The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations
Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a commonly encountered yet loosely defined clinical entity. ACOS accounts for approximately 15-25% of the obstructive airway diseases and patients experience worse outcomes compared with asthma or COPD alone. Patients wit...
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| Published in | Expert review of clinical pharmacology Vol. 6; no. 2; pp. 197 - 219 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Taylor & Francis
01.03.2013
Expert Reviews Ltd Informa Healthcare |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1751-2433 1751-2441 |
| DOI | 10.1586/ecp.13.2 |
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| Abstract | Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a commonly encountered yet loosely defined clinical entity. ACOS accounts for approximately 15-25% of the obstructive airway diseases and patients experience worse outcomes compared with asthma or COPD alone. Patients with ACOS have the combined risk factors of smoking and atopy, are generally younger than patients with COPD and experience acute exacerbations with higher frequency and greater severity than lone COPD. Pharmacotherapeutic considerations require an integrated approach, first to identify the relevant clinical phenotype(s), then to determine the best available therapy. The authors discuss the array of existing and emerging classes of drugs that could benefit those with ACOS and share their therapeutic approach. A consensus international definition of ACOS is needed to design prospective, randomized clinical trials to evaluate specific drug interventions on important outcomes such as lung function, acute exacerbations, quality of life and mortality. |
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| AbstractList | Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a commonly encountered yet loosely defined clinical entity. ACOS accounts for approximately 15-25% of the obstructive airway diseases and patients experience worse outcomes compared with asthma or COPD alone. Patients with ACOS have the combined risk factors of smoking and atopy, are generally younger than patients with COPD and experience acute exacerbations with higher frequency and greater severity than lone COPD. Pharmacotherapeutic considerations require an integrated approach, first to identify the relevant clinical phenotype(s), then to determine the best available therapy. The authors discuss the array of existing and emerging classes of drugs that could benefit those with ACOS and share their therapeutic approach. A consensus international definition of ACOS is needed to design prospective, randomized clinical trials to evaluate specific drug interventions on important outcomes such as lung function, acute exacerbations, quality of life and mortality. |
| Audience | Academic |
| Author | Schivo, Michael Yoneda, Ken Y Avdalovic, Mark Morrissey, Brian M Chan, Andrew L Albertson, Timothy E Louie, Samuel Zeki, Amir A |
| AuthorAffiliation | 2 Veterans Administration Northern California Health Care System, Martinez, CA 94553, USA 1 Division of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA |
| AuthorAffiliation_xml | – name: 2 Veterans Administration Northern California Health Care System, Martinez, CA 94553, USA – name: 1 Division of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA |
| Author_xml | – sequence: 1 givenname: Samuel surname: Louie fullname: Louie, Samuel – sequence: 2 givenname: Amir A surname: Zeki fullname: Zeki, Amir A – sequence: 3 givenname: Michael surname: Schivo fullname: Schivo, Michael – sequence: 4 givenname: Andrew L surname: Chan fullname: Chan, Andrew L – sequence: 5 givenname: Ken Y surname: Yoneda fullname: Yoneda, Ken Y – sequence: 6 givenname: Mark surname: Avdalovic fullname: Avdalovic, Mark – sequence: 7 givenname: Brian M surname: Morrissey fullname: Morrissey, Brian M – sequence: 8 givenname: Timothy E surname: Albertson fullname: Albertson, Timothy E |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23473596$$D View this record in MEDLINE/PubMed |
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| Snippet | Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a commonly encountered yet loosely defined clinical entity. ACOS accounts for... Asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a commonly encountered yet loosely defined clinical entity. ACOS accounts for... |
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| SubjectTerms | ACOS Algorithms asthma Asthma - drug therapy Asthma - genetics asthma-COPD overlap syndrome bronchodilators chronic obstructive pulmonary disease corticosteroids Diagnosis, Differential Humans novel therapies Pharmaceutical industry pharmacotherapy Phenotype Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - genetics Respiratory System Agents - therapeutic use Risk Factors Smoking - adverse effects Smoking Cessation - methods Syndrome |
| Title | The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations |
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