Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis

Microglia are the resident mononuclear phagocytes of the central nervous system and have been implicated in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). During neurodegeneration, microglial activation is accompanied by infiltration of circulating monocy...

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Published inActa neuropathologica Vol. 131; no. 3; pp. 465 - 480
Main Authors El Oussini, Hajer, Bayer, Hanna, Scekic-Zahirovic, Jelena, Vercruysse, Pauline, Sinniger, Jérôme, Dirrig-Grosch, Sylvie, Dieterlé, Stéphane, Echaniz-Laguna, Andoni, Larmet, Yves, Müller, Kathrin, Weishaupt, Jochen H., Thal, Dietmar R., van Rheenen, Wouter, van Eijk, Kristel, Lawson, Roland, Monassier, Laurent, Maroteaux, Luc, Roumier, Anne, Wong, Philip C., van den Berg, Leonard H., Ludolph, Albert C., Veldink, Jan H., Witting, Anke, Dupuis, Luc
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2016
Springer
Springer Nature B.V
Springer Verlag
Subjects
Ablation
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - pathology
Animal genetics
Animals
Biochemistry, Molecular Biology
Cardiology and cardiovascular system
Development and progression
Disease
Disease Models, Animal
Disease Progression
Female
Genetic engineering
Genetic polymorphisms
Genetics
Human health and pathology
Humans
Life Sciences
Male
Medicine
Medicine & Public Health
Mice
Mice, Transgenic
Microglia - pathology
Molecular biology
Mononuclear Phagocyte System - metabolism
Mononuclear Phagocyte System - pathology
Motor Neurons - pathology
Nervous system diseases
Neurobiology
Neurodegeneration
Neurology
Neurons
Neurons and Cognition
Neuropathology
Neurosciences
Original Paper
Pathology
Pharmaceutical sciences
Pharmacology
Phenols (Class of compounds)
Psychiatrics and mental health
Pulmonology and respiratory tract
Real-Time Polymerase Chain Reaction
Receptor, Serotonin, 5-HT2B - metabolism
Serotonin
Spinal cord
Spinal Cord - pathology
France
Germany
Amyotrophic lateral sclerosis
Motor neuron
Serotonin
Microglia
SOD1
Online AccessGet full text
ISSN0001-6322
1432-0533
DOI10.1007/s00401-016-1534-4

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Abstract Microglia are the resident mononuclear phagocytes of the central nervous system and have been implicated in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). During neurodegeneration, microglial activation is accompanied by infiltration of circulating monocytes, leading to production of multiple inflammatory mediators in the spinal cord. Degenerative alterations in mononuclear phagocytes are commonly observed during neurodegenerative diseases, yet little is known concerning the mechanisms leading to their degeneration, or the consequences on disease progression. Here we observed that the serotonin 2B receptor (5-HT 2B ), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of ALS. In mutant SOD1 mice, this upregulation was restricted to cells positive for CD11b, a marker of mononuclear phagocytes. Ablation of 5-HT 2B receptor in transgenic ALS mice expressing mutant SOD1 resulted in increased degeneration of mononuclear phagocytes, as evidenced by fragmentation of Iba1-positive cellular processes. This was accompanied by decreased expression of key neuroinflammatory genes but also loss of expression of homeostatic microglial genes. Importantly, the dramatic effect of 5-HT 2B receptor ablation on mononuclear phagocytes was associated with acceleration of disease progression. To determine the translational relevance of these results, we studied polymorphisms in the human HTR2B gene, which encodes the 5-HT 2B receptor, in a large cohort of ALS patients. In this cohort, the C allele of SNP rs10199752 in HTR2B was associated with longer survival. Moreover, patients carrying one copy of the C allele of SNP rs10199752 showed increased 5-HT 2B mRNA in spinal cord and displayed less pronounced degeneration of Iba1 positive cells than patients carrying two copies of the more common A allele. Thus, the 5-HT 2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in ALS. Targeting this receptor might be therapeutically useful.
AbstractList Microglia are the resident mononuclear phagocytes of the central nervous system and have been implicated in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). During neurodegeneration, microglial activation is accompanied by infiltration of circulating monocytes, leading to production of multiple inflammatory mediators in the spinal cord. Degenerative alterations in mononuclear phagocytes are commonly observed during neurodegenerative diseases, yet little is known concerning the mechanisms leading to their degeneration, or the consequences on disease progression. Here we observed that the serotonin 2B receptor (5-HT2B), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of ALS. In mutant SOD1 mice, this upregulation was restricted to cells positive for CD11b, a marker of mononuclear phagocytes. Ablation of 5-HT2B receptor in transgenic ALS mice expressing mutant SOD1 resulted in increased degeneration of mononuclear phagocytes, as evidenced by fragmentation of Iba1-positive cellular processes. This was accompanied by decreased expression of key neuroinflammatory genes but also loss of expression of homeostatic microglial genes. Importantly, the dramatic effect of 5-HT2B receptor ablation on mononuclear phagocytes was associated with acceleration of disease progression. To determine the translational relevance of these results, we studied polymorphisms in the human HTR2B gene, which encodes the 5-HT2B receptor, in a large cohort of ALS patients. In this cohort, the C allele of SNP rs10199752 in HTR2B was associated with longer survival. Moreover, patients carrying one copy of the C allele of SNP rs10199752 showed increased 5-HT2B mRNA in spinal cord and displayed less pronounced degeneration of Iba1 positive cells than patients carrying two copies of the more common A allele. Thus, the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in ALS. Targeting this receptor might be therapeutically useful.
