Dipeptidyl peptidase IV deficiency increases susceptibility to angiotensin-converting enzyme inhibitor–induced peritracheal edema - Byrd, James Brian; Shreevatsa, Ajai; Putlur, Pradeep; Foretia, Denis; McAlexander, Laurie; Sinha, Tuhin; Does, Mark D.; Brown, Nancy J. (Journal of allergy and clinical immunology, 2007)
Keywords: ACE inhibitors; Allergy and Immunology; Angioedema; angiotensin-converting enzyme inhibitor; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Animals, Genetically Modified; Blood Pressure - drug effects; Captopril - pharmacology; Clinical trials; Diabetes; Dipeptidyl Peptidase 4 - blood; Dipeptidyl Peptidase 4 - genetics; Dipeptidyl Peptidase 4 - metabolism; dipeptidyl peptidase IV; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - deficiency; Disease Susceptibility; Edema - chemically induced; Edema - diagnosis; Enzymes; Human subjects; Hypotheses; Laboratory animals; larynx; Magnetic Resonance Imaging; Male; neurokinin; NMR; Nuclear magnetic resonance; pharmacogenetics; Rats; Rats, Inbred F344 - genetics; Rodents; spantide; substance P; trachea; Tracheal Diseases - chemically induced; Tracheal Diseases - diagnosis; Japan; magnetic resonance imaging; ACE; trachea; MRI; Angioedema; neurokinin; spantide; larynx; DPPIV; angiotensin-converting enzyme inhibitor; NEP; dipeptidyl peptidase IV; substance P; MAP; pharmacogenetics; Mean arterial pressure; Fisher F344/DuCrl rats with normal DPPIV activity from American colonies; Neutral endopeptidase; Angiotensin-converting enzyme; Fisher F344/DuCrlCrlj DPPIV–deficient rats from Japanese colonies