MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression
MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water–s...
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| Published in | Biochemical and biophysical research communications Vol. 391; no. 1; pp. 727 - 732 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2010
Academic Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-291X 1090-2104 1090-2104 |
| DOI | 10.1016/j.bbrc.2009.11.128 |
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| Abstract | MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water–salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs. A luciferase assay demonstrated that miR-124 and miR-135a suppress NR3C2 3′UTR reporter construct activity 1.5- and 2.2-fold, respectively. As the tested miRNAs did not reduce the levels of target mRNA, we suggest that the binding of miR-124 and miR-135a to NR3C2 3′UTR contributes to the translational, not transcriptional regulation of the gene. Co-expression of two different miRNAs did not increase the repression of the reporter gene, indicating no additive or synergistic effects between the tested miRNAs.
Our results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2, miR-124 and miR-135a could participate in the regulation of renin–angiotensin–aldosterone system and thereby might be involved in blood pressure regulation. |
|---|---|
| AbstractList | MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water-salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs. A luciferase assay demonstrated that miR-124 and miR-135a suppress NR3C2 3a super(2)UTR reporter construct activity 1.5- and 2.2-fold, respectively. As the tested miRNAs did not reduce the levels of target mRNA, we suggest that the binding of miR-124 and miR-135a to NR3C2 3a super(2)UTR contributes to the translational, not transcriptional regulation of the gene. Co-expression of two different miRNAs did not increase the repression of the reporter gene, indicating no additive or synergistic effects between the tested miRNAs. Our results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2, miR-124 and miR-135a could participate in the regulation of renin-angiotensin-aldosterone system and thereby might be involved in blood pressure regulation. MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water-salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs. A luciferase assay demonstrated that miR-124 and miR-135a suppress NR3C2 3'UTR reporter construct activity 1.5- and 2.2-fold, respectively. As the tested miRNAs did not reduce the levels of target mRNA, we suggest that the binding of miR-124 and miR-135a to NR3C2 3'UTR contributes to the translational, not transcriptional regulation of the gene. Co-expression of two different miRNAs did not increase the repression of the reporter gene, indicating no additive or synergistic effects between the tested miRNAs. Our results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2, miR-124 and miR-135a could participate in the regulation of renin-angiotensin-aldosterone system and thereby might be involved in blood pressure regulation. MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water-salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs. A luciferase assay demonstrated that miR-124 and miR-135a suppress NR3C2 3'UTR reporter construct activity 1.5- and 2.2-fold, respectively. As the tested miRNAs did not reduce the levels of target mRNA, we suggest that the binding of miR-124 and miR-135a to NR3C2 3'UTR contributes to the translational, not transcriptional regulation of the gene. Co-expression of two different miRNAs did not increase the repression of the reporter gene, indicating no additive or synergistic effects between the tested miRNAs. Our results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2, miR-124 and miR-135a could participate in the regulation of renin-angiotensin-aldosterone system and thereby might be involved in blood pressure regulation.MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water-salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs. A luciferase assay demonstrated that miR-124 and miR-135a suppress NR3C2 3'UTR reporter construct activity 1.5- and 2.2-fold, respectively. As the tested miRNAs did not reduce the levels of target mRNA, we suggest that the binding of