Trends in the prescription of antidiabetic medications from 2009 to 2012 in a general practice of Southern Italy: A population-based study

To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes. This retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern I...

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Published in	Diabetes research and clinical practice Vol. 108; no. 1; pp. 157 - 163
Main Authors	Rafaniello, Concetta, Arcoraci, Vincenzo, Ferrajolo, Carmen, Sportiello, Liberata, Sullo, Maria Giuseppa, Giorgianni, Francesco, Trifirò, Gianluca, Tari, Michele, Caputi, Achille P., Rossi, Francesco, Esposito, Katherine, Giugliano, Dario, Capuano, Annalisa
Format	Journal Article
Language	English
Published	Ireland Elsevier Ireland Ltd 01.04.2015
Subjects	Adolescent Adult Aged Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - epidemiology Drug Prescriptions - statistics & numerical data Drug Utilization - trends Endocrinology & Metabolism Female General Practice Humans Hypoglycemic Agents - therapeutic use Italy - epidemiology Male Medical therapy Middle Aged Population Surveillance Prescribing patterns Prevalence Retrospective Studies Young Adult Italy Medical therapy Diabetes mellitus Prescribing patterns
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ISSN	0168-8227 1872-8227 1872-8227
DOI	10.1016/j.diabres.2014.12.007

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Abstract	To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes. This retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern Italy) including about 1 million citizens. The standardized prevalence of AD use was calculated within each study year. A sample cohort of 78,789 subjects with at least one prescription of AD was identified during the study period. There was an overall increase of the proportion of the patients treated with monotherapy, which was significant for insulin monotherapy (from 11.2 to 14.6%, p<0.001). The proportion of patients treated with metformin remained stable (from 68.3% to 67.8%, p=0.076), while those receiving sulfonylurea dropped from 18.4% to 12.5% (p<0.001); GLP-1 analogues and DPP-4 inhibitors showed the greatest increase (from 1.2% to 6.6%, p<0.001). In the whole sample of 25,148 new AD users, metformin was the most commonly prescribed drug in monotherapy (41.9%), while insulin ranked second (13.3%). This study shows a rising trend of AD monotherapy, with sulfonylureas and incretins showing the more negative and positive trend, respectively.
AbstractList	To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes. This retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern Italy) including about 1 million citizens. The standardized prevalence of AD use was calculated within each study year. A sample cohort of 78,789 subjects with at least one prescription of AD was identified during the study period. There was an overall increase of the proportion of the patients treated with monotherapy, which was significant for insulin monotherapy (from 11.2 to 14.6%, p<0.001). The proportion of patients treated with metformin remained stable (from 68.3% to 67.8%, p=0.076), while those receiving sulfonylurea dropped from 18.4% to 12.5% (p<0.001); GLP-1 analogues and DPP-4 inhibitors showed the greatest increase (from 1.2% to 6.6%, p<0.001). In the whole sample of 25,148 new AD users, metformin was the most commonly prescribed drug in monotherapy (41.9%), while insulin ranked second (13.3%). This study shows a rising trend of AD monotherapy, with sulfonylureas and incretins showing the more negative and positive trend, respectively. Abstract Objective To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes. Methods This retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern Italy) including about 1 million citizens. The standardized prevalence of AD use was calculated within each study year. A sample cohort of 78,789 subjects with at least one prescription of AD was identified during the study period. Results There was an overall increase of the proportion of the patients treated with monotherapy, which was significant for insulin monotherapy (from 11.2 to 14.6%, p < 0.001). The proportion of patients treated with metformin remained stable (from 68.3% to 67.8%, p = 0.076), while those receiving sulfonylurea dropped from 18.4% to 12.5% ( p < 0.001); GLP-1 analogues and DPP-4 inhibitors showed the greatest increase (from 1.2% to 6.6%, p < 0.001). In the whole sample of 25,148 new AD users, metformin was the most commonly prescribed drug in monotherapy (41.9%), while insulin ranked second (13.3%). Conclusion This study shows a rising trend of AD monotherapy, with sulfonylureas and incretins showing the more negative and positive trend, respectively. To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes.OBJECTIVETo assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing changes.This retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern Italy) including about 1 million citizens. The standardized prevalence of AD use was calculated within each study year. A sample cohort of 78,789 subjects with at least one prescription of AD was identified during the study period.METHODSThis retrospective, drug utilization study was conducted using administrative databases of the Local Health Unit of Caserta (Southern Italy) including about 1 million citizens. The standardized prevalence of AD use was calculated within each study year. A sample cohort of 78,789 subjects with at least one prescription of AD was identified during the study period.There was an overall increase of the proportion of the patients treated with monotherapy, which was significant for insulin monotherapy (from 11.2 to 14.6%, p<0.001). The proportion of patients treated with metformin remained stable (from 68.3% to 67.8%, p=0.076), while those receiving sulfonylurea dropped from 18.4% to 12.5% (p<0.001); GLP-1 analogues and DPP-4 inhibitors showed the greatest increase (from 1.2% to 6.6%, p<0.001). In the whole sample of 25,148 new AD users, metformin was the most commonly prescribed drug in monotherapy (41.9%), while insulin ranked second (13.3%).RESULTSThere was an overall increase of the proportion of the patients treated with monotherapy, which was significant for insulin monotherapy (from 11.2 to 14.6%, p<0.001). The proportion of patients treated with metformin remained stable (from 68.3% to 67.8%, p=0.076), while those receiving sulfonylurea dropped from 18.4% to 12.5% (p<0.001); GLP-1 analogues and DPP-4 inhibitors showed the greatest increase (from 1.2% to 6.6%, p<0.001). In the whole sample of 25,148 new AD users, metformin was the most commonly prescribed drug in monotherapy (41.9%), while insulin ranked second (13.3%).This study shows a rising trend of AD monotherapy, with sulfonylureas and incretins showing the more negative and positive trend, respectively.CONCLUSIONThis study shows a rising trend of AD monotherapy, with sulfonylureas and incretins showing the more negative and positive trend, respectively.
