绝经前、后子宫内膜息肉组织中Bcl-2,BAG-1,Ki-67,ER和PR的表达及临床意义

目的:探讨B淋巴细胞瘤2(Bcl-2),Bcl-2结合抗凋亡基因1(BAG-1),Ki-67,雌激素受体(ER)和孕激素受体(PR)在绝经前、后子宫内膜息肉(EP)中的表达及其临床意义。方法:免疫组织化学(SP)法检测30例绝经前和30例绝经后患者EP组织Bcl-2,BAG-1,Ki-67,ER和PR表达并分析其临床意义。结果:EP组织中Bcl-2、BAG-1和Ki-67的表达高于对照组,差异有统计学意义(P<0.05);但ER和PR在2组中的表达差异无统计学意义(均P>0.05)。绝经后EP组织中Ki-67的表达低于绝经前,差异有统计学意义(P<0.05);但绝经前、后EP组织中Bcl-2,...

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Published in国际妇产科学杂志 Vol. 41; no. 6; pp. 677 - 679
Main Author 郭慧梅 高希焕 陆颖仪 冯文栋 王燕燕
Format Journal Article
LanguageChinese
Published 广东省中西医结合医院, 广东省佛山市,528000%广东医学院附属厚街医院 2014
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ISSN1674-1870

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Summary:目的:探讨B淋巴细胞瘤2(Bcl-2),Bcl-2结合抗凋亡基因1(BAG-1),Ki-67,雌激素受体(ER)和孕激素受体(PR)在绝经前、后子宫内膜息肉(EP)中的表达及其临床意义。方法:免疫组织化学(SP)法检测30例绝经前和30例绝经后患者EP组织Bcl-2,BAG-1,Ki-67,ER和PR表达并分析其临床意义。结果:EP组织中Bcl-2、BAG-1和Ki-67的表达高于对照组,差异有统计学意义(P<0.05);但ER和PR在2组中的表达差异无统计学意义(均P>0.05)。绝经后EP组织中Ki-67的表达低于绝经前,差异有统计学意义(P<0.05);但绝经前、后EP组织中Bcl-2,BAG-1,ER和PR表达差异均无统计学意义(均P>0.05)。绝经后EP组织Ki-67与PR呈正相关(P<0.05),其他各组间均无相关性(均P>0.05)。结论:Bcl-2,BAG-1,Ki-67,ER和PR可能在EP的病理改变的不同时段中发挥重要作用。
Bibliography:12-1399/R
GUO Hui-mei, GAO Xi-huan, LU Ying-yi, FENG Wen-dong, WANG Yan-yan (Guangdong Province Hospital of Combination of Traditional Chinese and Western Medicine ,l'bshan 528000,China ( GUO Hui-mei,GA O Xi-huan,LU Ying--yi, FENG Wen-dong);Houjie Hospital Aff-diated to Guangdong Medical College ,Dongguan 523945,China)
Objective:To stduy the expression and clinical significance of Bcl-2,BAG-1,Ki-67,ER and PR on premenopausal and postmenopausal endometrial polyps. Methods:The expression of Bcl-2,BAG-1,Ki-67,ER and PR in 30 cases premenopausal endometrial polyps and 30 cases postmenopausal endometrial polyps tissues were detected by immunohistochemistry. Results:Bcl-2,BAG-1 and Ki-67 were higher expression in endometrial polyps than control group (P〉0.05),but no signification difference among ER and PR expression(P〉0.05). Ki-67 expression in postmenopausal endometrial polyps was significantly lower than premenopausal endometrial polyps tissues (P〈0.05). There were no signification difference among Bcl-2,BAG-1,ER
ISSN:1674-1870