A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening
Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhyt...
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| Published in | Cell reports (Cambridge) Vol. 22; no. 13; pp. 3521 - 3533 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
27.03.2018
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2211-1247 2211-1247 |
| DOI | 10.1016/j.celrep.2018.03.004 |
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| Abstract | Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.
[Display omitted]
•Fatty acid uptake by BAT is rhythmic and highest at the onset of wakening•Circadian pattern of fatty acid uptake by BAT depends on light exposure duration•Time of day dictates the capacity of BAT to clear postprandial lipids
van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions. |
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| AbstractList | Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. [Display omitted] •Fatty acid uptake by BAT is rhythmic and highest at the onset of wakening•Circadian pattern of fatty acid uptake by BAT depends on light exposure duration•Time of day dictates the capacity of BAT to clear postprandial lipids van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions. Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions. Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. : van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions. Keywords: circadian rhythm, diurnal rhythm, brown adipose tissue, triglycerides, fatty acids, lipoprotein lipase, angiopoietin-like 4, postprandial lipid response, APOE∗3-Leiden.CETP mice Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. |
| Author | de Ruiter, Evelien M. Karpe, Fredrik Meijer, Johanna H. Puig, Laura Sardón Ramkisoensing, Ashna Kooijman, Sander van den Berg, Rosa Dijk, Wieneke Noordam, Raymond van der Sluis, Ronald J. Meijer, Onno C. Gerhart-Hines, Zachary Kroon, Jan van Heemst, Diana Kersten, Sander Caputo, Rosanna Mol, Isabel M. Kramar, Barbara Christodoulides, Constantinos Coomans, Claudia P. Ruppert, Philip Willems van Dijk, Ko Rensen, Patrick C.N. Tambyrajah, Lauren L. Hoekstra, Menno van Kerkhof, Linda W.M. Biermasz, Nienke R. Abreu-Vieira, Gustavo |
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Leiden, the Netherlands – sequence: 19 givenname: Linda W.M. surname: van Kerkhof fullname: van Kerkhof, Linda W.M. organization: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, the Netherlands – sequence: 20 givenname: Constantinos surname: Christodoulides fullname: Christodoulides, Constantinos organization: Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK – sequence: 21 givenname: Fredrik surname: Karpe fullname: Karpe, Fredrik organization: Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK – sequence: 22 givenname: Zachary surname: Gerhart-Hines fullname: Gerhart-Hines, Zachary organization: Department of Neuroscience and Pharmacology, Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of 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fullname: Biermasz, Nienke R. organization: Department of Medicine, Division of Endocrinology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands – sequence: 28 givenname: Patrick C.N. surname: Rensen fullname: Rensen, Patrick C.N. organization: Department of Medicine, Division of Endocrinology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29590620$$D View this record in MEDLINE/PubMed https://hal.science/hal-03350273$$DView record in HAL |
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| Keywords | brown adipose tissue fatty acids lipoprotein lipase APOE∗3-Leiden.CETP mice circadian rhythm diurnal rhythm triglycerides angiopoietin-like 4 postprandial lipid response APOE(∗)3-Leiden.CETP mice |
| Language | English |
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| SubjectTerms | Adipose Tissue, Brown - metabolism angiopoietin-like 4 Animal biology Animals APOE3-Leiden.CETP mice APOE∗3-Leiden.CETP mice brown adipose tissue Circadian Rhythm diurnal rhythm fatty acids Fatty Acids - metabolism Humans Life Sciences Lipid Metabolism - physiology lipoprotein lipase Mice postprandial lipid response triglycerides Wakefulness |
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| Title | A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening |
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