GnRH类似物联合化疗对绝经前女性卵巢功能保护的Meta分析
目的：探讨在化疗过程中促性腺激素释放激素（Gn RH）类似物对绝经前女性卵巢功能的保护。方法：计算机检索Pub Med、EMbase、Cochrane Library、中国知识资源总库（CNKI系列数据库）、中国生物医学文献数据库（CBM）、维普数据库、万方数据库,检索时间2000年1月—2017年7月。全面收集Gn RH类似物联合化疗对绝经前女性卵巢功能影响的临床试验,采用Cochrane系统评价的方法,提取数据,评价研究质量,并采用Rev Man 5.3软件进行合并分析。结果：共纳入13项随机对照试验（RCT）研究,包括1 539例患者。Gn RH类似物联合化疗可明显保护绝经前女性卵巢功能...
Saved in:
| Published in | 国际妇产科学杂志 Vol. 45; no. 1; pp. 94 - 100 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
400016,重庆医科大学第一附属医院
2018
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-1870 |
| DOI | 10.3969/j.issn.1674-1870.2018.01.020 |
Cover
| Abstract | 目的：探讨在化疗过程中促性腺激素释放激素（Gn RH）类似物对绝经前女性卵巢功能的保护。方法：计算机检索Pub Med、EMbase、Cochrane Library、中国知识资源总库（CNKI系列数据库）、中国生物医学文献数据库（CBM）、维普数据库、万方数据库,检索时间2000年1月—2017年7月。全面收集Gn RH类似物联合化疗对绝经前女性卵巢功能影响的临床试验,采用Cochrane系统评价的方法,提取数据,评价研究质量,并采用Rev Man 5.3软件进行合并分析。结果：共纳入13项随机对照试验（RCT）研究,包括1 539例患者。Gn RH类似物联合化疗可明显保护绝经前女性卵巢功能（OR=2.42,95%CI：1.48-3.95,P=0.000 4）。其中7篇文献报道了妊娠率,结果显示Gn RH类似物联合化疗可增加妊娠率（OR=1.69,95%CI：1.06-2.69,P=0.03）。结论：Gn RH类似物联合化疗能够保护绝经前女性卵巢功能,提高妊娠率。 |
|---|---|
| AbstractList | 目的：探讨在化疗过程中促性腺激素释放激素（Gn RH）类似物对绝经前女性卵巢功能的保护。方法：计算机检索Pub Med、EMbase、Cochrane Library、中国知识资源总库（CNKI系列数据库）、中国生物医学文献数据库（CBM）、维普数据库、万方数据库,检索时间2000年1月—2017年7月。全面收集Gn RH类似物联合化疗对绝经前女性卵巢功能影响的临床试验,采用Cochrane系统评价的方法,提取数据,评价研究质量,并采用Rev Man 5.3软件进行合并分析。结果：共纳入13项随机对照试验（RCT）研究,包括1 539例患者。Gn RH类似物联合化疗可明显保护绝经前女性卵巢功能（OR=2.42,95%CI：1.48-3.95,P=0.000 4）。其中7篇文献报道了妊娠率,结果显示Gn RH类似物联合化疗可增加妊娠率（OR=1.69,95%CI：1.06-2.69,P=0.03）。结论：Gn RH类似物联合化疗能够保护绝经前女性卵巢功能,提高妊娠率。 目的:探讨在化疗过程中促性腺激素释放激素(GnRH)类似物对绝经前女性卵巢功能的保护.方法:计算机检索PubMed、EMbase、Cochrane Library、中国知识资源总库(CNKI系列数据库)、中国生物医学文献数据库(CBM)、维普数据库、万方数据库,检索时间2000年1月—2017年7月.全面收集GnRH类似物联合化疗对绝经前女性卵巢功能影响的临床试验,采用Cochrane系统评价的方法,提取数据,评价研究质量,并采用RevMan 5.3软件进行合并分析.结果:共纳入13项随机对照试验(RCT)研究,包括1539例患者.GnRH类似物联合化疗可明显保护绝经前女性卵巢功能(OR=2.42,95%CI:1.48~3.95,P=0.0004).其中7篇文献报道了妊娠率,结果显示GnRH类似物联合化疗可增加妊娠率(OR=1.69,95%CI:1.06~2.69,P=0.03).结论:GnRH类似物联合化疗能够保护绝经前女性卵巢功能,提高妊娠率. |
| Abstract_FL | Objective:To estimate whether gonadotropin-releasing hormone (GnRH) analog administration during chemotherapy can protect premenopausal women against the ovarian toxicity. Methods:We searched the electronic bibliographic databases,including the Cochrane Library,PubMed,EMbase,CBM,CNKI,VIP database and Wanfang database to assemble relevant clinical trials.The search covered January 2000 to July 2017 and clinical studies related to GnRH analog co-treatment with chemotherapy to ovarian function in premenopausal women. Data were extracted and evaluated using the methods recommended by Cochrane handbook.The RevMan 5.3 software was used for Meta-analysis. Results:Thirteen RCTs involving 1 539 patients were included.GnRH analog co-treatment significantly increase ovarian function resumption (OR=2.42,95%CI:1.48~3.95,P=0.000 4).Seven