肌少症、骨质疏松症的关系及研究进展
随着人均寿命的延长,与肌肉骨骼系统相关疾病的发病率随之增长,国内外学者对肌少症、骨质疏松症的关注度也越来越高。肌少症是指与增龄相关的进行性、全身肌量减少和/或肌强度下降或肌肉生理功能减退。骨质疏松症是以骨量减少、骨组织显微结构退化为特征,以至骨的脆性增高及骨折危险性增加的一种全身性骨病。肌少症、骨质疏松症是危害老年人健康的病理状态,使得老年人的生活质量大打折扣,患有肌少症的人群免疫功能、日常生活能力较常人降低,感染风险、跌倒风险、致残率、死亡风险较常人增加,患有骨质疏松症的人群跌倒风险、骨折风险、致残率也较常人高很多。肌少症与骨质疏松症相互影响、紧密关联的机制比较复杂,包括肌肉收缩力学负荷对骨...
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| Published in | 中国骨质疏松杂志 Vol. 23; no. 8; pp. 1112 - 1116 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
南京医科大学附属苏州医院,江苏苏州,215000
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-7108 |
| DOI | 10.3969/j.issn.1006-7108.2017.08.028 |
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| Abstract | 随着人均寿命的延长,与肌肉骨骼系统相关疾病的发病率随之增长,国内外学者对肌少症、骨质疏松症的关注度也越来越高。肌少症是指与增龄相关的进行性、全身肌量减少和/或肌强度下降或肌肉生理功能减退。骨质疏松症是以骨量减少、骨组织显微结构退化为特征,以至骨的脆性增高及骨折危险性增加的一种全身性骨病。肌少症、骨质疏松症是危害老年人健康的病理状态,使得老年人的生活质量大打折扣,患有肌少症的人群免疫功能、日常生活能力较常人降低,感染风险、跌倒风险、致残率、死亡风险较常人增加,患有骨质疏松症的人群跌倒风险、骨折风险、致残率也较常人高很多。肌少症与骨质疏松症相互影响、紧密关联的机制比较复杂,包括肌肉收缩力学负荷对骨骼机械力的影响,以及肌肉与骨骼间复杂精密内分泌调控的生物学机制。针对两者之间存在的许多共同危险因素及发病机制,进行运动干预、营养指导、药物治疗,有助于延缓肌少症、骨质疏松症的进展,改善不良预后。本文将结合国内外研究对两者概念、发病机制、临床表现、评估标准、干预及治疗等之间的相关关系及研究进展进行一一综述。 |
|---|---|
| AbstractList | 随着人均寿命的延长,与肌肉骨骼系统相关疾病的发病率随之增长,国内外学者对肌少症、骨质疏松症的关注度也越来越高。肌少症是指与增龄相关的进行性、全身肌量减少和/或肌强度下降或肌肉生理功能减退。骨质疏松症是以骨量减少、骨组织显微结构退化为特征,以至骨的脆性增高及骨折危险性增加的一种全身性骨病。肌少症、骨质疏松症是危害老年人健康的病理状态,使得老年人的生活质量大打折扣,患有肌少症的人群免疫功能、日常生活能力较常人降低,感染风险、跌倒风险、致残率、死亡风险较常人增加,患有骨质疏松症的人群跌倒风险、骨折风险、致残率也较常人高很多。肌少症与骨质疏松症相互影响、紧密关联的机制比较复杂,包括肌肉收缩力学负荷对骨骼机械力的影响,以及肌肉与骨骼间复杂精密内分泌调控的生物学机制。针对两者之间存在的许多共同危险因素及发病机制,进行运动干预、营养指导、药物治疗,有助于延缓肌少症、骨质疏松症的进展,改善不良预后。本文将结合国内外研究对两者概念、发病机制、临床表现、评估标准、干预及治疗等之间的相关关系及研究进展进行一一综述。 R592; 随着人均寿命的延长,与肌肉骨骼系统相关疾病的发病率随之增长,国内外学者对肌少症、骨质疏松症的关注度也越来越高.肌少症是指与增龄相关的进行性、全身肌量减少和/或肌强度下降或肌肉生理功能减退.骨质疏松症是以骨量减少、骨组织显微结构退化为特征,以至骨的脆性增高及骨折危险性增加的一种全身性骨病.肌少症、骨质疏松症是危害老年人健康的病理状态,使得老年人的生活质量大打折扣,患有肌少症的人群免疫功能、日常生活能力较常人降低,感染风险、跌倒风险、致残率、死亡风险较常人增加,患有骨质疏松症的人群跌倒风险、骨折风险、致残率也较常人高很多.肌少症与骨质疏松症相互影响、紧密关联的机制比较复杂,包括肌肉收缩力学负荷对骨骼机械力的影响,以及肌肉与骨骼间复杂精密内分泌调控的生物学机制.针对两者之间存在的许多共同危险因素及发病机制,进行运动干预、营养指导、药物治疗,有助于延缓肌少症、骨质疏松症的进展,改善不良预后.本文将结合国内外研究对两者概念、发病机制、临床表现、评估标准、干预及治疗等之间的相关关系及研究进展进行一一综述. |
| Abstract_FL | With the increase in life expectancy,the number of patients with musculoskeletal system diseases is growing.At the same time,more and more domestic and overseas scholars focused on the research of sarcopenia and osteoporosis.Sarcopenia is defined as the decrease of muscle mass and muscle strength or muscle function with aging.Osteoporosis is characterized by a decrease in bone mass as well as a deterioration of the bone architectureresult ing in an increased risk of fracture.Sarcopenia and osteoporosis are pathological conditions that endanger the health of the elderly and significantly reduce their quality of life.People suffer from sarcopenia have worse immune function and activity of daily living,and have higher risk of infection,falls,disability and death than healthy people.People with osteoporosis also have higher risk of falls,fracture and disability.Sarcopenia and osteoporosis are closely related and interact with each other,but the mechanism is quite complex.It includes the effects of mechanical load produced by muscle contraction on skeletal mechanical force,and the biological mechanism of complex and precise endocrine regulation between muscle and bone.There are many common risk factors and pathogenesis for sarcopenia and osteoporosis.If we can interpose in advance by exercise intervention,nutritional instruction,and drug therapy for them,the disease progression could be delayed and the prognosis could be improved.This paper reviews the relationships between the two diseases and the research progress by summarizing both domestic and foreign research on the concept,pathogenesis,clinical manifestation,evaluation criteria,intervention and treatment. |
| Author | 杨丽君 吴永华 张俐 |
| AuthorAffiliation | 南京医科大学附属苏州医院,江苏苏州215000 |
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| Author_FL | ZHANG Li WU Yonghua YANG Lijun |
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| Notes | With the increase in life expectancy,the number of patients with musculoskeletal system diseases is growing. At the same time,more and more domestic and overseas scholars focused on the research of sarcopenia and osteoporosis. Sarcopenia is defined as the decrease of muscle mass and muscle strength or muscle function with aging. Osteoporosis is characterized by a decrease in bone mass as well as a deterioration of the bone architectureresult ing in an increased risk of fracture. Sarcopenia and osteoporosis are pathological conditions that endanger the health of the elderly and significantly reduce their quality of life. People suffer from sarcopenia have worse immune function and activity of daily living,and have higher risk of infection,falls,disability and death than healthy people. People with osteoporosis also have higher risk of falls,fracture and disability. Sarcopenia and osteoporosis are closely related and interact with each other,but the mechanism is quite complex. It includes the effects of mechani |
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| Title | 肌少症、骨质疏松症的关系及研究进展 |
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