Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here...

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Published inNature biotechnology Vol. 39; no. 3; pp. 357 - 367
Main Authors Cui, Liyang, Gouw, Arvin M., LaGory, Edward L., Guo, Shenghao, Attarwala, Nabeel, Tang, Yao, Qi, Ji, Chen, Yun-Sheng, Gao, Zhou, Casey, Kerriann M., Bazhin, Arkadiy A., Chen, Min, Hu, Leeann, Xie, Jinghang, Fang, Mingxi, Zhang, Cissy, Zhu, Qihua, Wang, Zhiyuan, Giaccia, Amato J., Gambhir, Sanjiv Sam, Zhu, Weiping, Felsher, Dean W., Pegram, Mark D., Goun, Elena A., Le, Anne, Rao, Jianghong
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.03.2021
Nature Publishing Group
Subjects
631/67/2321
631/67/2327
639/925/352/152
639/925/352/2734
Adenosine triphosphate
Agriculture
Animal models
Animals
Apoptosis
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Breast cancer
Care and treatment
Cell Death
Cell Line, Tumor
Chelating agents
Chelating Agents - metabolism
Composition
Copper
Copper - metabolism
Depletion
Disease Models, Animal
Electron transport
Female
Glycolysis
Humans
Life Sciences
Membrane potential
Mice
Mitochondria
Mitochondria - metabolism
Nanoparticles
Oxidative Phosphorylation
Oxidative stress
Oxygen consumption
Phosphorylation
Physiological aspects
Toxicity
Triple Negative Breast Neoplasms - metabolism
Triple Negative Breast Neoplasms - pathology
United States
Online AccessGet full text
ISSN1087-0156
1546-1696
1546-1696
DOI10.1038/s41587-020-0707-9

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Abstract Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here we develop a safe, mitochondria-targeted, copper-depleting nanoparticle (CDN) and test it against triple-negative breast cancer (TNBC). We show that CDNs decrease oxygen consumption and oxidative phosphorylation, cause a metabolic switch to glycolysis and reduce ATP production in TNBC cells. This energy deficiency, together with compromised mitochondrial membrane potential and elevated oxidative stress, results in apoptosis. CDNs should be less toxic than existing copper chelators because they favorably deprive copper in the mitochondria in cancer cells instead of systemic depletion. Indeed, we demonstrate low toxicity of CDNs in healthy mice. In three mouse models of TNBC, CDN administration inhibits tumor growth and substantially improves survival. The efficacy and safety of CDNs suggest the potential clinical relevance of this approach. Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.
AbstractList Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here we develop a safe, mitochondria-targeted, copper-depleting nanoparticle (CDN) and test it against triple-negative breast cancer (TNBC). We show that CDNs decrease oxygen consumption and oxidative phosphorylation, cause a metabolic switch to glycolysis and reduce ATP production in TNBC cells. This energy deficiency, together with compromised mitochondrial membrane potential and elevated oxidative stress, results in apoptosis. CDNs should be less toxic than existing copper chelators because they favorably deprive copper in the mitochondria in cancer cells instead of systemic depletion. Indeed, we demonstrate low toxicity of CDNs in healthy mice. In three mouse models of TNBC, CDN administration inhibits tumor growth and substantially improves survival. The efficacy and safety of CDNs suggest the potential clinical relevance of this approach.