miR-124 and miR-135a to NR3C2 3'UTR contributes to the translational, not transcriptional regulation of the gene. Co-expression of two different miRNAs did not increase the repression of the reporter gene, indicating no additive or synergistic effects between the tested miRNAs. Our results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2, miR-124 and miR-135a could participate in the regulation of renin-angiotensin-aldosterone system and thereby might be involved in blood pressure regulation. MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water–salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs. A luciferase assay demonstrated that miR-124 and miR-135a suppress NR3C2 3′UTR reporter construct activity 1.5- and 2.2-fold, respectively. As the tested miRNAs did not reduce the levels of target mRNA, we suggest that the binding of miR-124 and miR-135a to NR3C2 3′UTR contributes to the translational, not transcriptional regulation of the gene. Co-expression of two different miRNAs did not increase the repression of the reporter gene, indicating no additive or synergistic effects between the tested miRNAs. Our results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2 , miR-124 and miR-135a could participate in the regulation of renin–angiotensin–aldosterone system and thereby might be involved in blood pressure regulation. MicroRNAs (miRNAs) comprise a post-transcriptional layer of gene regulation shown to be involved in diverse physiological processes. We aimed to study whether regulatory networks that determine susceptibility to hypertension may involve a miRNA component. Screening of loci, involved in renal water–salt balance regulation, highlighted the mineralocorticoid receptor gene NR3C2 as a potential target for several miRNAs. A luciferase assay demonstrated that miR-124 and miR-135a suppress NR3C2 3′UTR reporter construct activity 1.5- and 2.2-fold, respectively. As the tested miRNAs did not reduce the levels of target mRNA, we suggest that the binding of miR-124 and miR-135a to NR3C2 3′UTR contributes to the translational, not transcriptional regulation of the gene. Co-expression of two different miRNAs did not increase the repression of the reporter gene, indicating no additive or synergistic effects between the tested miRNAs. Our results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2, miR-124 and miR-135a could participate in the regulation of renin–angiotensin–aldosterone system and thereby might be involved in blood pressure regulation. |
| Author | Annilo, Tarmo Sõber, Siim Laan, Maris |
| AuthorAffiliation | Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia |
| AuthorAffiliation_xml | – name: Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia |
| Author_xml | – sequence: 1 givenname: Siim surname: Sõber fullname: Sõber, Siim email: siims@ut.ee – sequence: 2 givenname: Maris surname: Laan fullname: Laan, Maris email: maris.laan@ut.ee – sequence: 3 givenname: Tarmo surname: Annilo fullname: Annilo, Tarmo email: tannilo@ebc.ee |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19944075$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nrg1990 10.1261/rna.5248604 10.1016/S0092-8674(01)00241-0 10.1371/journal.pone.0006034 10.1086/519979 10.1093/nar/gkm1012 10.1074/jbc.M701050200 10.1073/pnas.0510928103 10.1126/science.1097434 10.1016/j.cell.2004.12.035 10.1161/01.HYP.32.5.825 10.1371/journal.pbio.0020363 10.1291/hypres.28.819 10.1161/01.HYP.33.3.844 10.2353/ajpath.2007.061170 10.1371/journal.pcbi.0030131 10.1016/j.cell.2005.11.023 10.1016/S0092-8674(04)00045-5 10.1016/j.molcel.2007.06.017 10.1126/science.289.5476.119 10.1073/pnas.0608791103 10.1186/gb-2004-5-3-r13 10.1038/ng1810 10.1038/ng1536 10.1161/01.HYP.0000222893.85662.cd 10.1126/science.1140481 10.1046/j.1523-1755.2000.00971.x 10.1101/gad.1064703 10.1038/nrg1967 10.1093/hmg/ddp135 10.1186/1471-2164-8-396 10.1093/hmg/ddm056 10.1101/gad.443107 10.1210/en.2008-1335 10.1073/pnas.95.16.9424 |
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| Keywords | Blood pressure MicroRNA Mineralocortocoid receptor NR3C2 |
