Association between cytokine levels, verbal memory and hippocampus volume in psychotic disorders and healthy controls
Objective We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls. Method In total, 230 patients with a broad DSM‐IV schizophrenia spectrum illness or bipolar...
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| Published in | Acta psychiatrica Scandinavica Vol. 133; no. 1; pp. 53 - 62 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.01.2016
Munksgaard Forlag |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0001-690X 1600-0447 1600-0447 |
| DOI | 10.1111/acps.12467 |
Cover
| Abstract | Objective
We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls.
Method
In total, 230 patients with a broad DSM‐IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory Scale‐Third Edition (WMS‐III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF‐R1), interleukin‐1 receptor antagonist, interleukin‐6, von Willebrand factor, osteoprotegerin, high‐sensitivity C‐reactive protein and sCD40 ligand. Hippocampal subfield estimates were obtained using FreeSurfer.
Results
We found a moderate negative association between sTNF‐R1 and performance on verbal memory learning and recall tests as measured by the WMS‐III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF‐R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes.
Conclusion
The findings suggest a role for immune involvement in memory independent of severe mental disorders and may support the ‘bigger is better’ hypothesis of hippocampal subfield volumes. |
|---|---|
| AbstractList | Objective: We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls.
Method: 230 patients with a broad DSM-IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory ScaleThird Edition (WMS-III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist, interleukin-6, von Willebrand factor, osteoprotegerin, high-sensitivity Creactive protein and sCD40 Ligand. Hippocampal subfield estimates were obtained using FreeSurfer.
Results: We found a moderate negative association between sTNF-R1 and performance on verbal memory learning and recall tests as measured by the WMS-III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF-R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes.
Conclusions: The findings suggest a role for immune involvement in memory independent of severe mental disorders, and may support the “bigger is better” hypothesis of hippocampal subfield volumes. Objective We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls. Method In total, 230 patients with a broad DSM‐IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory Scale‐Third Edition (WMS‐III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF‐R1), interleukin‐1 receptor antagonist, interleukin‐6, von Willebrand factor, osteoprotegerin, high‐sensitivity C‐reactive protein and sCD40 ligand. Hippocampal subfield estimates were obtained using FreeSurfer. Results We found a moderate negative association between sTNF‐R1 and performance on verbal memory learning and recall tests as measured by the WMS‐III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF‐R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes. Conclusion The findings suggest a role for immune involvement in memory independent of severe mental disorders and may support the ‘bigger is better’ hypothesis of hippocampal subfield volumes. Objective We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls. Method In total, 230 patients with a broad DSM-IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory Scale-Third Edition (WMS-III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist, interleukin-6, von Willebrand factor, osteoprotegerin, high-sensitivity C-reactive protein and sCD40 ligand. Hippocampal subfield estimates were obtained using FreeSurfer. Results We found a moderate negative association between sTNF-R1 and performance on verbal memory learning and recall tests as measured by the WMS-III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF-R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes. Conclusion The findings suggest a role for immune involvement in memory independent of severe mental disorders and may support the 'bigger is better' hypothesis of hippocampal subfield volumes. We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls.OBJECTIVEWe investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls.In total, 230 patients with a broad DSM-IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory Scale-Third Edition (WMS-III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist, interleukin-6, von Willebrand factor, osteoprotegerin, high-sensitivity C-reactive protein and sCD40 ligand. Hippocampal subfield estimates were obtained using FreeSurfer.METHODIn total, 230 patients with a broad DSM-IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory Scale-Third Edition (WMS-III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist, interleukin-6, von Willebrand factor, osteoprotegerin, high-sensitivity C-reactive protein and sCD40 ligand. Hippocampal subfield estimates were obtained using FreeSurfer.We found a moderate negative association between sTNF-R1 and performance on verbal memory learning and recall tests as measured by the WMS-III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF-R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes.RESULTSWe found a moderate negative