绝经后骨质疏松症药物治疗的现状与思考
绝经后骨质疏松症（postmenopausal osteoporosis,PMOP）是指绝经后妇女体内雌激素水平下降,骨形成和骨吸收失耦连,导致以骨量减少和骨组织显微结构破坏为特征的一种全身代谢性骨病,是绝经后妇女的常见病及多发病。随着我国人口老龄化,绝经后骨质疏松症以其高发病率、高致残率逐渐成为严峻的公共卫生及社会问题。临床治疗绝经后骨质疏松症的药物以西药为主,中药为辅,但西药严重的毒副作用和中药作用机制的不明确都制约着其进一步的推广。目前,随着骨代谢机制的进一步明确和相关诊疗技术的突破,临床用药有了新的进展。本文以临床药物治疗为出发点,从西药、中药两个方面入手,通过查阅国内外近期相关文献,...
Saved in:
| Published in | 中国骨质疏松杂志 Vol. 23; no. 6; pp. 818 - 823 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
福建中医药大学,福建福州,350122
2017
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-7108 |
| DOI | 10.3969/j.issn.1006-7108.2017.06.024 |
Cover
| Abstract | 绝经后骨质疏松症（postmenopausal osteoporosis,PMOP）是指绝经后妇女体内雌激素水平下降,骨形成和骨吸收失耦连,导致以骨量减少和骨组织显微结构破坏为特征的一种全身代谢性骨病,是绝经后妇女的常见病及多发病。随着我国人口老龄化,绝经后骨质疏松症以其高发病率、高致残率逐渐成为严峻的公共卫生及社会问题。临床治疗绝经后骨质疏松症的药物以西药为主,中药为辅,但西药严重的毒副作用和中药作用机制的不明确都制约着其进一步的推广。目前,随着骨代谢机制的进一步明确和相关诊疗技术的突破,临床用药有了新的进展。本文以临床药物治疗为出发点,从西药、中药两个方面入手,通过查阅国内外近期相关文献,对西药类（基础药物,抗骨吸收药物、促进骨形成药物、双重药理作用药物）和中药类（单味中药、中药提取物、复方制剂）的临床使用现状进行归纳总结,同时提出笔者对绝经后骨质疏松症药物治疗现状的思考。 |
|---|---|
| AbstractList | R681; 绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是指绝经后妇女体内雌激素水平下降,骨形成和骨吸收失耦连,导致以骨量减少和骨组织显微结构破坏为特征的一种全身代谢性骨病,是绝经后妇女的常见病及多发病.随着我国人口老龄化,绝经后骨质疏松症以其高发病率、高致残率逐渐成为严峻的公共卫生及社会问题.临床治疗绝经后骨质疏松症的药物以西药为主,中药为辅,但西药严重的毒副作用和中药作用机制的不明确都制约着其进一步的推广.目前,随着骨代谢机制的进一步明确和相关诊疗技术的突破,临床用药有了新的进展.本文以临床药物治疗为出发点,从西药、中药两个方面入手,通过查阅国内外近期相关文献,对西药类(基础药物,抗骨吸收药物、促进骨形成药物、双重药理作用药物)和中药类(单味中药、中药提取物、复方制剂)的临床使用现状进行归纳总结,同时提出笔者对绝经后骨质疏松症药物治疗现状的思考. 绝经后骨质疏松症（postmenopausal osteoporosis,PMOP）是指绝经后妇女体内雌激素水平下降,骨形成和骨吸收失耦连,导致以骨量减少和骨组织显微结构破坏为特征的一种全身代谢性骨病,是绝经后妇女的常见病及多发病。随着我国人口老龄化,绝经后骨质疏松症以其高发病率、高致残率逐渐成为严峻的公共卫生及社会问题。临床治疗绝经后骨质疏松症的药物以西药为主,中药为辅,但西药严重的毒副作用和中药作用机制的不明确都制约着其进一步的推广。目前,随着骨代谢机制的进一步明确和相关诊疗技术的突破,临床用药有了新的进展。本文以临床药物治疗为出发点,从西药、中药两个方面入手,通过查阅国内外近期相关文献,对西药类（基础药物,抗骨吸收药物、促进骨形成药物、双重药理作用药物）和中药类（单味中药、中药提取物、复方制剂）的临床使用现状进行归纳总结,同时提出笔者对绝经后骨质疏松症药物治疗现状的思考。 |
| Abstract_FL | Postmenopausal osteoporosis is a systemic metabolic disease characterized by reduced bone mass and microstructure destruction,and is caused by the decrease of estrogen in women after menopause and the uncoupling of bone formation and bone resorption.Postmenopausal osteoporosis is a common and frequently occurring disease in postmenopausal women.With the aging of the Chinese population,the high morbidity and disability rate associated with postmenopausal osteoporosis has become a serious public health and social problem.Clinical treatment drugs for postmenopausal osteoporosis are mainly western medicine,supplemented by Chinese medicine.However,the serious side effects of western medicine and the mechanism of traditional Chinese medicine are not clear and therefore restrict their wider application.At present,with the further development in the mechanisms of bone metabolism and the breakthrough of related diagnosis and treatment technology,clinical medicine has made new progress.Starting from clinical drug treatments,from the two aspects of western medicine and traditional Chinese medicine,through literature review of recent publications,we summarized the current situation on the clinical application of Western Medicine (basic drugs,anti-resorptive drugs,bone anabolic drugs and dual pharmacological action drugs) and traditional Chinese medicine (unit Chinese medicine,Chinese medicine extract and compound preparation),and put forward our perspectives on the current status of postmenopausal osteoporosis drug treatment. |