trials mentioned pregnancy rates.The occurrence of spontaneous pregnancy showed statistically significant difference between GnRH analog co-treatment and the control groups (OR=1.69,95%CI:1.06~2.69,P=0.03). Conclusions:Evidence from RCTs suggests a potential benefit of GnRH analog co-treatment with chemotherapy in premenopausal women,with higher rates of resumption of ovarian function and improvement in pregnancy. |
| Author | 王倩;郎琳;贾英 |
| AuthorAffiliation | 重庆医科大学第一附属医院,400016 |
| AuthorAffiliation_xml | – name: 400016,重庆医科大学第一附属医院 |
| Author_FL | JIA Ying WANG Qian LANG Lin |
| Author_FL_xml | – sequence: 1 fullname: WANG Qian – sequence: 2 fullname: LANG Lin – sequence: 3 fullname: JIA Ying |
| Author_xml | – sequence: 1 fullname: 王倩;郎琳;贾英 |
| BookMark | eNo9kFFLAkEUhefBIDP_RPQUuM3Ozu7MPIaUFkYQvi_j7qyt1Vhuob4VRagk-RAGgQVRRE8REREa_RnH9We0YvR0uYdz7uU7cyAmy1IAsKhDzWAWWy5pfhBITbcITumUQA1BnWpQ1yCCMRD_12dBMgj8AozkKIdxHGxk5HY2fOsPB4Ow-TI-vVadhrrsht0b9foV9nth_0o12-rpfXTyrNof6vNBte7HZ9_Dn96o9Rjenm-KI64aF6O7zjyY8fheIJJ_MwHya6v5dDaV28qsp1dyKcdCMIU5Qq4gkFAkDMyYYJaHXK5Hu4UFRY4BEaYmIS5zKYOOSwueYCblpkdMTxAjAZamZ6tcelwW7VL5uCKjh3axWq_ZnrNbm9BDfQKZAAtTs7NTlsVDP7IfVPx9XqnbUScmwgxi4xfr63ZX |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1674-1870.2018.01.020 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitle_FL | Adjuvant Gonadotropin-Releasing Hormone Analog for the Prevention of Chemotherapy to Preserve Ovarian Function in Premenopausal Women:A Meta-Analysis |
| EndPage | 100 |
| ExternalDocumentID | gwyx_fckx201801020 674524904 |
| GroupedDBID | 2RA 92L ALMA_UNASSIGNED_HOLDINGS CDYEO CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| ID | FETCH-LOGICAL-c620-4a22de70782e3499e96f2da178264e82c30248577d9d890cd8bfe958a5f75fe73 |
| ISSN | 1674-1870 |
| IngestDate | Thu May 29 04:07:05 EDT 2025 Wed Feb 14 10:01:31 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | premature 抗肿瘤联合化疗方案 Ovarian failure 肿瘤 促性腺素释放激素类似物 Antineoplastic combined chemotherapy protocols Gonadotropin-releasing hormone analog 卵巢功能早衰 Neoplasms |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c620-4a22de70782e3499e96f2da178264e82c30248577d9d890cd8bfe958a5f75fe73 |
| Notes | 12-1399/R |
| PageCount | 7 |
| ParticipantIDs | wanfang_journals_gwyx_fckx201801020 chongqing_primary_674524904 |
| PublicationCentury | 2000 |
| PublicationDate | 2018 |
| PublicationDateYYYYMMDD | 2018-01-01 |
| PublicationDate_xml | – year: 2018 text: 2018 |
| PublicationDecade | 2010 |
| PublicationTitle | 国际妇产科学杂志 |
| PublicationTitleAlternate | Foreign Medical Sciences（Obstet Gynecol Fascicle） |
| PublicationTitle_FL | Journal Of International Obstetrics And Gynecology |
| PublicationYear | 2018 |
| Publisher | 400016,重庆医科大学第一附属医院 |
| Publisher_xml | – name: 400016,重庆医科大学第一附属医院 |