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| References | C. Newton-Cheh, T. Johnson, V. Gateva, et al., Genome-wide association study identifies eight loci associated with blood pressure, Nat. Genet. (2009). Grimson, Farh, Johnston (bib28) 2007; 27 Cowley (bib8) 2006; 7 Kainulainen, Perola, Terwilliger (bib16) 1999; 33 RNAhybrid Eulalio, Rehwinkel, Stricker (bib4) 2007; 21 Osterop, Kofflard, Sandkuijl (bib17) 1998; 32 van Rooij, Sutherland, Liu (bib36) 2006; 103 Cheng, Ji, Yue (bib35) 2007; 170 de Kloet, Van Acker, Sibug (bib31) 2000; 57 Kim, Inoue, Ishii (bib30) 2007; 317 Krek, Grun, Poy (bib24) 2005; 37 Hsu, Chu, Tsou (bib39) 2008; 36 Lewis, Burge, Bartel (bib20) 2005; 120 TargetScan Naraba, Iwai (bib34) 2005; 28 Cameron, Mocatta, Pilbrow (bib15) 2006; 47 Vreugdenhil, Verissimo, Mariman (bib38) 2009; 150 PicTar Lifton, Gharavi, Geller (bib12) 2001; 104 Clop, Marcq, Takeda (bib13) 2006; 38 Blenkiron, Miska (bib7) 2007; 16 Martin, Buckenberger, Jiang (bib18) 2007; 282 . Chen, Rajewsky (bib5) 2007; 8 Zhou, Ferguson, Chang (bib6) 2007; 8 John, Enright, Aravin (bib22) 2004; 2 Shalgi, Lieber, Oren (bib29) 2007; 3 Geller, Farhi, Pinkerton (bib33) 2000; 289 Rehmsmeier, Steffen, Hochsmann (bib26) 2004; 10 Berger, Bleich, Schmid (bib32) 1998; 95 Yekta, Shih, Bartel (bib2) 2004; 304 Doench, Petersen, Sharp (bib40) 2003; 17 Org, Eyheramendy, Juhanson (bib10) 2009; 18 Sempere, Freemantle, Pitha-Rowe (bib37) 2004; 5 Stark, Brennecke, Bushati (bib27) 2005; 123 Wu, Fan, Belasco (bib3) 2006; 103 Sethupathy, Borel, Gagnebin (bib14) 2007; 81 Sober, Org, Kepp (bib9) 2009; 4 Bartel (bib1) 2004; 116 Sempere (10.1016/j.bbrc.2009.11.128_bib37) 2004; 5 10.1016/j.bbrc.2009.11.128_bib21 Stark (10.1016/j.bbrc.2009.11.128_bib27) 2005; 123 Osterop (10.1016/j.bbrc.2009.11.128_bib17) 1998; 32 Bartel (10.1016/j.bbrc.2009.11.128_bib1) 2004; 116 Yekta (10.1016/j.bbrc.2009.11.128_bib2) 2004; 304 Eulalio (10.1016/j.bbrc.2009.11.128_bib4) 2007; 21 Sethupathy (10.1016/j.bbrc.2009.11.128_bib14) 2007; 81 Grimson (10.1016/j.bbrc.2009.11.128_bib28) 2007; 27 Cheng (10.1016/j.bbrc.2009.11.128_bib35) 2007; 170 Cowley (10.1016/j.bbrc.2009.11.128_bib8) 2006; 7 Cameron (10.1016/j.bbrc.2009.11.128_bib15) 2006; 47 Vreugdenhil (10.1016/j.bbrc.2009.11.128_bib38) 2009; 150 Org (10.1016/j.bbrc.2009.11.128_bib10) 2009; 18 Krek (10.1016/j.bbrc.2009.11.128_bib24) 2005; 37 Zhou (10.1016/j.bbrc.2009.11.128_bib6) 2007; 8 Geller (10.1016/j.bbrc.2009.11.128_bib33) 2000; 289 Clop (10.1016/j.bbrc.2009.11.128_bib13) 2006; 38 Lewis (10.1016/j.bbrc.2009.11.128_bib20) 2005; 120 10.1016/j.bbrc.2009.11.128_bib23 Sober (10.1016/j.bbrc.2009.11.128_bib9) 2009; 4 10.1016/j.bbrc.2009.11.128_bib25 Rehmsmeier (10.1016/j.bbrc.2009.11.128_bib26) 2004; 10 van Rooij (10.1016/j.bbrc.2009.11.128_bib36) 2006; 103 10.1016/j.bbrc.2009.11.128_bib11 Wu (10.1016/j.bbrc.2009.11.128_bib3) 2006; 103 Chen (10.1016/j.bbrc.2009.11.128_bib5) 2007; 8 Naraba (10.1016/j.bbrc.2009.11.128_bib34) 2005; 28 Doench (10.1016/j.bbrc.2009.11.128_bib40) 2003; 17 Blenkiron (10.1016/j.bbrc.2009.11.128_bib7) 2007; 16 Lifton (10.1016/j.bbrc.2009.11.128_bib12) 2001; 104 Martin (10.1016/j.bbrc.2009.11.128_bib18) 2007; 282 Kainulainen (10.1016/j.bbrc.2009.11.128_bib16) 1999; 33 Hsu (10.1016/j.bbrc.2009.11.128_bib39) 2008; 36 John (10.1016/j.bbrc.2009.11.128_bib22) 2004; 2 Berger (10.1016/j.bbrc.2009.11.128_bib32) 1998; 95 Kim (10.1016/j.bbrc.2009.11.128_bib30) 2007; 317 Shalgi (10.1016/j.bbrc.2009.11.128_bib29) 2007; 3 de Kloet (10.1016/j.bbrc.2009.11.128_bib31) 2000; 57 10.1016/j.bbrc.2009.11.128_bib19 |
| References_xml | – volume: 170 start-page: 1831 year: 2007 end-page: 1840 ident: bib35 article-title: MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? publication-title: Am. J. Pathol. – volume: 289 start-page: 119 year: 2000 end-page: 123 ident: bib33 article-title: Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy publication-title: Science – volume: 8 start-page: 396 year: 2007 ident: bib6 article-title: Inter- and intra-combinatorial regulation by transcription factors and microRNAs publication-title: BMC Genomics – volume: 16 start-page: R106 year: 2007 end-page: R113 ident: bib7 article-title: miRNAs in cancer: approaches, aetiology, diagnostics and therapy publication-title: Hum. Mol. Genet. – volume: 36 start-page: D165 year: 2008 end-page: D169 ident: bib39 publication-title: Nucleic Acids Res. – volume: 18 start-page: 2288 year: 2009 end-page: 2296 ident: bib10 article-title: Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations publication-title: Hum. Mol. Genet. – volume: 123 start-page: 1133 year: 2005 