Germline Chd8 haploinsufficiency alters brain development in mouse
Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al . combine genomic, neuroanatomical and behavioral approaches to present an initial integrative picture of transcriptional mechanisms and wid...
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| Published in | Nature neuroscience Vol. 20; no. 8; pp. 1062 - 1073 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.08.2017
Nature Publishing Group Springer Nature |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1097-6256 1546-1726 1546-1726 |
| DOI | 10.1038/nn.4592 |
Cover
| Abstract | Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers
et al
. combine genomic, neuroanatomical and behavioral approaches to present an initial integrative picture of transcriptional mechanisms and widespread impacts of
Chd8
haploinsufficiency across brain development in mice.
The chromatin remodeling gene
CHD8
represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift
Chd8
mutation on neurodevelopment in mice.
Chd8
+/
del5
mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of
Chd8
+/
del5
mice overlap pathology reported in humans with
CHD8
mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in
Chd8
+/
del5
mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in
Chd8
+/
del5
mice. This integrative analysis offers an initial picture of the consequences of
Chd8
haploinsufficiency for brain development. |
|---|---|
| AbstractList | The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8
mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8
mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8
mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8
mice. This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al . combine genomic, neuroanatomical and behavioral approaches to present an initial integrative picture of transcriptional mechanisms and widespread impacts of Chd8 haploinsufficiency across brain development in mice. The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8 +/ del5 mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8 +/ del5 mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8 +/ del5 mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8 +/ del5 mice. This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. In this paper, we examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8+/del5 mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8+/del5 mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8+/del5 mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8+/del5 mice. Finally, this integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8 +/del5 mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8 +/del5 mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8 +/del5 mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8 +/del5 mice. This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency on brain development. The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8+/del5 mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8+/del5 mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8+/del5 mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8+/del5 mice. This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8[sup.+/del5] mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8[sup.+/del5] mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8[sup.+/del5] mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8[sup.+/del5] mice. This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8+/del5 mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8+/del5 mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8+/del5 mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8+/del5 mice. This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development.The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8+/del5 mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of Chd8+/del5 mice overlap pathology reported in humans with CHD8 mutations. We applied network analysis to characterize neurodevelopmental gene expression, revealing widespread transcriptional changes in Chd8+/del5 mice across pathways disrupted in neurodevelopmental disorders, including neurogenesis, synaptic processes and neuroimmune signaling. We identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by Chd8, and we validated increased neuronal proliferation and developmental splicing perturbation in Chd8+/del5 mice. This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. |
| Audience | Academic |
| Author | Riyadh, M Asrafuzzaman Crawley, Jacqueline N Kaushik, Gaurav Catta-Preta, Rinaldo Zarbalis, Konstantinos S Schaffler, Melanie D Gompers, Andrea L Lerch, Jason P Zdilar, Iva Afzal, Veena Su-Feher, Linda Copping, Nycole A Wade, A Ayanna Ellegood, Jacob Pride, Michael C Mannion, Brandon J Pennacchio, Len A Visel, Axel Dickel, Diane E Nord, Alex S Stradleigh, Tyler W Louis, Shreya Silverman, Jill L Plajzer-Frick, Ingrid |
| AuthorAffiliation | 6 Lawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, CA 2 University of California, Davis, Department of Neurobiology, Physiology and Behavior 1 University of California, Davis, Department of Psychiatry and Behavioral Sciences 4 University of California, Davis, MIND Institute, School of Medicine, Davis, CA 9 University of Toronto, Department of Medical Biophysics, Toronto, Canada 7 Department of Energy Joint Genome Institute, Walnut Creek, CA 5 University of California, Davis, Department of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, Sacramento, CA 3 The Hospital for Sick Children, Mouse Imaging Centre, Toronto, Canada 8 School of Natural Sciences, University of California, Merced, CA |
| AuthorAffiliation_xml | – name: 1 University of California, Davis, Department of Psychiatry and Behavioral Sciences – name: 5 University of California, Davis, Department of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, Sacramento, CA – name: 2 University of California, Davis, Department of Neurobiology, Physiology and Behavior – name: 4 University of California, Davis, MIND Institute, School of Medicine, Davis, CA – name: 6 Lawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, CA – name: 8 School of Natural Sciences, University of California, Merced, CA – name: 3 The Hospital for Sick Children, Mouse Imaging Centre, Toronto, Canada – name: 7 Department of Energy Joint Genome Institute, Walnut Creek, CA – name: 9 University of Toronto, Department of Medical Biophysics, Toronto, Canada |
