: Gender does not influence sympathetic neural reactivity to stress in healthy humans publication-title: Am. J. Phys. – volume: 5 start-page: 646 year: 2012 end-page: 653 ident: bb0080 article-title: Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's ischemia syndrome Evaluation) study publication-title: JACC Cardiovasc. Interv. – volume: 220 start-page: 224 year: 2020 ident: 10.1016/j.ahjo.2021.100080_bb0055 article-title: Design, methodology and baseline characteristics of the Women's ischemia syndrome evaluation-coronary vascular dysfunction (WISE-CVD) publication-title: Am. Heart J. doi: 10.1016/j.ahj.2019.11.017 – volume: 17 start-page: 56 year: 2015 ident: 10.1016/j.ahjo.2021.100080_bb0070 article-title: Myocardial perfusion is impaired in asymptomatic renal and liver transplant recipients: a cardiovascular magnetic resonance study publication-title: J Cardiovasc. Magn. Reson. doi: 10.1186/s12968-015-0166-5 – volume: 78 start-page: 526 issue: 5 year: 1996 ident: 10.1016/j.ahjo.2021.100080_bb0155 publication-title: Am. J. Cardiol. doi: 10.1016/S0002-9149(96)00357-8 – volume: 83 start-page: 391 issue: 2 year: 1991 ident: 10.1016/j.ahjo.2021.100080_bb0035 article-title: Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis publication-title: Circulation doi: 10.1161/01.CIR.83.2.391 – volume: 270 start-page: H350 issue: 1 Pt 2 year: 1996 ident: 10.1016/j.ahjo.2021.100080_bb0140 article-title: Gender does not influence sympathetic neural reactivity to stress in healthy humans publication-title: Am. J. Phys. – volume: 8 issue: 4 year: 2015 ident: 10.1016/j.ahjo.2021.100080_bb0015 article-title: Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction. A National Heart, Lung, and Blood Institute-sponsored study from the Women's ischemia syndrome evaluation publication-title: Circ. Cardiovasc. Imaging doi: 10.1161/CIRCIMAGING.114.002481 – volume: 41 start-page: 13 issue: 1 year: 2019 ident: 10.1016/j.ahjo.2021.100080_bb0160 article-title: Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases publication-title: Geroscience doi: 10.1007/s11357-018-0048-5 – volume: 40 start-page: 300 issue: 5 year: 2017 ident: 10.1016/j.ahjo.2021.100080_bb0090 article-title: Myocardial tissue deformation is reduced in subjects with coronary microvascular dysfunction but not rescued by treatment with ranolazine publication-title: Clin. Cardiol. doi: 10.1002/clc.22660 – volume: 26 start-page: 774 issue: 10 year: 1999 ident: 10.1016/j.ahjo.2021.100080_bb0125 article-title: Systemic adenosine increase during cold pressor test is dependent on sympathetic activation publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1046/j.1440-1681.1999.03126.x – volume: 73 start-page: 684 issue: 6 year: 2019 ident: 10.1016/j.ahjo.2021.100080_bb0020 article-title: Impact of abnormal coronary reactivity on long-term clinical outcomes in women publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2018.11.040 – volume: 10 issue: 12 year: 2017 ident: 10.1016/j.ahjo.2021.100080_bb0005 article-title: Ten-year mortality in the WISE study (Women's ischemia syndrome Evaluation) publication-title: Circ. Cardiovasc. Qual. Outcomes doi: 10.1161/CIRCOUTCOMES.116.003863 – volume: 5 start-page: 646 issue: 6 year: 2012 ident: 10.1016/j.ahjo.2021.100080_bb0080 article-title: Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's ischemia syndrome Evaluation) study publication-title: JACC Cardiovasc. Interv. doi: 10.1016/j.jcin.2012.01.023 – volume: 