Author	Capuano, Annalisa Rossi, Francesco Giugliano, Dario Esposito, Katherine Arcoraci, Vincenzo Sullo, Maria Giuseppa Giorgianni, Francesco Trifirò, Gianluca Rafaniello, Concetta Sportiello, Liberata Caputi, Achille P. Ferrajolo, Carmen Tari, Michele
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Cites_doi	10.1517/13543784.2013.828691 10.1002/pds.1089 10.2147/PPA.S33968 10.1001/archinternmed.2009.296 10.1517/14712598.2012.728584 10.1016/j.clinthera.2008.10.003 10.1016/j.diabres.2011.05.004 10.1536/ihj.54.93 10.1002/pds.1802 10.2337/dc14-S014 10.2337/diacare.28.12.2948 10.1007/s00125-006-0331-3 10.1111/j.1532-5415.2009.02484.x 10.1016/j.diabres.2013.11.002 10.1111/j.1365-2125.2006.02711.x 10.2337/dc12-0698 10.2337/diacare.26.6.1847 10.1001/archinte.168.19.2088 10.1016/j.phrs.2008.03.009 10.2337/dc08-0075 10.2337/diacare.26.6.1852
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References	Lub, Denig, van den Berg, Hoogenberg, de Jong-van den Berg (bib0205) 2006; 62 Alexander, Sehgal, Moloney, Stafford (bib0185) 2008; 168 Kohro, Yamazaki, Sato, Harada, Ohe, Komuro (bib0170) 2013; 54 (bib0135) 2011 Morgillo, Sasso, Della Corte, Festino, Manzo, Martinelli (bib0155) 2013; 33 Chen, Wu, Jap, Hsiao, Lee, Lin (bib0240) 2008; 31 Zamitt, Frier (bib0245) 2005; 28 Osservatorio Nazionale sull’Impiego dei Medicinali – L’uso dei farmaci in Italia gennaio–settembre 2012 (National Monitoring Center for Drug Use. The Use of Drug in Italy. Rome, National Ministry of Health). Guariguata, Whiting, Hambleton, Beagley, Linnenkamp, Shaw (bib0130) 2014; 103 Wysowski, Armstrong, Governale (bib0180) 2003; 26 Mann, Woodward, Ye, Krousel-Wood, Muntner (bib0190) 2009; 169 Italian national institute of statistics. Esposito, Chiodini, Capuano, Petrizzo, Improta, Giugliano (bib0160) 2012; 35 . Cohen, Neslusan, Conklin, Song (bib0175) 2003; 26 American Diabetes Association (bib0150) 2014; 37 Filion, Joseph, Boivin, Suissa, Brophy (bib0210) 2009; 18 Pratley, McCall, Fleck, Wilson, Mekki (bib0250) 2009; 57 Melander, Folino-Gallo, Walley, Schwabe, Groop, Klaukka (bib0200) 2006; 49 Mazzaglia, Yurgin, Boye, Trifirò, Cottrell, Allen (bib0215) 2008; 57 (bib0145) 1999 Cheong, Barner, Lawson, Johnsrud (bib0235) 2008; 30 Colombo, Rossi, De Rosa, Benedetto, Gaddi (bib0230) 2012; 6 Esposito, Capuano, Giugliano (bib0165) 2012; 12 Baviera, Monesi, Marzona, Avanzini, Monesi, Nobili (bib0220) 2011; 93 Walley, Hughes, Kendall (bib0195) 2005; 14 Kohro (10.1016/j.diabres.2014.12.007_bib0170) 2013; 54 Filion (10.1016/j.diabres.2014.12.007_bib0210) 2009; 18 Cohen (10.1016/j.diabres.2014.12.007_bib0175) 2003; 26 Alexander (10.1016/j.diabres.2014.12.007_bib0185) 2008; 168 Mann (10.1016/j.diabres.2014.12.007_bib0190) 2009; 169 Chen (10.1016/j.diabres.2014.12.007_bib0240) 2008; 31 Guariguata (10.1016/j.diabres.2014.12.007_bib0130) 2014; 103 Walley (10.1016/j.diabres.2014.12.007_bib0195) 2005; 14 (10.1016/j.diabres.2014.12.007_bib0145) 1999 Morgillo (10.1016/j.diabres.2014.12.007_bib0155) 2013; 33 Zamitt (10.1016/j.diabres.2014.12.007_bib0245) 2005; 28 10.1016/j.diabres.2014.12.007_bib0225 (10.1016/j.diabres.2014.12.007_bib0135) 2011 10.1016/j.diabres.2014.12.007_bib0140 Esposito (10.1016/j.diabres.2014.12.007_bib0160) 2012; 35 Pratley (10.1016/j.diabres.2014.12.007_bib0250) 2009; 57 Colombo (10.1016/j.diabres.2014.12.007_bib0230) 2012; 6 Melander (10.1016/j.diabres.2014.12.007_bib0200) 2006; 49 Lub (10.1016/j.diabres.2014.12.007_bib0205) 2006; 62 Mazzaglia (10.1016/j.diabres.2014.12.007_bib0215) 2008; 57 American Diabetes Association (10.1016/j.diabres.2014.12.007_bib0150) 2014; 37 Baviera (10.1016/j.diabres.2014.12.007_bib0220) 2011; 93 Esposito (10.1016/j.diabres.2014.12.007_bib0165) 2012; 12 Wysowski (10.1016/j.diabres.2014.12.007_bib0180) 2003; 26 Cheong (10.1016/j.diabres.2014.12.007_bib0235) 2008; 30
