Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen
Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containi...
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| Published in | BMC cancer Vol. 24; no. 1; pp. 1227 - 11 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
05.10.2024
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1471-2407 1471-2407 |
| DOI | 10.1186/s12885-024-12425-0 |
Cover
| Abstract | Background
In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population.
Methods
This study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS.
Results
A total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 – 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OS≦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44–13.61), 7.5 months (95% CI 7.33–8.17), and 4.01 months (95% CI 3.94–4.08), respectively, with a log-rank test
p
-value < 0.001.
Conclusion
This study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. |
|---|---|
| AbstractList | Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population. Methods This study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS. Results A total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 - 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OSâ¦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44-13.61), 7.5 months (95% CI 7.33-8.17), and 4.01 months (95% CI 3.94-4.08), respectively, with a log-rank test p-value < 0.001. Conclusion This study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. Keywords: Cetuximab, Head and neck squamous cell carcinoma, Prognostic factor, Risk-stratification model Abstract Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population. Methods This study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS. Results A total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 – 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OS≦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44–13.61), 7.5 months (95% CI 7.33–8.17), and 4.01 months (95% CI 3.94–4.08), respectively, with a log-rank test p-value < 0.001. Conclusion This study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population. This study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS. A total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 - 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OS≦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44-13.61), 7.5 months (95% CI 7.33-8.17), and 4.01 months (95% CI 3.94-4.08), respectively, with a log-rank test p-value < 0.001. This study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population. This study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS. A total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 - 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OSâ¦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44-13.61), 7.5 months (95% CI 7.33-8.17), and 4.01 months (95% CI 3.94-4.08), respectively, with a log-rank test p-value < 0.001. This study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population.BACKGROUNDIn recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population.This study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS.METHODSThis study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS.A total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 - 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OS≦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44-13.61), 7.5 months (95% CI 7.33-8.17), and 4.01 months (95% CI 3.94-4.08), respectively, with a log-rank test p-value < 0.001.RESULTSA total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 - 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OS≦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44-13.61), 7.5 months (95% CI 7.33-8.17), and 4.01 months (95% CI 3.94-4.08), respectively, with a log-rank test p-value < 0.001.This study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development.CONCLUSIONThis study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. BackgroundIn recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population.MethodsThis study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS.ResultsA total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 – 