氢在代谢性疾病中的应用及其研究进展

氧化应激和炎症参与多种疾病的病理过程，包括代谢性疾病，如糖尿病、脂代谢紊乱、代谢综合征、肥胖和动脉粥样硬化等。目前多数抗氧化及抗炎药物剂量窗较窄、毒性较大，因此临床需要一种更加有效、安全的抗氧化应激及抗炎药物。近期大量研究提示氢分子具有选择性抗氧化及抗炎作用，对多种缺血再灌注损伤、炎症、神经疾病、消化疾病及代谢性疾病的动物模型均有很好的效果，提示氢分子有作为临床治疗代谢性疾病药物的潜能。本文综述了最新的相关研究并对未来研究方向作了展望。...

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Published in复旦学报（医学版） Vol. 41; no. 5; pp. 701 - 705
Main Author 吕朝阳（综述） 张尧 何顺梅 于明香（审校）
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院内分泌科 上海200032 2014
Subjects
代谢性疾病
氢
氧化应激
炎症
氢
inflammation
氧化应激
炎症
hydrogen
代谢性疾病
metabolic disease
oxidative stress
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ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2014.05.024

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Summary:氧化应激和炎症参与多种疾病的病理过程，包括代谢性疾病，如糖尿病、脂代谢紊乱、代谢综合征、肥胖和动脉粥样硬化等。目前多数抗氧化及抗炎药物剂量窗较窄、毒性较大，因此临床需要一种更加有效、安全的抗氧化应激及抗炎药物。近期大量研究提示氢分子具有选择性抗氧化及抗炎作用，对多种缺血再灌注损伤、炎症、神经疾病、消化疾病及代谢性疾病的动物模型均有很好的效果，提示氢分子有作为临床治疗代谢性疾病药物的潜能。本文综述了最新的相关研究并对未来研究方向作了展望。
Bibliography:Oxidative stress and inflammation play important roles in many diseases, including metabolic diseases, such as diabetes, dyslipidemia, metabolic syndrome, obesity, atherosclerosis and so on. However,the therapeutic windows of a majority of anti-oxidant and anti-inflammatory medicines at present are narrow. So there is a need for a more effective and safer anti-oxidant and anti-inflammatory medicine in clinic. A large number of recent studies show that hydrogen has anti-oxidant and anti- inflammatory effects on a variety of animal models of ischemia-reperfusion injury, inflammation, neurological diseases,digestive diseases and metabolic diseases, suggesting that hydrogen is a potential drug for metabolic diseases. This article reviews the latest development of the researches related and prospects for future research directions.
LV Chao-yang, ZHANG Yao, HE Shun-mei, YU Ming-xiang（ Department of Endocrinology, Zhong,shan Hosipital, Fudan University, Shanghai 200032, China）
31-1885/R
hydrogen; metabolic disease; oxi
ISSN:1672-8467
DOI:10.3969/j.issn.1672-8467.2014.05.024