Artificial intelligence, drug repurposing and peer review

Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?

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Bibliographic Details
Published inNature biotechnology Vol. 38; no. 10; pp. 1127 - 1131
Main Authors Levin, Jeremy M., Oprea, Tudor I., Davidovich, Sagie, Clozel, Thomas, Overington, John P., Vanhaelen, Quentin, Cantor, Charles R., Bischof, Evelyne, Zhavoronkov, Alex
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.10.2020
Nature Publishing Group
Subjects
692/308
692/700
706/648/496
Agriculture
Artificial Intelligence
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Comment
Computational Biology - trends
Computer applications
COVID-19 - drug therapy
Drug Repositioning - trends
Humans
Learning algorithms
Life Sciences
Machine learning
Medical colleges
Medical research
Medicine, Experimental
Methods
Off-label prescribing
Pandemics
Peer Review
United States
China
Online AccessGet full text
ISSN1087-0156
1546-1696
1546-1696
DOI10.1038/s41587-020-0686-x

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Abstract Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?
AbstractList Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?
Audience Academic
Author Zhavoronkov, Alex
Oprea, Tudor I.
Davidovich, Sagie
Cantor, Charles R.
Overington, John P.
Vanhaelen, Quentin
Clozel, Thomas
Levin, Jeremy M.
Bischof, Evelyne
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Cites_doi 10.1089/adt.2015.29011.tiodrrr
10.5582/bst.2020.01047
10.1101/2020.03.22.20040758
10.1101/2020.04.08.20054551
10.1093/cid/ciaa237
10.1016/j.patter.2020.100090
10.1016/S0140-6736(20)30628-0
10.1136/bmj.m689
10.1016/j.medmal.2020.03.006
10.1056/NEJMoa2019014
10.1093/bioinformatics/btz682
10.1093/bioinformatics/bty275
10.1016/j.antiviral.2020.104762
10.1136/bmj.m1849
10.1016/S1473-3099(20)30430-8
10.1056/NEJMe2020388
10.1038/s41598-020-70143-6
10.1016/S2665-9913(20)30164-8
10.1056/NEJMoa2007764
10.1038/s41422-020-0282-0
10.1021/acs.molpharmaceut.6b00248
10.1016/S0140-6736(05)79085-1
10.1503/cmaj.109-3179
10.1007/978-1-4939-9089-4_5
10.1016/S2665-9913(20)30173-9
10.1016/S2589-7500(20)30054-6
10.1002/jmv.26256
10.1093/cid/ciaa879
10.1001/jamanetworkopen.2020.8857
10.1021/acs.jproteome.0c00316
10.1039/C9SC04336E
10.1038/s41562-020-0911-0
10.1016/j.ijantimicag.2020.105949
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References A Aliper (686_CR23) 2016; 13
M Wang (686_CR4) 2020; 30
X Yao (686_CR10) 2020; 71
A Palayew (686_CR1) 2020; 4
TI Oprea (686_CR24) 2015; 13
G Guaraldi (686_CR31) 2020; 2
F Touret (686_CR6) 2020; 10
S Seo (686_CR26) 2018; 34
L Eggertson (686_CR3) 2010; 182
MGS Borba (686_CR20) 2020; 3
J Lee (686_CR22) 2020; 36
JM Molina (686_CR17) 2020; 50
J Gao (686_CR8) 2020; 14
J Chen (686_CR13) 2020; 49
P Mehta (686_CR7) 2020; 395
X Zeng (686_CR27) 2020; 11
T Huet (686_CR30) 2020; 2
686_CR5
686_CR19
F Touret (686_CR18) 2020; 177
686_CR14
686_CR32
686_CR11
686_CR33
686_CR12
686_CR34
W Tang (686_CR15) 2020; 369
M Nagendran (686_CR28) 2020; 368
R Bhatt (686_CR2) 1998; 351
HV Cook (686_CR21) 2019; 1939
B McCall (686_CR25) 2020; 2
MSN Cohen (686_CR16) 2020; 383
P Gautret (686_CR9) 2020; 56
686_CR29
References_xml – volume: 13
  start-page: 299
  year: 2015
  ident: 686_CR24
  publication-title: Assay Drug Dev. Technol.
  doi: 10.1089/adt.2015.29011.tiodrrr
– volume: 14
  start-page: 72
  year: 2020
  ident: 686_CR8
  publication-title: Biosci. Trends
  doi: 10.5582/bst.2020.01047
– ident: 686_CR14
  doi: 10.1101/2020.03.22.20040758
– ident: 686_CR19
  doi: 10.1101/2020.04.08.20054551
– volume: 71
  start-page: 732
  year: 2020
  ident: 686_CR10
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciaa237
– ident: 686_CR33