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OS≦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44–13.61), 7.5 months (95% CI 7.33–8.17), and 4.01 months (95% CI 3.94–4.08), respectively, with a log-rank test p-value < 0.001.ConclusionThis study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world survival data of R/M HNSCC patients who received cetuximab-containing regimens from thirteen medical centers in Taiwan, as well as a three-level risk stratification model for this patient population. Methods This study enrolled R/M HNSCC patients from thirteen medical centers in Taiwan who received cetuximab-containing regimens from January 1, 2017 to June 6, 2022. The cases were divided into a training cohort and a validation cohort based on the start of treatment. Overall survival (OS) was evaluated in both cohorts and exploratory analysis was performed to identify associated adverse clinical and laboratory factors. The results of the exploratory analysis were used to construct a three-level risk stratification prediction model for OS. Results A total of 1434 patients with R/M HNSCC were enrolled in this study and received cetuximab-containing regimens. The overall population had a median OS of 8.57 months (95% CI: 8.07 – 9.08). Multivariate analysis of the training cohort identified poor ECOG performance status, heavy alcohol consumption, and prior adjuvant CCRT or lack of prior RT as adverse prognostic factors. Comparison of laboratory data between patients with OS≦6 and OS > 6 also revealed unfavorable factors, including increased white blood cell count, decreased hemoglobin level, increased platelet count, increased absolute neutrophil count, decreased absolute lymphocyte count, and increased neutrophil-to-lymphocyte ratio. Using forward prediction, a three-level risk stratification prediction model was constructed using the variables of ECOG performance status, alcohol consumption, skin metastasis, modality of radiation therapy, hemoglobin level, and neutrophil-to-lymphocyte ratio. The median OS in the low-risk, intermediate-risk, and high-risk groups were 12.02 months (95% CI 10.44–13.61), 7.5 months (95% CI 7.33–8.17), and 4.01 months (95% CI 3.94–4.08), respectively, with a log-rank test p -value < 0.001. Conclusion This study presents a three-level risk stratification model with strong prediction ability for OS in R/M HNSCC patients who received cetuximab-containing regimens. The results are based on real-world data and may provide valuable information for clinicians in treatment planning and future drug development. |
| ArticleNumber | 1227 |
| Audience | Academic |
| Author | Yen, Chia-Jui Wang, Chen-Chi Lien, Ming-Yu Huang, Tai-Lin Chien, Chih-Yen Hsieh, Jason Chia-Hsun Yiu, Ching-Yi Chen, Jo-Pai Chang, Yi-Fang Wang, Hui-Ching Lu, Wei-Chen Wang, Hung-Ming Hua, Chun-Hung Huang, Huai-Cheng Chu, Pen-Yuan Wu, Shang-Yin Lin, Jin-Ching Liu, Yi-Chun Chen, Tien-Hua Lin, Chien-Liang Yang, Muh-Hwa Lou, Pei-Jen Hsieh, Meng-Che Lu, Hsueh-Ju |
| Author_xml | – sequence: 1 givenname: Muh-Hwa surname: Yang fullname: Yang, Muh-Hwa organization: Department of Oncology, Division of Medical Oncology, Taipei Veterans General Hospital – sequence: 2 givenname: Tien-Hua surname: Chen fullname: Chen, Tien-Hua organization: Department of Oncology, Division of Medical Oncology, Taipei Veterans General Hospital – sequence: 3 givenname: Hung-Ming surname: Wang fullname: Wang, Hung-Ming organization: Department of Internal Medicine, Division of Hematology-Oncology, Chang Gung Memorial Hospital – sequence: 4 givenname: Jason Chia-Hsun surname: Hsieh fullname: Hsieh, Jason Chia-Hsun organization: Department of Internal Medicine, Division of Hematology-Oncology, New Taipei City Municipal TuCheng Hospital – sequence: 5 givenname: Huai-Cheng surname: Huang fullname: Huang, Huai-Cheng organization: Department of Oncology, National Taiwan University Hospital and College of Medicine – sequence: 6 givenname: Meng-Che surname: Hsieh fullname: Hsieh, Meng-Che organization: Department of Hematology and Oncology, E-Da Cancer Hospital – sequence: 7 givenname: Chia-Jui surname: Yen fullname: Yen, Chia-Jui organization: Department of Oncology, National Cheng Kung University Hospital – sequence: 