References_xml	– volume: 28 start-page: 2948 year: 2005 end-page: 2961 ident: bib0245 article-title: Hypoglycemia in type 2 diabetes publication-title: Diabetes Care – volume: 30 start-page: 1893 year: 2008 end-page: 1907 ident: bib0235 article-title: Patient adherence and reimbursement amount for antidiabetic fixed-dose combination products compared with dual therapy among Texas Medicaid recipients publication-title: Clin Ther – reference: Italian national institute of statistics. – volume: 57 start-page: 2011 year: 2009 end-page: 2019 ident: bib0250 article-title: Alogliptin use in elderly people: a pooled analysis from phase 2 and 3 studies publication-title: J Am Geriatr Soc – volume: 18 start-page: 973 year: 2009 end-page: 976 ident: bib0210 article-title: Trends in the prescription of anti-diabetic medications in the United Kingdom: a population-based analysis publication-title: Pharmacoepidemiol Drug Saf – volume: 49 start-page: 2024 year: 2006 end-page: 2029 ident: bib0200 article-title: Utilisation of antihyperglycaemic drugs in ten European countries: different developments and different levels publication-title: Diabetologia – volume: 37 start-page: S14 year: 2014 end-page: S20 ident: bib0150 article-title: Standards of medical care in diabetes – 2014 publication-title: Diabetes Care – year: 2011 ident: bib0135 article-title: Global status report on non communicable diseases 2010 – volume: 35 start-page: 2698 year: 2012 end-page: 2705 ident: bib0160 article-title: Basal supplementation of insulin lispro protamine suspension versus insulin glargine and detemir for type 2 diabetes: meta-analysis of randomized controlled trials publication-title: Diabetes Care – volume: 62 start-page: 660 year: 2006 end-page: 665 ident: bib0205 article-title: The impact of new insights and revised practice guidelines on prescribing drugs in the treatment of Type 2 diabetes mellitus publication-title: Br J Clin Pharmacol – volume: 168 start-page: 2088 year: 2008 end-page: 2094 ident: bib0185 article-title: National trends in treatment of type 2 diabetes mellitus, 1994–2007 publication-title: Arch Intern Med – year: 1999 ident: bib0145 article-title: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus – volume: 31 start-page: 1927 year: 2008 end-page: 1932 ident: bib0240 article-title: Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy publication-title: Diabetes Care – volume: 57 start-page: 358 year: 2008 end-page: 363 ident: bib0215 article-title: Prevalence and antihyperglycemic prescribing trends for patients with type 2 diabetes in Italy: a 4-year retrospective study from national primary care data publication-title: Pharmacol Res – volume: 26 start-page: 1847 year: 2003 end-page: 1851 ident: bib0175 article-title: Recent antihyperglycemic prescribing trends for US privately insured patients with type 2 diabetes publication-title: Diabetes Care – reference: Osservatorio Nazionale sull’Impiego dei Medicinali – L’uso dei farmaci in Italia gennaio–settembre 2012 (National Monitoring Center for Drug Use. The Use of Drug in Italy. Rome, National Ministry of Health). – volume: 14 start-page: 769 year: 2005 end-page: 773 ident: bib0195 article-title: Trends and influences on use of antidiabetic drugs in England, 1992–2003 