Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans
Background: Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans. Objective: To examine the impact of BAT on glucose metabolism, independent of that of body...
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| Published in | International Journal of Obesity Vol. 38; no. 6; pp. 812 - 817 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.06.2014
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0307-0565 1476-5497 1476-5497 |
| DOI | 10.1038/ijo.2013.206 |
Cover
| Abstract | Background:
Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans.
Objective:
To examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans.
Methods:
Two hundred and sixty healthy volunteers (184 males and 76 females, 20–72 years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein-cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models.
Results:
Cold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c.
Conclusion:
BAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans. |
|---|---|
| AbstractList | Background:
Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans.
Objective:
To examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans.
Methods:
Two hundred and sixty healthy volunteers (184 males and 76 females, 20–72 years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein-cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models.
Results:
Cold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c.
Conclusion:
BAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans. BACKGROUND: Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans. OBJECTIVE: To examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans. METHODS: Two hundred and sixty healthy volunteers (184 males and 76 females, 20-72 years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein- cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models. RESULTS: Cold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c. CONCLUSION: BAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans. International Journal of Obesity (2014) 38, 812-817;doi:10.1038/ijo.2013.206 Keywords: brown adipose tissue; humans; body fatness; glucose metabolism Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans. To examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans. Two hundred and sixty healthy volunteers (184 males and 76 females, 20-72years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein-cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models. Cold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c. BAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans. Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans. To examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans. Two hundred and sixty healthy volunteers (184 males and 76 females, 20-72 years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein-cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models. Cold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c. BAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans. International Journal of Obesity (2014) 38, 812-817;doi:10.1038/ijo.2013.206 Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans.BACKGROUNDBrown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans.To examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans.OBJECTIVETo examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans.Two hundred and sixty healthy volunteers (184 males and 76 females, 20-72 years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein-cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models.METHODSTwo hundred and sixty healthy volunteers (184 males and 76 females, 20-72 years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein-cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models.Cold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c.RESULTSCold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c.BAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans.CONCLUSIONBAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans. Background:Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association between BAT and blood glucose in humans.Objective:To examine the impact of BAT on glucose metabolism, independent of that of body fatness, age and sex in healthy adult humans.Methods:Two hundred and sixty healthy volunteers (184 males and 76 females, 20–72 years old) underwent fluorodeoxyglucose-positron emission tomography and computed tomography after 2 h of cold exposure to assess maximal BAT activity. Blood parameters including glucose, HbA1c and low-density lipoprotein (LDL)/high-density lipoprotein-cholesterol were measured by conventional methods, and body fatness was estimated from body mass index (BMI), body fat mass and abdominal fat area. The impact of BAT on body fatness and blood parameters was determined by logistic regression with the use of univariate and multivariate models.Results:Cold-activated BAT was detected in 125 (48%) out of 260 subjects. When compared with subjects without detectable BAT, those with detectable BAT were younger and showed lower adiposity-related parameters such as the BMI, body fat mass and abdominal fat area. Although blood parameters were within the normal range in the two subject groups, HbA1c, total cholesterol and LDL-cholesterol were significantly lower in the BAT-positive group. Blood glucose also tended to be lower in the BAT-positive group. Logistic regression demonstrated that BAT, in addition to age and sex, was independently associated with BMI, body fat mass, and abdominal visceral and subcutaneous fat areas. For blood parameters, multivariate analysis after adjustment for age, sex and body fatness revealed that BAT was a significantly independent determinant of glucose and HbA1c.Conclusion:BAT, independent of age, sex and body fatness, has a significant impact on glucose metabolism in adult healthy humans. |
| Audience | Academic |
| Author | Sugie, H Matsushita, M Saito, M Aita, S Yoneshiro, T Kameya, T |
| Author_xml | – sequence: 1 givenname: M surname: Matsushita fullname: Matsushita, M organization: Department of Nutrition, School of Nursing and Nutrition, Tenshi College – sequence: 2 givenname: T surname: Yoneshiro fullname: Yoneshiro, T organization: Department of Anatomy, Laboratory of Histology and Cytology, Hokkaido University Graduate School of Medicine – sequence: 3 givenname: S surname: Aita fullname: Aita, S organization: Department of Food and Nutrition, Hakodate Junior College – sequence: 4 givenname: T surname: Kameya fullname: Kameya, T organization: LSI Sapporo Clinic – sequence: 5 givenname: H surname: Sugie fullname: Sugie, H organization: LSI Sapporo Clinic – sequence: 6 givenname: M surname: Saito fullname: Saito, M email: saito@tenshi.ac.jp organization: Department of Nutrition, School of Nursing and Nutrition, Tenshi College |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28483218$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24213309$$D View this record in MEDLINE/PubMed |
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Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an... Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an association... BACKGROUND: Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an... International Journal of Obesity (2014) 38, 812-817;doi:10.1038/ijo.2013.206 Background:Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. Some clinical studies have reported an... |
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| SubjectTerms | 631/443/319 692/699/317 Abdomen Adipose tissue Adipose tissue (brown) Adipose Tissue - metabolism Adipose Tissue, Brown - diagnostic imaging Adipose Tissue, Brown - metabolism Adipose Tissue, Brown - physiology Adipose tissues Adiposity - physiology Adult Age Aged Bioenergetics Biological and medical sciences Biological control systems Blood Body Composition Body fat Body mass index Body size Cholesterol Cold Cold Temperature Community colleges Computed tomography Density Emissions Energy expenditure Energy metabolism Energy Metabolism - physiology Epidemiology Female Fluorodeoxyglucose F18 Glucose Glucose - metabolism Glycated Hemoglobin A - metabolism Health Promotion and Disease Prevention High density lipoprotein Humans Internal Medicine Low density lipoprotein Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Middle Aged Multivariate analysis Nursing schools Nutrition Obesity original-article Parameters Physiological aspects Physiological research Positron emission Positron emission tomography Public Health Radiopharmaceuticals Regression analysis Sex Tomography Tomography, X-Ray Computed Weights & measures |
| Title | Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans |
| URI | https://link.springer.com/article/10.1038/ijo.2013.206 https://www.ncbi.nlm.nih.gov/pubmed/24213309 https://www.proquest.com/docview/1534303424 https://www.proquest.com/docview/2639127440 https://www.proquest.com/docview/1534796302 |
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