骨微损伤形成与修复机制的研究进展

骨微损伤是在光学显微镜下能够观察到的骨基质损害,骨微损伤的产生、发展与疲劳载荷有关,骨微损伤能够启动骨重建来进行修复,但不同微损伤类型对骨重建的影响不同。骨微损伤有五种类型,目前研究多集中在线性微裂纹与弥散性微损伤,它们具有完全不同的形态特征和修复方式。本文通过对骨微损伤的分类、检测方法、形成及修复机制进行综述,深入研究神经肽对骨重建的作用,旨在进一步探讨骨微损伤的修复机制,为骨质疏松性骨折的防治奠定基础。...

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Published in中国骨质疏松杂志 Vol. 23; no. 5; pp. 683 - 689
Main Author 韩燚 王双磊 李展春
Format Journal Article
LanguageChinese
Published 上海交通大学医学院附属仁济医院骨科,上海,200127 2017
Subjects
修复机制
神经肽
骨微损伤
骨质疏松
骨重建
骨质疏松
Osteoporosis
骨重建
Bone microdamage
Repair mechanism
骨微损伤
修复机制
神经肽
Bone remodeling
Neuropeptide
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ISSN1006-7108
DOI10.3969/j.issn.1006-7108.2017.05.026

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Summary:骨微损伤是在光学显微镜下能够观察到的骨基质损害,骨微损伤的产生、发展与疲劳载荷有关,骨微损伤能够启动骨重建来进行修复,但不同微损伤类型对骨重建的影响不同。骨微损伤有五种类型,目前研究多集中在线性微裂纹与弥散性微损伤,它们具有完全不同的形态特征和修复方式。本文通过对骨微损伤的分类、检测方法、形成及修复机制进行综述,深入研究神经肽对骨重建的作用,旨在进一步探讨骨微损伤的修复机制,为骨质疏松性骨折的防治奠定基础。
Bibliography:Bone microdamage is generally defined as matrix failure detectable by light microscope. The accumulation and development of bone microdamage is associated with fatigue loading. Bone remodeling can be activated to target the repair of bone microdamage. But different types of bone microdamage have different effects on bone remodeling. There are five types of bone microdamage. Most research are focused on the linear microcrack and diffuse microdamage,and they have completely different morphological characters and repair mechanisms. This paper reviews the classification,measurement,development and repair mechanisms of bone microdamage,evaluate the role of neuropeptide on bone remodeling,with the aim of further exploring the possible repair mechanisms of bone microdamage and laying the foundation for the prevention of osteoporotic fracture.
HAN Yi, WANG Shuanglei, LI Zhanchun（Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 20012, China）
11-3701/R
Bone microdamage;
ISSN:1006-7108
DOI:10.3969/j.issn.1006-7108.2017.05.026