41 start-page: 1387 issue: 8 year: 2003 ident: 10.1016/j.ahjo.2021.100080_bb0120 article-title: Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(03)00166-9 – volume: 7 start-page: 510 issue: 3 year: 2014 ident: 10.1016/j.ahjo.2021.100080_bb0085 article-title: Diastolic dysfunction in women with signs and symptoms of ischemia in the absence of obstructive coronary artery disease: a hypothesis-generating study publication-title: Circ. Cardiovasc. Imaging doi: 10.1161/CIRCIMAGING.114.001714 – volume: 86 start-page: 203 issue: Suppl 2 year: 1991 ident: 10.1016/j.ahjo.2021.100080_bb0030 article-title: Coronary hemodynamic determinants of epicardial artery vasomotor responses during sympathetic stimulation in humans publication-title: Basic Res. Cardiol. – volume: 79 start-page: 455 issue: 3 year: 1996 ident: 10.1016/j.ahjo.2021.100080_bb0100 article-title: Activation of beta-adrenergic receptor kinase during myocardial ischemia publication-title: Circ. Res. doi: 10.1161/01.RES.79.3.455 – volume: 29 start-page: 984 issue: 8 year: 2002 ident: 10.1016/j.ahjo.2021.100080_bb0115 article-title: Decreased endothelium-dependent coronary vasomotion in healthy young smokers publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-002-0818-1 – volume: 135 start-page: 1075 issue: 11 year: 2017 ident: 10.1016/j.ahjo.2021.100080_bb0040 article-title: Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.116.024534 – volume: 4 start-page: 320 issue: 6 year: 2013 ident: 10.1016/j.ahjo.2021.100080_bb0130 article-title: Autonomic cardiovascular damage during post-menopause: the role of physical training publication-title: Aging Dis. doi: 10.14336/AD.2013.0400320 – volume: 96 start-page: 821 issue: 3 year: 1997 ident: 10.1016/j.ahjo.2021.100080_bb0045 article-title: Abnormal cardiac adrenergic nerve function in patients with syndrome X detected by [123I]metaiodobenzylguanidine myocardial scintigraphy publication-title: Circulation doi: 10.1161/01.CIR.96.3.821 – volume: 12 issue: 1 year: 2017 ident: 10.1016/j.ahjo.2021.100080_bb0060 article-title: Cold pressor stress cardiac magnetic resonance myocardial flow reserve is not useful for detection of coronary endothelial dysfunction in women with signs and symptoms of ischemia and no obstructive CAD publication-title: PLoS One doi: 10.1371/journal.pone.0169818 – volume: 10 start-page: 17 issue: 1 year: 2018 ident: 10.1016/j.ahjo.2021.100080_bb0105 article-title: The crosstalk between autonomic nervous system and blood vessels publication-title: Int. J. Physiol. Pathophysiol. Pharmacol. – volume: 245 start-page: 315 issue: 4 year: 1999 ident: 10.1016/j.ahjo.2021.100080_bb0050 article-title: Clinical importance of coronary endothelial vasodilator dysfunction and therapeutic options publication-title: J. Intern. Med. doi: 10.1046/j.1365-2796.1999.00449.x – volume: 137 start-page: 874 issue: 8 year: 2018 ident: 10.1016/j.ahjo.2021.100080_bb0075 article-title: Myocardial scar is prevalent and associated with subclinical myocardial dysfunction in women with suspected ischemia but no obstructive coronary artery disease: from the Women's ischemia syndrome evaluation-coronary vascular dysfunction study publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.031999 – volume: 336 start-page: 1208 issue: 17 year: 1997 ident: 10.1016/j.ahjo.2021.100080_bb0095 article-title: Effects of cardiac sympathetic innervation on coronary blood flow publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199704243361703 – volume: 58 start-page: 83 issue: 1 year: 2009 ident: 10.1016/j.ahjo.2021.100080_bb0150 article-title: Effects of the cold pressor test on cardiac autonomic control in normal subjects publication-title: Physiol. Res. doi: 10.33549/physiolres.931360 – volume: 301 start-page: R193 issue: 1 year: 2011 ident: 10.1016/j.ahjo.2021.100080_bb0135 article-title: Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00562.2010 – volume: 2019 start-page: 8 year: 2019 ident: 10.1016/j.ahjo.2021.100080_bb0010 publication-title: J. Interv. Cardiol. doi: 10.1155/2019/7169275 – volume: 5 start-page: 1877 issue: 4 year: 2015 ident: 10.1016/j.ahjo.2021.100080_bb0145 article-title: Physiological implications of myocardial scar structure publication-title: Compr. Physiol. doi: 10.1002/j.2040-4603.2015.tb00658.x – volume: 77 start-page: 43 issue: 1 year: 1988 ident: 10.1016/j.ahjo.2021.100080_bb0110 article-title: Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test publication-title: Circulation doi: 10.1161/01.CIR.77.1.43 – volume: 12 issue: 2 year: 2017 ident: 10.1016/j.ahjo.2021.100080_bb0025 article-title: Acetylcholine versus cold pressor testing for evaluation of coronary endothelial function publication-title: PLoS One doi: 10.1371/journal.pone.0172538 – volume: 37 start-page: 1504 issue: 19 year: 2016 ident: 10.1016/j.ahjo.2021.100080_bb0065 article-title: A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehv647 |
| SSID | ssj0002513168 |
| Score | 2.2144988 |
| Snippet | Cold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow... AbstractStudy objectiveCold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to... Cold Pressor Testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to coronary blood flow... Study objective: Cold pressor testing (CPT) is a known stimulus of the sympathetic nervous system (SNS). To better understand sympathetic contribution to... |
| SourceID | doaj unpaywall pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 100080 |
| SubjectTerms | Cardiovascular Magnetic resonance imaging Microcirculation Perfusion Sympathetic nervous system |
| SummonAdditionalLinks | – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZge4ALD_FaXjISEgdItXYce8OtLK0Kh6qiFJWT5Xjtdss2qZosaPmf_B9mHGdFaFXKdWPH6_ibh-2Zbwh5mY2VhW2JT3I7GiVCpEVScKsSK5UcFVJ530Zb7MjtffHxIDuINDmYC9O7vw9xWOboGJP0OMMLffBvrpM1iZdJA7K2v7O78RWrx4EPnkiwRjEr5uKOPcsTCPp7Bui8g3k-TvLGojw1yx9mPv_DCG3dbqsZ1YG7EGNPvq0vmmLd_vyL2fFq87tDbkVflG604LlLrrnyHvk1qeZTGsJjqzPaIAlHeUhNOaX18gTrF2PWIy1BxVSLmrZE0DQEvMfKWbSp6Az2zO5kZige89KyolURiWq_O2h8VmESMA3hpEsa74je0k-uXsybmmLKC4WBaCiv-aqmH7rX7UV-Bbq5IilPJt3rvsSgWvp-WaO5Dn9mtz1puk_2tzY_T7aTWPsBUMJVA06_d2PBDOBFeDPNnSyc9OAfStgQMcc4IMrnhZGZk6mbjsY-lcpwIxiT3GY2fUAGZVW6R4QWgvkxB8xhrXfwd4z1PLXCAmBykcvpkLAOF9pGYnSszzHXXQTcscZF0rhIul2kIXm96nPa0oJc2vodwm3VEim9ww-ABB01hPYKk4gL0MC5FZkSubUM5sdd4Z01Sg5J2oFVd1mzoOfhRbNLh1YX9XJ1VFW1ZrrmeqT3UIhQhjgLfiMbkmzVM3pjrZf1zxFfdJKkQVXh_ZMpHUBSc8UlbPdhizokD1vJWn0SZEXiSsAsVU_met-s_6ScHQU69ByNjoRx36yk8wpr8vj_mj8hNzkmvoTDt6dkADLjnoE72hTPox76DQiQim4 priority: 102 providerName: Unpaywall |
| Title | Cold pressor testing and sympathetic nervous system contribution to ischemia with no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Project |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S2666602221000781 https://www.clinicalkey.es/playcontent/1-s2.0-S2666602221000781 https://dx.doi.org/10.1016/j.ahjo.2021.100080 https://www.ncbi.nlm.nih.gov/pubmed/36262746 https://www.proquest.com/docview/2726924675 https://pubmed.ncbi.nlm.nih.gov/PMC9578760 https://doi.org/10.1016/j.ahjo.2021.100080 https://doaj.org/article/f72519b7039c45749cc1ba62ebfeca76 |
