Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma - Jacquelot, Nicolas; Seillet, Cyril; Wang, Minyu; Pizzolla, Angela; Liao, Yang; Hediyeh-zadeh, Soroor; Grisaru-Tal, Sharon; Louis, Cynthia; Huang, Qiutong; Schreuder, Jaring; Souza-Fonseca-Guimaraes, Fernando; de Graaf, Carolyn A.; et al. (Nature immunology, 2021)
Keywords: 631/250/2504/2506; 631/67/580/1884; Animals; Antibodies - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Antitumor activity; Apoptosis; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell activation; Cell death; Cell Line, Tumor; Cell receptors; Chemotaxis, Leukocyte - drug effects; Colonies; Colony-stimulating factor; Cytokines; Cytotoxicity, Immunologic - drug effects; Development and progression; Eosinophils - drug effects; Eosinophils - immunology; Eosinophils - metabolism; Female; Genetic aspects; Granulocyte-macrophage colony-stimulating factor; Granulocyte-Macrophage Colony-Stimulating Factor - genetics; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Granulocytes; Health aspects; Homeostasis; Humans; Immune Checkpoint Inhibitors - pharmacology; Immune response; Immunity; Immunology; Immunotherapy; Infectious Diseases; Inflammation; Interleukin-33 - pharmacology; Leukocytes (eosinophilic); Life Sciences; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - immunology; Lymphocytes - metabolism; Lymphoid cells; Male; Melanoma; Melanoma, Experimental - drug therapy; Melanoma, Experimental - genetics; Melanoma, Experimental - immunology; Melanoma, Experimental - metabolism; Metastases; Mice; Mice, Inbred C57BL; Mice, Knockout; PD-1 protein; Phenotype; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - metabolism; Skin Neoplasms - drug therapy; Skin Neoplasms - genetics; Skin Neoplasms - immunology; Skin Neoplasms - metabolism; Tumor microenvironment; Australia