  doi: 10.1016/j.patter.2020.100090
– volume: 395
  start-page: 1033
  year: 2020
  ident: 686_CR7
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30628-0
– volume: 368
  start-page: m689
  year: 2020
  ident: 686_CR28
  publication-title: Br. Med. J.
  doi: 10.1136/bmj.m689
– volume: 50
  start-page: 384
  year: 2020
  ident: 686_CR17
  publication-title: Med. Mal. Infect.
  doi: 10.1016/j.medmal.2020.03.006
– ident: 686_CR11
  doi: 10.1056/NEJMoa2019014
– volume: 36
  start-page: 1234
  year: 2020
  ident: 686_CR22
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btz682
– volume: 34
  start-page: i254
  year: 2018
  ident: 686_CR26
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bty275
– volume: 177
  start-page: 104762
  year: 2020
  ident: 686_CR18
  publication-title: Antiviral Res.
  doi: 10.1016/j.antiviral.2020.104762
– volume: 369
  start-page: 1849
  year: 2020
  ident: 686_CR15
  publication-title: Br. Med. J.
  doi: 10.1136/bmj.m1849
– ident: 686_CR12
  doi: 10.1016/S1473-3099(20)30430-8
– volume: 383
  start-page: 585
  year: 2020
  ident: 686_CR16
  publication-title: Engl. J. Med.
  doi: 10.1056/NEJMe2020388
– volume: 10
  year: 2020
  ident: 686_CR6
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-70143-6
– volume: 2
  start-page: e393
  year: 2020
  ident: 686_CR30
  publication-title: Lancet Rheumatol.
  doi: 10.1016/S2665-9913(20)30164-8
– ident: 686_CR29
  doi: 10.1056/NEJMoa2007764
– volume: 30
  start-page: 269
  year: 2020
  ident: 686_CR4
  publication-title: Cell Res.
  doi: 10.1038/s41422-020-0282-0
– volume: 13
  start-page: 2524
  year: 2016
  ident: 686_CR23
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.6b00248
– volume: 351
  start-page: 1357
  year: 1998
  ident: 686_CR2
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)79085-1
– volume: 182
  start-page: E199
  year: 2010
  ident: 686_CR3
  publication-title: CMAJ
  doi: 10.1503/cmaj.109-3179
– volume: 1939
  start-page: 73
  year: 2019
  ident: 686_CR21
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-9089-4_5
– volume: 2
  start-page: e474
  year: 2020
  ident: 686_CR31
  publication-title: Lancet Rheumatol.
  doi: 10.1016/S2665-9913(20)30173-9
– volume: 2
  start-page: e166
  year: 2020
  ident: 686_CR25
  publication-title: Lancet Digit. Health
  doi: 10.1016/S2589-7500(20)30054-6
– ident: 686_CR5
  doi: 10.1002/jmv.26256
– ident: 686_CR32
  doi: 10.1093/cid/ciaa879
– volume: 3
  start-page: e208857
  year: 2020
  ident: 686_CR20
  publication-title: JAMA Netw. Open
  doi: 10.1001/jamanetworkopen.2020.8857
– ident: 686_CR34
  doi: 10.1021/acs.jproteome.0c00316
– volume: 11
  start-page: 1775
  year: 2020
  ident: 686_CR27
  publication-title: Chem. Sci.
  doi: 10.1039/C9SC04336E
– volume: 49
  start-page: 215
  year: 2020
  ident: 686_CR13
  publication-title: Zhejiang Da Xue Xue Bao Yi Xue Ban
– volume: 4
  start-page: 666
  year: 2020
  ident: 686_CR1
  publication-title: Nat. Hum. Behav.
  doi: 10.1038/s41562-020-0911-0
– volume: 56
  start-page: 105949
  year: 2020
  ident: 686_CR9
  publication-title: Int. J. Antimicrob. Agents
  doi: 10.1016/j.ijantimicag.2020.105949
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Agriculture
Artificial Intelligence
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Comment
Computational Biology - trends
Computer applications
COVID-19 - drug therapy
Drug Repositioning - trends
Humans
Learning algorithms
Life Sciences
Machine learning
Medical colleges
Medical research
Medicine, Experimental
Methods
Off-label prescribing
Pandemics
Peer Review
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Title Artificial intelligence, drug repurposing and peer review
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