| SSID | ssib002039644 ssib008858041 ssib005319428 ssib051371002 ssib025873268 ssib008679380 ssib002039729 ssib010102505 ssib017477451 ssib036437542 |
| Score | 2.127421 |
| Snippet | 目的：探讨在化疗过程中促性腺激素释放激素（Gn RH）类似物对绝经前女性卵巢功能的保护。方法：计算机检索Pub Med、EMbase、Cochrane Library、中国知识资源总库（CNKI系列数... 目的:探讨在化疗过程中促性腺激素释放激素(GnRH)类似物对绝经前女性卵巢功能的保护.方法:计算机检索PubMed、EMbase、Cochrane Library、中国知识资源总库(CNKI系列数据库)、中... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 94 |
| SubjectTerms | 促性腺素释放激素类似物 卵巢功能早衰 抗肿瘤联合化疗方案 肿瘤 |
| Title | GnRH类似物联合化疗对绝经前女性卵巢功能保护的Meta分析 |
| URI | http://lib.cqvip.com/qk/94965A/201801/674524904.html https://d.wanfangdata.com.cn/periodical/gwyx-fckx201801020 |
| Volume | 45 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate issn: 1674-1870 databaseCode: ABDBF dateStart: 20131201 customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn isFulltext: true dateEnd: 99991231 titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn omitProxy: true ssIdentifier: ssib025873268 providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1NaxUxMJQWxIsoKtaqFGyOW3c3m93kuOnbZynUg1To7bEf2RaEVz9arD0pirTFYg9SQaiCKOJJRESkFf-Jp25ff4Yz2X37XlGKCktIJtnJJJOdzGSTCSFjeeLGCYtdK3fAREGVwUp8llqu5jzPPKkdjQeFp6_5kze8qVk-OzDws2_X0tJiMp6u_PFcyf9wFWDAVzwl-w-crZECAOLAXwiBwxD-FY-vtq9P0iigyqFK0cijagIfgAhJQ0kjAYoilR6NOJU2FQIjYoJKH8tAKAOEhE2qpMGjqGxUEdE0hSUVDVOGU8Vo5OPOiNC8BXDFMaICGroGElLZNJUyqhqGnqZB6GNW6JlKQyq8aQ06K74ARX3MlhEtr_Ps6smGYmWwSCqBCFNTCIgCgzc0RAQYSsdkNTAXUTWoMNRg3fUka_okokKZam3sHKYQN5AKcCTMxgYiUFAFNUSmIUCC078wckiK-4FnOaK8kaQr5kuvlYeGcymzy0uWq9nfMX5Tf5tYmPSlmVgQ_3iNH7cGitLtq92bUOttjlCMg3mL7mqHXFwvGiRDoWqoZk9BsgFzv4IF6f7_qCgh-w1EdI_I-iSuEBwdSHXTDnoI5D0JDuYmqPe9_74uFwHo6zU-hr9tu1cgQ5o7DL09mS0C3TYeI2NVB1w5qvnom2R-oT13GzQucwCuncftuT5dbeYkOVEZWaNh-cWcIgMr86fJFH4tnU87e7u7nbUPBw-fF5urxdOtztaL4uO3zs52Z-dZsbZRvPu8_-B9sfGl-PqmWH998Oj73o_t_fW3nZePcdQWq0_2X22eITPNaGZi0qpuErFS37UtL3bdTBvfkJqBia-ln7tZDNIJzAEt3JQZz35BkMlMSDvNRJJryUXM84DnOmBnyWB7oa3PkdHUznQexww3kXhO7sVcZ0nKtOPGXp6JYJiM1N3QulU6jGnV42CYXK46plWJkbutuXv3l1t5enMZOxP5Z58_EscIOY4ly2XAC2Rw8c6SvgiK8WJyqRpdvwBNAZC- |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=GnRH%E7%B1%BB%E4%BC%BC%E7%89%A9%E8%81%94%E5%90%88%E5%8C%96%E7%96%97%E5%AF%B9%E7%BB%9D%E7%BB%8F%E5%89%8D%E5%A5%B3%E6%80%A7%E5%8D%B5%E5%B7%A2%E5%8A%9F%E8%83%BD%E4%BF%9D%E6%8A%A4%E7%9A%84Meta%E5%88%86%E6%9E%90&rft.jtitle=%E5%9B%BD%E9%99%85%E5%A6%87%E4%BA%A7%E7%A7%91%E5%AD%A6%E6%9D%82%E5%BF%97&rft.au=%E7%8E%8B%E5%80%A9%3B%E9%83%8E%E7%90%B3%3B%E8%B4%BE%E8%8B%B1&rft.date=2018&rft.issn=1674-1870&rft.volume=45&rft.issue=1&rft.spage=94&rft.epage=100&rft_id=info:doi/10.3969%2Fj.issn.1674-1870.2018.01.020&rft.externalDocID=674524904 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F94965A%2F94965A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fgwyx-fckx%2Fgwyx-fckx.jpg |