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here we develop a safe, mitochondria-targeted, copper-depleting nanoparticle (CDN) and test it against triple-negative breast cancer (TNBC). We show that CDNs decrease oxygen consumption and oxidative phosphorylation, cause a metabolic switch to glycolysis and reduce ATP production in TNBC cells. This energy deficiency, together with compromised mitochondrial membrane potential and elevated oxidative stress, results in apoptosis. CDNs should be less toxic than existing copper chelators because they favorably deprive copper in the mitochondria in cancer cells instead of systemic depletion. Indeed, we demonstrate low toxicity of CDNs in healthy mice. In three mouse models of TNBC, CDN administration inhibits tumor growth and substantially improves survival. The efficacy and safety of CDNs suggest the potential clinical relevance of this approach.Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here we develop a safe, mitochondria-targeted, copper-depleting nanoparticle (CDN) and test it against triple-negative breast cancer (TNBC). We show that CDNs decrease oxygen consumption and oxidative phosphorylation, cause a metabolic switch to glycolysis and reduce ATP production in TNBC cells. This energy deficiency, together with compromised mitochondrial membrane potential and elevated oxidative stress, results in apoptosis. CDNs should be less toxic than existing copper chelators because they favorably deprive copper in the mitochondria in cancer cells instead of systemic depletion. Indeed, we demonstrate low toxicity of CDNs in healthy mice. In three mouse models of TNBC, CDN administration inhibits tumor growth and substantially improves survival. The efficacy and safety of CDNs suggest the potential clinical relevance of this approach. Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here we develop a safe, mitochondria-targeted, copper-depleting nanoparticle (CDN) and test it against triple-negative breast cancer (TNBC). We show that CDNs decrease oxygen consumption and oxidative phosphorylation, cause a metabolic switch to glycolysis and reduce ATP production in TNBC cells. This energy deficiency, together with compromised mitochondrial membrane potential and elevated oxidative stress, results in apoptosis. CDNs should be less toxic than existing copper chelators because they favorably deprive copper in the mitochondria in cancer cells instead of systemic depletion. Indeed, we demonstrate low toxicity of CDNs in healthy mice. In three mouse models of TNBC, CDN administration inhibits tumor growth and substantially improves survival. The efficacy and safety of CDNs suggest the potential clinical relevance of this approach.Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for cancer treatment. Here we develop a safe, mitochondria-targeted, copper-depleting nanoparticle (CDN) and test it against triple-negative breast cancer (TNBC). We show that CDNs decrease oxygen consumption and oxidative phosphorylation, cause a metabolic switch to glycolysis and reduce ATP production in TNBC cells. This energy deficiency, together with compromised mitochondrial membrane potential and elevated oxidative stress, results in apoptosis. CDNs should be less toxic than existing copper chelators because they favorably deprive copper in the mitochondria in cancer cells instead of systemic depletion. Indeed, we demonstrate low toxicity of CDNs in healthy mice. In three mouse models of TNBC, CDN administration inhibits tumor growth and substantially improves survival. The efficacy and safety of CDNs suggest the potential clinical relevance of this approach.
Audience Academic
Author Cui, Liyang
Rao, Jianghong
Fang, Mingxi
Bazhin, Arkadiy A.
Casey, Kerriann M.
Hu, Leeann
Zhang, Cissy
Xie, Jinghang
Wang, Zhiyuan
Zhu, Weiping
Gouw, Arvin M.
Zhu, Qihua
Qi, Ji