| Author | 王柄棋 孙雨晴 陈翔 郑雪峰 林燕萍 |
| AuthorAffiliation | 福建中医药大学,福建福州350122 |
| AuthorAffiliation_xml | – name: 福建中医药大学,福建福州,350122 |
| Author_FL | LIN Yanping SUN Yuqing WANG Bingqi CHEN Xiang ZHENG Xuefeng |
| Author_FL_xml | – sequence: 1 fullname: WANG Bingqi – sequence: 2 fullname: SUN Yuqing – sequence: 3 fullname: CHEN Xiang – sequence: 4 fullname: ZHENG Xuefeng – sequence: 5 fullname: LIN Yanping |
| Author_xml | – sequence: 1 fullname: 王柄棋 孙雨晴 陈翔 郑雪峰 林燕萍 |
| BookMark | eNo9j71KA0EUhaeIYIx5CbGx2PXOzM5fKcE_CNikD7PJ7rpBJ5pBxK0CCmLAxCoBIX20UURECPg0molv4UrE6sA5H-fes4IKpm0ihNYx-FRxtdnyU2uNjwG4JzBInwAWPnAfSFBAxX9_GZWtTUMAQjhRRBYRd9Oxmw6-7vrfj5P568QNB7Pxhxtdz2-f3M3D7GXqhiN3f-X6z6739vnen3XH8-7lKlqK9ZGNyn9aQrWd7Vplz6se7O5Xtqpeg-PAI0xFAQGFtcShBEExVSHGzSaJ8mcAZBRoooRUQkRUshjygFEchyymAWhGS2hjUXuuTaxNUm-1zzomP1jPkiSzNst-hwLPZ-bs2oJtHLZNcprm9EknPdadizoXhDEMOKA_ZU5poA |
| ClassificationCodes | R681 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1006-7108.2017.06.024 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Drug therapy for postmenopausal osteoporosis： current situation and perspective |
| DocumentTitle_FL | Drug therapy for postmenopausal osteoporosis: current situation and perspective |
| EndPage | 823 |
| ExternalDocumentID | zggzsszz201706024 672551014 |
| GrantInformation_xml | – fundername: 国家自然科学基金资助项目; 福建省科技厅引导性项目; 陈可冀中西医结合发展基金资助 funderid: (81574003); (2015Y0069); (CKJ201411) |
| GroupedDBID | -05 2B. 2C~ 2RA 92F 92I 92L ABDBF ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CQIGP CW9 EAD EAP EAS EOJEC EPL ESX OBODZ TCJ TGQ U1G U5O W91 ~WA 4A8 93N ABJNI ACUHS PSX |
| ID | FETCH-LOGICAL-c614-259e42091a81b8073139b11dd2e108008e4a2978977e385f0d2e531fb5f340a53 |
| ISSN | 1006-7108 |
| IngestDate | Thu May 29 03:55:34 EDT 2025 Wed Feb 14 09:59:52 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 6 |
| Keywords | 治疗药物 临床现状 西药 Therapeutic drugs 绝经后骨质疏松症 Western medicine Traditional Chinese medicine Clinical status 中药 PMOP |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c614-259e42091a81b8073139b11dd2e108008e4a2978977e385f0d2e531fb5f340a53 |
| Notes | PMOP; Clinical status; Therapeutic drugs; Traditional Chinese medicine; Western medicine Postmenopausal osteoporosis is a systemic metabolic disease characterized by reduced bone mass and microstructure destruction,and is caused by the decrease of estrogen in women after menopause and the uncoupling of bone formation and bone resorption. Postmenopausal osteoporosis is a common and frequently occurring disease in postmenopausal women. With the aging of the Chinese population,the high morbidity and disability rate associated with postmenopausal osteoporosis has become a serious public health and social problem. Clinical treatment drugs for postmenopausal osteoporosis are mainly western medicine,supplemented by Chinese medicine. However,the serious side effects of western medicine and the mechanism of traditional Chinese medicine are not clear and therefore restrict their wider application. At present,with the further development in the mechanisms of bone metabolism and the breakthrough of related diagnosis and t |
