Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice - Mizushige, Takafumi; Uchida, Tomoki; Ohinata, Kousaku (Scientific reports, 2020)
Keywords: 13/51; 38/35; 38/77; 631/378/1831; 631/45/611; 64/60; Amino acids; Animals; Antidepressants; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; c-Fos protein; Casein; Cell proliferation; Cow's milk; Dentate gyrus; Depression - drug therapy; Dipeptides - pharmacology; Dipeptides - therapeutic use; Doublecortin protein; Drug Discovery; Gene expression; Hippocampus; Humanities and Social Sciences; Hypothalamic-pituitary-adrenal axis; Hypothalamo-Hypophyseal System - drug effects; Leucine; Male; Mental depression; Mice; mRNA; multidisciplinary; Neural stem cells; Neurogenesis; Oligopeptides - therapeutic use; Oral administration; Peptides; Pituitary; Progenitor cells; Science; Science (multidisciplinary); Stress response