Gambhir, Sanjiv Sam
LaGory, Edward L.
Attarwala, Nabeel
Pegram, Mark D.
Goun, Elena A.
Felsher, Dean W.
Chen, Yun-Sheng
Le, Anne
Chen, Min
Giaccia, Amato J.
Guo, Shenghao
Gao, Zhou
Tang, Yao
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  organization: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine
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  surname: Chen
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  givenname: Zhou
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33077961$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/s41589-020-0602-1
10.1016/j.cell.2016.07.002
10.1515/bmc-2015-0030
10.1158/1078-0432.CCR-05-1167
10.1039/C5MT00149H
10.1093/toxsci/kfn092
10.1016/j.cell.2011.02.013
10.1073/pnas.1611406113
10.1073/pnas.1613628113
10.1016/j.mito.2007.02.001
10.1126/science.349.6244.128
10.1158/1078-0432.CCR-16-1326
10.1017/erm.2014.11
10.1016/j.ccell.2018.02.001
10.1038/nm.2492
10.1038/srep14296
10.1200/JCO.2017.35.15_suppl.2557
10.1158/0008-5472.CAN-05-2444
10.1038/nnano.2013.302
10.18632/oncotarget.12992
10.1002/pmic.201800451
10.1016/j.celrep.2019.03.036
10.1038/sj.bjc.6604226
10.1021/ar0200807
10.1038/nchem.2381
10.1246/cl.1999.451
10.1016/j.celrep.2016.02.004
10.1016/j.cmet.2019.04.004
10.1039/C6MT00202A
10.1007/s10637-012-9864-0
10.1038/s41467-019-10592-4
10.1016/S0169-409X(01)00125-9
10.1042/BJ20140620
10.1074/jbc.R117.000176
10.1073/pnas.1318431110
10.1074/jbc.R800055200
10.1038/nrclinonc.2016.66
10.1016/j.cmet.2019.07.012
10.1016/j.molmed.2017.02.009
10.1172/JCI108764
10.1038/s41591-018-0052-4
10.1056/NEJMra1001389
10.1038/s41551-017-0130-9
10.1038/sj.pcan.4500879
10.1038/nchembio.2098
10.1038/nrc3038
10.1016/j.cell.2013.09.025
10.1016/S0021-9258(17)34693-8
10.1074/jbc.M701056200
10.1038/nchembio.1712
10.1038/s41586-019-0993-x
10.1186/s12885-017-3230-8
10.3390/ijms18040871
10.1038/nm.4055
10.1002/cam4.112
10.1038/sj.onc.1209265
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References Ariaans, Jalving, Vries, Jong (CR32) 2017; 17
Denoyer, Masaldan, La Fontaine, Cater (CR44) 2015; 7
Turski, Thiele (CR42) 2009; 284
Grubman, White (CR46) 2014; 16
Weinberg, Chandel (CR23) 2015; 11
Duman (CR29) 2019; 30
Liu (CR26) 2006; 9
Modica-Napolitano, Aprille (CR34) 2001; 49
Molina (CR20) 2018; 24
Sahota (CR57) 2017; 35
Chan (CR56) 2017; 23
Pan (CR49) 2002; 62
Redman (CR53) 2003; 9
Krebs (CR37) 1972; 8
Koppenol, Bounds, Dang (CR7) 2011; 11
Sanchez, Gastaldi, Remedi, Cáceres, Landa (CR33) 2008; 104
Shao (CR48) 2017; 1
Heerdt, Houston, Augenlicht (CR35) 2005; 65
Blockhuys (CR10) 2017; 9
Shi (CR36) 2019; 567
Carr, Winge (CR13) 2003; 36
Nieman (CR27) 2011; 17
Bianchini, Balko, Mayer, Sanders, Gianni (CR2) 2016; 13
McGarry, Leatherman, Foster (CR39) 1978; 253
Blockhuys, Wittung-Stafshede (CR43) 2017; 18
Udupa (CR60) 2019; 19
Camarda (CR4) 2016; 22
Srirangam (CR6) 2006; 12
Chisholm (CR51) 2016; 7
Ellinghaus (CR19) 2013; 2
Heffern (CR58) 2016; 113
Pu (CR17) 2014; 9
Bazhin (CR22) 2020
Gouw (CR8) 2019; 30
Israelsen (CR30) 2013; 155
Garber (CR55) 2015; 349
Wang (CR14) 2015; 7
Ackerman, Chang (CR40) 2018; 293
Hoy, Balaban, Saunders (CR25) 2017; 23
Vyas, Zaganjor, Haigis (CR24) 2016; 166
McGarry, Mannaerts, Foster (CR38) 1977; 60
Schild, Low, Blenis, Gomes (CR28) 2018; 33
Heffern (CR18) 2016; 113
Park (CR3) 2016; 14
Krishnamoorthy (CR41) 2016; 12
Ishida, Andreux, Poitry-Yamate, Auwerx, Hanahan (CR15) 2013; 110
Yasuta, Takenaka, Takemura (CR21) 1999; 28
Kim (CR16) 2015; 5
Foulkes, Smith, Reis-Filho (CR1) 2010; 363
Nagaraja (CR9) 2006; 25
Doñate (CR50) 2008; 98
Bridges, Jones, Pollak, Hirst (CR31) 2014; 462
Elgogary (CR61) 2016; 113
Nguyen (CR59) 2019; 27
Hargreaves (CR11) 2007; 7
Hanahan, Weinberg (CR45) 2011; 144
Matson Dzebo, Ariöz, Wittung-Stafshede (CR47) 2016; 7
van Weverwijk (CR5) 2019; 10
Schneider (CR54) 2013; 31
Li (CR12) 2007; 282
Lin (CR52) 2013; 31