Microglia are the resident mononuclear phagocytes of the central nervous system and have been implicated in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). During neurodegeneration, microglial activation is accompanied by infiltration of circulating monocytes, leading to production of multiple inflammatory mediators in the spinal cord. Degenerative alterations in mononuclear phagocytes are commonly observed during neurodegenerative diseases, yet little is known concerning the mechanisms leading to their degeneration, or the consequences on disease progression. Here we observed that the serotonin 2B receptor (5-HT^sub 2B^), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of ALS. In mutant SOD1 mice, this upregulation was restricted to cells positive for CD11b, a marker of mononuclear phagocytes. Ablation of 5-HT^sub 2B^ receptor in transgenic ALS mice expressing mutant SOD1 resulted in increased degeneration of mononuclear phagocytes, as evidenced by fragmentation of Iba1-positive cellular processes. This was accompanied by decreased expression of key neuroinflammatory genes but also loss of expression of homeostatic microglial genes. Importantly, the dramatic effect of 5-HT^sub 2B^ receptor ablation on mononuclear phagocytes was associated with acceleration of disease progression. To determine the translational relevance of these results, we studied polymorphisms in the human HTR2B gene, which encodes the 5-HT^sub 2B^ receptor, in a large cohort of ALS patients. In this cohort, the C allele of SNP rs10199752 in HTR2B was associated with longer survival. Moreover, patients carrying one copy of the C allele of SNP rs10199752 showed increased 5-HT^sub 2B^ mRNA in spinal cord and displayed less pronounced degeneration of Iba1 positive cells than patients carrying two copies of the more common A allele. Thus, the 5-HT^sub 2B^ receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in ALS. Targeting this receptor might be therapeutically useful.
Microglia are the resident mononuclear phagocytes of the central nervous system and have been implicated in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). During neurodegeneration, microglial activation is accompanied by infiltration of circulating monocytes, leading to production of multiple inflammatory mediators in the spinal cord. Degenerative alterations in mononuclear phagocytes are commonly observed during neurodegenerative diseases, yet little is known concerning the mechanisms leading to their degeneration, or the consequences on disease progression. Here we observed that the serotonin 2B receptor (5-HT 2B ), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of ALS. In mutant SOD1 mice, this upregulation was restricted to cells positive for CD11b, a marker of mononuclear phagocytes. Ablation of 5-HT 2B receptor in transgenic ALS mice expressing mutant SOD1 resulted in increased degeneration of mononuclear phagocytes, as evidenced by fragmentation of Iba1-positive cellular processes. This was accompanied by decreased expression of key neuroinflammatory genes but also loss of expression of homeostatic microglial genes. Importantly, the dramatic effect of 5-HT 2B receptor ablation on mononuclear phagocytes was associated with acceleration of disease progression. To determine the translational relevance of these results, we studied polymorphisms in the human HTR2B gene, which encodes the 5-HT 2B receptor, in a large cohort of ALS patients. In this cohort, the C allele of SNP rs10199752 in HTR2B was associated with longer survival. Moreover, patients carrying one copy of the C allele of SNP rs10199752 showed increased 5-HT 2B mRNA in spinal cord and displayed less pronounced degeneration of Iba1 positive cells than patients carrying two copies of the more common A allele. Thus, the 5-HT 2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in ALS. Targeting this receptor might be therapeutically useful.
Audience Academic
Author van Rheenen, Wouter
Veldink, Jan H.
Ludolph, Albert C.
Dieterlé, Stéphane
Lawson, Roland
Dirrig-Grosch, Sylvie
Weishaupt, Jochen H.
Sinniger, Jérôme
Bayer, Hanna
Scekic-Zahirovic, Jelena
Echaniz-Laguna, Andoni
Thal, Dietmar R.
van Eijk, Kristel
Müller, Kathrin
Witting, Anke
Vercruysse, Pauline
Monassier, Laurent
Wong, Philip C.
El Oussini, Hajer
Larmet, Yves
Roumier, Anne
van den Berg, Leonard H.
Maroteaux, Luc
Dupuis, Luc
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Cites_doi 10.1038/nn.3599
10.1136/jnnp.2011.244939
10.1038/nrn3638
10.1523/JNEUROSCI.5723-07.2008
10.3109/17482968.2010.550626
10.1371/journal.pone.0013346
10.1056/NEJMoa1211103
10.1016/S0140-6736(10)61156-7
10.1038/nm764
10.1016/j.celrep.2015.03.053
10.1016/j.neuron.2006.09.018
10.1007/s00401-015-1388-1
10.1016/j.celrep.2013.06.018
10.1038/nn2014
10.1080/146608200300079536
10.1126/science.1123511
10.1038/nmeth.2089
10.1523/JNEUROSCI.3644-14.2015
10.1523/JNEUROSCI.4231-07.2008
10.1016/S1474-4422(10)70224-6
10.1161/01.CIR.0000074224.57016.01
10.1073/pnas.0402026101
10.1186/1742-2094-4-9
10.1002/glia.20859
10.1038/sj.embor.7400826
10.1007/s12031-011-9609-0
10.1001/jamaneurol.2013.579
10.1016/j.neuron.2014.01.013
10.1371/journal.pone.0082654
10.1152/physrev.00011.2010
10.1007/978-1-61779-170-3_4
10.1016/j.expneurol.2012.06.011
10.1016/j.cell.2015.01.049
10.1016/j.pharmthera.2011.03.008
10.1152/jn.00425.2013
10.1084/jem.20142322
10.1080/14660820310009389
10.1172/JCI62636
10.1038/ng.442
10.3389/fimmu.2015.00406
10.1186/gb-2002-3-7-research0034
10.1002/ana.24304
10.1016/S1474-4422(11)70015-1
10.1093/brain/awh428
10.1001/jamaneurol.2013.6237
10.1038/mp.2011.159
10.1172/JCI77983
10.2174/187152710791011982
10.1212/01.wnl.0000259083.31837.64
10.1006/nbdi.2000.0292
10.3389/fimmu.2015.00486
10.1007/s11481-013-9489-x
10.1016/j.expneurol.2008.09.019