| PageCount | 6 |
| ParticipantIDs | wanfang_journals_zggzsszz201706024 chongqing_primary_672551014 |
| PublicationCentury | 2000 |
| PublicationDate | 2017 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationTitle | 中国骨质疏松杂志 |
| PublicationTitleAlternate | Chinese Journal of Osteoporosis |
| PublicationTitle_FL | Chinese Journal of Osteoporosis |
| PublicationYear | 2017 |
| Publisher | 福建中医药大学,福建福州,350122 |
| Publisher_xml | – name: 福建中医药大学,福建福州,350122 |
| SSID | ssib002262928 ssj0058516 ssib001103816 ssib051369297 |
| Score | 2.0889373 |
| Snippet | 绝经后骨质疏松症（postmenopausal osteoporosis,PMOP）是指绝经后妇女体内雌激素水平下降,骨形成和骨吸收失耦连,导致以骨量减少和骨组织显微结构破坏为特征的一种全身代... R681; 绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是指绝经后妇女体内雌激素水平下降,骨形成和骨吸收失耦连,导致以骨量减少和骨组织显微结构破坏为特征的一种全... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 818 |
| SubjectTerms | 中药 临床现状 治疗药物 绝经后骨质疏松症 西药 |
| Title | 绝经后骨质疏松症药物治疗的现状与思考 |
| URI | http://lib.cqvip.com/qk/80679X/201706/672551014.html https://d.wanfangdata.com.cn/periodical/zggzsszz201706024 |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate issn: 1006-7108 databaseCode: ABDBF dateStart: 20140201 customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn isFulltext: true dateEnd: 99991231 titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn omitProxy: true ssIdentifier: ssj0058516 providerName: EBSCOhost |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1PaxNBFB_aFMSLKCq2VSnSOW7dv7Mzx5lkQ_HgKUJvYTfZpKdUm_Syp4KCKJh6akHIvXpRREQI-Gk0G7-F781Ok20tEr2El7dv5r2Zl837vdl5s4Rs8kR4cUt4ViLageXzNLaSlu9ZrTaAezuFmJrq3RaP2fYT_9FOsLO0vF_atXQwSLZa2aV1Jf_jVeCBX7FK9h88O-sUGECDf-ETPAyfC_mYRiFVioqaIXidRgEVNuURjQSVkkpOI06Vr4mQCqZlGDZRkeaElIcow2tU1pHDoaFAGeVin0UrEENCUu5rmYgqWxOSKkYjnyqulTK9c6KmOwQzvDL2NWKypo1UVNUWM1IT3MVWqk7FLHAaQ7jSInVtGqPSA85cJEB9QqAmUIkKGH5V_lxEIINr1dj_uSvco8I5ayy1CR4MvbxWUhSF6t81diGZcQPMnZLnxsyrekJncw22wZhDYyQ0dKuX9VDmwOzg9lV8TuuWFmwdXLEBFMfLEaeosDZ3Vjl8cBOLDBIp5C4GOU8woYMcKtiaKcBtiqE-i7YoSr9wjHjW7Wb9fpa5xYFJrr9MVtwQ0FmFrEhVU_U5iHb00-QSyGOumCepgeMxwNSzZQ18rqxr-M4MuUI2jZUP_2YjHmayu9frPgOIpivmep241y2Bu8Z1cs1kZRuyuMVukKVs9yZh-XiUj49-vh3--nA6_XKaHx9NRt_zk5fTNx_zV-8nn8f58Un-7kU-_JS__vrj23ByOJoePr9FGvWoUd22zGtGrBZgUwvy_9R3ATbHkMFxiHiQEyWO0267Ke6_tXnqxzBcDolS6vGgY8MFCFydJOh4vh0H3m1S6e310jtkA1KfOHDagSti1xcp5EZ20OIJi9uAE1ORrpL12ZCbT4vTZJoshKwe35i9Sh6YSWia_5h-8w-vrS0itE6uIl2sFN4llcH-QXoPsPMguW-c_RvOMpO- |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%BB%9D%E7%BB%8F%E5%90%8E%E9%AA%A8%E8%B4%A8%E7%96%8F%E6%9D%BE%E7%97%87%E8%8D%AF%E7%89%A9%E6%B2%BB%E7%96%97%E7%9A%84%E7%8E%B0%E7%8A%B6%E4%B8%8E%E6%80%9D%E8%80%83&rft.jtitle=%E4%B8%AD%E5%9B%BD%E9%AA%A8%E8%B4%A8%E7%96%8F%E6%9D%BE%E6%9D%82%E5%BF%97&rft.au=%E7%8E%8B%E6%9F%84%E6%A3%8B&rft.au=%E5%AD%99%E9%9B%A8%E6%99%B4&rft.au=%E9%99%88%E7%BF%94&rft.au=%E9%83%91%E9%9B%AA%E5%B3%B0&rft.date=2017&rft.pub=%E7%A6%8F%E5%BB%BA%E4%B8%AD%E5%8C%BB%E8%8D%AF%E5%A4%A7%E5%AD%A6%2C%E7%A6%8F%E5%BB%BA%E7%A6%8F%E5%B7%9E%2C350122&rft.issn=1006-7108&rft.volume=23&rft.issue=6&rft.spage=818&rft.epage=823&rft_id=info:doi/10.3969%2Fj.issn.1006-7108.2017.06.024&rft.externalDocID=zggzsszz201706024 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F80679X%2F80679X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzggzsszz%2Fzggzsszz.jpg |