CM Ackerman (707_CR40) 2018; 293
S Shao (707_CR48) 2017; 1
Y Shi (707_CR36) 2019; 567
L Krishnamoorthy (707_CR41) 2016; 12
JosephineS Modica-Napolitano (707_CR34) 2001; 49
SE Weinberg (707_CR23) 2015; 11
Y Li (707_CR12) 2007; 282
Q Pan (707_CR49) 2002; 62
D Denoyer (707_CR44) 2015; 7
A Grubman (707_CR46) 2014; 16
JHH Park (707_CR3) 2016; 14
J Wang (707_CR14) 2015; 7
D Hanahan (707_CR45) 2011; 144
C Duman (707_CR29) 2019; 30
S Blockhuys (707_CR43) 2017; 18
J Lin (707_CR52) 2013; 31
N Yasuta (707_CR21) 1999; 28
S Vyas (707_CR24) 2016; 166
T Schild (707_CR28) 2018; 33
S Sahota (707_CR57) 2017; 35
A van Weverwijk (707_CR5) 2019; 10
IP Hargreaves (707_CR11) 2007; 7
WH Koppenol (707_CR7) 2011; 11
BJ Schneider (707_CR54) 2013; 31
A Srirangam (707_CR6) 2006; 12
KM Nieman (707_CR27) 2011; 17
S Blockhuys (707_CR10) 2017; 9
M Matson Dzebo (707_CR47) 2016; 7
BG Redman (707_CR53) 2003; 9
HS Carr (707_CR13) 2003; 36
BG Heerdt (707_CR35) 2005; 65
N Chan (707_CR56) 2017; 23
A Elgogary (707_CR61) 2016; 113
F Doñate (707_CR50) 2008; 98
HR Bridges (707_CR31) 2014; 462
AM Gouw (707_CR8) 2019; 30
HA Krebs (707_CR37) 1972; 8
K Garber (707_CR55) 2015; 349
JD McGarry (707_CR39) 1978; 253
R Camarda (707_CR4) 2016; 22
MC Heffern (707_CR58) 2016; 113
GM Nagaraja (707_CR9) 2006; 25
K Pu (707_CR17) 2014; 9
T Nguyen (707_CR59) 2019; 27
G Bianchini (707_CR2) 2016; 13
S Ishida (707_CR15) 2013; 110
AJ Hoy (707_CR25) 2017; 23
ML Turski (707_CR42) 2009; 284
KK Kim (707_CR16) 2015; 5
Y Liu (707_CR26) 2006; 9
JR Molina (707_CR20) 2018; 24
CL Chisholm (707_CR51) 2016; 7
P Ellinghaus (707_CR19) 2013; 2
WD Foulkes (707_CR1) 2010; 363
G Ariaans (707_CR32) 2017; 17
JD McGarry (707_CR38) 1977; 60
MC Heffern (707_CR18) 2016; 113
WJ Israelsen (707_CR30) 2013; 155
M Sanchez (707_CR33) 2008; 104
AA Bazhin (707_CR22) 2020
S Udupa (707_CR60) 2019; 19
References_xml – volume: 11
  start-page: 325
  year: 2011
  end-page: 337
  ident: CR7
  article-title: Otto Warburg’s contributions to current concepts of cancer metabolism
  publication-title: Nat. Rev. Cancer
– volume: 567
  start-page: 341
  year: 2019
  end-page: 346
  ident: CR36
  article-title: Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma
  publication-title: Nature
– volume: 7
  start-page: 29
  year: 2016
  end-page: 39
  ident: CR47
  article-title: Extended functional repertoire for human copper chaperones
  publication-title: Biomol. Concepts
– volume: 12
  start-page: 1883
  year: 2006
  end-page: 1896
  ident: CR6
  article-title: Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer
  publication-title: Clin. Cancer Res.
– volume: 10
  year: 2019
  ident: CR5
  article-title: Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
  publication-title: Nat. Commun.
– volume: 30
  start-page: 274
  year: 2019
  end-page: 289
  ident: CR29
  article-title: Acyl-CoA-binding protein drives glioblastoma tumorigenesis by sustaining fatty acid oxidation
  publication-title: Cell Metab.
– volume: 144
  start-page: 646
  year: 2011
  end-page: 674
  ident: CR45
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
– volume: 23
  start-page: 381
  year: 2017
  end-page: 392
  ident: CR25
  article-title: Adipocyte–tumor cell metabolic crosstalk in breast cancer
  publication-title: Trends Mol. Med.
– volume: 8
  start-page: 1
  year: 1972
  end-page: 34
  ident: CR37
  article-title: The Pasteur effect and the relations between respiration and fermentation
  publication-title: Essays Biochem.
– volume: 104
  start-page: 352
  year: 2008
  end-page: 361
  ident: CR33
  article-title: Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons
  publication-title: Toxicol. Sci.
– volume: 31
  start-page: 581
  year: 2013
  end-page: 588
  ident: CR52
  article-title: A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naïve prostate cancer
  publication-title: Urol. Oncol. Semin. Orig. Investig.