association between sTNF-R1 and performance on verbal memory learning and recall tests as measured by the WMS-III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF-R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes.The findings suggest a role for immune involvement in memory independent of severe mental disorders and may support the 'bigger is better' hypothesis of hippocampal subfield volumes.CONCLUSIONThe findings suggest a role for immune involvement in memory independent of severe mental disorders and may support the 'bigger is better' hypothesis of hippocampal subfield volumes. We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls. In total, 230 patients with a broad DSM-IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory Scale-Third Edition (WMS-III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist, interleukin-6, von Willebrand factor, osteoprotegerin, high-sensitivity C-reactive protein and sCD40 ligand. Hippocampal subfield estimates were obtained using FreeSurfer. We found a moderate negative association between sTNF-R1 and performance on verbal memory learning and recall tests as measured by the WMS-III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF-R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes. The findings suggest a role for immune involvement in memory independent of severe mental disorders and may support the 'bigger is better' hypothesis of hippocampal subfield volumes. |
| Author | Westlye, L. T. Hope, S. Ueland, T. Agartz, I. Hoseth, E. Z. Melle, I. Haukvik, U. K. Andreassen, O. A. Dieset, I. Aukrust, P. |
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| Notes | ark:/67375/WNG-8Z96SWMR-2 istex:C2C83208FB4D640BCA5A8553A6548E89221AB45B Table S1. Demographic and clinical characteristics of participants in the MRI subgroup (N = 224). Table S2. Immune and verbal memory characteristics for the Main group (N = 462). Table S3. Immune, verbal memory and hippocampal volume characteristics for the MRI subgroup (N = 224). Table S4. Linear regression models investigating the associations between verbal memory and cytokines in whole sample (N = 462) after controlling for age, sex and diagnosis. Table S5. Linear regression analyses of associations between verbal memory and hippocampal volumes in subsample (N = 224) after controlling for age, sex, estimated total intracranial volume and diagnosis (patient or control). Table S6. Linear regression analyses investigating associations between hippocampal subvolumes and cytokines in MRI subgroup (N = 224) after controlling for age, sex, estimated total intracranial volume and diagnosis (patient or control). Table S7. Spearman's rank correlation between cytokines and time of blood sampling for the control group (N = 174) ArticleID:ACPS12467 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 NFR/204966 |
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Am J Med Genet B Neuropsychiatr Genet 2013;162b:122-136. 2004; 22 2010; 53 2004; 124 2015; 77 2004; 23 2013; 20 2013; 128 2012; 19 2014; 130 1993; 1 2013; 5 2014; 129 2009; 11 2014; 5 2013; 15 2006; 20 2010; 68 2013; 53 2011; 72 2011; 25 2012; 26 2014; 52 2009; 19 2012; 62 2006; 1071 2015; 284 2013; 47 2010; 35 2009; 64 2013; 42 2010; 167 2002; 33 2013; 145 2008 2011; 35 2004 2013; 162b 2011; 37 2014; 40 2014; 111 2012; 35 2013; 381 2006; 113 2009; 33 2012; 90 2005; 365 2014; 172c 2013; 30 2014; 38 2011; 43 2011; 45 2009; 460 2009; 5 2014; 71 e_1_2_9_31_1 e_1_2_9_52_1 e_1_2_9_50_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_56_1 e_1_2_9_12_1 Hufner K (e_1_2_9_23_1) 2014; 172 e_1_2_9_54_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_18_1 e_1_2_9_41_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_4_1 e_1_2_9_2_1 Drew PD (e_1_2_9_45_1) 1993; 1 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 Delis DC (e_1_2_9_32_1) 2004 Seguin JA (e_1_2_9_55_1) 2009; 5 e_1_2_9_30_1 e_1_2_9_53_1 e_1_2_9_51_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_57_1 e_1_2_9_13_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_19_1 e_1_2_9_42_1 e_1_2_9_40_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_44_1 e_1_2_9_7_1 e_1_2_9_5_1 e_1_2_9_3_1 Wechsler D (e_1_2_9_33_1) 2008 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_29_1 |
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We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with... We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe... Objective We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with... Objective: We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients... |
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| SubjectTerms | Adolescent Adult Bipolar Disorder - blood Bipolar Disorder - pathology Bipolar Disorder - psychology Cytokines Cytokines - blood Diffusion Magnetic Resonance Imaging - methods Female Hippocampus - pathology Humans Male Memory Memory - physiology Mental disorders Mental Recall - physiology Middle Aged neurocognition neuroimaging Neuropsychological Tests - standards Psychopathology psychoses Psychotic Disorders - blood Psychotic Disorders - pathology Psychotic Disorders - psychology Schizophrenia - blood Schizophrenia - pathology Verbal Learning - physiology |
| Title | Association between cytokine levels, verbal memory and hippocampus volume in psychotic disorders and healthy controls |
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