8 givenname: Shang-Yin surname: Wu fullname: Wu, Shang-Yin organization: Department of Oncology, National Cheng Kung University Hospital – sequence: 9 givenname: Chun-Hung surname: Hua fullname: Hua, Chun-Hung organization: Department of Otorhinolaryngology, China Medical University Hospital – sequence: 10 givenname: Ming-Yu surname: Lien fullname: Lien, Ming-Yu organization: Department of Internal Medicine, Division of Hematology and Oncology, China Medical University Hospital – sequence: 11 givenname: Yi-Fang surname: Chang fullname: Chang, Yi-Fang organization: Department of Hematology, MacKay Memorial Hospital – sequence: 12 givenname: Hui-Ching surname: Wang fullname: Wang, Hui-Ching organization: Department of Internal Medicine, Division of Hematology and Oncology, Kaohsiung Medical University Hospital – sequence: 13 givenname: Chih-Yen surname: Chien fullname: Chien, Chih-Yen organization: Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine – sequence: 14 givenname: Tai-Lin surname: Huang fullname: Huang, Tai-Lin organization: Department of Hematology-Oncology, Kaohsiung Chang Gung Memorial Hospital – sequence: 15 givenname: Hsueh-Ju surname: Lu fullname: Lu, Hsueh-Ju organization: Department of Internal Medicine, Division of Hematology and Oncology, Chung Shan Medical University Hospital – sequence: 16 givenname: Jin-Ching surname: Lin fullname: Lin, Jin-Ching organization: Department of Radiation Oncology, Changhua Christian Hospital – sequence: 17 givenname: Chen-Chi surname: Wang fullname: Wang, Chen-Chi organization: Department of Otolaryngology-Head and Neck Surgery, Taichung Veterans General Hospital – sequence: 18 givenname: Yi-Chun surname: Liu fullname: Liu, Yi-Chun organization: Department of Radiation Oncology, Taichung Veterans General Hospital – sequence: 19 givenname: Jo-Pai surname: Chen fullname: Chen, Jo-Pai organization: Department of Oncology, National Taiwan University Hospital Yunlin Branch – sequence: 20 givenname: Wei-Chen surname: Lu fullname: Lu, Wei-Chen organization: Department of Oncology, National Taiwan University Hospital Yunlin Branch – sequence: 21 givenname: Ching-Yi surname: Yiu fullname: Yiu, Ching-Yi organization: Department of Otolaryngology, Chi Mei Medical Center, Liouying – sequence: 22 givenname: Chien-Liang surname: Lin fullname: Lin, Chien-Liang organization: Department of Internal Medicine, Division of Hematology-Oncology, Chi Mei Medical Center – sequence: 23 givenname: Pei-Jen surname: Lou fullname: Lou, Pei-Jen organization: Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine – sequence: 24 givenname: Pen-Yuan surname: Chu fullname: Chu, Pen-Yuan email: pychu@vghtpe.gov.tw organization: Department of Otolaryngology, Taipei Veterans General Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39369189$$D View this record in MEDLINE/PubMed |
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| DOI | 10.1186/s12885-024-12425-0 |
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| Keywords | Prognostic factor Head and neck squamous cell carcinoma Cetuximab Risk-stratification model |
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| License | 2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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| References | Y Takenaka (12425_CR16) 2018; 40 S Kano (12425_CR14) 2017; 39 K Hu (12425_CR18) 2005; 6 A Argiris (12425_CR12) 2004; 101 J Bernier (12425_CR4) 2004; 350 KA Price (12425_CR6) 2012; 13 JB Vermorken (12425_CR7) 2008; 359 H Sung (12425_CR1) 2021; 71 YC Huang (12425_CR2) 2020; 2020 TL Lee (12425_CR20) 2023; 35 YK So (12425_CR15) 2018; 159 RL Siegel (12425_CR3) 2021; 71 J Guigay (12425_CR8) 2021; 22 JB Vermorken (12425_CR9) 2007; 25 R Depenni (12425_CR13) 2019; 115 G Cadoni (12425_CR11) 2017; 37 P Kumar (12425_CR19) 2000; 5 Y Takenaka (12425_CR17) 2018; 40 A Mirabile (12425_CR21) 2019; 41 TH Chen (12425_CR10) 2022; 22 12425_CR5 |