– volume: 31
  start-page: 435
  year: 2013
  end-page: 442
  ident: CR54
  article-title: Pre-operative chemoradiation followed by post-operative adjuvant therapy with tetrathiomolybdate, a novel copper chelator, for patients with resectable esophageal cancer
  publication-title: Invest. New Drugs
– volume: 27
  start-page: 491
  year: 2019
  end-page: 501
  ident: CR59
  article-title: Uncovering the role of N-acetyl-aspartyl-glutamate as a glutamate reservoir in cancer
  publication-title: Cell Reports
– volume: 9
  start-page: 230
  year: 2006
  end-page: 234
  ident: CR26
  article-title: Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
  publication-title: Prostate Cancer Prostatic Dis.
– volume: 24
  start-page: 1036
  year: 2018
  end-page: 1046
  ident: CR20
  article-title: An inhibitor of oxidative phosphorylation exploits cancer vulnerability
  publication-title: Nat. Med.
– volume: 13
  start-page: 674
  year: 2016
  end-page: 690
  ident: CR2
  article-title: Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
  publication-title: Nat. Rev. Clin. Oncol.
– volume: 293
  start-page: 4628
  year: 2018
  end-page: 4635
  ident: CR40
  article-title: Copper signaling in the brain and beyond
  publication-title: J. Biol. Chem.
– volume: 363
  start-page: 1938
  year: 2010
  end-page: 1948
  ident: CR1
  article-title: Triple-negative breast cancer
  publication-title: N. Engl. J. Med.
– volume: 349
  start-page: 128
  year: 2015
  end-page: 129
  ident: CR55
  article-title: Targeting copper to treat breast cancer
  publication-title: Science
– volume: 9
  start-page: 1666
  year: 2003
  end-page: 1672
  ident: CR53
  article-title: Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
  publication-title: Clin. Cancer Res.
– volume: 30
  start-page: 556
  year: 2019
  end-page: 572
  ident: CR8
  article-title: The MYC oncogene cooperates with sterol-regulated element-binding protein to regulate lipogenesis essential for neoplastic growth
  publication-title: Cell Metab.
– volume: 18
  start-page: 871
  year: 2017
  ident: CR43
  article-title: Roles of copper-binding proteins in breast cancer
  publication-title: Int. J. Mol. Sci.
– volume: 253
  start-page: 4128
  year: 1978
  end-page: 4136
  ident: CR39
  article-title: Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA
  publication-title: J. Biol. Chem.
– volume: 28
  start-page: 451
  year: 1999
  end-page: 452
  ident: CR21
  article-title: Mechanism of photosensitized chemiluminescence of 2-methyl-6-phenylimidazo[1,2-a]pyrazin-3(7 H)-one (CLA) in aqueous solution
  publication-title: Chem. Lett.
– volume: 11
  start-page: 9
  year: 2015
  end-page: 15
  ident: CR23
  article-title: Targeting mitochondria metabolism for cancer therapy
  publication-title: Nat. Chem. Biol.
– volume: 33
  start-page: 347
  year: 2018
  end-page: 354
  ident: CR28
  article-title: Unique metabolic adaptations dictate distal organ-specific metastatic colonization
  publication-title: Cancer Cell
– volume: 1
  start-page: 745
  year: 2017
  end-page: 757
  ident: CR48
  article-title: A non-cytotoxic dendrimer with innate and potent anticancer and anti-metastatic activities
  publication-title: Nat. Biomed. Eng.
– year: 2020
  ident: CR22
  article-title: A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-020-0602-1
– volume: 12
  start-page: 586
  year: 2016
  end-page: 592
  ident: CR41
  article-title: Copper regulates cyclic-AMP-dependent lipolysis
  publication-title: Nat. Chem. Biol.
– volume: 60
  start-page: 265
  year: 1977
  end-page: 270
  ident: CR38
  article-title: A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
  publication-title: J. Clin. Invest.
– volume: 462
  start-page: 475
  year: 2014
  end-page: 487
  ident: CR31
  article-title: Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
  publication-title: Biochem. J.
– volume: 65
  start-page: 9861
  year: 2005
  end-page: 9867
  ident: CR35
  article-title: The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression
  publication-title: Cancer Res.
– volume: 23
  start-page: 666
  year: 2017
  end-page: 676
  ident: CR56
  article-title: Influencing the tumor microenvironment: a phase II study of copper depletion using tetrathiomolybdate in patients with breast cancer at high risk for recurrence and in preclinical models of lung metastases
  publication-title: Clin. Cancer Res.