10.1186/s40478-014-0142-6
10.1016/j.neuroimage.2012.11.048
10.1007/s00210-004-0951-4
10.1007/s00401-009-0556-6
10.1016/j.bcp.2014.01.008
10.1073/pnas.97.17.9508
10.1161/01.CIR.103.24.2973
10.1007/s00401-011-0864-5
10.1038/nn.3554
10.1038/npp.2010.173
10.1038/nature09629
10.1093/brain/aws274
10.1016/j.expneurol.2014.05.015
10.4049/jimmunol.1201133
10.1096/fj.02-1122fje
10.1126/scitranslmed.3009093
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Issue 3
Keywords Amyotrophic lateral sclerosis
Motor neuron
Serotonin
Microglia
SOD1
Language English
License Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
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PublicationSubtitle Pathology and Mechanisms of Neurological Disease
PublicationTitle Acta neuropathologica
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References Nebigil, Hickel, Messaddeq, Vonesch, Douchet, Monassier, Gyorgy, Matz, Andriantsitohaina, Manivet, Launay, Maroteaux (CR55) 2001; 103
Cady, Koval, Benitez, Zaidman, Jockel-Balsarotti, Allred, Baloh, Ravits, Simpson, Appel, Pestronk, Goate, Miller, Cruchaga, Harms (CR10) 2014; 71
Vandesompele, De Preter, Pattyn, Poppe, Van Roy, De Paepe, Speleman (CR69) 2002; 3
Doly, Valjent, Setola, Callebert, Herve, Launay, Maroteaux (CR17) 2008; 28
Streit, Xue, Tischer, Bechmann (CR63) 2014; 2
Boillee, Yamanaka, Lobsiger, Copeland, Jenkins, Kassiotis, Kollias, Cleveland (CR5) 2006; 312
Pitychoutis, Belmer, Moutkine, Adrien, Maroteaux (CR59) 2015
Brooks, Miller, Swash, Munsat (CR6) 2000; 1
Jonsson, Stefansson, Steinberg, Jonsdottir, Jonsson, Snaedal, Bjornsson, Huttenlocher, Levey, Lah, Rujescu, Hampel, Giegling, Andreassen, Engedal, Ulstein, Djurovic, Ibrahim-Verbaas, Hofman, Ikram, van Duijn, Thorsteinsdottir, Kong, Stefansson (CR39) 2013; 368
Butovsky, Siddiqui, Gabriely, Lanser, Dake, Murugaiyan, Doykan, Wu, Gali, Iyer, Lawson, Berry, Krichevsky, Cudkowicz, Weiner (CR9) 2012; 122
Witting, Moller (CR73) 2011; 758
Ajami, Bennett, Krieger, Tetzlaff, Rossi (CR1) 2007; 10
Nebigil, Jaffre, Messaddeq, Hickel, Monassier, Launay, Maroteaux (CR56) 2003; 107
Dupuis, de Tapia, Rene, Lutz-Bucher, Gordon, Mercken, Pradier, Loeffler (CR18) 2000; 7
d’Errico, Boido, Piras, Valsecchi, De Amicis, Locatelli, Capra, Vagni, Vercelli, Battaglia (CR13) 2013; 8
ElAli, Rivest (CR23) 2015
Liao, Zhao, Beers, Henkel, Appel (CR51) 2012; 237
Xue, Streit (CR74) 2011; 122
Poliani, Wang, Fontana, Robinette, Yamanishi, Gilfillan, Colonna (CR60) 2015; 125
Huisman, de Jong, van Doormaal, Weinreich, Schelhaas, van der Kooi, de Visser, Veldink, van den Berg (CR35) 2011; 82
CR42
Kunis, Baruch, Miller, Schwartz (CR46) 2015; 35
Wiesner, Sinniger, Henriques, Dieterle, Muller, Rasche, Ferger, Dirrig-Grosch, Soylu-Kucharz, Petersen, Walther, Linkus, Kassubek, Wong, Ludolph, Dupuis (CR72) 2014; 15
Boillee, Vande Velde, Cleveland (CR4) 2006; 52
Guilliams, van de Laar (CR28) 2015; 6
Hickman, El Khoury (CR32) 2013; 33
Banas, Doly, Boutourlinsky, Diaz, Belmer, Callebert, Collet, Launay, Maroteaux (CR2) 2011; 36
Butovsky, Jedrychowski, Moore, Cialic, Lanser, Gabriely, Koeglsperger, Dake, Wu, Doykan, Fanek, Liu, Chen, Rothstein, Ransohoff, Gygi, Antel, Weiner (CR8) 2014; 17
Kiernan, Vucic, Cheah, Turner, Eisen, Hardiman, Burrell, Zoing (CR41) 2011; 377
Schneider, Rasband, Eliceiri (CR61) 2012; 9
Lattante, Ciura, Rouleau, Kabashi (CR48) 2015
Nebigil, Choi, Dierich, Hickel, Le Meur, Messaddeq, Launay, Maroteaux (CR53) 2000; 97
Nebigil, Etienne, Messaddeq, Maroteaux (CR54) 2003; 17
Dupuis, Fergani, Braunstein, Eschbach, Holl, Rene, Gonzalez De Aguilar, Zoerner, Schwalenstocker, Ludolph, Loeffler (CR19) 2009; 215
Harrison, O’Brien, Adams, Cowin, Ruitenberg, Sengul, Watson (CR29) 2013; 68
Walsh, Muruve, Power (CR70) 2014; 15
Bevilacqua, Doly, Kaprio, Yuan, Tikkanen, Paunio, Zhou, Wedenoja, Maroteaux, Diaz, Belmer, Hodgkinson, Dell’osso, Suvisaari, Coccaro, Rose, Peltonen, Virkkunen, Goldman (CR3) 2010; 468
Laird, Farah, Ackerley, Hoke, Maragakis, Rothstein, Griffin, Price, Martin, Wong (CR47) 2008; 28
Dentel, Palamiuc, Henriques, Lannes, Spreux-Varoquaux, Gutknecht, Rene, Echaniz-Laguna, Gonzalez de Aguilar, Lesch, Meininger, Loeffler, Dupuis (CR15) 2013; 136
Hickman, El Khoury (CR31) 2010; 9
Frakes, Ferraiuolo, Haidet-Phillips, Schmelzer, Braun, Miranda, Ladner, Bevan, Foust, Godbout, Popovich, Guttridge, Kaspar (CR26) 2014; 81
Zhao, Beers, Appel (CR75) 2013; 8
Mosher, Wyss-Coray (CR52) 2014; 88
CR14
Fendrick, Xue, Streit (CR25) 2007; 4
Koschnitzky, Quinlan, Lukas, Kajtaz, Kocevar, Mayers, Siddique, Heckman (CR45) 2014; 111
CR58
Jokic, Gonzalez de Aguilar, Dimou, Lin, Fergani, Ruegg, Schwab, Dupuis, Loeffler (CR38) 2006; 7
van Es, Veldink, Saris, Blauw, van Vught, Birve, Lemmens, Schelhaas, Groen, Huisman, van der Kooi, de Visser, Dahlberg, Estrada, Rivadeneira, Hofman, Zwarts, van Doormaal, Rujescu, Strengman, Giegling, Muglia, Tomik, Slowik, Uitterlinden, Hendrich, Waibel, Meyer, Ludolph, Glass, Purcell, Cichon, Nothen, Wichmann, Schreiber, Vermeulen, Kiemeney, Wokke, Cronin, McLaughlin, Hardiman, Fumoto, Pasterkamp, Meininger, Melki, Leigh, Shaw, Landers, Al-Chalabi, Brown, Robberecht, Andersen, Ophoff, van den Berg (CR68) 2009; 41
Turner, Lopes, Cheema (CR65) 2003; 4
Hickman, Kingery, Ohsumi, Borowsky, Wang, Means, El Khoury (CR33) 2013; 16
Strong, Yang (CR64) 2011; 45
Jay, Miller, Cheng, Graham, Bemiller, Broihier, Xu, Margevicius, Karlo, Sousa, Cotleur, Butovsky, Bekris, Staugaitis, Leverenz, Pimplikar, Landreth, Howell, Ransohoff, Lamb (CR37) 2015; 212
Wang, Cella, Mallinson, Ulrich, Young, Robinette, Gilfillan, Krishnan, Sudhakar, Zinselmeyer, Holtzman, Cirrito, Colonna (CR71) 2015; 160
Streit, Braak, Xue, Bechmann (CR62) 2009; 118
Heiman-Patterson, Sher, Blankenhorn, Alexander, Deitch, Kunst, Maragakis, Cox (CR30) 2011; 12