| Author_xml | – sequence: 1 givenname: Andrea L surname: Gompers fullname: Gompers, Andrea L organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis – sequence: 2 givenname: Linda orcidid: 0000-0002-0660-7925 surname: Su-Feher fullname: Su-Feher, Linda organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis – sequence: 3 givenname: Jacob surname: Ellegood fullname: Ellegood, Jacob organization: Mouse Imaging Centre, The Hospital for Sick Children – sequence: 4 givenname: Nycole A surname: Copping fullname: Copping, Nycole A organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, MIND Institute, School of Medicine, University of California, Davis – sequence: 5 givenname: M Asrafuzzaman surname: Riyadh fullname: Riyadh, M Asrafuzzaman organization: Department of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, University of California, Davis – sequence: 6 givenname: Tyler W surname: Stradleigh fullname: Stradleigh, Tyler W organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis – sequence: 7 givenname: Michael C surname: Pride fullname: Pride, Michael C organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, MIND Institute, School of Medicine, University of California, Davis – sequence: 8 givenname: Melanie D surname: Schaffler fullname: Schaffler, Melanie D organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, MIND Institute, School of Medicine, University of California, Davis – sequence: 9 givenname: A Ayanna orcidid: 0000-0002-3318-2117 surname: Wade fullname: Wade, A Ayanna organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis – sequence: 10 givenname: Rinaldo orcidid: 0000-0001-9833-1278 surname: Catta-Preta fullname: Catta-Preta, Rinaldo organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis – sequence: 11 givenname: Iva surname: Zdilar fullname: Zdilar, Iva organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis – sequence: 12 givenname: Shreya orcidid: 0000-0001-5752-6271 surname: Louis fullname: Louis, Shreya organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis – sequence: 13 givenname: Gaurav surname: Kaushik fullname: Kaushik, Gaurav organization: Department of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, University of California, Davis – sequence: 14 givenname: Brandon J surname: Mannion fullname: Mannion, Brandon J organization: Functional Genomics Department, Lawrence Berkeley National Laboratory – sequence: 15 givenname: Ingrid surname: Plajzer-Frick fullname: Plajzer-Frick, Ingrid organization: Functional Genomics Department, Lawrence Berkeley National Laboratory – sequence: 16 givenname: Veena surname: Afzal fullname: Afzal, Veena organization: Functional Genomics Department, Lawrence Berkeley National Laboratory – sequence: 17 givenname: Axel orcidid: 0000-0002-4130-7784 surname: Visel fullname: Visel, Axel organization: Functional Genomics Department, Lawrence Berkeley National Laboratory, Department of Energy Joint Genome Institute, School of Natural Sciences, University of California – sequence: 18 givenname: Len A surname: Pennacchio fullname: Pennacchio, Len A organization: Functional Genomics Department, Lawrence Berkeley National Laboratory, Department of Energy Joint Genome Institute – sequence: 19 givenname: Diane E surname: Dickel fullname: Dickel, Diane E organization: Functional Genomics Department, Lawrence Berkeley National Laboratory – sequence: 20 givenname: Jason P surname: Lerch fullname: Lerch, Jason P organization: Mouse Imaging Centre, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto – sequence: 21 givenname: Jacqueline N surname: Crawley fullname: Crawley, Jacqueline N organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, MIND Institute, School of Medicine, University of California, Davis – sequence: 22 givenname: Konstantinos S surname: Zarbalis fullname: Zarbalis, Konstantinos S organization: Department of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, University of California, Davis – sequence: 23 givenname: Jill L surname: Silverman fullname: Silverman, Jill L organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, MIND Institute, School of Medicine, University of California, Davis – sequence: 24 givenname: Alex S orcidid: 0000-0003-4259-7514 surname: Nord fullname: Nord, Alex S email: asnord@ucdavis.edu organization: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Department of Neurobiology, Physiology and Behavior, University of California, Davis |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28671691$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1436635$$D View this record in Osti.gov |
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| Cites_doi | 10.1016/j.gde.2015.10.002 10.1038/nature10110 10.1016/j.neuroimage.2012.01.100 10.1002/mrm.20590 10.1093/bioinformatics/bts356 10.1101/lm.039602.115 10.1038/nature20612 10.1152/physiolgenomics.00217.2005 10.1007/s003359900551 10.1016/j.cell.2016.07.025 10.1016/j.neuroimage.2010.09.025 10.1002/aur.1344 10.1016/j.ntt.2014.10.008 10.1016/j.neuropharm.2012.07.042 10.1016/j.neuron.2015.09.016 10.1093/bioinformatics/btp616 10.1038/nrg3607 10.1093/nar/gkn760 10.1016/j.vascn.2006.05.006 10.1016/j.bbr.2013.05.047 10.1016/S0022-2836(05)80360-2 10.1186/1471-2105-14-128 10.1101/lm.035261.114 10.1126/scitranslmed.3004218 10.1016/j.neuron.2017.02.001 10.1194/jlr.M047555 10.1002/cne.23029 10.2202/1544-6115.1128 10.1097/00004728-199403000-00005 10.1038/nrg3999 10.1093/nar/gkt1102 10.1016/j.cell.2011.06.013 10.1038/mp.2009.14 10.1073/pnas.0910297106 10.1016/j.neuron.2016.05.024 10.1007/s00213-009-1466-y 10.1038/nature19357 10.1038/nrg3413 10.1038/ncomms5692 10.1523/JNEUROSCI.4385-15.2016 10.1002/aur.22 10.1038/tp.2014.117 10.1006/nimg.2001.1037 10.1016/j.cell.2013.11.033 10.1007/s11689-011-9084-5 10.1371/journal.pone.0134572 10.1038/mp.2014.98 10.1016/j.neuroimage.2008.02.019 10.1038/nature08911 10.1002/cne.24064 10.1016/j.neuroscience.2010.09.059 10.1016/j.neuron.2015.11.025 10.1111/j.1601-183X.2010.00623.x 10.1186/1471-2105-9-559 10.1016/j.cell.2013.10.020 10.1038/nmeth.1528 10.1002/cne.23678 10.1093/bioinformatics/btt656 10.1093/bioinformatics/btp324 10.1073/pnas.1405266111 10.1038/npp.2015.66 10.1016/j.neuroimage.2008.03.037 10.1002/0471250953.bi0214s34 10.1126/scitranslmed.3003501 10.1038/sj.bjc.6603967 10.1038/mp.2014.29 10.1007/s00213-011-2375-4 10.1038/nature13772 10.1016/j.cell.2013.10.031 10.1016/j.celrep.2017.03.052 10.1186/s13041-015-0122-1 10.1016/j.cell.2014.06.017 10.1186/gb-2010-11-2-r14 10.1126/science.1232033 10.1002/cne.22772 10.1038/nmeth.2019 10.1038/nature13908 10.1128/MCB.24.19.8386-8394.2004 10.1093/nar/gkv362 10.1038/nn.4400 10.1093/bioinformatics/bts635 10.1210/en.2014-1271 10.1038/nrn2851 10.1371/journal.pgen.1001273 10.1016/j.media.2007.06.004 10.1101/gr.178855.114 10.1523/JNEUROSCI.5438-05.2006 10.1002/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q 10.1038/ncomms7404 |
