Metabolite alterations in the hippocampus of high-functioning adult subjects with autism
The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PC...
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| Published in | The international journal of neuropsychopharmacology Vol. 13; no. 4; pp. 529 - 534 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.05.2010
Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1461-1457 1469-5111 1469-5111 |
| DOI | 10.1017/S1461145709990952 |
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| Abstract | The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male subjects with autism and 12 age- and sex-matched controls. Aggression was scored in the autistic subjects using the Buss–Perry Aggression Questionnaire. The concentrations of Cho and Cr+PCr in the hippocampal formation in autistic subjects were significantly higher than the corresponding values in control subjects, and a significant positive correlation was observed between the concentrations of these metabolites in the hippocampal formation and scores on the Buss–Perry Aggression Questionnaire in autistic subjects. Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression. |
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| AbstractList | The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male subjects with autism and 12 age- and sex-matched controls. Aggression was scored in the autistic subjects using the Buss–Perry Aggression Questionnaire. The concentrations of Cho and Cr+PCr in the hippocampal formation in autistic subjects were significantly higher than the corresponding values in control subjects, and a significant positive correlation was observed between the concentrations of these metabolites in the hippocampal formation and scores on the Buss–Perry Aggression Questionnaire in autistic subjects. Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression. Abstract The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male subjects with autism and 12 age- and sex-matched controls. Aggression was scored in the autistic subjects using the Buss-Perry Aggression Questionnaire. The concentrations of Cho and Cr+PCr in the hippocampal formation in autistic subjects were significantly higher than the corresponding values in control subjects, and a significant positive correlation was observed between the concentrations of these metabolites in the hippocampal formation and scores on the Buss-Perry Aggression Questionnaire in autistic subjects. Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression. [PUBLICATION ABSTRACT] The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male subjects with autism and 12 age- and sex-matched controls. Aggression was scored in the autistic subjects using the Buss-Perry Aggression Questionnaire. The concentrations of Cho and Cr+PCr in the hippocampal formation in autistic subjects were significantly higher than the corresponding values in control subjects, and a significant positive correlation was observed between the concentrations of these metabolites in the hippocampal formation and scores on the Buss-Perry Aggression Questionnaire in autistic subjects. Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression.The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male subjects with autism and 12 age- and sex-matched controls. Aggression was scored in the autistic subjects using the Buss-Perry Aggression Questionnaire. The concentrations of Cho and Cr+PCr in the hippocampal formation in autistic subjects were significantly higher than the corresponding values in control subjects, and a significant positive correlation was observed between the concentrations of these metabolites in the hippocampal formation and scores on the Buss-Perry Aggression Questionnaire in autistic subjects. Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression. |
| Author | Sugihara, Genichi Tsuchiya, Kenji J. Isoda, Haruo Mori, Norio Nishimura, Katsuhiko Sugiyama, Toshiro Tsujii, Masatsugu Takei, Nori Sakahara, Harumi Matsumoto, Kaori Nakamura, Kazuhiko Takebayashi, Kiyokazu Suzuki, Katsuaki |
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| Cites_doi | 10.1159/000017321 10.1176/appi.ajp.161.11.2038 10.1016/0024-3205(96)00182-8 10.1016/S0911-6044(00)00011-7 10.1523/JNEUROSCI.1297-04.2004 10.1523/JNEUROSCI.1285-06.2006 10.1016/j.ridd.2005.12.004 10.1037/0022-3514.63.3.452 10.1016/S0278-5846(99)00022-6 10.1016/S0278-5846(00)00150-0 10.1007/s002340050795 10.1093/brain/123.2.234 10.1016/0031-9384(90)90058-C 10.1016/j.jneumeth.2008.04.028 10.1176/appi.ajp.163.12.2189 10.1176/ajp.143.7.862 10.1016/j.ijdevneu.2004.09.006 10.1016/S0074-7742(08)60349-9 10.1007/BF02172145 10.1016/j.pscychresns.2006.05.010 10.1002/hbm.20077 10.1023/A:1005592401947 10.4992/jjpsy.70.384 10.1093/brain/121.5.889 |
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| SubjectTerms | Adolescent Adult Aggression - psychology Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Autistic Disorder - complications Autistic Disorder - diagnosis Autistic Disorder - metabolism Cerebellum - metabolism Choline - analogs & derivatives Choline - metabolism Creatine - metabolism Hippocampus - metabolism Humans Male Phosphocreatine - metabolism |
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| Title | Metabolite alterations in the hippocampus of high-functioning adult subjects with autism |
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