新生儿局灶性白质损伤的MRI研究现状及其核心问题的思考

近年来,我国早产儿数量居高不下,该人群极易受到各种因素的影响而发生脑损伤,其中局灶性白质损伤最为 常见（发生率超过20% ）, 该类脑损伤对发育结局具有严重的危害性且不易被探测, 如何进行早期诊断与预后评估是 目前关注的热点.本文阐述了局灶性白质损伤的类型及其空间分布特点, 个体差异、 发育因素在疾病诊断与预后评 估中的作用;指出了发育脑模板构建、 个体化分析与早期预测方法中存在的核心问题....

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Bibliographic Details
Published in西安交通大学学报（医学版） Vol. 39; no. 2; pp. 153 - 159
Main Author 杨健;李贤军
Format Journal Article
LanguageChinese
Published 西安交通大学第一附属医院医学影像科,陕西西安,710061 2018
Subjects
个体化诊断
新生儿局灶性白质损伤
早期预测
病变类型
脑功能与结构
病变类型
个体化诊断
degeneration pattern
individualized diagnosis
early prediction
早期预测
脑功能与结构
brain function and structure
新生儿局灶性白质损伤
neonatal punctate white matter lesion
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ISSN1671-8259
DOI10.7652/jdyxb201802001

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Summary:近年来,我国早产儿数量居高不下,该人群极易受到各种因素的影响而发生脑损伤,其中局灶性白质损伤最为 常见（发生率超过20% ）, 该类脑损伤对发育结局具有严重的危害性且不易被探测, 如何进行早期诊断与预后评估是 目前关注的热点.本文阐述了局灶性白质损伤的类型及其空间分布特点, 个体差异、 发育因素在疾病诊断与预后评 估中的作用;指出了发育脑模板构建、 个体化分析与早期预测方法中存在的核心问题.
Bibliography:The number of preterm neonates appears to remain high in China in recent years. These subjecSs are vulnerable to pathogenic factors and have brain lesions easily. Punctate white matter lesions （PWML） are very common （the incidence〉20%） . The degeneration in the brain associated with PWML is harmful to the outcomes and hard to be detected. Early diagnosis and prediction of PWML are focuses for pediatric researchers. This paper describes the change patterns and spatial distributions associated with PWML. The factors of and development during the diagnosis and prognosis are discussed as well. Finally, the paper points out the coreproblems in developmental brain template construction, individualized diagnosis, and early prediction.
neonatal punctate white matter lesion; brain function and structure; degeneration pattern;individualized diagnosis; early prediction
YANG Jian,LI Xian-jun（Department of Radiology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China）
61-1399/R
ISSN:1671-8259
DOI:10.7652/jdyxb201802001