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| References | Silverman, Yang, Lord, Crawley (CR16) 2010; 11 Henderson (CR59) 2012; 4 Alrahbeni (CR28) 2015; 8 Li, Durbin (CR83) 2009; 25 Yoo, Motari, Schnaar (CR41) 2017; 525 Liao, Smyth, Shi (CR78) 2014; 30 Van Laere (CR88) 2007; 97 Jones, Horsfield, Simmons (CR67) 1999; 42 Young, Wakefield, Smyth, Oshlack (CR89) 2010; 11 Ullmann, Janke, Reutens, Watson (CR75) 2015; 523 Katz, Wang, Airoldi, Burge (CR30) 2010; 7 Katayama (CR13) 2016; 537 Lloyd-Burton, Roskams (CR47) 2012; 520 Iossifov (CR8) 2014; 515 Altschul, Gish, Miller, Myers, Lipman (CR80) 1990; 215 Cahill (CR64) 2012; 60 Nord (CR82) 2013; 155 Vissers, Gilissen, Veltman (CR6) 2016; 17 Chen (CR85) 2013; 14 Darnell (CR22) 2011; 146 Rossin (CR90) 2011; 7 Cotney (CR12) 2015; 6 Silverman (CR51) 2012; 4 Ellegood (CR34) 2015; 20 Parikshak (CR26) 2013; 155 Langfelder, Horvath (CR25) 2008; 9 Flannery (CR50) 2015; 47 Yang, Lewis, Sarvi, Foley, Crawley (CR56) 2015; 22 Nieman (CR66) 2005; 54 Zhang, Horvath (CR87) 2005; 4 Ho, Crabtree (CR1) 2010; 463 Brunner (CR33) 2015; 10 Wöhr, Scattoni (CR53) 2013; 251 Huang, Yu, Shimoda, Watanabe, Liu (CR46) 2012; 520 Collins, Neelin, Peters, Evans (CR69) 1994; 18 Bernier (CR9) 2014; 158 Orosco (CR36) 2014; 5 CR84 Yeung, Ha, Swanson, Goldowitz (CR42) 2016; 36 Chadman (CR54) 2008; 1 Avants (CR70) 2011; 54 Laumonnier (CR29) 2010; 15 Dobin (CR77) 2013; 29 Thomas, Bui, Perkins, Yuva-Paylor, Paylor (CR57) 2012; 219 Skrzypiec-Spring, Grotthus, Szelag, Schulz (CR63) 2007; 55 Hormozdiari, Penn, Borenstein, Eichler (CR20) 2015; 25 Espuny-Camacho (CR45) 2017; 93 Durak (CR15) 2016; 19 Croft (CR18) 2014; 42 Bales (CR62) 2014; 4 Dorr, Lerch, Spring, Kabani, Henkelman (CR68) 2008; 42 McCarthy (CR5) 2014; 19 Nieman, Flenniken, Adamson, Henkelman, Sled (CR73) 2006; 24 Lee (CR38) 2016; 89 Robinson, McCarthy, Smyth (CR81) 2010; 26 Silverman, Babineau, Oliver, Karras, Crawley (CR17) 2013; 68 Sanders (CR4) 2015; 33 Tipps, Raybuck, Buck, Lattal (CR32) 2014; 21 Rogers (CR55) 1997; 8 Genovese, Lazar, Nichols (CR76) 2002; 15 Schindelin (CR48) 2012; 9 Etherton, Blaiss, Powell, Südhof (CR35) 2009; 106 Jensen (CR27) 2009; 37 Avants, Epstein, Grossman, Gee (CR71) 2008; 12 Willsey (CR21) 2013; 155 Scattoni, Ricceri, Crawley (CR61) 2011; 10 Hagerman, Au, Hagerman (CR37) 2011; 3 Sanders (CR19) 2015; 87 Du, Ma, Meruvu, Hugendubler, Mueller (CR40) 2014; 55 Voineagu (CR23) 2011; 474 Wang, Wang, Li (CR79) 2012; 28 Chen, Dent (CR2) 2014; 15 Galazo, Emsley, Macklis (CR44) 2016; 91 De Rubeis (CR7) 2014; 515 Platt (CR14) 2017; 19 Parikshak (CR24) 2016; 540 Mali (CR39) 2013; 339 Lerch (CR72) 2008; 41 Zhang (CR31) 2016; 166 Medina-Rivera (CR86) 2015; 43 Nishiyama (CR10) 2004; 24 CR60 Silverman (CR49) 2015; 40 Steadman (CR74) 2014; 7 Ronan, Wu, Crabtree (CR3) 2013; 14 Thomas (CR58) 2009; 204 Bock (CR65) 2006; 26 Sugathan (CR11) 2014; 111 Nguyen, Yao, Erickson, Mishra, Nyomba (CR43) 2015; 156 Silverman (CR52) 2010; 171 P Langfelder (BFnn4592_CR25) 2008; 9 J-A Lee (BFnn4592_CR38) 2016; 89 ML Scattoni (BFnn4592_CR61) 2011; 10 JFP Ullmann (BFnn4592_CR75) 2015; 523 SE McCarthy (BFnn4592_CR5) 2014; 19 F Hormozdiari (BFnn4592_CR20) 2015; 25 BFnn4592_CR60 M Skrzypiec-Spring (BFnn4592_CR63) 2007; 55 JL Silverman (BFnn4592_CR52) 2010; 171 DK Jones (BFnn4592_CR67) 1999; 42 A Dobin (BFnn4592_CR77) 2013; 29 KL Bales (BFnn4592_CR62) 2014; 4 L Ho (BFnn4592_CR1) 2010; 463 JL Ronan (BFnn4592_CR3) 2013; 14 PE Steadman (BFnn4592_CR74) 2014; 7 SJ Sanders (BFnn4592_CR4) 2015; 33 A Sugathan (BFnn4592_CR11) 2014; 111 LJ Jensen (BFnn4592_CR27) 2009; 37 AM Thomas (BFnn4592_CR57) 2012; 219 B Zhang (BFnn4592_CR87) 2005; 4 JC Darnell (BFnn4592_CR22) 2011; 146 AE Dorr (BFnn4592_CR68) 2008; 42 P Mali (BFnn4592_CR39) 2013; 339 J Yeung (BFnn4592_CR42) 2016; 36 BJ Nieman (BFnn4592_CR66) 2005; 54 Z Huang (BFnn4592_CR46) 2012; 520 JL Silverman (BFnn4592_CR51) 2012; 4 I Iossifov (BFnn4592_CR8) 2014; 515 Y Katayama (BFnn4592_CR13) 2016; 537 SF Altschul (BFnn4592_CR80) 1990; 215 MD Young (BFnn4592_CR89) 2010; 11 RJ Platt (BFnn4592_CR14) 2017; 19 Y Liao (BFnn4592_CR78) 2014; 30 DC Rogers (BFnn4592_CR55) 1997; 8 KH Nguyen (BFnn4592_CR43) 2015; 156 JL Silverman (BFnn4592_CR16) 2010; 11 NN Parikshak (BFnn4592_CR24) 2016; 540 LA Orosco (BFnn4592_CR36) 2014; 5 BB Avants (BFnn4592_CR71) 2008; 12 A Thomas (BFnn4592_CR58) 2009; 204 H Li (BFnn4592_CR83) 2009; 25 L Wang (BFnn4592_CR79) 2012; 28 T Chen (BFnn4592_CR2) 2014; 15 R Bernier (BFnn4592_CR9) 2014; 158 X Zhang (BFnn4592_CR31) 2016; 166 A Medina-Rivera (BFnn4592_CR86) 2015; 43 C Henderson (BFnn4592_CR59) 2012; 4 O Durak (BFnn4592_CR15) 2016; 19 R Hagerman (BFnn4592_CR37) 2011; 3 MJ Galazo (BFnn4592_CR44) 2016; 91 LS Cahill (BFnn4592_CR64) 2012; 60 AS Nord (BFnn4592_CR82) 2013; 155 I Espuny-Camacho (BFnn4592_CR45) 2017; 93 S-W Yoo (BFnn4592_CR41) 2017; 525 BB Avants (BFnn4592_CR70) 2011; 54 S Van Laere (BFnn4592_CR88) 2007; 97 BJ Nieman (BFnn4592_CR73) 2006; 24 ME Tipps (BFnn4592_CR32) 2014; 21 C Du (BFnn4592_CR40) 2014; 55 JL Silverman (BFnn4592_CR17) 2013; 68 BFnn4592_CR84 F Laumonnier (BFnn4592_CR29) 2010; 15 CR Genovese (BFnn4592_CR76) 2002; 15 D Brunner (BFnn4592_CR33) 2015; 10 J Cotney (BFnn4592_CR12) 2015; 6 M Yang (BFnn4592_CR56) 2015; 22 S De Rubeis (BFnn4592_CR7) 2014; 515 I Voineagu (BFnn4592_CR23) 2011; 474 MR Etherton (BFnn4592_CR35) 2009; 106 KK Chadman (BFnn4592_CR54) 2008; 1 NA Bock (BFnn4592_CR65) 2006; 26 M Wöhr (BFnn4592_CR53) 2013; 251 AJ Willsey (BFnn4592_CR21) 2013; 155 EJ Rossin (BFnn4592_CR90) 2011; 7 DL Collins (BFnn4592_CR69) 1994; 18 Y Katz (BFnn4592_CR30) 2010; 7 SJ Sanders (BFnn4592_CR19) 2015; 87 EY Chen (BFnn4592_CR85) 2013; 14 NN Parikshak (BFnn4592_CR26) 2013; 155 T Alrahbeni (BFnn4592_CR28) 2015; 8 J Schindelin (BFnn4592_CR48) 2012; 9 BM Flannery (BFnn4592_CR50) 2015; 47 LELM Vissers (BFnn4592_CR6) 2016; 17 JL Silverman (BFnn4592_CR49) 2015; 40 D Croft (BFnn4592_CR18) 2014; 42 JP Lerch (BFnn4592_CR72) 2008; 41 M Nishiyama (BFnn4592_CR10) 2004; 24 J Ellegood (BFnn4592_CR34) 2015; 20 MD Robinson (BFnn4592_CR81) 2010; 26 S Lloyd-Burton (BFnn4592_CR47) 2012; 520 22743772 - Nat Methods. 2012 Jun 28;9(7):676-82 24366184 - Nat Rev Genet. 2014 Feb;15(2):93-106 27565344 - Cell. 2016 Aug 25;166(5):1147-1162.e15 2231712 - J Mol Biol. 1990 Oct 5;215(3):403-10 26503795 - Nat Rev Genet. 2016 Jan;17(1):9-18 23104886 - Bioinformatics. 2013 Jan 1;29(1):15-21 28402856 - Cell Rep. 2017 Apr 11;19(2):335-350 26687839 - Neuron. 2016 Jan 6;89(1):113-28 16086298 - Magn Reson Med. 2005 Sep;54(3):532-7 24151012 - Autism Res. 2014 Feb;7(1):124-37 27339102 - J Comp Neurol. 2017 Feb 1;525(2):291-301 25031364 - Learn Mem. 2014 Jul 16;21(8):380-93 22743226 - Bioinformatics. 2012 Aug 15;28(16):2184-5 11906227 - Neuroimage. 2002 Apr;15(4):870-8 23287722 - Science. 2013 Feb 15;339(6121):823-6 15367660 - Mol Cell Biol. 2004 Oct;24(19):8386-94 8126267 - J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205 9321461 - Mamm Genome. 1997 Oct;8(10):711-3 21614001 - Nature. 2011 May 25;474(7351):380-4 25024404 - J Lipid Res. 2014 Sep;55(9):1886-96 26402605 - Neuron. 2015 Sep 23;87(6):1215-33 24267887 - Cell. 2013 Nov 21;155(5):1008-21 27581449 - J Neurosci. 2016 Aug 31;36(35):9057-69 17659998 - Med Image Anal. 2008 Feb;12(1):26-41 20132535 - Genome Biol. 2010;11(2):R14 23568486 - Nat Rev Genet. 2013 May;14 (5):347-59 24227677 - Bioinformatics. 2014 Apr 1;30(7):923-30 25199916 - Mol Psychiatry. 2015 Feb;20(1):118-25 25754761 - Neuropsychopharmacology. 2015 Aug;40(9):2228-39 25446016 - Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45 16641223 - J Neurosci. 2006 Apr 26;26(17):4455-9 23769995 - Behav Brain Res. 2013 Aug 15;251:5-17 20851191 - Neuroimage. 2011 Feb 1;54(3):2033-44 25363768 - Nature. 2014 Nov 13;515(7526):216-21 21057496 - Nat Methods. 2010 Dec;7(12):1009-15 25363760 - Nature. 2014 Nov 13;515(7526):209-15 10467296 - Magn Reson Med. 1999 Sep;42(3):515-25 24243840 - Nucleic Acids Res. 2014 Jan;42(Database issue):D472-7 22173850 - J Comp Neurol. 2012 Aug 15;520(12):2575-90 21656124 - Psychopharmacology (Berl). 2012 Jan;219(1):47-58 25904632 - Nucleic Acids Res. 2015 Jul 1;43(W1):W50-6 21935948 - J Comp Neurol. 2012 Apr 15;520(6):1227-45 27602517 - Nature. 2016 Sep 29;537(7622):675-679 21784246 - Cell. 2011 Jul 22;146(2):247-61 18502665 - Neuroimage. 2008 Aug 1;42(1):60-9 20559336 - Nat Rev Neurosci. 