Preserved effector functions of human ORAI1- and STIM1-deficient neutrophils
[...]we compared expression levels of ORAI and STIM homologues between PMNs, B lymphocytes, and T lymphocytes by using publicly available RNA sequencing data from healthy subjects.7 ORAI1 and STIM1 were similarly expressed in PMNs and lymphocytes. [...]mRNA levels of the different ORAI and STIM homo...
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| Published in | Journal of allergy and clinical immunology Vol. 137; no. 5; pp. 1587 - 1591.e7 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.05.2016
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0091-6749 1097-6825 1085-8725 1097-6825 |
| DOI | 10.1016/j.jaci.2015.09.047 |
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| Abstract | [...]we compared expression levels of ORAI and STIM homologues between PMNs, B lymphocytes, and T lymphocytes by using publicly available RNA sequencing data from healthy subjects.7 ORAI1 and STIM1 were similarly expressed in PMNs and lymphocytes. [...]mRNA levels of the different ORAI and STIM homologues are comparable across leukocyte subsets (see Fig E1 in this article's Online Repository at www.jacionline.org). [...]FcγRIII (CD16) cross-linking also induced Ca2+ influx in ORAI1 p.R91W PMN that was only moderately reduced compared with that in control PMNs (see Fig E4 in this article's Online Repository at www.jacionline.org). Because cytosolic Ca2+ concentrations are considered essential for antibacterial PMN functions, we examined whether ORAI1 deficiency impaired the PMN response to various microbial and nonmicrobial ligands. |
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| AbstractList | [...]we compared expression levels of ORAI and STIM homologues between PMNs, B lymphocytes, and T lymphocytes by using publicly available RNA sequencing data from healthy subjects.7 ORAI1 and STIM1 were similarly expressed in PMNs and lymphocytes. [...]mRNA levels of the different ORAI and STIM homologues are comparable across leukocyte subsets (see Fig E1 in this article's Online Repository at www.jacionline.org). [...]FcγRIII (CD16) cross-linking also induced Ca2+ influx in ORAI1 p.R91W PMN that was only moderately reduced compared with that in control PMNs (see Fig E4 in this article's Online Repository at www.jacionline.org). Because cytosolic Ca2+ concentrations are considered essential for antibacterial PMN functions, we examined whether ORAI1 deficiency impaired the PMN response to various microbial and nonmicrobial ligands. |
| Author | Deshmukh, Sachin D. Elling, Roland Zee, Isabelle Ehl, Stephan Speckmann, Carsten Feske, Stefan Häffner, Monika Schwarz, Klaus Keller, Baerbel Henneke, Philipp Weidinger, Carl |
| AuthorAffiliation | 2 Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA 5 Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Germany 3 Department of Pathology, New York University School of Medicine, New York, USA 1 Center for Chronic Immunodeficiency, University Medical Center Freiburg, Germany 4 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood, Service Baden-Wuerttemberg - Hessen and Institute for Transfusion Medicine University Ulm, Ulm, Germany |
| AuthorAffiliation_xml | – name: 1 Center for Chronic Immunodeficiency, University Medical Center Freiburg, Germany – name: 4 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood, Service Baden-Wuerttemberg - Hessen and Institute for Transfusion Medicine University Ulm, Ulm, Germany – name: 2 Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA – name: 3 Department of Pathology, New York University School of Medicine, New York, USA – name: 5 Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Germany |
| Author_xml | – sequence: 1 givenname: Roland surname: Elling fullname: Elling, Roland email: roland.elling@umassmed.edu, roland.elling@uniklinik-freiburg.de organization: Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany – sequence: 2 givenname: Baerbel surname: Keller fullname: Keller, Baerbel organization: Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany – sequence: 3 givenname: Carl surname: Weidinger fullname: Weidinger, Carl organization: Department of Pathology, New York University School of Medicine, New York, NY – sequence: 4 givenname: Monika surname: Häffner fullname: Häffner, Monika organization: Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany – sequence: 5 givenname: Sachin D. surname: Deshmukh fullname: Deshmukh, Sachin D. organization: Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany – sequence: 6 givenname: Isabelle surname: Zee fullname: Zee, Isabelle organization: Department of Pathology, New York University School of Medicine, New York, NY – sequence: 7 givenname: Carsten surname: Speckmann fullname: Speckmann, Carsten organization: Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany – sequence: 8 givenname: Stephan surname: Ehl fullname: Ehl, Stephan organization: Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany – sequence: 9 givenname: Klaus surname: Schwarz fullname: Schwarz, Klaus organization: Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Wuerttemberg–Hessen and Institute for Transfusion Medicine University Ulm, Ulm, Germany – sequence: 10 givenname: Stefan surname: Feske fullname: Feske, Stefan organization: Department of Pathology, New York University School of Medicine, New York, NY – sequence: 11 givenname: Philipp surname: Henneke fullname: Henneke, Philipp email: philipp.henneke@uniklinik-freiburg.de organization: Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany |
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| Title | Preserved effector functions of human ORAI1- and STIM1-deficient neutrophils |
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