Optical Treatment of Strabismic and Combined Strabismic–Anisometropic Amblyopia

• Published in: Ophthalmology (Rochester, Minn.) Vol. 119; no. 1; pp. 150 - 158
• Main Authors: Cotter, Susan A., Foster, Nicole C., Holmes, Jonathan M., Melia, B. Michele, Wallace, David K., Repka, Michael X., Tamkins, Susanna M., Kraker, Raymond T., Beck, Roy W., Hoover, Darren L., Crouch, Eric R., Miller, Aaron M., Morse, Christie L., Suh, Donny W.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.2012; Elsevier
• Subjects: Amblyopia - complications; Amblyopia - physiopathology; Amblyopia - therapy; Anisometropia - complications; Anisometropia - physiopathology; Anisometropia - therapy; Biological and medical sciences; Child; Child, Preschool; Cohort Studies; Depth Perception - physiology; Eyeglasses; Female; Humans; Male; Medical sciences; Miscellaneous; Ophthalmology; Prognosis; Prospective Studies; Strabismus - complications; Strabismus - physiopathology; Strabismus - therapy; Vision disorders; Visual Acuity - physiology; Anisometropía; Eye disease; Treatment; Vision disorder; Refractive error; Amblyopia; Ophthalmology
• ISSN: 0161-6420; 1549-4713; 1549-4713
• DOI: 10.1016/j.ophtha.2011.06.043

To determine visual acuity improvement in children with strabismic and combined strabismic–anisometropic (combined-mechanism) amblyopia treated with optical correction alone and to explore factors associated with improvement. Prospective, multicenter, cohort study. We included 146 children 3 to <7 years old with previously untreated strabismic amblyopia (n = 52) or combined-mechanism amblyopia (n = 94). Optical treatment was provided as spectacles (prescription based on a cycloplegic refraction) that were worn for the first time at the baseline visit. Visual acuity with spectacles was measured using the Amblyopia Treatment Study HOTV visual acuity protocol at baseline and every 9 weeks thereafter until no further improvement in visual acuity. Ocular alignment was assessed at each visit. Visual acuity 18 weeks after baseline. Overall, amblyopic eye visual acuity improved a mean of 2.6 lines (95% confidence interval [CI], 2.3–3.0), with 75% of children improving ≥2 lines and 54% improving ≥3 lines. Resolution of amblyopia occurred in 32% (95% CI, 24%–41%) of the children. The treatment effect was greater for strabismic amblyopia than for combined-mechanism amblyopia (3.2 vs 2.3 lines; adjusted P = 0.003). Visual acuity improved regardless of whether eye alignment improved. Optical treatment alone of strabismic and combined-mechanism amblyopia results in clinically meaningful improvement in amblyopic eye visual acuity for most 3- to <7-year-old children, resolving in at least one quarter without the need for additional treatment. Consideration should be given to prescribing refractive correction as the sole initial treatment for children with strabismic or combined-mechanism amblyopia before initiating other therapies. The authors have no proprietary or commercial interest in any of the materials discussed in this article.