2010 Jul;11(7):490-502 19114008 - BMC Bioinformatics. 2008 Dec 29;9:559 19238151 - Mol Psychiatry. 2010 Jul;15(7):767-76 19451168 - Bioinformatics. 2009 Jul 15;25(14):1754-60 25236843 - J Comp Neurol. 2015 Feb 15;523(3):391-405 16844390 - J Pharmacol Toxicol Methods. 2007 Mar-Apr;55(2):113-26 20110991 - Nature. 2010 Jan 28;463(7280):474-84 21617890 - J Neurodev Disord. 2011 Sep;3(3):211-24 24360275 - Cell. 2013 Dec 19;155(7):1521-31 26273832 - PLoS One. 2015 Aug 14;10(8):e0134572 19822762 - Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17998-8003 25198012 - Nat Commun. 2014 Sep 08;5:4692 25378250 - Genome Res. 2015 Jan;25(1):142-54 27321927 - Neuron. 2016 Jul 6;91(1):90-106 20888890 - Neuroscience. 2010 Dec 29;171(4):1197-208 27919067 - Nature. 2016 Dec 15;540(7633):423-427 18940858 - Nucleic Acids Res. 2009 Jan;37(Database issue):D412-6 17848951 - Br J Cancer. 2007 Oct 22;97(8):1165-74 22539775 - Sci Transl Med. 2012 Apr 25;4(131):131ra51 26572653 - Learn Mem. 2015 Nov 16;22(12):622-32 20618443 - Genes Brain Behav. 2011 Feb;10(1):44-56 25294932 - Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4468-77 22993295 - Sci Transl Med. 2012 Sep 19;4(152):152ra128 23586463 - BMC Bioinformatics. 2013 Apr 15;14:128 27694995 - Nat Neurosci. 2016 Nov;19(11):1477-1488 19910308 - Bioinformatics. 2010 Jan 1;26(1):139-40 19189082 - Psychopharmacology (Berl). 2009 Jun;204(2):361-73 28238547 - Neuron. 2017 Mar 8;93(5):1066-1081.e8 21249183 - PLoS Genet. 2011 Jan 13;7(1):e1001273 26547130 - Curr Opin Genet Dev. 2015 Aug;33:80-92 16410543 - Physiol Genomics. 2006 Jan 12;24(2):154-62 25752243 - Nat Commun. 2015 Mar 10;6:6404 24267886 - Cell. 2013 Nov 21;155(5):997-1007 25490144 - Endocrinology. 2015 Feb;156(2):462-74 24776741 - Mol Psychiatry. 2014 Jun;19(6):652-8 25386957 - Transl Psychiatry. 2014 Nov 11;4:e480 16646834 - Stat Appl Genet Mol Biol. 2005;4:Article17 22305951 - Neuroimage. 2012 Apr 2;60(2):933-9 26012578 - Mol Brain. 2015 May 27;8:33 19360662 - Autism Res. 2008 Jun;1(3):147-58 22968082 - Neuropharmacology. 2013 May;68:210-22 18387826 - Neuroimage. 2008 Jun;41(2):243-51 24998929 - Cell. 2014 Jul 17;158(2):263-76 |
| References_xml | – volume: 15 start-page: 870 year: 2002 end-page: 878 ident: CR76 article-title: Thresholding of statistical maps in functional neuroimaging using the false discovery rate publication-title: Neuroimage – volume: 7 start-page: e1001273 year: 2011 ident: CR90 article-title: Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology publication-title: PLoS Genet. – volume: 42 start-page: D472 year: 2014 end-page: D477 ident: CR18 article-title: The Reactome pathway knowledgebase publication-title: Nucleic Acids Res. – volume: 4 start-page: e480 year: 2014 ident: CR62 article-title: Long-term exposure to intranasal oxytocin in a mouse autism model publication-title: Transl. Psychiatry – volume: 520 start-page: 2575 year: 2012 end-page: 2590 ident: CR47 article-title: SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS publication-title: J. Comp. Neurol. – volume: 540 start-page: 423 year: 2016 end-page: 427 ident: CR24 article-title: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism publication-title: Nature – volume: 520 start-page: 1227 year: 2012 end-page: 1245 ident: CR46 article-title: Loss of neural recognition molecule NB-3 delays the normal projection and terminal branching of developing corticospinal tract axons in the mouse publication-title: J. Comp. Neurol. – volume: 54 start-page: 532 year: 2005 end-page: 537 ident: CR66 article-title: Fast spin-echo for multiple mouse magnetic resonance phenotyping publication-title: Magn. Reson. Med. – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: CR77 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics – volume: 22 start-page: 622 year: 2015 end-page: 632 ident: CR56 article-title: 16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks publication-title: Learn Mem. – volume: 28 start-page: 2184 year: 2012 end-page: 2185 ident: CR79 article-title: RSeQC: quality control of RNA-seq experiments publication-title: Bioinformatics – volume: 17 start-page: 9 year: 2016 end-page: 18 ident: CR6 article-title: Genetic studies in intellectual disability and related disorders publication-title: Nat. Rev. Genet. – volume: 87 start-page: 1215 year: 2015 end-page: 1233 ident: CR19 article-title: Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci publication-title: Neuron – ident: CR84 – volume: 10 start-page: 44 year: 2011 end-page: 56 ident: CR61 article-title: Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters publication-title: Genes Brain Behav. – volume: 523 start-page: 391 year: 2015 end-page: 405 ident: CR75 article-title: Development of MRI-based atlases of non-human brains publication-title: J. Comp. Neurol. – volume: 25 start-page: 142 year: 2015 end-page: 154 ident: CR20 article-title: The discovery of integrated gene networks for autism and related disorders publication-title: Genome Res. – volume: 4 start-page: e17 year: 2005 ident: CR87 article-title: A general framework for weighted gene co-expression network analysis publication-title: Stat. Appl. Genet. Mol. Biol. – volume: 5 start-page: 4692 year: 2014 ident: CR36 article-title: Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology publication-title: Nat. Commun. – volume: 515 start-page: 209 year: 2014 end-page: 215 ident: CR7 article-title: Synaptic, transcriptional and chromatin genes disrupted in autism publication-title: Nature – volume: 19 start-page: 335 year: 2017 end-page: 350 ident: CR14 article-title: Mutation Leads to autistic-like behaviors and impaired striatal circuits publication-title: Cell Rep. – volume: 11 start-page: 490 year: 2010 end-page: 502 ident: CR16 article-title: Behavioural phenotyping assays for mouse models of autism publication-title: Nat. Rev. Neurosci. – volume: 41 start-page: 243 year: 2008 end-page: 251 ident: CR72 article-title: Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease publication-title: Neuroimage – volume: 155 start-page: 1008 year: 2013 end-page: 1021 ident: CR26 article-title: Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism publication-title: Cell – volume: 30 start-page: 923 year: 2014 end-page: 930 ident: CR78 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics – volume: 1 start-page: 147 year: 2008 end-page: 158 ident: CR54 article-title: Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice publication-title: Autism Res. – volume: 10 start-page: e0134572 year: 2015 ident: CR33 article-title: Comprehensive analysis of the 16p11.2 deletion and null Cntnap2 mouse models of autism spectrum disorder publication-title: PLoS One – volume: 36 start-page: 9057 year: 2016 end-page: 9069 ident: CR42 article-title: A novel and multivalent role of Pax6 in cerebellar development publication-title: J. Neurosci. – volume: 40 start-page: 2228 year: 2015 end-page: 2239 ident: CR49 article-title: GABAB receptor agonist R-baclofen reverses social deficits and reduces repetitive behavior in two mouse models of autism publication-title: Neuropsychopharmacology – volume: 42 start-page: 60 year: 2008 end-page: 69 ident: CR68 article-title: High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice