恶性肿瘤患者血浆和胸腹水可溶性Apo-1/Fas的检测及其临床意义

R730.231; 目的:研究恶性肿瘤患者血浆和胸腹水可溶性Apo-1/Fas水平变化及其临床意义.方法:用ELISA法检测157例恶性肿瘤患者和25例正常对照组血浆以及129例不同性质胸腹水可溶性Apo-1/Fas浓度变化.结果:恶性血液病中急性白血病、慢性白血病和多发性骨髓瘤(MM)患者血浆可溶性Apo-1/Fas水平均显著高于正常对照组(P<0.05);慢性粒细胞白血病高于急性粒细胞白血病,慢性淋巴细胞白血病高于急性淋巴细胞白血病(P<0.05);急性白血病和MM化疗完全缓解时Apo-1/Fas水平显著下降(P<0.05),无效和复发病例均为高值.在实体恶性肿瘤中血浆可...

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Published in浙江大学学报(医学版) Vol. 32; no. 4; pp. 335 - 338
Main Authors 徐根波, 卢兴国, 罗吕宏, 朱蕾
Format Journal Article
LanguageChinese
Published 浙江大学医学院附属第二医院,浙江,杭州,310009 2003
Subjects
实体恶性肿瘤
白血病/病理生理
胸膜积液,恶性
腹水
多发性骨髓瘤/病理生理
可溶性Apo-1/Fas
Online AccessGet full text
ISSN1008-9292
DOI10.3785/j.issn.1008-9292.2003.04.016

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Abstract R730.231; 目的:研究恶性肿瘤患者血浆和胸腹水可溶性Apo-1/Fas水平变化及其临床意义.方法:用ELISA法检测157例恶性肿瘤患者和25例正常对照组血浆以及129例不同性质胸腹水可溶性Apo-1/Fas浓度变化.结果:恶性血液病中急性白血病、慢性白血病和多发性骨髓瘤(MM)患者血浆可溶性Apo-1/Fas水平均显著高于正常对照组(P<0.05);慢性粒细胞白血病高于急性粒细胞白血病,慢性淋巴细胞白血病高于急性淋巴细胞白血病(P<0.05);急性白血病和MM化疗完全缓解时Apo-1/Fas水平显著下降(P<0.05),无效和复发病例均为高值.在实体恶性肿瘤中血浆可溶性Apo-1/Fas水平也均显著高于正常对照组(P<0.01),且转移性癌显著高于非转移癌(P<0.01),术后好转或放疗后缓解患者较术前或放疗前明显回落(P<0.01),而术后复发转移患者显著升高(P<0.01).恶性肿瘤患者胸腹水可溶性Apo-1/Fas水平明显增高,并明显高于结核性和漏出性胸腹水(P<0.01).结论:恶性肿瘤患者血浆和胸腹水可溶性Apo-1/Fas水平明显升高,并可能与肿瘤的发生、发展有关,观察其水平变化,有助于了解肿瘤的病理过程,鉴别胸腹水的不同性质.
AbstractList R730.231; 目的:研究恶性肿瘤患者血浆和胸腹水可溶性Apo-1/Fas水平变化及其临床意义.方法:用ELISA法检测157例恶性肿瘤患者和25例正常对照组血浆以及129例不同性质胸腹水可溶性Apo-1/Fas浓度变化.结果:恶性血液病中急性白血病、慢性白血病和多发性骨髓瘤(MM)患者血浆可溶性Apo-1/Fas水平均显著高于正常对照组(P<0.05);慢性粒细胞白血病高于急性粒细胞白血病,慢性淋巴细胞白血病高于急性淋巴细胞白血病(P<0.05);急性白血病和MM化疗完全缓解时Apo-1/Fas水平显著下降(P<0.05),无效和复发病例均为高值.在实体恶性肿瘤中血浆可溶性Apo-1/Fas水平也均显著高于正常对照组(P<0.01),且转移性癌显著高于非转移癌(P<0.01),术后好转或放疗后缓解患者较术前或放疗前明显回落(P<0.01),而术后复发转移患者显著升高(P<0.01).恶性肿瘤患者胸腹水可溶性Apo-1/Fas水平明显增高,并明显高于结核性和漏出性胸腹水(P<0.01).结论:恶性肿瘤患者血浆和胸腹水可溶性Apo-1/Fas水平明显升高,并可能与肿瘤的发生、发展有关,观察其水平变化,有助于了解肿瘤的病理过程,鉴别胸腹水的不同性质.
Author 朱蕾
卢兴国
罗吕宏
徐根波
AuthorAffiliation 浙江大学医学院附属第二医院,浙江,杭州,310009
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Keywords 实体恶性肿瘤
白血病/病理生理
胸膜积液,恶性
腹水
多发性骨髓瘤/病理生理
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Title 恶性肿瘤患者血浆和胸腹水可溶性Apo-1/Fas的检测及其临床意义
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