| UnpaywallVersion | publishedVersion |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2666-6022 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0002513168 issn: 2666-6022 databaseCode: DOA dateStart: 20210101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2666-6022 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0002513168 issn: 2666-6022 databaseCode: M~E dateStart: 20200101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 2666-6022 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0002513168 issn: 2666-6022 databaseCode: AKRWK dateStart: 20210101 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2666-6022 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0002513168 issn: 2666-6022 databaseCode: RPM dateStart: 20210101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELZQOcAFgXiFR2QkJA6wIvZ67Sy3EloVDlVFKSony-vYbap0t-omoPxQ_g8ztneVqKjlwDXrR9bz2TPjnfmGkNfFWFlwS3xW2tEoEyKvsopblVmp5KiSyvsYbbEv947El-PieK3UF8aERXrguHDvvcLcygqAWVpRKFFayyojuau8s0YFsm1QY2vOFJ7B0AcrMmFlObDPMwmaKmXMxOAuc3qGmX-cYZRA4IRc00qBvH9DOV01Pq_GUN5Z1hdm9cvM52sKavc-uZcsS7od3-gBueXqh-T3pJlPaQh2bS7pAik16hNq6iltV-dYjRhzGGkNB0azbGmkdaYhfD3VwaKLhs7AA3bnM0Px0pbWDW2qRDv700HjywZTemkIDl3R9MXnA_3q2uV80VJMYKEwEQ3FMt-09HM33GFiS6A7PeV4NumG-55CZOmnVYvKN_yZg3hv9Igc7e58m-xlqZIDyJyrBZjw3o0FMyB94c20dLJy0oO1J8G9YY5xwIcvQayFk7mbjsY-l8pwIxiT3BY2f0y26qZ2TwmtBPNjDgjCyu1gvRjreW6FBRGXopTTAWGdJLVNNOdYbWOuu3i2M43S1yh9HaU_IG_7PheR5OPa1h8RIH1LJOgOPwBsdYKtvgm2A5J38NJdDiyc2jDQ7Nqp1d96uTYdPK1muuV6pA8R9oh6zoIVyAak6Hsm2yraTDfO-KrDvoaDB78mmdoBJDVXXILzDg7ngDyJe6FfEuQ44krAW6qNXbKxZptP6tlpIDcvUYVImPddv5_-QSbP_odMnpO7HJNbwgXbC7IFO8m9BJNzUQ3D6TIMd4FDcvto_2D7xx-ew4VR |
| linkProvider | Directory of Open Access Journals |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZge4ALD_FaXjISEgdItXYce8OtLK0Kh6qiFJWT5Xjtdss2qZosaPmf_B9mHGdFaFXKdWPH6_ibh-2Zbwh5mY2VhW2JT3I7GiVCpEVScKsSK5UcFVJ530Zb7MjtffHxIDuINDmYC9O7vw9xWOboGJP0OMMLffBvrpM1iZdJA7K2v7O78RWrx4EPnkiwRjEr5uKOPcsTCPp7Bui8g3k-TvLGojw1yx9mPv_DCG3dbqsZ1YG7EGNPvq0vmmLd_vyL2fFq87tDbkVflG604LlLrrnyHvk1qeZTGsJjqzPaIAlHeUhNOaX18gTrF2PWIy1BxVSLmrZE0DQEvMfKWbSp6Az2zO5kZige89KyolURiWq_O2h8VmESMA3hpEsa74je0k-uXsybmmLKC4WBaCiv-aqmH7rX7UV-Bbq5IilPJt3rvsSgWvp-WaO5Dn9mtz1puk_2tzY_T7aTWPsBUMJVA06_d2PBDOBFeDPNnSyc9OAfStgQMcc4IMrnhZGZk6mbjsY-lcpwIxiT3GY2fUAGZVW6R4QWgvkxB8xhrXfwd4z1PLXCAmBykcvpkLAOF9pGYnSszzHXXQTcscZF0rhIul2kIXm96nPa0oJc2vodwm3VEim9ww-ABB01hPYKk4gL0MC5FZkSubUM5sdd4Z01Sg5J2oFVd1mzoOfhRbNLh1YX9XJ1VFW1ZrrmeqT3UIhQhjgLfiMbkmzVM3pjrZf1zxFfdJKkQVXh_ZMpHUBSc8UlbPdhizokD1vJWn0SZEXiSsAsVU_met-s_6ScHQU69ByNjoRx36yk8wpr8vj_mj8hNzkmvoTDt6dkADLjnoE72hTPox76DQiQim4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cold+pressor+testing+and+sympathetic+nervous+system+contribution+to+ischemia+with+no+obstructive+coronary+artery+disease%3A+Results+from+the+Women%27s+Ischemia+Syndrome+Evaluation-Coronary+Vascular+Dysfunction+Project&rft.jtitle=American+heart+journal+plus&rft.au=Wei%2C+J.&rft.au=Barsky%2C+L.L.&rft.au=Jalnapurkar%2C+S.&rft.au=Zarrini%2C+P.&rft.date=2022-01-01&rft.pub=Elsevier+Inc&rft.issn=2666-6022&rft.eissn=2666-6022&rft.volume=13&rft_id=info:doi/10.1016%2Fj.ahjo.2021.100080&rft.externalDocID=S2666602221000781 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F26666022%2FS2666602221X00134%2Fcov150h.gif |