| References_xml | – ident: 12425_CR5 doi: 10.3390/cancers13020338 – volume: 159 start-page: 303 issue: 2 year: 2018 ident: 12425_CR15 publication-title: Otolaryngol Head Neck Surg doi: 10.1177/0194599818764651 – volume: 2020 start-page: 1408793 year: 2020 ident: 12425_CR2 publication-title: J Oncol doi: 10.1155/2020/1408793 – volume: 22 start-page: 1336 issue: 1 year: 2022 ident: 12425_CR10 publication-title: BMC Cancer doi: 10.1186/s12885-022-10440-7 – volume: 350 start-page: 1945 issue: 19 year: 2004 ident: 12425_CR4 publication-title: N Engl J Med doi: 10.1056/NEJMoa032641 – volume: 13 start-page: 35 issue: 1 year: 2012 ident: 12425_CR6 publication-title: Curr Treat Options Oncol doi: 10.1007/s11864-011-0176-y – volume: 5 start-page: 13 issue: 90002 year: 2000 ident: 12425_CR19 publication-title: Oncologist doi: 10.1634/theoncologist.5-suppl_2-13 – volume: 71 start-page: 209 issue: 3 year: 2021 ident: 12425_CR1 publication-title: CA Cancer J Clin doi: 10.3322/caac.21660 – volume: 6 start-page: 31 issue: 1 year: 2005 ident: 12425_CR18 publication-title: Curr Treat Options Oncol doi: 10.1007/s11864-005-0011-4 – volume: 115 start-page: 4 year: 2019 ident: 12425_CR13 publication-title: Eur J Cancer doi: 10.1016/j.ejca.2019.03.022 – volume: 71 start-page: 7 issue: 1 year: 2021 ident: 12425_CR3 publication-title: CA Cancer J Clin doi: 10.3322/caac.21654 – volume: 359 start-page: 1116 issue: 11 year: 2008 ident: 12425_CR7 publication-title: N Engl J Med doi: 10.1056/NEJMoa0802656 – volume: 40 start-page: 647 issue: 3 year: 2018 ident: 12425_CR16 publication-title: Head Neck doi: 10.1002/hed.24986 – volume: 41 start-page: 1895 issue: 6 year: 2019 ident: 12425_CR21 publication-title: Head Neck doi: 10.1002/hed.25636 – volume: 101 start-page: 2222 issue: 10 year: 2004 ident: 12425_CR12 publication-title: Cancer doi: 10.1002/cncr.20640 – volume: 40 start-page: 2714 issue: 12 year: 2018 ident: 12425_CR17 publication-title: Head Neck doi: 10.1002/hed.25366 – volume: 25 start-page: 2171 issue: 16 year: 2007 ident: 12425_CR9 publication-title: J Clin Oncol doi: 10.1200/JCO.2006.06.7447 – volume: 35 start-page: 100855 year: 2023 ident: 12425_CR20 publication-title: Neoplasia doi: 10.1016/j.neo.2022.100855 – volume: 22 start-page: 463 issue: 4 year: 2021 ident: 12425_CR8 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(20)30755-5 – volume: 39 start-page: 247 issue: 2 year: 2017 ident: 12425_CR14 publication-title: Head Neck doi: 10.1002/hed.24576 – volume: 37 start-page: 458 issue: 6 year: 2017 ident: 12425_CR11 publication-title: Acta Otorhinolaryngol Ital doi: 10.14639/0392-100X-1246 |
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In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck... In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell... Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck... BackgroundIn recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck... Abstract Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and... |
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| SubjectTerms | Adult Aged Alcohol Alcohol use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Blood cell count Blood levels Cancer Cancer Research Cancer therapies Care and treatment Cell number Cetuximab Cetuximab - administration & dosage Cetuximab - therapeutic use Chemotherapy Clinical outcomes Drug development Female Head & neck cancer Head and neck cancer Head and neck carcinoma Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and neck squamous cell carcinoma Health aspects Health Promotion and Disease Prevention Hematology Hemoglobin Human papillomavirus Humans Induction therapy Leukocytes (neutrophilic) Lymphocytes Male Medical centers Medical prognosis Medical research Medicine, Experimental Medicine/Public Health Metastases Metastasis Middle Aged Monoclonal antibodies Multivariate analysis Neoplasm Recurrence, Local Neutrophils Oncology Patients Population studies Prediction models Prevention Prognosis Prognostic factor Radiation therapy Radiotherapy Relapse Response rates Retrospective Studies Risk Assessment - methods Risk Factors Risk groups Risk-stratification model Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - mortality Squamous Cell Carcinoma of Head and Neck - pathology Statistical significance Surgery Surgical Oncology Survival analysis Taiwan - epidemiology Targeted cancer therapy Variables |
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| Title | Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen |
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