Diaz, Doly, Narboux-Neme, Fernandez, Mazot, Banas, Boutourlinsky, Moutkine, Belmer, Roumier, Maroteaux (CR16) 2012; 17
Endo, Komine, Fujimori-Tonou, Katsuno, Jin, Watanabe, Sobue, Dezawa, Wyss-Coray, Yamanaka (CR24) 2015; 11
Cantoni, Bollman, Licastro, Xie, Mikesell, Schmidt, Yuede, Galimberti, Olivecrona, Klein, Cross, Otero, Piccio (CR11) 2015; 129
Dupuis, Pradat, Ludolph, Loeffler (CR21) 2011; 10
Kettenmann, Hanisch, Noda, Verkhratsky (CR40) 2011; 91
Butovsky, Jedrychowski, Cialic, Krasemann, Murugaiyan, Fanek, Greco, Wu, Doykan, Kiner, Lawson, Frosch, Pochet, Fatimy, Krichevsky, Gygi, Lassmann, Berry, Cudkowicz, Weiner (CR7) 2015; 77
Hoeffel, Ginhoux (CR34) 2015; 6
Knight, Misra, Quirk, Benwell, Revell, Kennett, Bickerdike (CR43) 2004; 370
Turner, Rabiner, Al-Chalabi, Shaw, Brooks, Leigh, Andersen (CR66) 2007; 68
Lewis, Solomon, Rossi, Krieger (CR50) 2009; 57
Philips, Robberecht (CR57) 2011; 10
Guerreiro, Lohmann, Bras, Gibbs, Rohrer, Gurunlian, Dursun, Bilgic, Hanagasi, Gurvit, Emre, Singleton, Hardy (CR27) 2013; 70
Kolodziejczak, Bechade, Gervasi, Irinopoulou, Banas, Cordier, Rebsam, Roumier, Maroteaux (CR44) 2015
Chiu, Morimoto, Goodarzi, Liao, O’Keeffe, Phatnani, Muratet, Carroll, Levy, Tavazoie, Myers, Maniatis (CR12) 2013; 4
Dupuis, Spreux-Varoquaux, Bensimon, Jullien, Lacomblez, Salachas, Bruneteau, Pradat, Loeffler, Meininger (CR22) 2010; 5
Hutcheson, Setola, Roth, Merryman (CR36) 2011; 132
Turner, Rabiner, Hammers, Al-Chalabi, Grasby, Shaw, Brooks, Leigh (CR67) 2005; 128
Launay, Herve, Peoc’h, Tournois, Callebert, Nebigil, Etienne, Drouet, Humbert, Simonneau, Maroteaux (CR49) 2002; 8
Dupuis, Oudart, Rene, Gonzalez de Aguilar, Loeffler (CR20) 2004; 101
SM Banas (1534_CR2) 2011; 36
CA Schneider (1534_CR61) 2012; 9
W Zhao (1534_CR75) 2013; 8
PM Pitychoutis (1534_CR59) 2015
1534_CR42
J Vandesompele (1534_CR69) 2002; 3
L Dupuis (1534_CR22) 2010; 5
F Endo (1534_CR24) 2015; 11
C Dentel (1534_CR15) 2013; 136
C Cantoni (1534_CR11) 2015; 129
JM Launay (1534_CR49) 2002; 8
JE Koschnitzky (1534_CR45) 2014; 111
BJ Turner (1534_CR65) 2003; 4
PL Poliani (1534_CR60) 2015; 125
CG Nebigil (1534_CR55) 2001; 103
O Butovsky (1534_CR9) 2012; 122
CA Lewis (1534_CR50) 2009; 57
SE Fendrick (1534_CR25) 2007; 4
B Ajami (1534_CR1) 2007; 10
WJ Streit (1534_CR63) 2014; 2
M Guilliams (1534_CR28) 2015; 6
B Liao (1534_CR51) 2012; 237
RJ Guerreiro (1534_CR27) 2013; 70
H Kettenmann (1534_CR40) 2011; 91
T Philips (1534_CR57) 2011; 10
S Boillee (1534_CR4) 2006; 52
G Hoeffel (1534_CR34) 2015; 6
T Jonsson (1534_CR39) 2013; 368
S Lattante (1534_CR48) 2015
QS Xue (1534_CR74) 2011; 122
O Butovsky (1534_CR7) 2015; 77
D Wiesner (1534_CR72) 2014; 15
S Doly (1534_CR17) 2008; 28
AR Knight (1534_CR43) 2004; 370
SE Hickman (1534_CR31) 2010; 9
MR Turner (1534_CR66) 2007; 68
SE Hickman (1534_CR32) 2013; 33
P d’Errico (1534_CR13) 2013; 8
L Bevilacqua (1534_CR3) 2010; 468
SL Diaz (1534_CR16) 2012; 17
L Dupuis (1534_CR18) 2000; 7
JD Hutcheson (1534_CR36) 2011; 132
G Kunis (1534_CR46) 2015; 35
CG Nebigil (1534_CR54) 2003; 17
O Butovsky (1534_CR8) 2014; 17
WJ Streit (1534_CR62) 2009; 118
MA Es van (1534_CR68) 2009; 41
TD Heiman-Patterson (1534_CR30) 2011; 12
FM Laird (1534_CR47) 2008; 28
BR Brooks (1534_CR6) 2000; 1
N Jokic (1534_CR38) 2006; 7
MC Kiernan (1534_CR41) 2011; 377
KI Mosher (1534_CR52) 2014; 88
SE Hickman (1534_CR33) 2013; 16
S Boillee (1534_CR5) 2006; 312
L Dupuis (1534_CR20) 2004; 101
A ElAli (1534_CR23) 2015
Y Wang (1534_CR71) 2015; 160
1534_CR14
1534_CR58
IM Chiu (1534_CR12) 2013; 4
MJ Strong (1534_CR64) 2011; 45
MR Turner (1534_CR67) 2005; 128
TR Jay (1534_CR37) 2015; 212
L Dupuis (1534_CR19) 2009; 215
M Harrison (1534_CR29) 2013; 68
CG Nebigil (1534_CR56) 2003; 107
MH Huisman (1534_CR35) 2011; 82
AE Frakes (1534_CR26) 2014; 81
CG Nebigil (1534_CR53) 2000; 97
M Kolodziejczak (1534_CR44) 2015
J Cady (1534_CR10) 2014; 71
L Dupuis (1534_CR21) 2011; 10
A Witting (1534_CR73) 2011; 758
JG Walsh (1534_CR70) 2014; 15
References_xml – volume: 17
  start-page: 131
  year: 2014
  end-page: 143
  ident: CR8
  article-title: Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3599
– volume: 82
  start-page: 1165
  year: 2011
  end-page: 1170
  ident: CR35
  article-title: Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.2011.244939
– volume: 15
  start-page: 84
  year: 2014
  end-page: 97
  ident: CR70
  article-title: Inflammasomes in the CNS
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn3638
– volume: 28
  start-page: 2933
  year: 2008
  end-page: 2940
  ident: CR17
  article-title: Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5723-07.2008
– volume: 12
  start-page: 79
  year: 2011
  end-page: 86
  ident: CR30
  article-title: Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: a window of opportunity in the search for genetic modifiers
  publication-title: Amyotroph Lateral Scler
  doi: 10.3109/17482968.2010.550626
– volume: 5
  start-page: e13346
  year: 2010
  ident: CR22
  article-title: Platelet serotonin level predicts survival in amyotrophic lateral sclerosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0013346
– volume: 368
  start-page: 107
  year: 2013
  end-page: 116
  ident: CR39
  article-title: Variant of TREM2 associated with the risk of Alzheimer’s disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1211103
– volume: 377
  start-page: 942
  year: 2011
  end-page: 955
  ident: CR41
  article-title: Amyotrophic lateral sclerosis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(10)61156-7
– year: 2015
  ident: CR44
  article-title: Serotonin modulates developmental microglia via 5-HT receptors: potential implication during synaptic refinement of retinogeniculate projections
  publication-title: ACS Chem Neurosci
– volume: 8
  start-page: 1129
  year: 2002
  end-page: 1135
