白藜芦醇对大鼠重症急性胰腺炎肠黏膜细胞凋亡的影响
目的探讨白藜芦醇对试验性大鼠重症急性胰腺炎肠黏膜细胞凋亡及凋亡调控基因Bax蛋白表达的影响。方法54只成年雄性SD大鼠随机分为假手术组（sham operation group，SO）、模型组（severe acute pancreatitis，SAP）、治疗组（resveratrol-treated group，RES）。假手术组于开腹翻动十二指肠后关腹，模型组以40g／L牛磺胆酸钠1mL／kg胰胆管逆行注射制造重症急性胰腺炎模型。治疗组制模后立即于阴茎背静脉注射等剂量白藜芦醇（5mg／mL、10mg／kg）。于3、6、12h3个时间点各剖杀6只大鼠。TUNEL法检测肠黏膜上皮细胞凋亡，免疫...
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| Published in | Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban Vol. 27; no. 6; pp. 593 - 595 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
西安交通大学医学院第一附属医院肝胆外科,陕西,西安,710061
2006
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1671-8259 |
| DOI | 10.3969/j.issn.1671-8259.2006.06.021 |
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| Abstract | 目的探讨白藜芦醇对试验性大鼠重症急性胰腺炎肠黏膜细胞凋亡及凋亡调控基因Bax蛋白表达的影响。方法54只成年雄性SD大鼠随机分为假手术组（sham operation group，SO）、模型组（severe acute pancreatitis，SAP）、治疗组（resveratrol-treated group，RES）。假手术组于开腹翻动十二指肠后关腹，模型组以40g／L牛磺胆酸钠1mL／kg胰胆管逆行注射制造重症急性胰腺炎模型。治疗组制模后立即于阴茎背静脉注射等剂量白藜芦醇（5mg／mL、10mg／kg）。于3、6、12h3个时间点各剖杀6只大鼠。TUNEL法检测肠黏膜上皮细胞凋亡，免疫组化法检测小肠组织中Bax蛋白的表达。结果治疗组3、6、12h肠黏膜细胞凋亡指数明显低于模型组（P〈0．01）。治疗组各时间点Bax蛋白表达阳性率显著低于模型组（P〈0．01）。结论白藜芦醇可通过抑制肠黏膜上皮细胞的凋亡，维持肠黏膜屏障的完整性，从而防止了急性重症胰腺炎细菌和毒素的移居。 |
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| AbstractList | R657.4; 目的 探讨白藜芦醇对试验性大鼠重症急性胰腺炎肠黏膜细胞凋亡及凋亡调控基因Bax蛋白表达的影响.方法 54只成年雄性SD大鼠随机分为假手术组(sham operation group,SO)、模型组(severe acute pancreatitis,SAP)、治疗组(resveratrol-treated group,RES).假手术组于开腹翻动十二指肠后关腹,模型组以40 g/L牛磺胆酸钠1 mL/kg胰胆管逆行注射制造重症急性胰腺炎模型.治疗组制模后立即于阴茎背静脉注射等剂量白藜芦醇(5 mg/mL、10 mg/kg).于3、6、12 h 3个时间点各剖杀6只大鼠.TUNEL法检测肠黏膜上皮细胞凋亡,免疫组化法检测小肠组织中Bax蛋白的表达.结果 治疗组3、6、12 h肠黏膜细胞凋亡指数明显低于模型组(P＜0.01).治疗组各时间点Bax蛋白表达阳性率显著低于模型组(P＜0.01).结论 白藜芦醇可通过抑制肠黏膜上皮细胞的凋亡,维持肠黏膜屏障的完整性,从而防止了急性重症胰腺炎细菌和毒素的移居. 目的探讨白藜芦醇对试验性大鼠重症急性胰腺炎肠黏膜细胞凋亡及凋亡调控基因Bax蛋白表达的影响。方法54只成年雄性SD大鼠随机分为假手术组（sham operation group，SO）、模型组（severe acute pancreatitis，SAP）、治疗组（resveratrol-treated group，RES）。假手术组于开腹翻动十二指肠后关腹，模型组以40g／L牛磺胆酸钠1mL／kg胰胆管逆行注射制造重症急性胰腺炎模型。治疗组制模后立即于阴茎背静脉注射等剂量白藜芦醇（5mg／mL、10mg／kg）。于3、6、12h3个时间点各剖杀6只大鼠。TUNEL法检测肠黏膜上皮细胞凋亡，免疫组化法检测小肠组织中Bax蛋白的表达。结果治疗组3、6、12h肠黏膜细胞凋亡指数明显低于模型组（P〈0．01）。治疗组各时间点Bax蛋白表达阳性率显著低于模型组（P〈0．01）。结论白藜芦醇可通过抑制肠黏膜上皮细胞的凋亡，维持肠黏膜屏障的完整性，从而防止了急性重症胰腺炎细菌和毒素的移居。 |
| Author | 沙焕臣 马清涌 王连才 |
| AuthorAffiliation | 西安交通大学医学院第一附属医院肝胆外科,陕西西安710061 |
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| Author_FL | Wang Liancai Ma Qingyong Sha Huanchen |
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| DocumentTitleAlternate | Effects of resveratrol on apoptosis of intestinal mucosal cells in rats with severe acute pancreatitis |
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| Snippet | 目的探讨白藜芦醇对试验性大鼠重症急性胰腺炎肠黏膜细胞凋亡及凋亡调控基因Bax蛋白表达的影响。方法54只成年雄性SD大鼠随机分为假手术组（sham operation group，SO）、模型... R657.4; 目的 探讨白藜芦醇对试验性大鼠重症急性胰腺炎肠黏膜细胞凋亡及凋亡调控基因Bax蛋白表达的影响.方法 54只成年雄性SD大鼠随机分为假手术组(sham operation... |
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| Title | 白藜芦醇对大鼠重症急性胰腺炎肠黏膜细胞凋亡的影响 |
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