Click chemistry enables preclinical evaluation of targeted epigenetic therapies - Tyler, Dean S.; Vappiani, Johanna; Cañeque, Tatiana; Lam, Enid Y. N.; Ward, Aoife; Gilan, Omer; Chan, Yih-Chih; Hienzsch, Antje; Rutkowska, Anna; Werner, Thilo; Wagner, Anne J.; Lugo, Dave; et al. (Science (American Association for the Advancement of Science), 2017)
Keywords: Animal models; Animals; Benzodiazepines - pharmacology; Benzodiazepines - therapeutic use; Bone marrow; Cancer; Cells, Cultured; Chemical Sciences; Chemical synthesis; Chemistry; Chromatin; Click Chemistry; Compartments; Cytometry; Differential distribution; Disease Models, Animal; Drug Delivery Systems; Drugs; Epigenetics; Epigenomics; Flow cytometry; Gene expression; Gene sequencing; Genes; Heterogeneity; In vivo methods and tests; Inhibitors; Leukemia; Leukemia - drug therapy; Leukemia - pathology; Leukemias; Life Sciences; Localization; Mice; Narcotics; Organic Chemistry; Position (location); Precision Medicine; Probes; Proteomics; Spleen; Synthesis (chemistry); Therapy; Tissue Distribution; Transcription; Transcription Factors - antagonists & inhibitors; Tumor cells