Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals, confirming an association at the CHRNA5 – CHRNA3 locus on 15q25 to smoking quantity. They use imputation based on 1,000 Genomes Project Pilot 1 data...

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Published inNature genetics Vol. 42; no. 5; pp. 436 - 440
Main Authors Liu, Jason Z, Tozzi, Federica, Waterworth, Dawn M, Pillai, Sreekumar G, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher W, Yuan, Xin, Waeber, Gérard, Vollenweider, Peter, Preisig, Martin, Wareham, Nicholas J, Zhao, Jing Hua, Loos, Ruth J F, Barroso, Inês, Khaw, Kay-Tee, Grundy, Scott, Barter, Philip, Mahley, Robert, Kesaniemi, Antero, McPherson, Ruth, Vincent, John B, Strauss, John, Kennedy, James L, Farmer, Anne, McGuffin, Peter, Day, Richard, Matthews, Keith, Bakke, Per, Gulsvik, Amund, Lucae, Susanne, Ising, Marcus, Brueckl, Tanja, Horstmann, Sonja, Wichmann, H-Erich, Dahmen, Norbert, Lamina, Claudia, Polasek, Ozren, Zgaga, Lina, Campbell, Susan, Kooner, Jaspal, Chambers, John C, Burnett, Mary Susan, Devaney, Joseph M, Pichard, Augusto D, Kent, Kenneth M, Satler, Lowell, Lindsay, Joseph M, Waksman, Ron, Epstein, Stephen, Wilson, James F, Wild, Sarah H, Campbell, Harry, Vitart, Veronique, Reilly, Muredach P, Li, Mingyao, Qu, Liming, Wilensky, Robert, Matthai, William, Hakonarson, Hakon H, Rader, Daniel J, Franke, Andre, Wittig, Michael, Schäfer, Arne, Uda, Manuela, Terracciano, Antonio, Busonero, Fabio, Scheet, Paul, Schlessinger, David, Clair, David St, Rujescu, Dan, Abecasis, Gonçalo R, Grabe, Hans Jörgen, Völzke, Henry, Petersmann, Astrid, John, Ulrich, Rudan, Igor, Hayward, Caroline, Wright, Alan F, Kolcic, Ivana, Wright, Benjamin J, Balmforth, Anthony J, Hall, Alistair S, Samani, Nilesh J, Anderson, Carl A, Ahmad, Tariq, Mathew, Christopher G, Parkes, Miles, Satsangi, Jack, Caulfield, Mark, Munroe, Patricia B, Farrall, Martin, Dominiczak, Anna, Worthington, Jane, Thomson, Wendy, Eyre, Steve, Barton, Anne, Mooser, Vincent, Francks, Clyde, Marchini, Jonathan
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.05.2010
Nature Publishing Group
Subjects
631/208/205/2138
631/208/729/743
692/699/476/5
Adult
Aged
Agriculture
Alleles
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Chromosome Mapping - methods
Chromosomes
Chromosomes, Human, Pair 15
Cohort Studies
Confidence intervals
Female
Fundamental and applied biological sciences. Psychology
Gene Function
Genetic aspects
Genetic Markers - genetics
Genetic susceptibility
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human
Human Genetics
Humans
letter
Male
Medical sciences
Meta-analysis
Middle Aged
Models, Genetic
Neurons - metabolism
Neurosciences
Nicotine
Polymorphism, Single Nucleotide
Receptors, Nicotinic - metabolism
Risk factors
Single nucleotide polymorphisms
Smoking
Software
Tobacco habit
Tobacco, tobacco smoking
Toxicology
United Kingdom
Association
Tobacco smoking
Metaanalysis
Online AccessGet full text
ISSN1061-4036
1546-1718
1546-1718
DOI10.1038/ng.572

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Abstract Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals, confirming an association at the CHRNA5 – CHRNA3 locus on 15q25 to smoking quantity. They use imputation based on 1,000 Genomes Project Pilot 1 data to refine the association at this locus. Smoking is a leading global cause of disease and mortality 1 . We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 ( P = 9.45 × 10 −19 ) that includes CHRNA5 , CHRNA3 and CHRNB4 , three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2 ) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5 . Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3 .
AbstractList Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 × 10^sup -19^) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3. [PUBLICATION ABSTRACT]
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals, confirming an association at the CHRNA5 – CHRNA3 locus on 15q25 to smoking quantity. They use imputation based on 1,000 Genomes Project Pilot 1 data to refine the association at this locus. Smoking is a leading global cause of disease and mortality 1 . We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 ( P = 9.45 × 10 −19 ) that includes CHRNA5 , CHRNA3 and CHRNB4 , three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2 ) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5 . Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3 .