publication-title: Neuroimage – volume: 155 start-page: 997 year: 2013 end-page: 1007 ident: CR21 article-title: Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism publication-title: Cell – volume: 537 start-page: 675 year: 2016 end-page: 679 ident: CR13 article-title: haploinsufficiency results in autistic-like phenotypes in mice publication-title: Nature – volume: 204 start-page: 361 year: 2009 end-page: 373 ident: CR58 article-title: Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety publication-title: Psychopharmacology (Berl.) – volume: 8 start-page: 33 year: 2015 ident: CR28 article-title: Full UPF3B function is critical for neuronal differentiation of neural stem cells publication-title: Mol. Brain – ident: CR60 – volume: 9 start-page: 676 year: 2012 end-page: 682 ident: CR48 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods – volume: 219 start-page: 47 year: 2012 end-page: 58 ident: CR57 article-title: Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome publication-title: Psychopharmacology (Berl.) – volume: 15 start-page: 93 year: 2014 end-page: 106 ident: CR2 article-title: Chromatin modifiers and remodellers: regulators of cellular differentiation publication-title: Nat. Rev. Genet. – volume: 7 start-page: 1009 year: 2010 end-page: 1015 ident: CR30 article-title: Analysis and design of RNA sequencing experiments for identifying isoform regulation publication-title: Nat. Methods – volume: 106 start-page: 17998 year: 2009 end-page: 18003 ident: CR35 article-title: Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments publication-title: Proc. Natl. Acad. Sci. USA – volume: 515 start-page: 216 year: 2014 end-page: 221 ident: CR8 article-title: The contribution of coding mutations to autism spectrum disorder publication-title: Nature – volume: 26 start-page: 4455 year: 2006 end-page: 4459 ident: CR65 article-title: In vivo magnetic resonance imaging and semiautomated image analysis extend the brain phenotype for cdf/cdf mice publication-title: J. Neurosci. – volume: 155 start-page: 1521 year: 2013 end-page: 1531 ident: CR82 article-title: Rapid and pervasive changes in genome-wide enhancer usage during mammalian development publication-title: Cell – volume: 43 start-page: W50-6 year: 2015 ident: CR86 article-title: RSAT 2015: regulatory sequence analysis tools publication-title: Nucleic Acids Res. – volume: 3 start-page: 211 year: 2011 end-page: 224 ident: CR37 article-title: FMR1 premutation and full mutation molecular mechanisms related to autism publication-title: J. Neurodev. Disord. – volume: 156 start-page: 462 year: 2015 end-page: 474 ident: CR43 article-title: Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability publication-title: Endocrinology – volume: 14 start-page: 347 year: 2013 end-page: 359 ident: CR3 article-title: From neural development to cognition: unexpected roles for chromatin publication-title: Nat. Rev. Genet. – volume: 146 start-page: 247 year: 2011 end-page: 261 ident: CR22 article-title: FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism publication-title: Cell – volume: 24 start-page: 8386 year: 2004 end-page: 8394 ident: CR10 article-title: Early embryonic death in mice lacking the beta-catenin-binding protein Duplin publication-title: Mol. Cell. Biol. – volume: 54 start-page: 2033 year: 2011 end-page: 2044 ident: CR70 article-title: A reproducible evaluation of ANTs similarity metric performance in brain image registration publication-title: Neuroimage – volume: 8 start-page: 711 year: 1997 end-page: 713 ident: CR55 article-title: Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment publication-title: Mamm. Genome – volume: 18 start-page: 192 year: 1994 end-page: 205 ident: CR69 article-title: Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space publication-title: J. Comput. Assist. Tomogr. – volume: 91 start-page: 90 year: 2016 end-page: 106 ident: CR44 article-title: Corticothalamic projection neuron development beyond subtype specification: Fog2 and intersectional controls regulate intraclass neuronal diversity publication-title: Neuron – volume: 15 start-page: 767 year: 2010 end-page: 776 ident: CR29 article-title: Mutations of the gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism publication-title: Mol. Psychiatry – volume: 215 start-page: 403 year: 1990 end-page: 410 ident: CR80 article-title: Basic local alignment search tool publication-title: J. Mol. Biol. – volume: 525 start-page: 291 year: 2017 end-page: 301 ident: CR41 article-title: Agenesis of the corpus callosum in Nogo receptor deficient mice publication-title: J. Comp. Neurol. – volume: 42 start-page: 515 year: 1999 end-page: 525 ident: CR67 article-title: Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging publication-title: Magn. Reson. Med. – volume: 171 start-page: 1197 year: 2010 end-page: 1208 ident: CR52 article-title: Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism publication-title: Neuroscience – volume: 4 start-page: 152ra128 year: 2012 ident: CR59 article-title: Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen publication-title: Sci. Transl. Med. – volume: 21 start-page: 380 year: 2014 end-page: 393 ident: CR32 article-title: Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: issues of measurement and performance publication-title: Learn. Mem. – volume: 33 start-page: 80 year: 2015 end-page: 92 ident: CR4 article-title: First glimpses of the neurobiology of autism spectrum disorder publication-title: Curr. Opin. Genet. Dev. – volume: 20 start-page: 118 year: 2015 end-page: 125 ident: CR34 article-title: Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity publication-title: Mol. Psychiatry – volume: 111 start-page: E4468 year: 2014 end-page: E4477 ident: CR11 article-title: CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors publication-title: Proc. Natl. Acad. Sci. USA – volume: 19 start-page: 1477 year: 2016 end-page: 1488 ident: CR15 article-title: Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling publication-title: Nat. Neurosci. – volume: 25 start-page: 1754 year: 2009 end-page: 1760 ident: CR83 article-title: Fast and accurate short read alignment with Burrows-Wheeler transform publication-title: Bioinformatics – volume: 11 start-page: R14 year: 2010 ident: CR89 article-title: Gene ontology analysis for RNA-seq: accounting for selection bias publication-title: Genome Biol. – volume: 55 start-page: 1886 year: 2014 end-page: 1896 ident: CR40 article-title: The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing publication-title: J. Lipid Res. – volume: 89 start-page: 113 year: 2016 end-page: 128 ident: CR38 article-title: Cytoplasmic Rbfox1 regulates the expression of synaptic and autism-related genes publication-title: Neuron – volume: 93 start-page: 1066 year: 2017 end-page: 1081.e8 ident: CR45 article-title: Hallmarks of Alzheimer's disease in stem-cell-derived human neurons transplanted into mouse brain publication-title: Neuron – volume: 7 start-page: 124 year: 2014 end-page: 137 ident: CR74 article-title: Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas publication-title: Autism Res. – volume: 12 start-page: 26 year: 2008 end-page: 41 ident: CR71 