  ident: CR49
  article-title: Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
  publication-title: Nat Med
  doi: 10.1038/nm764
– volume: 11
  start-page: 592
  year: 2015
  end-page: 604
  ident: CR24
  article-title: Astrocyte-derived TGF-beta1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2015.03.053
– ident: CR58
– volume: 52
  start-page: 39
  year: 2006
  end-page: 59
  ident: CR4
  article-title: ALS: a disease of motor neurons and their nonneuronal neighbors
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.09.018
– ident: CR42
– volume: 17
  start-page: 1373
  year: 2003
  end-page: 1375
  ident: CR54
  article-title: Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling
  publication-title: FASEB J
– volume: 129
  start-page: 429
  year: 2015
  end-page: 447
  ident: CR11
  article-title: TREM2 regulates microglial cell activation in response to demyelination in vivo
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-015-1388-1
– volume: 4
  start-page: 385
  year: 2013
  end-page: 401
  ident: CR12
  article-title: A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2013.06.018
– volume: 33
  start-page: S295
  issue: Suppl 1
  year: 2013
  end-page: S302
  ident: CR32
  article-title: The neuroimmune system in Alzheimer’s disease: the glass is half full
  publication-title: J Alzheimers Dis
– volume: 10
  start-page: 1538
  year: 2007
  end-page: 1543
  ident: CR1
  article-title: Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
  publication-title: Nat Neurosci
  doi: 10.1038/nn2014
– volume: 1
  start-page: 293
  year: 2000
  end-page: 299
  ident: CR6
  article-title: El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis
  publication-title: Amyotroph Lateral Scler Other Motor Neuron Disord
  doi: 10.1080/146608200300079536
– volume: 312
  start-page: 1389
  year: 2006
  end-page: 1392
  ident: CR5
  article-title: Onset and progression in inherited ALS determined by motor neurons and microglia
  publication-title: Science
  doi: 10.1126/science.1123511
– volume: 9
  start-page: 671
  year: 2012
  end-page: 675
  ident: CR61
  article-title: NIH Image to ImageJ: 25 years of image analysis
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2089
– volume: 35
  start-page: 6381
  year: 2015
  end-page: 6393
  ident: CR46
  article-title: Immunization with a myelin-derived antigen activates the brain’s choroid plexus for recruitment of immunoregulatory cells to the CNS and attenuates disease progression in a mouse model of ALS
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3644-14.2015
– volume: 28
  start-page: 1997
  year: 2008
  end-page: 2005
  ident: CR47
  article-title: Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4231-07.2008
– volume: 10
  start-page: 75
  year: 2011
  end-page: 82
  ident: CR21
  article-title: Energy metabolism in amyotrophic lateral sclerosis
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(10)70224-6
– volume: 107
  start-page: 3223
  year: 2003
  end-page: 3229
  ident: CR56
  article-title: Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000074224.57016.01
– volume: 101
  start-page: 11159
  year: 2004
  end-page: 11164
  ident: CR20
  article-title: Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0402026101
– volume: 4
  start-page: 9
  year: 2007
  ident: CR25
  article-title: Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene
  publication-title: J Neuroinflammation
  doi: 10.1186/1742-2094-4-9
– volume: 57
  start-page: 1410
  year: 2009
  end-page: 1419
  ident: CR50
  article-title: Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1
  publication-title: Glia
  doi: 10.1002/glia.20859
– year: 2015
  ident: CR23
  article-title: Microglia in Alzheimer’s disease: a multifaceted relationship
  publication-title: Brain Behav Immun
– volume: 7
  start-page: 1162
  year: 2006
  end-page: 1167
  ident: CR38
  article-title: The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model
  publication-title: EMBO Rep
  doi: 10.1038/sj.embor.7400826
– volume: 45
  start-page: 648
  year: 2011
  end-page: 655
  ident: CR64
  article-title: The frontotemporal syndromes of ALS. Clinicopathological correlates
  publication-title: J Mol Neurosci
  doi: 10.1007/s12031-011-9609-0
– volume: 70
  start-page: 78
  year: 2013
  end-page: 84
  ident: CR27
  article-title: Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2013.579
– volume: 81
  start-page: 1009
  year: 2014
  end-page: 1023
  ident: CR26
  article-title: Microglia induce motor neuron death via the classical NF-kappaB pathway in amyotrophic lateral sclerosis
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.01.013
– volume: 8
  start-page: e82654
  year: 2013
  ident: CR13
  article-title: Selective vulnerability of spinal and cortical motor neuron subpopulations in delta7 SMA mice
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0082654
– ident: CR14
– volume: 91
  start-page: 461
  year: 2011
  end-page: 553
  ident: CR40
  article-title: Physiology of microglia
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00011.2010
– volume: 758
  start-page: 49
  year: 2011
  end-page: 66
  ident: CR73
  article-title: Microglia cell culture: a primer for the novice
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-61779-170-3_4
– volume: 237
  start-page: 147
  year: 2012
  end-page: 152
  ident: CR51
  article-title: Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2012.06.011
– volume: 160
  start-page: 1061
  year: 2015
  end-page: 1071
  ident: CR71
  article-title: TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model
  publication-title: Cell
  doi: 10.1016/j.cell.2015.01.049
– volume: 132
  start-page: 146
  year: 2011
  end-page: 157
  ident: CR36
  article-title: Serotonin receptors and heart valve disease–it was meant 2B