– volume: 113
  start-page: E5328
  year: 2016
  end-page: E5336
  ident: CR61
  article-title: Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 9
  start-page: 112
  year: 2017
  end-page: 123
  ident: CR10
  article-title: Defining the human copper proteome and analysis of its expression variation in cancers
  publication-title: Metallomics
– volume: 16
  start-page: e11
  year: 2014
  ident: CR46
  article-title: Copper as a key regulator of cell signalling pathways
  publication-title: Expert Rev. Mol. Med.
– volume: 25
  start-page: 2328
  year: 2006
  end-page: 2338
  ident: CR9
  article-title: Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics
  publication-title: Oncogene
– volume: 19
  start-page: 1800451
  year: 2019
  ident: CR60
  article-title: Upregulation of the glutaminase II pathway contributes to glutamate production upon glutaminase 1 inhibition in pancreatic cancer
  publication-title: Proteomics
– volume: 282
  start-page: 17557
  year: 2007
  end-page: 17562
  ident: CR12
  article-title: An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria
  publication-title: J. Biol. Chem.
– volume: 7
  start-page: 968
  year: 2015
  end-page: 979
  ident: CR14
  article-title: Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation
  publication-title: Nat. Chem.
– volume: 17
  start-page: 1498
  year: 2011
  end-page: 1503
  ident: CR27
  article-title: Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
  publication-title: Nat. Med.
– volume: 14
  start-page: 2154
  year: 2016
  end-page: 2165
  ident: CR3
  article-title: Fatty acid oxidation-driven Src links mitochondrial energy reprogramming and oncogenic properties in triple-negative breast cancer
  publication-title: Cell Rep.
– volume: 7
  start-page: 1459
  year: 2015
  end-page: 1476
  ident: CR44
  article-title: Targeting copper in cancer therapy: ‘Copper That Cancer’
  publication-title: Metallomics
– volume: 5
  start-page: 14296
  year: 2015
  ident: CR16
  article-title: Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells
  publication-title: Sci. Rep.
– volume: 284
  start-page: 717
  year: 2009
  end-page: 721
  ident: CR42
  article-title: New roles for copper metabolism in cell proliferation, signaling, and disease
  publication-title: J. Biol. Chem.
– volume: 49
  start-page: 63
  year: 2001
  end-page: 70
  ident: CR34
  article-title: Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
  publication-title: Adv. Drug Deliv. Rev.
– volume: 7
  start-page: 84439
  year: 2016
  end-page: 84452
  ident: CR51
  article-title: Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin
  publication-title: Oncotarget
– volume: 35
  start-page: 2557
  year: 2017
  end-page: 2557
  ident: CR57
  article-title: A phase II study of copper-depletion using tetrathiomolybdate (TM) in patients (pts) with breast cancer (BC) at high risk for recurrence: updated results
  publication-title: J. Clin. Oncol.
– volume: 17
  year: 2017
  ident: CR32
  article-title: Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells
  publication-title: BMC Cancer
– volume: 7
  start-page: 284
  year: 2007
  end-page: 287
  ident: CR11
  article-title: Inhibition of mitochondrial complex IV leads to secondary loss complex II–III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies
  publication-title: Mitochondrion
– volume: 36
  start-page: 309
  year: 2003
  end-page: 316
  ident: CR13
  article-title: Assembly of cytochrome oxidase within the mitochondrion
  publication-title: Acc. Chem. Res.
– volume: 62
  start-page: 4854
  year: 2002
  end-page: 4859
  ident: CR49
  article-title: Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
  publication-title: Cancer Res.
– volume: 166
  start-page: 555
  year: 2016
  end-page: 566
  ident: CR24
  article-title: Mitochondria and cancer
  publication-title: Cell
– volume: 110
  start-page: 19507
  year: 2013
  end-page: 19512
  ident: CR15
  article-title: Bioavailable copper modulates oxidative phosphorylation and growth of tumors
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 113
  start-page: 14219
  year: 2016
  end-page: 14224
  ident: CR18
  article-title: In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 2
  start-page: 611
  year: 2013
  end-page: 624
  ident: CR19
  article-title: BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I
  publication-title: Cancer Med.
– volume: 113
  start-page: 14219
  year: 2016
  end-page: 14224
  ident: CR58
  article-title: In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 155
  start-page: 397
  year: 2013
  end-page: 409
  ident: CR30
  article-title: PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
  publication-title: Cell
– volume: 98
  start-page: 776
  year: 2008
  end-page: 783
  ident: CR50
  article-title: Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)
  publication-title: Br. J. Cancer
– volume: 22
  start-page: 427
  year: 2016
  end-page: 432
  ident: CR4
  article-title: Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
  publication-title: Nat. Med.