end-page: 1146 ident: bib27 article-title: Animal microRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution publication-title: Cell – volume: 27 start-page: 91 year: 2007 end-page: 105 ident: bib28 article-title: MicroRNA targeting specificity in mammals: determinants beyond seed pairing publication-title: Mol. Cell – volume: 7 start-page: 829 year: 2006 end-page: 840 ident: bib8 article-title: The genetic dissection of essential hypertension publication-title: Nat. Rev. Genet. – volume: 4 start-page: e6034 year: 2009 ident: bib9 article-title: Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array publication-title: PLoS One – volume: 116 start-page: 281 year: 2004 end-page: 297 ident: bib1 article-title: MicroRNAs: genomics, biogenesis, mechanism, and function publication-title: Cell – volume: 150 start-page: 2220 year: 2009 end-page: 2228 ident: bib38 article-title: MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain publication-title: Endocrinology – volume: 282 start-page: 24262 year: 2007 end-page: 24269 ident: bib18 article-title: The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microrna-155 binding publication-title: J. Biol. Chem. – reference: PicTar, – volume: 28 start-page: 819 year: 2005 end-page: 826 ident: bib34 article-title: Assessment of the microRNA system in salt-sensitive hypertension publication-title: Hypertens. Res. – volume: 8 start-page: 93 year: 2007 end-page: 103 ident: bib5 article-title: The evolution of gene regulation by transcription factors and microRNAs publication-title: Nat. Rev. Genet. – volume: 104 start-page: 545 year: 2001 end-page: 556 ident: bib12 article-title: Molecular mechanisms of human hypertension publication-title: Cell – reference: TargetScan, – volume: 33 start-page: 844 year: 1999 end-page: 849 ident: bib16 article-title: Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension publication-title: Hypertension – volume: 17 start-page: 438 year: 2003 end-page: 442 ident: bib40 article-title: siRNAs can function as miRNAs publication-title: Genes Dev. – volume: 47 start-page: 1155 year: 2006 end-page: 1161 ident: bib15 article-title: Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure publication-title: Hypertension – volume: 103 start-page: 18255 year: 2006 end-page: 18260 ident: bib36 article-title: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure publication-title: Proc. Natl. Acad. Sci. USA – volume: 95 start-page: 9424 year: 1998 end-page: 9429 ident: bib32 article-title: Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism publication-title: Proc. Natl. Acad. Sci. USA – volume: 2 start-page: e363 year: 2004 ident: bib22 article-title: Human microRNA targets publication-title: PLoS Biol. – reference: C. Newton-Cheh, T. Johnson, V. Gateva, et al., Genome-wide association study identifies eight loci associated with blood pressure, Nat. Genet. (2009). – reference: . – volume: 38 start-page: 813 year: 2006 end-page: 818 ident: bib13 article-title: A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep publication-title: Nat. Genet. – volume: 32 start-page: 825 year: 1998 end-page: 830 ident: bib17 article-title: AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy publication-title: Hypertension – volume: 10 start-page: 1507 year: 2004 end-page: 1517 ident: bib26 article-title: Fast and effective prediction of microRNA/target duplexes publication-title: RNA – volume: 81 start-page: 405 year: 2007 end-page: 413 ident: bib14 article-title: Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes publication-title: Am. J. Hum. Genet. – reference: RNAhybrid, – volume: 317 start-page: 1220 year: 2007 end-page: 1224 ident: bib30 article-title: A MicroRNA feedback circuit in midbrain dopamine neurons publication-title: Science – volume: 37 start-page: 495 year: 2005 end-page: 500 ident: bib24 article-title: Combinatorial microRNA target predictions publication-title: Nat. Genet. – volume: 120 start-page: 15 year: 2005 end-page: 20 ident: bib20 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell – volume: 3 start-page: e131 year: 2007 ident: bib29 article-title: Global and local architecture of the mammalian microRNA-transcription factor regulatory network publication-title: PLoS Comput. Biol. – volume: 304 start-page: 594 year: 2004 end-page: 596 ident: bib2 article-title: MicroRNA-directed