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 10 super(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Smoking is a leading global cause of disease and mortality (1). We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x [10.sup.-19]) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Smoking is a leading global cause of disease and mortality 1 . We performed a genomewide meta-analytic association study of smoking-related behavioral traits in a total sample of 41,150 individuals drawn from 20 disease, population, and control cohorts. Our analysis confirmed an effect on smoking quantity (SQ) at a locus on 15q25 (P=9.45e-19) that includes three genes encoding neuronal nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3, CHRNB4). We used data from the 1000 Genomes project to investigate the region using imputation, which allowed analysis of virtually all common variants in the region and offered a five-fold increase in coverage over the HapMap. This increased the spectrum of potentially causal single nucleotide polymorphisms (SNPs), which included a novel SNP that showed the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Audience Academic
Author Lindsay, Joseph M
Kent, Kenneth M
Worthington, Jane
Barton, Anne
Thompson, John R
Epstein, Stephen
Middleton, Lefkos
Tozzi, Federica
Khaw, Kay-Tee
Farrall, Martin
Munroe, Patricia B
Farmer, Anne
Knouff, Christopher W
Zgaga, Lina
Anderson, Carl A
Rudan, Igor
Berrettini, Wade
Franke, Andre
Samani, Nilesh J
Satsangi, Jack
Terracciano, Antonio
Rader, Daniel J
Mathew, Christopher G
Dahmen, Norbert
Vollenweider, Peter
Kooner, Jaspal
Wittig, Michael
Schäfer, Arne
Parkes, Miles
Balmforth, Anthony J
Wilson, James F
Hayward, Caroline
Campbell, Harry
Eyre, Steve
Pichard, Augusto D
Devaney, Joseph M
Barroso, Inês
Waeber, Gérard
Loos, Ruth J F
Caulfield, Mark
Xiao, Xiangjun
Busonero, Fabio
Chambers, John C
Mooser, Vincent
Grabe, Hans Jörgen
Lucae, Susanne
Preisig, Martin
Muglia, Pierandrea
Ising, Marcus
Liu, Jason Z
Wichmann, H-Erich
Burnett, Mary Susan
Li, Mingyao
Rawal, Rajesh
Rujescu, Dan
Strauss, John
Waterworth, Dawn M
Wright, Alan F
Huffman, Jennifer
Satler, Lowell
Qu, Liming
Mahley, Robert
Polasek, Ozren
Wareham, Nicholas J
Barter, Philip
Bakke, Per
Horstm
AuthorAffiliation 19 Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
31 Centre for Population Health Sciences, University of Edinburgh, UK
17 Department of Internal Medicine, University of Oulu, Oulu, Finland
5 Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
23 Institute of Medicine, University of Bergen, Bergen, Norway
34 Division of Epidemiology, Imperial College London, UK
16 American Hospital, Istanbul, Turkey
55 Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
58 Gastroenterology Research Unit, Addenbrooke's Hospital, Cambridge, UK
6 Genetics Division, GlaxoSmithKline, Research Triangle Park, NC, USA
46 Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
13 Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA
21 Medical Research Council Social, Genetic and Developmental Ps
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  surname: Kent
  fullname: Kent, Kenneth M
  organization: Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center
– sequence: 50
  givenname: Lowell
  surname: Satler
  fullname: Satler, Lowell
  organization: Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center
– sequence: 51
  givenname: Joseph M
  surname: Lindsay
  fullname: Lindsay, Joseph M
  organization: Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center
– sequence: 52
  givenname: Ron
  surname: Waksman
  fullname: Waksman, Ron
  organization: Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center
– sequence: 53
  givenname: Stephen
  surname: Epstein
  fullname: Epstein, Stephen
  organization: Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center
– sequence: 54
  givenname: James F
  surname: Wilson
  fullname: Wilson, James F
  organization: Centre for Population Health Sciences, University of Edinburgh
– sequence: 55
  givenname: Sarah H
  surname: Wild
  fullname: Wild, Sarah H
  organization: Centre for Population Health Sciences, University of Edinburgh
– sequence: 56
  givenname: Harry
  surname: Campbell
  fullname: Campbell, Harry
  organization: Centre for Population Health Sciences, University of Edinburgh
– sequence: 57
  givenname: Veronique
  surname: Vitart
  fullname: Vitart, Veronique
  organization: Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit
– sequence: 58
  givenname: Muredach P
  surname: Reilly
  fullname: Reilly, Muredach P