– volume: 9
  start-page: 233
  year: 2014
  end-page: 239
  ident: CR17
  article-title: Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice
  publication-title: Nat. Nanotechnol.
– volume: 166
  start-page: 555
  year: 2016
  ident: 707_CR24
  publication-title: Cell
  doi: 10.1016/j.cell.2016.07.002
– volume: 7
  start-page: 29
  year: 2016
  ident: 707_CR47
  publication-title: Biomol. Concepts
  doi: 10.1515/bmc-2015-0030
– volume: 12
  start-page: 1883
  year: 2006
  ident: 707_CR6
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-05-1167
– volume: 7
  start-page: 1459
  year: 2015
  ident: 707_CR44
  publication-title: Metallomics
  doi: 10.1039/C5MT00149H
– volume: 104
  start-page: 352
  year: 2008
  ident: 707_CR33
  publication-title: Toxicol. Sci.
  doi: 10.1093/toxsci/kfn092
– volume: 144
  start-page: 646
  year: 2011
  ident: 707_CR45
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 113
  start-page: E5328
  year: 2016
  ident: 707_CR61
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1611406113
– volume: 113
  start-page: 14219
  year: 2016
  ident: 707_CR18
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1613628113
– volume: 7
  start-page: 284
  year: 2007
  ident: 707_CR11
  publication-title: Mitochondrion
  doi: 10.1016/j.mito.2007.02.001
– volume: 349
  start-page: 128
  year: 2015
  ident: 707_CR55
  publication-title: Science
  doi: 10.1126/science.349.6244.128
– volume: 23
  start-page: 666
  year: 2017
  ident: 707_CR56
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-1326
– volume: 16
  start-page: e11
  year: 2014
  ident: 707_CR46
  publication-title: Expert Rev. Mol. Med.
  doi: 10.1017/erm.2014.11
– volume: 62
  start-page: 4854
  year: 2002
  ident: 707_CR49
  publication-title: Cancer Res.
– year: 2020
  ident: 707_CR22
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-020-0602-1
– volume: 33
  start-page: 347
  year: 2018
  ident: 707_CR28
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2018.02.001
– volume: 17
  start-page: 1498
  year: 2011
  ident: 707_CR27
  publication-title: Nat. Med.
  doi: 10.1038/nm.2492
– volume: 5
  start-page: 14296
  year: 2015
  ident: 707_CR16
  publication-title: Sci. Rep.
  doi: 10.1038/srep14296
– volume: 35
  start-page: 2557
  year: 2017
  ident: 707_CR57
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.35.15_suppl.2557
– volume: 65
  start-page: 9861
  year: 2005
  ident: 707_CR35
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-2444
– volume: 9
  start-page: 233
  year: 2014
  ident: 707_CR17
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2013.302
– volume: 7
  start-page: 84439
  year: 2016
  ident: 707_CR51
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12992
– volume: 19
  start-page: 1800451
  year: 2019
  ident: 707_CR60
  publication-title: Proteomics
  doi: 10.1002/pmic.201800451
– volume: 27
  start-page: 491
  year: 2019
  ident: 707_CR59
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2019.03.036
– volume: 98
  start-page: 776
  year: 2008
  ident: 707_CR50
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6604226
– volume: 36
  start-page: 309
  year: 2003
  ident: 707_CR13
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar0200807
– volume: 7
  start-page: 968
  year: 2015
  ident: 707_CR14
  publication-title: Nat. Chem.
  doi: 10.1038/nchem.2381
– volume: 28
  start-page: 451
  year: 1999
  ident: 707_CR21
  publication-title: Chem. Lett.
  doi: 10.1246/cl.1999.451
– volume: 14
  start-page: 2154
  year: 2016
  ident: 707_CR3
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.02.004
– volume: 30
  start-page: 274
  year: 2019
  ident: 707_CR29
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2019.04.004
– volume: 31
  start-page: 581
  year: 2013
  ident: 707_CR52
  publication-title: Urol. Oncol. Semin. Orig. Investig.
– volume: 9
  start-page: 112
  year: 2017
  ident: 707_CR10
  publication-title: Metallomics
  doi: 10.1039/C6MT00202A
– volume: 9
  start-page: 1666
  year: 2003
  ident: 707_CR53
  publication-title: Clin. Cancer Res.