article-title: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain publication-title: Med. Image Anal. – volume: 158 start-page: 263 year: 2014 end-page: 276 ident: CR9 article-title: Disruptive mutations define a subtype of autism early in development publication-title: Cell – volume: 474 start-page: 380 year: 2011 end-page: 384 ident: CR23 article-title: Transcriptomic analysis of autistic brain reveals convergent molecular pathology publication-title: Nature – volume: 37 start-page: D412 year: 2009 end-page: D416 ident: CR27 article-title: STRING 8--a global view on proteins and their functional interactions in 630 organisms publication-title: Nucleic Acids Res. – volume: 6 start-page: 6404 year: 2015 ident: CR12 article-title: The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment publication-title: Nat. Commun. – volume: 97 start-page: 1165 year: 2007 end-page: 1174 ident: CR88 article-title: Distinct molecular phenotype of inflammatory breast cancer compared to non-inflammatory breast cancer using Affymetrix-based genome-wide gene-expression analysis publication-title: Br. J. Cancer – volume: 55 start-page: 113 year: 2007 end-page: 126 ident: CR63 article-title: Isolated heart perfusion according to Langendorff---still viable in the new millennium publication-title: J. Pharmacol. Toxicol. Methods – volume: 4 start-page: 131ra51 year: 2012 ident: CR51 article-title: Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism publication-title: Sci. Transl. Med. – volume: 47 start-page: 36 year: 2015 end-page: 45 ident: CR50 article-title: Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine publication-title: Neurotoxicol. Teratol. – volume: 339 start-page: 823 year: 2013 end-page: 826 ident: CR39 article-title: RNA-guided human genome engineering via Cas9 publication-title: Science – volume: 251 start-page: 5 year: 2013 end-page: 17 ident: CR53 article-title: Behavioural methods used in rodent models of autism spectrum disorders: current standards and new developments publication-title: Behav. Brain Res. – volume: 463 start-page: 474 year: 2010 end-page: 484 ident: CR1 article-title: Chromatin remodelling during development publication-title: Nature – volume: 19 start-page: 652 year: 2014 end-page: 658 ident: CR5 article-title: mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability publication-title: Mol. Psychiatry – volume: 60 start-page: 933 year: 2012 end-page: 939 ident: CR64 article-title: Preparation of fixed mouse brains for MRI publication-title: Neuroimage – volume: 9 start-page: 559 year: 2008 ident: CR25 article-title: WGCNA: an R package for weighted correlation network analysis publication-title: BMC Bioinformatics – volume: 14 start-page: 128 year: 2013 ident: CR85 article-title: Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool publication-title: BMC Bioinformatics – volume: 166 start-page: 1147 year: 2016 end-page: 1162.e15 ident: CR31 article-title: Cell-type-specific alternative splicing governs cell fate in the developing cerebral cortex publication-title: Cell – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: CR81 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics – volume: 24 start-page: 154 year: 2006 end-page: 162 ident: CR73 article-title: Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography publication-title: Physiol. Genomics – volume: 68 start-page: 210 year: 2013 end-page: 222 ident: CR17 article-title: Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism publication-title: Neuropharmacology – volume: 33 start-page: 80 year: 2015 ident: BFnn4592_CR4 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2015.10.002 – volume: 474 start-page: 380 year: 2011 ident: BFnn4592_CR23 publication-title: Nature doi: 10.1038/nature10110 – volume: 60 start-page: 933 year: 2012 ident: BFnn4592_CR64 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2012.01.100 – volume: 54 start-page: 532 year: 2005 ident: BFnn4592_CR66 publication-title: Magn. Reson. Med. doi: 10.1002/mrm.20590 – volume: 28 start-page: 2184 year: 2012 ident: BFnn4592_CR79 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts356 – volume: 22 start-page: 622 year: 2015 ident: BFnn4592_CR56 publication-title: Learn Mem. doi: 10.1101/lm.039602.115 – volume: 540 start-page: 423 year: 2016 ident: BFnn4592_CR24 publication-title: Nature doi: 10.1038/nature20612 – volume: 24 start-page: 154 year: 2006 ident: BFnn4592_CR73 publication-title: Physiol. Genomics doi: 10.1152/physiolgenomics.00217.2005 – volume: 8 start-page: 711 year: 1997 ident: BFnn4592_CR55 publication-title: Mamm. Genome doi: 10.1007/s003359900551 – volume: 166 start-page: 1147 year: 2016 ident: BFnn4592_CR31 publication-title: Cell doi: 10.1016/j.cell.2016.07.025 – volume: 54 start-page: 2033 year: 2011 ident: BFnn4592_CR70 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.09.025 – volume: 7 start-page: 124 year: 2014 ident: BFnn4592_CR74 publication-title: Autism Res. doi: 10.1002/aur.1344 – volume: 47 start-page: 36 year: 2015 ident: BFnn4592_CR50 publication-title: Neurotoxicol. Teratol. doi: 10.1016/j.ntt.2014.10.008 – volume: 68 start-page: 210 year: 2013 ident: BFnn4592_CR17 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2012.07.042 – volume: 87 start-page: 1215 year: 2015 ident: BFnn4592_CR19 publication-title: Neuron doi: 10.1016/j.neuron.2015.09.016 – volume: 26 start-page: 139 year: 2010 ident: BFnn4592_CR81 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 15 start-page: 93 year: 2014 ident: BFnn4592_CR2 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3607 – volume: 37 start-page: D412 year: 2009 ident: BFnn4592_CR27 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn760 – volume: 55 start-page: 113 year: 2007 ident: BFnn4592_CR63 publication-title: J. Pharmacol. Toxicol. Methods doi: 10.1016/j.vascn.2006.05.006 – volume: 251 start-page: 5 year: 2013 ident: BFnn4592_CR53 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2013.05.047 – volume: 215 start-page: 403 year: 1990 ident: BFnn4592_CR80 publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(05)80360-2 – volume: 14 start-page: 128 year: 2013 ident: BFnn4592_CR85 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-14-128 – volume: 21 start-page: 380 year: 2014 ident: BFnn4592_CR32 publication-title: Learn. Mem. doi: 10.1101/lm.035261.114 – volume: 4 start-page: 152ra128 year: 2012 ident: BFnn4592_CR59 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3004218 – volume: 93 start-page: 1066 year: 2017 ident: BFnn4592_CR45 publication-title: Neuron doi: 10.1016/j.neuron.2017.02.001 – volume: 55 start-page: 1886 year: 2014 ident: BFnn4592_CR40 publication-title: J. Lipid Res. doi: 10.1194/jlr.M047555 – volume: 520 start-page: 2575 year: 2012 ident: BFnn4592_CR47 publication-title: J. Comp. Neurol. doi: 10.1002/cne.23029 – volume: 4 start-page: e17 year: 2005 ident: BFnn4592_CR87 publication-title: Stat. Appl. Genet. Mol. Biol. doi: 10.2202/1544-6115.1128 – volume: 18 start-page: 192 year: 1994 ident: BFnn4592_CR69 publication-title: J. Comput. Assist. Tomogr. doi: 10.1097/00004728-199403000-00005 – volume: 17 start-page: 9 year: 2016 ident: BFnn4592_CR6 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3999 – volume: 42 start-page: D472 year: 2014 ident: BFnn4592_CR18 