  organization: The Cardiovascular Institute, University of Pennsylvania, The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania
– sequence: 59
  givenname: Mingyao
  surname: Li
  fullname: Li, Mingyao
  organization: Biostatistics and Epidemiology, University of Pennsylvania
– sequence: 60
  givenname: Liming
  surname: Qu
  fullname: Qu, Liming
  organization: Biostatistics and Epidemiology, University of Pennsylvania
– sequence: 61
  givenname: Robert
  surname: Wilensky
  fullname: Wilensky, Robert
  organization: The Cardiovascular Institute, University of Pennsylvania
– sequence: 62
  givenname: William
  surname: Matthai
  fullname: Matthai, William
  organization: The Cardiovascular Institute, University of Pennsylvania
– sequence: 63
  givenname: Hakon H
  surname: Hakonarson
  fullname: Hakonarson, Hakon H
  organization: The Center for Applied Genomics, Children's Hospital of Philadelphia
– sequence: 64
  givenname: Daniel J
  surname: Rader
  fullname: Rader, Daniel J
  organization: The Cardiovascular Institute, University of Pennsylvania, The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania
– sequence: 65
  givenname: Andre
  surname: Franke
  fullname: Franke, Andre
  organization: Institute of Clinical Molecular Biology, Christian-Albrechts-University
– sequence: 66
  givenname: Michael
  surname: Wittig
  fullname: Wittig, Michael
  organization: Institute of Clinical Molecular Biology, Christian-Albrechts-University
– sequence: 67
  givenname: Arne
  surname: Schäfer
  fullname: Schäfer, Arne
  organization: Institute of Clinical Molecular Biology, Christian-Albrechts-University
– sequence: 68
  givenname: Manuela
  surname: Uda
  fullname: Uda, Manuela
  organization: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche
– sequence: 69
  givenname: Antonio
  surname: Terracciano
  fullname: Terracciano, Antonio
  organization: National Institute on Aging
– sequence: 71
  givenname: Fabio
  surname: Busonero
  fullname: Busonero, Fabio
  organization: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche
– sequence: 72
  givenname: Paul
  surname: Scheet
  fullname: Scheet, Paul
  organization: Department of Epidemiology, University of Texas M.D. Anderson Cancer Center
– sequence: 73
  givenname: David
  surname: Schlessinger
  fullname: Schlessinger, David
  organization: National Institute on Aging
– sequence: 74
  givenname: David St
  surname: Clair
  fullname: Clair, David St
  organization: Department of Mental Health, University of Aberdeen
– sequence: 75
  givenname: Dan
  surname: Rujescu
  fullname: Rujescu, Dan
  organization: Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians-University
– sequence: 76
  givenname: Gonçalo R
  surname: Abecasis
  fullname: Abecasis, Gonçalo R
  organization: Department of Biostatistics, Center for Statistical Genetics, University of Michigan
– sequence: 77
  givenname: Hans Jörgen
  surname: Grabe
  fullname: Grabe, Hans Jörgen
  organization: Department of Psychiatry and Psychotherapy, University of Greifswald
– sequence: 79
  givenname: Henry
  surname: Völzke
  fullname: Völzke, Henry
  organization: Institute for Community Medicine, University of Greifswald
– sequence: 80
  givenname: Astrid
  surname: Petersmann
  fullname: Petersmann, Astrid
  organization: Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald
– sequence: 81
  givenname: Ulrich
  surname: John
  fullname: John, Ulrich
  organization: Department of Social Medicine and Epidemiology, University of Greifswald
– sequence: 82
  givenname: Igor
  surname: Rudan
  fullname: Rudan, Igor
  organization: Centre for Population Health Sciences, University of Edinburgh, Croatian Centre for Global Health, University of Split
– sequence: 83
  givenname: Caroline
  surname: Hayward
  fullname: Hayward, Caroline
  organization: Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit
– sequence: 84
  givenname: Alan F
  surname: Wright
  fullname: Wright, Alan F
  organization: Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit
– sequence: 85
  givenname: Ivana
  surname: Kolcic
  fullname: Kolcic, Ivana
  organization: School of Public Health, School of Medicine, University of Zagreb
– sequence: 86
  givenname: Benjamin J
  surname: Wright
  fullname: Wright, Benjamin J
  organization: Department of Health Sciences, University of Leicester
– sequence: 88
  givenname: Anthony J
  surname: Balmforth
  fullname: Balmforth, Anthony J
  organization: Mulitdisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds
– sequence: 89
  givenname: Alistair S
  surname: Hall
  fullname: Hall, Alistair S