– volume: 31
  start-page: 435
  year: 2013
  ident: 707_CR54
  publication-title: Invest. New Drugs
  doi: 10.1007/s10637-012-9864-0
– volume: 10
  year: 2019
  ident: 707_CR5
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10592-4
– volume: 49
  start-page: 63
  year: 2001
  ident: 707_CR34
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(01)00125-9
– volume: 462
  start-page: 475
  year: 2014
  ident: 707_CR31
  publication-title: Biochem. J.
  doi: 10.1042/BJ20140620
– volume: 293
  start-page: 4628
  year: 2018
  ident: 707_CR40
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R117.000176
– volume: 8
  start-page: 1
  year: 1972
  ident: 707_CR37
  publication-title: Essays Biochem.
– volume: 110
  start-page: 19507
  year: 2013
  ident: 707_CR15
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1318431110
– volume: 284
  start-page: 717
  year: 2009
  ident: 707_CR42
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R800055200
– volume: 13
  start-page: 674
  year: 2016
  ident: 707_CR2
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2016.66
– volume: 30
  start-page: 556
  year: 2019
  ident: 707_CR8
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2019.07.012
– volume: 23
  start-page: 381
  year: 2017
  ident: 707_CR25
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2017.02.009
– volume: 60
  start-page: 265
  year: 1977
  ident: 707_CR38
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI108764
– volume: 24
  start-page: 1036
  year: 2018
  ident: 707_CR20
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0052-4
– volume: 363
  start-page: 1938
  year: 2010
  ident: 707_CR1
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra1001389
– volume: 1
  start-page: 745
  year: 2017
  ident: 707_CR48
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-017-0130-9
– volume: 9
  start-page: 230
  year: 2006
  ident: 707_CR26
  publication-title: Prostate Cancer Prostatic Dis.
  doi: 10.1038/sj.pcan.4500879
– volume: 12
  start-page: 586
  year: 2016
  ident: 707_CR41
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2098
– volume: 11
  start-page: 325
  year: 2011
  ident: 707_CR7
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3038
– volume: 155
  start-page: 397
  year: 2013
  ident: 707_CR30
  publication-title: Cell
  doi: 10.1016/j.cell.2013.09.025
– volume: 253
  start-page: 4128
  year: 1978
  ident: 707_CR39
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)34693-8
– volume: 282
  start-page: 17557
  year: 2007
  ident: 707_CR12
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M701056200
– volume: 11
  start-page: 9
  year: 2015
  ident: 707_CR23
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1712
– volume: 567
  start-page: 341
  year: 2019
  ident: 707_CR36
  publication-title: Nature
  doi: 10.1038/s41586-019-0993-x
– volume: 17
  year: 2017
  ident: 707_CR32
  publication-title: BMC Cancer
  doi: 10.1186/s12885-017-3230-8
– volume: 18
  start-page: 871
  year: 2017
  ident: 707_CR43
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18040871
– volume: 22
  start-page: 427
  year: 2016
  ident: 707_CR4
  publication-title: Nat. Med.
  doi: 10.1038/nm.4055
– volume: 2
  start-page: 611
  year: 2013
  ident: 707_CR19
  publication-title: Cancer Med.
  doi: 10.1002/cam4.112
– volume: 113
  start-page: 14219
  year: 2016
  ident: 707_CR58
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1613628113
– volume: 25
  start-page: 2328
  year: 2006
  ident: 707_CR9
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209265
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Snippet Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against...
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SubjectTerms 631/67/2321
631/67/2327
639/925/352/152
639/925/352/2734
Adenosine triphosphate
Agriculture
Animal models
Animals
Apoptosis
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Breast cancer
Care and treatment
Cell Death
Cell Line, Tumor
Chelating agents
Chelating Agents - metabolism
Composition
Copper
Copper - metabolism
Depletion
Disease Models, Animal
Electron transport
Female
Glycolysis
Humans
Life Sciences
Membrane potential
Mice
Mitochondria
Mitochondria - metabolism
Nanoparticles
Oxidative Phosphorylation
Oxidative stress
Oxygen consumption
Phosphorylation
Physiological aspects
Toxicity
Triple Negative Breast Neoplasms - metabolism
Triple Negative Breast Neoplasms - pathology
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Title Mitochondrial copper depletion suppresses triple-negative breast cancer in mice
URI https://link.springer.com/article/10.1038/s41587-020-0707-9
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