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt1102 – volume: 146 start-page: 247 year: 2011 ident: BFnn4592_CR22 publication-title: Cell doi: 10.1016/j.cell.2011.06.013 – volume: 15 start-page: 767 year: 2010 ident: BFnn4592_CR29 publication-title: Mol. Psychiatry doi: 10.1038/mp.2009.14 – volume: 106 start-page: 17998 year: 2009 ident: BFnn4592_CR35 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0910297106 – volume: 91 start-page: 90 year: 2016 ident: BFnn4592_CR44 publication-title: Neuron doi: 10.1016/j.neuron.2016.05.024 – volume: 204 start-page: 361 year: 2009 ident: BFnn4592_CR58 publication-title: Psychopharmacology (Berl.) doi: 10.1007/s00213-009-1466-y – volume: 537 start-page: 675 year: 2016 ident: BFnn4592_CR13 publication-title: Nature doi: 10.1038/nature19357 – volume: 14 start-page: 347 year: 2013 ident: BFnn4592_CR3 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3413 – volume: 5 start-page: 4692 year: 2014 ident: BFnn4592_CR36 publication-title: Nat. Commun. doi: 10.1038/ncomms5692 – volume: 36 start-page: 9057 year: 2016 ident: BFnn4592_CR42 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4385-15.2016 – ident: BFnn4592_CR60 – volume: 1 start-page: 147 year: 2008 ident: BFnn4592_CR54 publication-title: Autism Res. doi: 10.1002/aur.22 – volume: 4 start-page: e480 year: 2014 ident: BFnn4592_CR62 publication-title: Transl. Psychiatry doi: 10.1038/tp.2014.117 – volume: 15 start-page: 870 year: 2002 ident: BFnn4592_CR76 publication-title: Neuroimage doi: 10.1006/nimg.2001.1037 – volume: 155 start-page: 1521 year: 2013 ident: BFnn4592_CR82 publication-title: Cell doi: 10.1016/j.cell.2013.11.033 – volume: 3 start-page: 211 year: 2011 ident: BFnn4592_CR37 publication-title: J. Neurodev. Disord. doi: 10.1007/s11689-011-9084-5 – volume: 10 start-page: e0134572 year: 2015 ident: BFnn4592_CR33 publication-title: PLoS One doi: 10.1371/journal.pone.0134572 – volume: 20 start-page: 118 year: 2015 ident: BFnn4592_CR34 publication-title: Mol. Psychiatry doi: 10.1038/mp.2014.98 – volume: 41 start-page: 243 year: 2008 ident: BFnn4592_CR72 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.02.019 – volume: 463 start-page: 474 year: 2010 ident: BFnn4592_CR1 publication-title: Nature doi: 10.1038/nature08911 – volume: 525 start-page: 291 year: 2017 ident: BFnn4592_CR41 publication-title: J. Comp. Neurol. doi: 10.1002/cne.24064 – volume: 171 start-page: 1197 year: 2010 ident: BFnn4592_CR52 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.09.059 – volume: 89 start-page: 113 year: 2016 ident: BFnn4592_CR38 publication-title: Neuron doi: 10.1016/j.neuron.2015.11.025 – volume: 10 start-page: 44 year: 2011 ident: BFnn4592_CR61 publication-title: Genes Brain Behav. doi: 10.1111/j.1601-183X.2010.00623.x – volume: 9 start-page: 559 year: 2008 ident: BFnn4592_CR25 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-9-559 – volume: 155 start-page: 997 year: 2013 ident: BFnn4592_CR21 publication-title: Cell doi: 10.1016/j.cell.2013.10.020 – volume: 7 start-page: 1009 year: 2010 ident: BFnn4592_CR30 publication-title: Nat. Methods doi: 10.1038/nmeth.1528 – volume: 523 start-page: 391 year: 2015 ident: BFnn4592_CR75 publication-title: J. Comp. Neurol. doi: 10.1002/cne.23678 – volume: 30 start-page: 923 year: 2014 ident: BFnn4592_CR78 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt656 – volume: 25 start-page: 1754 year: 2009 ident: BFnn4592_CR83 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp324 – volume: 111 start-page: E4468 year: 2014 ident: BFnn4592_CR11 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1405266111 – volume: 40 start-page: 2228 year: 2015 ident: BFnn4592_CR49 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2015.66 – volume: 42 start-page: 60 year: 2008 ident: BFnn4592_CR68 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.03.037 – ident: BFnn4592_CR84 doi: 10.1002/0471250953.bi0214s34 – volume: 4 start-page: 131ra51 year: 2012 ident: BFnn4592_CR51 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3003501 – volume: 97 start-page: 1165 year: 2007 ident: BFnn4592_CR88 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603967 – volume: 19 start-page: 652 year: 2014 ident: BFnn4592_CR5 publication-title: Mol. Psychiatry doi: 10.1038/mp.2014.29 – volume: 219 start-page: 47 year: 2012 ident: BFnn4592_CR57 publication-title: Psychopharmacology (Berl.) doi: 10.1007/s00213-011-2375-4 – volume: 515 start-page: 209 year: 2014 ident: BFnn4592_CR7 publication-title: Nature doi: 10.1038/nature13772 – volume: 155 start-page: 1008 year: 2013 ident: BFnn4592_CR26 publication-title: Cell doi: 10.1016/j.cell.2013.10.031 – volume: 19 start-page: 335 year: 2017 ident: BFnn4592_CR14 publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.03.052 – volume: 8 start-page: 33 year: 2015 ident: BFnn4592_CR28 publication-title: Mol. Brain doi: 10.1186/s13041-015-0122-1 – volume: 158 start-page: 263 year: 2014 ident: BFnn4592_CR9 publication-title: Cell doi: 10.1016/j.cell.2014.06.017 – volume: 11 start-page: R14 year: 2010 ident: BFnn4592_CR89 publication-title: Genome Biol. doi: 10.1186/gb-2010-11-2-r14 – volume: 339 start-page: 823 year: 2013 ident: BFnn4592_CR39 publication-title: Science doi: 10.1126/science.1232033 – volume: 520 start-page: 1227 year: 2012 ident: BFnn4592_CR46 publication-title: J. Comp. Neurol. doi: 10.1002/cne.22772 – volume: 9 start-page: 676 year: 2012 ident: BFnn4592_CR48 publication-title: Nat. Methods doi: 10.1038/nmeth.2019 – volume: 515 start-page: 216 year: 2014 ident: BFnn4592_CR8 publication-title: Nature doi: 10.1038/nature13908 – volume: 24 start-page: 8386 year: 2004 ident: BFnn4592_CR10 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.19.8386-8394.2004 – volume: 43 start-page: W50-6 year: 2015 ident: BFnn4592_CR86 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv362 – volume: 19 start-page: 1477 year: 2016 ident: BFnn4592_CR15 publication-title: Nat. Neurosci. doi: 10.1038/nn.4400 – volume: 29 start-page: 15 year: 2013 ident: BFnn4592_CR77 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 156 start-page: 462 year: 2015 ident: BFnn4592_CR43 publication-title: Endocrinology doi: 10.1210/en.2014-1271 – volume: 11 start-page: 490 year: 2010 ident: BFnn4592_CR16 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2851 – volume: 7 start-page: e1001273 year: 2011 ident: BFnn4592_CR90 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001273 – volume: 12 start-page: 26 year: 2008 ident: BFnn4592_CR71 publication-title: Med. Image Anal. doi: 10.1016/j.media.2007.06.004 – volume: 25 start-page: 142 year: 2015 ident: BFnn4592_CR20 publication-title: Genome Res. doi: 10.1101/gr.178855.114 – volume: 26 start-page: 4455 year: 2006 ident: BFnn4592_CR65 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5438-05.2006 – volume: 42 start-page: 515 year: 1999 ident: BFnn4592_CR67 publication-title: Magn. Reson. Med. doi: 10.1002/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q – volume: 6 start-page: 6404 year: 2015 ident: BFnn4592_CR12 publication-title: Nat. Commun. doi: 10.1038/ncomms7404 – reference: 27565344 - Cell. 2016 Aug 25;166(5):1147-1162.e15 – reference: 19189082 - Psychopharmacology (Berl). 2009 Jun;204(2):361-73 – reference: 16410543 - Physiol Genomics. 