  organization: Mulitdisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds
– sequence: 90
  givenname: Nilesh J
  surname: Samani
  fullname: Samani, Nilesh J
  organization: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital
– sequence: 91
  givenname: Carl A
  surname: Anderson
  fullname: Anderson, Carl A
  organization: Wellcome Trust Sanger Institute
– sequence: 92
  givenname: Tariq
  surname: Ahmad
  fullname: Ahmad, Tariq
  organization: Peninsula College of Medicine and Dentistry
– sequence: 93
  givenname: Christopher G
  surname: Mathew
  fullname: Mathew, Christopher G
  organization: Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital
– sequence: 94
  givenname: Miles
  surname: Parkes
  fullname: Parkes, Miles
  organization: Gastroenterology Research Unit, Addenbrooke's Hospital
– sequence: 95
  givenname: Jack
  surname: Satsangi
  fullname: Satsangi, Jack
  organization: Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital
– sequence: 96
  givenname: Mark
  surname: Caulfield
  fullname: Caulfield, Mark
  organization: Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London
– sequence: 97
  givenname: Patricia B
  surname: Munroe
  fullname: Munroe, Patricia B
  organization: Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London
– sequence: 98
  givenname: Martin
  surname: Farrall
  fullname: Farrall, Martin
  organization: Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics
– sequence: 99
  givenname: Anna
  surname: Dominiczak
  fullname: Dominiczak, Anna
  organization: Division of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Western Infirmary, Glasgow, UK
– sequence: 100
  givenname: Jane
  surname: Worthington
  fullname: Worthington, Jane
  organization: arc Epidemiology Research Unit, School of Translational Medicine, Faculty of Medical and Human Sciences, University of Manchester
– sequence: 101
  givenname: Wendy
  surname: Thomson
  fullname: Thomson, Wendy
  organization: arc Epidemiology Research Unit, School of Translational Medicine, Faculty of Medical and Human Sciences, University of Manchester
– sequence: 102
  givenname: Steve
  surname: Eyre
  fullname: Eyre, Steve
  organization: arc Epidemiology Research Unit, School of Translational Medicine, Faculty of Medical and Human Sciences, University of Manchester
– sequence: 103
  givenname: Anne
  surname: Barton
  fullname: Barton, Anne
  organization: arc Epidemiology Research Unit, School of Translational Medicine, Faculty of Medical and Human Sciences, University of Manchester
– sequence: 105
  givenname: Vincent
  surname: Mooser
  fullname: Mooser, Vincent
  organization: Genetics Division, GlaxoSmithKline
– sequence: 106
  givenname: Clyde
  surname: Francks
  fullname: Francks, Clyde
  email: clyde.francks@well.ox.ac.uk
  organization: Genetics Division, GlaxoSmithKline, Wellcome Trust Centre for Human Genetics, University of Oxford
– sequence: 107
  givenname: Jonathan
  surname: Marchini
  fullname: Marchini, Jonathan
  email: marchini@stats.ox.ac.uk
  organization: Department of Statistics, University of Oxford
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23092431$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/20418889$$D View this record in MEDLINE/PubMed
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CODEN NGENEC
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T Thorgeirsson (BFng572_CR15) 2010; 42
HE Wichmann (BFng572_CR29) 2005; 67
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LJ Bierut (BFng572_CR6) 2007; 16
CI Amos (BFng572_CR10) 2008; 40
JC Wang (BFng572_CR18) 2009; 18
20428092 - Nat Genet. 2010 May;42(5):366-8. doi: 10.1038/ng0510-366.
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Snippet Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals,...
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of...
Smoking is a leading global cause of disease and mortality (1). We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis...
Smoking is a leading global cause of disease and mortality 1 . We performed a genomewide meta-analytic association study of smoking-related behavioral traits...
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Title Meta-analysis and imputation refines the association of 15q25 with smoking quantity
URI https://link.springer.com/article/10.1038/ng.572
https://www.ncbi.nlm.nih.gov/pubmed/20418889
https://www.proquest.com/docview/222682801
https://www.proquest.com/docview/733087244
https://www.proquest.com/docview/746234209
https://pubmed.ncbi.nlm.nih.gov/PMC3612983
Volume 42
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