The pre-B cell receptor checkpoint
B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody reper...
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| Published in | FEBS letters Vol. 584; no. 12; pp. 2572 - 2579 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
18.06.2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-5793 1873-3468 1873-3468 |
| DOI | 10.1016/j.febslet.2010.04.057 |
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| Abstract | B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity. |
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| AbstractList | B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity. B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity.B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity. |
| Author | Bernardi, Angelina I. Mårtensson, Inga-Lill Almqvist, Nina Grimsholm, Ola |
| Author_xml | – sequence: 1 givenname: Inga-Lill surname: Mårtensson fullname: Mårtensson, Inga-Lill email: lill.martensson@rheuma.gu.se – sequence: 2 givenname: Nina surname: Almqvist fullname: Almqvist, Nina – sequence: 3 givenname: Ola surname: Grimsholm fullname: Grimsholm, Ola – sequence: 4 givenname: Angelina I. surname: Bernardi fullname: Bernardi, Angelina I. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20420836$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/130441$$DView record from Swedish Publication Index |
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| Keywords | aa pre-BCR SL chain CD D Antibody Positive selection Pre-B cell receptor checkpoint J Negative selection μMT SLE BCR CDR B cell L chain H chain V RAG λ5-UR λ5 T Ig |
| Language | English |
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| Snippet | B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a... B lymphocytes are essential antibody‐producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a... |
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| SubjectTerms | amino acids Animals Antibody Autoimmunity Autoimmunity - genetics B cell B cell receptor B-Lymphocyte B-Lymphoid BCR CDR Cell Differentiation Cell Differentiation - immunology Cell Membrane Cell Membrane - immunology cluster of differentiation complementarity determining region cytology diversity Gene Rearrangement Gene Rearrangement, B-Lymphocyte genetics H chain heavy chain Humans immunoglobulin Immunologi inom det medicinska området Immunologic Deficiency Syndromes Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - immunology Immunological immunology Immunology in the Medical Area joining L chain light chain Mice mice lacking the transmembrane region of μH chain Models, Immunological Mutation Negative selection Positive selection pre-B cell receptor Pre-B cell receptor checkpoint Pre-B Cell Receptors Pre-B Cell Receptors - immunology pre-BCR Precursor Cells Precursor Cells, B-Lymphoid - cytology Precursor Cells, B-Lymphoid - immunology RAG recombination-activating genes Signal Transduction Signal Transduction - immunology SL chain SLE surrogate light chain systemic lupus erythematosus variable λ5 T λ5 unique region λ5-deficient mice λ5-UR μMT |
| Title | The pre-B cell receptor checkpoint |
| URI | https://dx.doi.org/10.1016/j.febslet.2010.04.057 https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.febslet.2010.04.057 https://www.ncbi.nlm.nih.gov/pubmed/20420836 https://www.proquest.com/docview/733125632 https://www.proquest.com/docview/877574419 https://gup.ub.gu.se/publication/130441 |
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