2006 Jan 12;24(2):154-62 – reference: 24998929 - Cell. 2014 Jul 17;158(2):263-76 – reference: 21617890 - J Neurodev Disord. 2011 Sep;3(3):211-24 – reference: 21656124 - Psychopharmacology (Berl). 2012 Jan;219(1):47-58 – reference: 20559336 - Nat Rev Neurosci. 2010 Jul;11(7):490-502 – reference: 18387826 - Neuroimage. 2008 Jun;41(2):243-51 – reference: 20132535 - Genome Biol. 2010;11(2):R14 – reference: 25024404 - J Lipid Res. 2014 Sep;55(9):1886-96 – reference: 23769995 - Behav Brain Res. 2013 Aug 15;251:5-17 – reference: 16844390 - J Pharmacol Toxicol Methods. 2007 Mar-Apr;55(2):113-26 – reference: 25446016 - Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45 – reference: 25386957 - Transl Psychiatry. 2014 Nov 11;4:e480 – reference: 24151012 - Autism Res. 2014 Feb;7(1):124-37 – reference: 20618443 - Genes Brain Behav. 2011 Feb;10(1):44-56 – reference: 27581449 - J Neurosci. 2016 Aug 31;36(35):9057-69 – reference: 19910308 - Bioinformatics. 2010 Jan 1;26(1):139-40 – reference: 9321461 - Mamm Genome. 1997 Oct;8(10):711-3 – reference: 21784246 - Cell. 2011 Jul 22;146(2):247-61 – reference: 27321927 - Neuron. 2016 Jul 6;91(1):90-106 – reference: 25198012 - Nat Commun. 2014 Sep 08;5:4692 – reference: 28402856 - Cell Rep. 2017 Apr 11;19(2):335-350 – reference: 18940858 - Nucleic Acids Res. 2009 Jan;37(Database issue):D412-6 – reference: 22539775 - Sci Transl Med. 2012 Apr 25;4(131):131ra51 – reference: 23104886 - Bioinformatics. 2013 Jan 1;29(1):15-21 – reference: 20851191 - Neuroimage. 2011 Feb 1;54(3):2033-44 – reference: 25363768 - Nature. 2014 Nov 13;515(7526):216-21 – reference: 17659998 - Med Image Anal. 2008 Feb;12(1):26-41 – reference: 26547130 - Curr Opin Genet Dev. 2015 Aug;33:80-92 – reference: 25294932 - Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4468-77 – reference: 24243840 - Nucleic Acids Res. 2014 Jan;42(Database issue):D472-7 – reference: 26012578 - Mol Brain. 2015 May 27;8:33 – reference: 22305951 - Neuroimage. 2012 Apr 2;60(2):933-9 – reference: 25904632 - Nucleic Acids Res. 2015 Jul 1;43(W1):W50-6 – reference: 26572653 - Learn Mem. 2015 Nov 16;22(12):622-32 – reference: 19360662 - Autism Res. 2008 Jun;1(3):147-58 – reference: 24227677 - Bioinformatics. 2014 Apr 1;30(7):923-30 – reference: 26402605 - Neuron. 2015 Sep 23;87(6):1215-33 – reference: 22173850 - J Comp Neurol. 2012 Aug 15;520(12):2575-90 – reference: 19114008 - BMC Bioinformatics. 2008 Dec 29;9:559 – reference: 23586463 - BMC Bioinformatics. 2013 Apr 15;14:128 – reference: 17848951 - Br J Cancer. 2007 Oct 22;97(8):1165-74 – reference: 22968082 - Neuropharmacology. 2013 May;68:210-22 – reference: 21614001 - Nature. 2011 May 25;474(7351):380-4 – reference: 26687839 - Neuron. 2016 Jan 6;89(1):113-28 – reference: 22993295 - Sci Transl Med. 2012 Sep 19;4(152):152ra128 – reference: 25378250 - Genome Res. 2015 Jan;25(1):142-54 – reference: 28238547 - Neuron. 2017 Mar 8;93(5):1066-1081.e8 – reference: 11906227 - Neuroimage. 2002 Apr;15(4):870-8 – reference: 26503795 - Nat Rev Genet. 2016 Jan;17(1):9-18 – reference: 24366184 - Nat Rev Genet. 2014 Feb;15(2):93-106 – reference: 25490144 - Endocrinology. 2015 Feb;156(2):462-74 – reference: 25754761 - Neuropsychopharmacology. 2015 Aug;40(9):2228-39 – reference: 16646834 - Stat Appl Genet Mol Biol. 2005;4:Article17 – reference: 22743226 - Bioinformatics. 2012 Aug 15;28(16):2184-5 – reference: 25031364 - Learn Mem. 2014 Jul 16;21(8):380-93 – reference: 25199916 - Mol Psychiatry. 2015 Feb;20(1):118-25 – reference: 24360275 - Cell. 2013 Dec 19;155(7):1521-31 – reference: 25752243 - Nat Commun. 2015 Mar 10;6:6404 – reference: 21935948 - J Comp Neurol. 2012 Apr 15;520(6):1227-45 – reference: 23287722 - Science. 2013 Feb 15;339(6121):823-6 – reference: 8126267 - J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205 – reference: 21057496 - Nat Methods. 2010 Dec;7(12):1009-15 – reference: 19238151 - Mol Psychiatry. 2010 Jul;15(7):767-76 – reference: 27694995 - Nat Neurosci. 2016 Nov;19(11):1477-1488 – reference: 18502665 - Neuroimage. 2008 Aug 1;42(1):60-9 – reference: 25236843 - J Comp Neurol. 2015 Feb 15;523(3):391-405 – reference: 2231712 - J Mol Biol. 1990 Oct 5;215(3):403-10 – reference: 20110991 - Nature. 2010 Jan 28;463(7280):474-84 – reference: 23568486 - Nat Rev Genet. 2013 May;14 (5):347-59 – reference: 16086298 - Magn Reson Med. 2005 Sep;54(3):532-7 – reference: 15367660 - Mol Cell Biol. 2004 Oct;24(19):8386-94 – reference: 25363760 - Nature. 2014 Nov 13;515(7526):209-15 – reference: 27339102 - J Comp Neurol. 2017 Feb 1;525(2):291-301 – reference: 10467296 - Magn Reson Med. 1999 Sep;42(3):515-25 – reference: 19822762 - Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17998-8003 – reference: 27602517 - Nature. 2016 Sep 29;537(7622):675-679 – reference: 20888890 - Neuroscience. 2010 Dec 29;171(4):1197-208 – reference: 26273832 - PLoS One. 2015 Aug 14;10(8):e0134572 – reference: 22743772 - Nat Methods. 2012 Jun 28;9(7):676-82 – reference: 19451168 - Bioinformatics. 2009 Jul 15;25(14):1754-60 – reference: 27919067 - Nature. 2016 Dec 15;540(7633):423-427 – reference: 24776741 - Mol Psychiatry. 2014 Jun;19(6):652-8 – reference: 24267886 - Cell. 2013 Nov 21;155(5):997-1007 – reference: 21249183 - PLoS Genet. 2011 Jan 13;7(1):e1001273 – reference: 24267887 - Cell. 2013 Nov 21;155(5):1008-21 – reference: 16641223 - J Neurosci. 2006 Apr 26;26(17):4455-9 |
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| Snippet | Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers
et al... The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline... The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. In this paper, we examined the impact of... The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline... |
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| SubjectTerms | 13/51 14/19 38/23 38/77 45/15 45/88 45/91 49/1 49/22 49/39 49/90 59/57 60 APPLIED LIFE SCIENCES 631/208/191 631/208/366/1373 631/378/2571/1696 64/60 82/29 Animal Genetics and Genomics Animals Autism autism spectrum disorders Behavioral Sciences Biological Techniques Biomedicine Brain Brain - metabolism Cell Cycle Proteins - genetics Chromatin Chromatin - metabolism Chromatin remodeling Cognitive ability Developmental neurology DNA-Binding Proteins - genetics Frameshift mutation functional genomics Gene expression Gene Expression Regulation, Developmental - genetics Gene Regulatory Networks - genetics Genetic aspects Haploinsufficiency Haploinsufficiency - genetics Mice Mice, Transgenic Mutation Mutation - genetics Network analysis Neurobiology Neurodevelopmental disorders Neurogenesis neuronal development Neurosciences Perturbation methods Phenotype Physiological aspects Ribonucleic acid RNA RNA processing Social factors Social interactions Splicing Transcription Transcription Factors - genetics |
| Title | Germline Chd8 haploinsufficiency alters brain development in mouse |
| URI | https://link.springer.com/article/10.1038/nn.4592 https://www.ncbi.nlm.nih.gov/pubmed/28671691 https://www.proquest.com/docview/1946506920 https://www.proquest.com/docview/1915559319 https://www.osti.gov/servlets/purl/1436635 https://pubmed.ncbi.nlm.nih.gov/PMC6008102 |
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