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2011.03.008
– volume: 111
  start-page: 2164
  year: 2014
  end-page: 2176
  ident: CR45
  article-title: Effect of fluoxetine on disease progression in a mouse model of ALS
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00425.2013
– volume: 212
  start-page: 287
  year: 2015
  end-page: 295
  ident: CR37
  article-title: TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
  publication-title: J Exp Med
  doi: 10.1084/jem.20142322
– volume: 4
  start-page: 171
  issue: 3
  year: 2003
  end-page: 176
  ident: CR65
  article-title: The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis
  publication-title: Amyotroph Lateral Scler Other Motor Neuron Disord
  doi: 10.1080/14660820310009389
– volume: 122
  start-page: 3063
  year: 2012
  end-page: 3087
  ident: CR9
  article-title: Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
  publication-title: J Clin Invest
  doi: 10.1172/JCI62636
– volume: 41
  start-page: 1083
  year: 2009
  end-page: 1087
  ident: CR68
  article-title: Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
  publication-title: Nat Genet
  doi: 10.1038/ng.442
– volume: 6
  start-page: 406
  year: 2015
  ident: CR28
  article-title: A Hitchhiker’s guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2015.00406
– volume: 3
  start-page: research0034.1
  year: 2002
  end-page: research0034.11
  ident: CR69
  article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
  publication-title: Genome Biol
  doi: 10.1186/gb-2002-3-7-research0034
– volume: 77
  start-page: 75
  year: 2015
  end-page: 99
  ident: CR7
  article-title: Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice
  publication-title: Ann Neurol
  doi: 10.1002/ana.24304
– volume: 10
  start-page: 253
  year: 2011
  end-page: 263
  ident: CR57
  article-title: Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(11)70015-1
– volume: 128
  start-page: 896
  year: 2005
  end-page: 905
  ident: CR67
  article-title: [11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS
  publication-title: Brain
  doi: 10.1093/brain/awh428
– volume: 15
  start-page: 2228
  year: 2014
  end-page: 2240
  ident: CR72
  article-title: Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein mediated neurodegeneration
  publication-title: Hum Mol Genet
– volume: 71
  start-page: 449
  year: 2014
  end-page: 453
  ident: CR10
  article-title: TREM2 variant p. R47H as a risk factor for sporadic amyotrophic lateral sclerosis
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2013.6237
– volume: 17
  start-page: 154
  year: 2012
  end-page: 163
  ident: CR16
  article-title: 5-HT(2B) receptors are required for serotonin-selective antidepressant actions
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2011.159
– volume: 125
  start-page: 2161
  year: 2015
  end-page: 2170
  ident: CR60
  article-title: TREM2 sustains microglial expansion during aging and response to demyelination
  publication-title: J Clin Invest
  doi: 10.1172/JCI77983
– volume: 9
  start-page: 168
  year: 2010
  end-page: 173
  ident: CR31
  article-title: Mechanisms of mononuclear phagocyte recruitment in Alzheimer’s disease
  publication-title: CNS Neurol Disord: Drug Targets
  doi: 10.2174/187152710791011982
– volume: 68
  start-page: 1233
  year: 2007
  end-page: 1235
  ident: CR66
  article-title: Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000259083.31837.64
– volume: 7
  start-page: 274
  year: 2000
  end-page: 285
  ident: CR18
  article-title: Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal cord motor neurons
  publication-title: Neurobiol Dis
  doi: 10.1006/nbdi.2000.0292
– volume: 6
  start-page: 486
  year: 2015
  ident: CR34
  article-title: Ontogeny of tissue-resident macrophages
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2015.00486
– volume: 8
  start-page: 888
  year: 2013
  end-page: 899
  ident: CR75
  article-title: Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis
  publication-title: J Neuroimmune Pharmacol
  doi: 10.1007/s11481-013-9489-x
– volume: 215
  start-page: 146
  year: 2009
  end-page: 152
  ident: CR19
  article-title: Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2008.09.019
– volume: 2
  start-page: 142
  year: 2014
  ident: CR63
  article-title: Microglial pathology
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-014-0142-6
– volume: 68
  start-page: 22
  year: 2013
  end-page: 29
  ident: CR29
  article-title: Vertebral landmarks for the identification of spinal cord segments in the mouse
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.11.048
– volume: 370
  start-page: 114
  year: 2004
  end-page: 123
  ident: CR43
  article-title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors
  publication-title: Naunyn Schmiedebergs Arch Pharmacol
  doi: 10.1007/s00210-004-0951-4
– volume: 118
  start-page: 475
  year: 2009
  end-page: 485
  ident: CR62
  article-title: Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-009-0556-6
– volume: 88
  start-page: 594
  year: 2014
  end-page: 604
  ident: CR52
  article-title: Microglial dysfunction in brain aging and Alzheimer’s disease
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2014.01.008
– volume: 97
  start-page: 9508
  year: 2000
  end-page: 9513
  ident: CR53
  article-title: Serotonin 2B receptor is required for heart development
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.97.17.9508
– volume: 103
  start-page: 2973
  year: 2001
  end-page: 2979
  ident: CR55
  article-title: Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function
  publication-title: Circulation
  doi: 10.1161/01.CIR.103.24.2973
– year: 2015
  ident: CR59
  article-title: Mice lacking the serotonin Htr receptor gene present an antipsychotic-sensitive schizophrenic-like phenotype
