Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly - Sheline, Yvette I.; Raichle, Marcus E.; Snyder, Abraham Z.; Morris, John C.; Head, Denise; Wang, Suzhi; Mintun, Mark A. (Biological psychiatry (1969), 2010)
Keywords: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; amyloid; Amyloid beta-Peptides - metabolism; Aniline Compounds; Biological and medical sciences; Brain - blood supply; Brain - diagnostic imaging; Brain - pathology; Brain Mapping - methods; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; fMRI; Geriatric Assessment; hippocampus; Humans; Image Processing, Computer-Assisted - methods; Longitudinal Studies; Magnetic Resonance Imaging - methods; Male; Medical sciences; Nerve Net - blood supply; Nerve Net - diagnostic imaging; Nerve Net - pathology; Neurology; Organic mental disorders. Neuropsychology; Oxygen - blood; PIB; Positron-Emission Tomography - methods; precuneus; Psychiatric Status Rating Scales; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rest - physiology; resting state; Statistics as Topic; Thiazoles; fMRI; resting state; amyloid; hippocampus; precuneus; PIB; Alzheimer's disease; Human; Nervous system diseases; Alzheimer disease; Central nervous system; Nuclear magnetic resonance imaging; Encephalon; Cerebral disorder; Rest; Central nervous system disease; Medical imagery; Degenerative disease; Amyloid; Elderly; Hippocampus; Functional imaging