cleavage of HOXB8 mRNA publication-title: Science – volume: 21 start-page: 2558 year: 2007 end-page: 2570 ident: bib4 article-title: Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing publication-title: Genes Dev. – volume: 5 start-page: R13 year: 2004 ident: bib37 article-title: Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation publication-title: Genome Biol. – volume: 57 start-page: 1329 year: 2000 end-page: 1336 ident: bib31 article-title: Brain mineralocorticoid receptors and centrally regulated functions publication-title: Kidney Int. – volume: 103 start-page: 4034 year: 2006 end-page: 4039 ident: bib3 article-title: MicroRNAs direct rapid deadenylation of mRNA publication-title: Proc. Natl. Acad. Sci. USA – volume: 8 start-page: 93 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib5 article-title: The evolution of gene regulation by transcription factors and microRNAs publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1990 – volume: 10 start-page: 1507 year: 2004 ident: 10.1016/j.bbrc.2009.11.128_bib26 article-title: Fast and effective prediction of microRNA/target duplexes publication-title: RNA doi: 10.1261/rna.5248604 – volume: 104 start-page: 545 year: 2001 ident: 10.1016/j.bbrc.2009.11.128_bib12 article-title: Molecular mechanisms of human hypertension publication-title: Cell doi: 10.1016/S0092-8674(01)00241-0 – volume: 4 start-page: e6034 year: 2009 ident: 10.1016/j.bbrc.2009.11.128_bib9 article-title: Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array publication-title: PLoS One doi: 10.1371/journal.pone.0006034 – ident: 10.1016/j.bbrc.2009.11.128_bib11 – volume: 81 start-page: 405 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib14 article-title: Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes publication-title: Am. J. Hum. Genet. doi: 10.1086/519979 – volume: 36 start-page: D165 year: 2008 ident: 10.1016/j.bbrc.2009.11.128_bib39 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkm1012 – volume: 282 start-page: 24262 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib18 article-title: The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microrna-155 binding publication-title: J. Biol. Chem. doi: 10.1074/jbc.M701050200 – ident: 10.1016/j.bbrc.2009.11.128_bib19 – volume: 103 start-page: 4034 year: 2006 ident: 10.1016/j.bbrc.2009.11.128_bib3 article-title: MicroRNAs direct rapid deadenylation of mRNA publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0510928103 – volume: 304 start-page: 594 year: 2004 ident: 10.1016/j.bbrc.2009.11.128_bib2 article-title: MicroRNA-directed cleavage of HOXB8 mRNA publication-title: Science doi: 10.1126/science.1097434 – volume: 120 start-page: 15 year: 2005 ident: 10.1016/j.bbrc.2009.11.128_bib20 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell doi: 10.1016/j.cell.2004.12.035 – volume: 32 start-page: 825 year: 1998 ident: 10.1016/j.bbrc.2009.11.128_bib17 article-title: AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy publication-title: Hypertension doi: 10.1161/01.HYP.32.5.825 – volume: 2 start-page: e363 year: 2004 ident: 10.1016/j.bbrc.2009.11.128_bib22 article-title: Human microRNA targets publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0020363 – volume: 28 start-page: 819 year: 2005 ident: 10.1016/j.bbrc.2009.11.128_bib34 article-title: Assessment of the microRNA system in salt-sensitive hypertension publication-title: Hypertens. Res. doi: 10.1291/hypres.28.819 – volume: 33 start-page: 844 year: 1999 ident: 10.1016/j.bbrc.2009.11.128_bib16 article-title: Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension publication-title: Hypertension doi: 10.1161/01.HYP.33.3.844 – volume: 170 start-page: 1831 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib35 article-title: MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2007.061170 – volume: 3 start-page: e131 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib29 article-title: Global and local architecture of the mammalian microRNA-transcription factor regulatory network publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.0030131 – volume: 123 start-page: 1133 year: 2005 ident: 10.1016/j.bbrc.2009.11.128_bib27 article-title: Animal microRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution publication-title: Cell doi: 10.1016/j.cell.2005.11.023 – volume: 116 start-page: 