视神经脊髓炎谱系疾病全身表现分析及其机制探讨

目的 研究视神经脊髓炎谱系疾病合并中枢神经系统以外受累脏器或组织的免疫学改变。方法 回顾分析56例视神经脊髓炎谱系疾病患者（视神经脊髓炎33例、非视神经脊髓炎23例）临床资料，逐一记录是否合并其他自身免疫性疾病，并行血清免疫学检测。结果 视神经脊髓炎患者伴桥本甲状腺炎2例，以及系统性红斑狼疮和干燥综合征、哮喘、甲状腺功能亢进、风湿性关节炎和虹膜睫状体炎各1例。血清免疫学指标异常检出率较高者分别为甲状腺功能异常（10／17例）、抗核抗体阳性（14／28例）和补体c3阳性（8／19例），2例于分娩后发病。结论视神经脊髓炎谱系疾病患者可合并多种自身免疫性疾病，同时存在多种自身抗体，可能与视神经脊髓炎...

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Published in中国现代神经疾病杂志 Vol. 14; no. 9; pp. 795 - 799
Main Author 姜红 何洋 杨亭亭 向雅娟 敖东慧 高旭光 刘广志
Format Journal Article
LanguageChinese
Published 100044,北京大学人民医院神经内科 2014
Subjects
生物学标记
自身免疫疾病
视神经脊髓炎
自身免疫疾病
Neuromyelitis optica
生物学标记
Autoimmune diseases
Biological markers
视神经脊髓炎
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2014.09.009

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Abstract 目的 研究视神经脊髓炎谱系疾病合并中枢神经系统以外受累脏器或组织的免疫学改变。方法 回顾分析56例视神经脊髓炎谱系疾病患者（视神经脊髓炎33例、非视神经脊髓炎23例）临床资料，逐一记录是否合并其他自身免疫性疾病，并行血清免疫学检测。结果 视神经脊髓炎患者伴桥本甲状腺炎2例，以及系统性红斑狼疮和干燥综合征、哮喘、甲状腺功能亢进、风湿性关节炎和虹膜睫状体炎各1例。血清免疫学指标异常检出率较高者分别为甲状腺功能异常（10／17例）、抗核抗体阳性（14／28例）和补体c3阳性（8／19例），2例于分娩后发病。结论视神经脊髓炎谱系疾病患者可合并多种自身免疫性疾病，同时存在多种自身抗体，可能与视神经脊髓炎谱系疾病的发病有关。此外，妊娠期或分娩可能加重患者病情。
AbstractList 目的 研究视神经脊髓炎谱系疾病合并中枢神经系统以外受累脏器或组织的免疫学改变。方法 回顾分析56例视神经脊髓炎谱系疾病患者（视神经脊髓炎33例、非视神经脊髓炎23例）临床资料，逐一记录是否合并其他自身免疫性疾病，并行血清免疫学检测。结果 视神经脊髓炎患者伴桥本甲状腺炎2例，以及系统性红斑狼疮和干燥综合征、哮喘、甲状腺功能亢进、风湿性关节炎和虹膜睫状体炎各1例。血清免疫学指标异常检出率较高者分别为甲状腺功能异常（10／17例）、抗核抗体阳性（14／28例）和补体c3阳性（8／19例），2例于分娩后发病。结论视神经脊髓炎谱系疾病患者可合并多种自身免疫性疾病，同时存在多种自身抗体，可能与视神经脊髓炎谱系疾病的发病有关。此外，妊娠期或分娩可能加重患者病情。
目的 研究视神经脊髓炎谱系疾病合并中枢神经系统以外受累脏器或组织的免疫学改变.方法 回顾分析56例视神经脊髓炎谱系疾病患者(视神经脊髓炎33例、非视神经脊髓炎23例)临床资料,逐一记录是否合并其他自身免疫性疾病,并行血清免疫学检测.结果 视神经脊髓炎患者伴桥本甲状腺炎2例,以及系统性红斑狼疮和干燥综合征、哮喘、甲状腺功能亢进、风湿性关节炎和虹膜睫状体炎各1例.血清免疫学指标异常检出率较高者分别为甲状腺功能异常(10/17例)、抗核抗体阳性(14/28例)和补体C3阳性(8/19例),2例于分娩后发病.结论 视神经脊髓炎谱系疾病患者可合并多种自身免疫性疾病,同时存在多种自身抗体,可能与视神经脊髓炎谱系疾病的发病有关.此外,妊娠期或分娩可能加重患者病情.
Author 姜红 何洋 杨亭亭 向雅娟 敖东慧 高旭光 刘广志
AuthorAffiliation 北京大学人民医院神经内科,100044
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YANG Ting-ting
AO Dong-hui
XIANG Ya-juan
JIANG Hong
GAO Xu-guang
HE Yang
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DocumentTitleAlternate Systemic manifestations and pathogenesis exploration of neuromyelitis optica spectrum disorders
DocumentTitle_FL Systemic manifestations and pathogenesis exploration of neuromyelitis optica spectrum disorders
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Issue 9
Keywords 自身免疫疾病
Neuromyelitis optica
生物学标记
Autoimmune diseases
Biological markers
视神经脊髓炎
Language Chinese
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Notes Neuromyelitis optica; Autoimmune diseases; Biological markersThis study was supported by National Natural Science Foundation of China （No. 81171123）.
Objective To investigate the immunological abnormalities beyond central nervous system （CNS） associated with neuromyelitis optica spectrum disorders （NMOSDs）. Methods Clinical data of 56 patients with NMOSDs from January 2010 to December 2013 enrolled in Department of Neurology at Peking University People＇s Hospital were analyzed retrospectively. All patients were divided into 2 groups： neuromyelitis optica （N = 33） and non-neuromyelitis optiea （N = 23）. Each patient underwent detailed physical examination including internal medicine and nervous system. Records of complicated autoimmune diseases as well as scoring of Expanded Disability Status Scale （EDSS） were used to evaluate disease severity. Part of patients received detection of multiple immunological indicators. Results In all patients with NMOSDs, there were 3 cases with Hashimoto thyroiditis, one case wit
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PublicationTitle 中国现代神经疾病杂志
PublicationTitleAlternate Chinese Journal of Contemporary Neurology and Neurosurgery
PublicationTitle_FL Chinese Journal of Contemporary Neurology and Neurosurgery
PublicationYear 2014
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Snippet 目的 研究视神经脊髓炎谱系疾病合并中枢神经系统以外受累脏器或组织的免疫学改变。方法 回顾分析56例视神经脊髓炎谱系疾病患者（视神经脊髓炎33例、非视神经脊髓炎23例）临...
目的 研究视神经脊髓炎谱系疾病合并中枢神经系统以外受累脏器或组织的免疫学改变.方法 回顾分析56例视神经脊髓炎谱系疾病患者(视神经脊髓炎33例、非视神经脊髓炎23例)临床...
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SubjectTerms 生物学标记
自身免疫疾病
视神经脊髓炎
Title 视神经脊髓炎谱系疾病全身表现分析及其机制探讨
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