  publication-title: Neuropsychopharmacology
– volume: 122
  start-page: 455
  year: 2011
  end-page: 466
  ident: CR74
  article-title: Microglial pathology in Down syndrome
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-011-0864-5
– volume: 16
  start-page: 1896
  year: 2013
  end-page: 1905
  ident: CR33
  article-title: The microglial sensome revealed by direct RNA sequencing
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3554
– volume: 36
  start-page: 423
  year: 2011
  end-page: 433
  ident: CR2
  article-title: Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2010.173
– volume: 468
  start-page: 1061
  year: 2010
  end-page: 1066
  ident: CR3
  article-title: A population-specific HTR2B stop codon predisposes to severe impulsivity
  publication-title: Nature
  doi: 10.1038/nature09629
– volume: 136
  start-page: 483
  year: 2013
  end-page: 493
  ident: CR15
  article-title: Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity
  publication-title: Brain
  doi: 10.1093/brain/aws274
– year: 2015
  ident: CR48
  article-title: Defining the genetic connection linking amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD)
  publication-title: Trends Genet
– volume: 17
  start-page: 131
  year: 2014
  ident: 1534_CR8
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3599
– volume: 215
  start-page: 146
  year: 2009
  ident: 1534_CR19
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2008.09.019
– volume: 16
  start-page: 1896
  year: 2013
  ident: 1534_CR33
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3554
– volume: 97
  start-page: 9508
  year: 2000
  ident: 1534_CR53
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.97.17.9508
– volume: 8
  start-page: e82654
  year: 2013
  ident: 1534_CR13
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0082654
– volume: 160
  start-page: 1061
  year: 2015
  ident: 1534_CR71
  publication-title: Cell
  doi: 10.1016/j.cell.2015.01.049
– volume: 368
  start-page: 107
  year: 2013
  ident: 1534_CR39
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1211103
– volume: 28
  start-page: 1997
  year: 2008
  ident: 1534_CR47
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4231-07.2008
– volume: 758
  start-page: 49
  year: 2011
  ident: 1534_CR73
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-61779-170-3_4
– volume: 4
  start-page: 9
  year: 2007
  ident: 1534_CR25
  publication-title: J Neuroinflammation
  doi: 10.1186/1742-2094-4-9
– volume: 370
  start-page: 114
  year: 2004
  ident: 1534_CR43
  publication-title: Naunyn Schmiedebergs Arch Pharmacol
  doi: 10.1007/s00210-004-0951-4
– volume: 10
  start-page: 253
  year: 2011
  ident: 1534_CR57
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(11)70015-1
– year: 2015
  ident: 1534_CR48
  publication-title: Trends Genet
– volume: 68
  start-page: 1233
  year: 2007
  ident: 1534_CR66
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000259083.31837.64
– volume: 237
  start-page: 147
  year: 2012
  ident: 1534_CR51
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2012.06.011
– volume: 129
  start-page: 429
  year: 2015
  ident: 1534_CR11
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-015-1388-1
– volume: 122
  start-page: 3063
  year: 2012
  ident: 1534_CR9
  publication-title: J Clin Invest
  doi: 10.1172/JCI62636
– volume: 7
  start-page: 1162
  year: 2006
  ident: 1534_CR38
  publication-title: EMBO Rep
  doi: 10.1038/sj.embor.7400826
– volume: 77
  start-page: 75
  year: 2015
  ident: 1534_CR7
  publication-title: Ann Neurol
  doi: 10.1002/ana.24304
– volume: 118
  start-page: 475
  year: 2009
  ident: 1534_CR62
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-009-0556-6
– volume: 41
  start-page: 1083
  year: 2009
  ident: 1534_CR68
  publication-title: Nat Genet
  doi: 10.1038/ng.442
– ident: 1534_CR58
  doi: 10.1016/j.expneurol.2014.05.015
– volume: 3
  start-page: research0034.1
  year: 2002
  ident: 1534_CR69
  publication-title: Genome Biol
  doi: 10.1186/gb-2002-3-7-research0034
– year: 2015
  ident: 1534_CR59
  publication-title: Neuropsychopharmacology
– volume: 377
  start-page: 942
  year: 2011
  ident: 1534_CR41
  publication-title: Lancet
  doi: 10.1016/S0140-6736(10)61156-7
– volume: 11
  start-page: 592
  year: 2015
  ident: 1534_CR24
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2015.03.053
– volume: 70
  start-page: 78
  year: 2013
  ident: 1534_CR27
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2013.579
– ident: 1534_CR14
  doi: 10.4049/jimmunol.1201133
– volume: 35
  start-page: 6381
  year: 2015
  ident: 1534_CR46
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3644-14.2015
– volume: 2
  start-page: 142
  year: 2014
  ident: 1534_CR63
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-014-0142-6
– volume: 17
  start-page: 1373
  year: 2003
  ident: 1534_CR54
  publication-title: FASEB J
  doi: 10.1096/fj.02-1122fje
– volume: 10
  start-page: 1538
  year: 2007
  ident: 1534_CR1
  publication-title: Nat Neurosci
  doi: 10.1038/nn2014
– volume: 17
  start-page: 154
  year: 2012
  ident: 1534_CR16
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2011.159
– volume: 45
  start-page: 648
  year: 2011
  ident: 1534_CR64
  publication-title: J Mol Neurosci
  doi: 10.1007/s12031-011-9609-0
– volume: 212
  start-page: 287
  year: 2015
  ident: 1534_CR37
  publication-title: J Exp Med
  doi: 10.1084/jem.20142322
– volume: 122
  start-page: 455
  year: 2011
  ident: 1534_CR74
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-011-0864-5
– volume: 111
  start-page: 2164
  year: 2014
  ident: 1534_CR45
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00425.2013
– volume: 8
  start-page: 888
  year: 2013
  ident: 1534_CR75
  publication-title: J Neuroimmune Pharmacol