281 year: 2004 ident: 10.1016/j.bbrc.2009.11.128_bib1 article-title: MicroRNAs: genomics, biogenesis, mechanism, and function publication-title: Cell doi: 10.1016/S0092-8674(04)00045-5 – volume: 27 start-page: 91 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib28 article-title: MicroRNA targeting specificity in mammals: determinants beyond seed pairing publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.06.017 – volume: 289 start-page: 119 year: 2000 ident: 10.1016/j.bbrc.2009.11.128_bib33 article-title: Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy publication-title: Science doi: 10.1126/science.289.5476.119 – volume: 103 start-page: 18255 year: 2006 ident: 10.1016/j.bbrc.2009.11.128_bib36 article-title: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0608791103 – volume: 5 start-page: R13 year: 2004 ident: 10.1016/j.bbrc.2009.11.128_bib37 article-title: Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation publication-title: Genome Biol. doi: 10.1186/gb-2004-5-3-r13 – volume: 38 start-page: 813 year: 2006 ident: 10.1016/j.bbrc.2009.11.128_bib13 article-title: A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep publication-title: Nat. Genet. doi: 10.1038/ng1810 – volume: 37 start-page: 495 year: 2005 ident: 10.1016/j.bbrc.2009.11.128_bib24 article-title: Combinatorial microRNA target predictions publication-title: Nat. Genet. doi: 10.1038/ng1536 – volume: 47 start-page: 1155 year: 2006 ident: 10.1016/j.bbrc.2009.11.128_bib15 article-title: Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure publication-title: Hypertension doi: 10.1161/01.HYP.0000222893.85662.cd – volume: 317 start-page: 1220 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib30 article-title: A MicroRNA feedback circuit in midbrain dopamine neurons publication-title: Science doi: 10.1126/science.1140481 – volume: 57 start-page: 1329 year: 2000 ident: 10.1016/j.bbrc.2009.11.128_bib31 article-title: Brain mineralocorticoid receptors and centrally regulated functions publication-title: Kidney Int. doi: 10.1046/j.1523-1755.2000.00971.x – volume: 17 start-page: 438 year: 2003 ident: 10.1016/j.bbrc.2009.11.128_bib40 article-title: siRNAs can function as miRNAs publication-title: Genes Dev. doi: 10.1101/gad.1064703 – volume: 7 start-page: 829 year: 2006 ident: 10.1016/j.bbrc.2009.11.128_bib8 article-title: The genetic dissection of essential hypertension publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1967 – volume: 18 start-page: 2288 year: 2009 ident: 10.1016/j.bbrc.2009.11.128_bib10 article-title: Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddp135 – volume: 8 start-page: 396 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib6 article-title: Inter- and intra-combinatorial regulation by transcription factors and microRNAs publication-title: BMC Genomics doi: 10.1186/1471-2164-8-396 – volume: 16 start-page: R106 issue: Spec No. 1 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib7 article-title: miRNAs in cancer: approaches, aetiology, diagnostics and therapy publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddm056 – volume: 21 start-page: 2558 year: 2007 ident: 10.1016/j.bbrc.2009.11.128_bib4 article-title: Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing publication-title: Genes Dev. doi: 10.1101/gad.443107 – ident: 10.1016/j.bbrc.2009.11.128_bib21 – ident: 10.1016/j.bbrc.2009.11.128_bib23 – ident: 10.1016/j.bbrc.2009.11.128_bib25 – volume: 150 start-page: 2220 year: 2009 ident: 10.1016/j.bbrc.2009.11.128_bib38 article-title: MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain publication-title: Endocrinology doi: 10.1210/en.2008-1335 – volume: 95 start-page: 9424 year: 1998 ident: 10.1016/j.bbrc.2009.11.128_bib32 article-title: Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.16.9424 |
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| SubjectTerms | Blood pressure Blood Pressure - genetics Computational Biology Gene Expression Regulation Genes, Reporter HeLa Cells Humans Luciferases - genetics MicroRNA MicroRNAs - metabolism Mineralocortocoid receptor NR3C2 Receptors, Mineralocorticoid - genetics Renin-Angiotensin System - genetics RNA, Messenger - biosynthesis Transcription, Genetic |
| Title | MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression |
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