  doi: 10.1007/s11481-013-9489-x
– volume: 132
  start-page: 146
  year: 2011
  ident: 1534_CR36
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2011.03.008
– volume: 52
  start-page: 39
  year: 2006
  ident: 1534_CR4
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.09.018
– volume: 5
  start-page: e13346
  year: 2010
  ident: 1534_CR22
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0013346
– volume: 71
  start-page: 449
  year: 2014
  ident: 1534_CR10
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2013.6237
– volume: 8
  start-page: 1129
  year: 2002
  ident: 1534_CR49
  publication-title: Nat Med
  doi: 10.1038/nm764
– volume: 12
  start-page: 79
  year: 2011
  ident: 1534_CR30
  publication-title: Amyotroph Lateral Scler
  doi: 10.3109/17482968.2010.550626
– volume: 103
  start-page: 2973
  year: 2001
  ident: 1534_CR55
  publication-title: Circulation
  doi: 10.1161/01.CIR.103.24.2973
– volume: 91
  start-page: 461
  year: 2011
  ident: 1534_CR40
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00011.2010
– volume: 107
  start-page: 3223
  year: 2003
  ident: 1534_CR56
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000074224.57016.01
– year: 2015
  ident: 1534_CR44
  publication-title: ACS Chem Neurosci
– volume: 15
  start-page: 84
  year: 2014
  ident: 1534_CR70
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn3638
– volume: 9
  start-page: 671
  year: 2012
  ident: 1534_CR61
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2089
– volume: 28
  start-page: 2933
  year: 2008
  ident: 1534_CR17
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5723-07.2008
– volume: 81
  start-page: 1009
  year: 2014
  ident: 1534_CR26
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.01.013
– volume: 33
  start-page: S295
  issue: Suppl 1
  year: 2013
  ident: 1534_CR32
  publication-title: J Alzheimers Dis
– volume: 128
  start-page: 896
  year: 2005
  ident: 1534_CR67
  publication-title: Brain
  doi: 10.1093/brain/awh428
– volume: 6
  start-page: 406
  year: 2015
  ident: 1534_CR28
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2015.00406
– volume: 36
  start-page: 423
  year: 2011
  ident: 1534_CR2
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2010.173
– volume: 10
  start-page: 75
  year: 2011
  ident: 1534_CR21
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(10)70224-6
– volume: 57
  start-page: 1410
  year: 2009
  ident: 1534_CR50
  publication-title: Glia
  doi: 10.1002/glia.20859
– volume: 1
  start-page: 293
  year: 2000
  ident: 1534_CR6
  publication-title: Amyotroph Lateral Scler Other Motor Neuron Disord
  doi: 10.1080/146608200300079536
– year: 2015
  ident: 1534_CR23
  publication-title: Brain Behav Immun
– volume: 9
  start-page: 168
  year: 2010
  ident: 1534_CR31
  publication-title: CNS Neurol Disord: Drug Targets
  doi: 10.2174/187152710791011982
– volume: 82
  start-page: 1165
  year: 2011
  ident: 1534_CR35
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.2011.244939
– volume: 312
  start-page: 1389
  year: 2006
  ident: 1534_CR5
  publication-title: Science
  doi: 10.1126/science.1123511
– volume: 101
  start-page: 11159
  year: 2004
  ident: 1534_CR20
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0402026101
– volume: 125
  start-page: 2161
  year: 2015
  ident: 1534_CR60
  publication-title: J Clin Invest
  doi: 10.1172/JCI77983
– volume: 4
  start-page: 171
  issue: 3
  year: 2003
  ident: 1534_CR65
  publication-title: Amyotroph Lateral Scler Other Motor Neuron Disord
  doi: 10.1080/14660820310009389
– volume: 468
  start-page: 1061
  year: 2010
  ident: 1534_CR3
  publication-title: Nature
  doi: 10.1038/nature09629
– volume: 4
  start-page: 385
  year: 2013
  ident: 1534_CR12
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2013.06.018
– volume: 68
  start-page: 22
  year: 2013
  ident: 1534_CR29
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.11.048
– volume: 88
  start-page: 594
  year: 2014
  ident: 1534_CR52
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2014.01.008
– volume: 7
  start-page: 274
  year: 2000
  ident: 1534_CR18
  publication-title: Neurobiol Dis
  doi: 10.1006/nbdi.2000.0292
– volume: 15
  start-page: 2228
  year: 2014
  ident: 1534_CR72
  publication-title: Hum Mol Genet
– ident: 1534_CR42
  doi: 10.1126/scitranslmed.3009093
– volume: 6
  start-page: 486
  year: 2015
  ident: 1534_CR34
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2015.00486
– volume: 136
  start-page: 483
  year: 2013
  ident: 1534_CR15
  publication-title: Brain
  doi: 10.1093/brain/aws274
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SubjectTerms Ablation
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - pathology
Animal genetics
Animals
Biochemistry, Molecular Biology
Cardiology and cardiovascular system
Development and progression
Disease
Disease Models, Animal
Disease Progression
Female
Genetic engineering
Genetic polymorphisms
Genetics
Human health and pathology
Humans
Life Sciences
Male
Medicine
Medicine & Public Health
Mice
Mice, Transgenic
Microglia - pathology
Molecular biology
Mononuclear Phagocyte System - metabolism
Mononuclear Phagocyte System - pathology
Motor Neurons - pathology
Nervous system diseases
Neurobiology
Neurodegeneration
Neurology
Neurons
Neurons and Cognition
Neuropathology
Neurosciences
Original Paper
Pathology
Pharmaceutical sciences
Pharmacology
Phenols (Class of compounds)
Psychiatrics and mental health
Pulmonology and respiratory tract
Real-Time Polymerase Chain Reaction
Receptor, Serotonin, 5-HT2B - metabolism
Serotonin
Spinal cord
Spinal Cord - pathology
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Title Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis
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