publication-title: Pharmacoepidemiol Drug Saf – volume: 6 start-page: 653 year: 2012 end-page: 661 ident: bib0230 article-title: Antidiabetic therapy in real practice: indicators for adherence and treatment cost publication-title: Patient Prefer Adherence – reference: . – volume: 93 start-page: 123 year: 2011 end-page: 130 ident: bib0220 article-title: Trends in drug prescriptions to diabetic patients from 2000 to 2008 in Italy's Lombardy Region: a large population-based study publication-title: Diabetes Res Clin Pract – volume: 169 start-page: 1718 year: 2009 end-page: 1720 ident: bib0190 article-title: Trends in medication use among US adults with diabetes mellitus: glycemic control at the expense of controlling cardiovascular risk factors publication-title: Arch Intern Med – volume: 103 start-page: 137 year: 2014 end-page: 149 ident: bib0130 article-title: Global estimates of diabetes prevalence in adults for 2013 and projections for 2035 publication-title: Diabetes Res Clin Pract – volume: 26 start-page: 1852 year: 2003 end-page: 1855 ident: bib0180 article-title: Rapid increase in the use of oral antidiabetic drugs in the United States, 1990–2001 publication-title: Diabetes Care – volume: 12 start-page: 1541 year: 2012 end-page: 1550 ident: bib0165 article-title: Humalog (lispro) for type 2 diabetes publication-title: Expert Opin Biol Ther – volume: 54 start-page: 93 year: 2013 end-page: 97 ident: bib0170 article-title: Trends in antidiabetic prescription patterns in Japan from 2005 to 2011 publication-title: Int Heart J – volume: 33 start-page: 1401 year: 2013 end-page: 1409 ident: bib0155 article-title: Metformin in lung cancer: rationale for a combination therapy publication-title: Expert Opin Investig Drugs – volume: 33 start-page: 1401 year: 2013 ident: 10.1016/j.diabres.2014.12.007_bib0155 article-title: Metformin in lung cancer: rationale for a combination therapy publication-title: Expert Opin Investig Drugs doi: 10.1517/13543784.2013.828691 – volume: 14 start-page: 769 year: 2005 ident: 10.1016/j.diabres.2014.12.007_bib0195 article-title: Trends and influences on use of antidiabetic drugs in England, 1992–2003 publication-title: Pharmacoepidemiol Drug Saf doi: 10.1002/pds.1089 – ident: 10.1016/j.diabres.2014.12.007_bib0225 – volume: 6 start-page: 653 year: 2012 ident: 10.1016/j.diabres.2014.12.007_bib0230 article-title: Antidiabetic therapy in real practice: indicators for adherence and treatment cost publication-title: Patient Prefer Adherence doi: 10.2147/PPA.S33968 – volume: 169 start-page: 1718 year: 2009 ident: 10.1016/j.diabres.2014.12.007_bib0190 article-title: Trends in medication use among US adults with diabetes mellitus: glycemic control at the expense of controlling cardiovascular risk factors publication-title: Arch Intern Med doi: 10.1001/archinternmed.2009.296 – volume: 12 start-page: 1541 year: 2012 ident: 10.1016/j.diabres.2014.12.007_bib0165 article-title: Humalog (lispro) for type 2 diabetes publication-title: Expert Opin Biol Ther doi: 10.1517/14712598.2012.728584 – volume: 30 start-page: 1893 year: 2008 ident: 10.1016/j.diabres.2014.12.007_bib0235 article-title: Patient adherence and reimbursement amount for antidiabetic fixed-dose combination products compared with dual therapy among Texas Medicaid recipients publication-title: Clin Ther doi: 10.1016/j.clinthera.2008.10.003 – volume: 93 start-page: 123 year: 2011 ident: 10.1016/j.diabres.2014.12.007_bib0220 article-title: Trends in drug prescriptions to diabetic patients from 2000 to 2008 in Italy's Lombardy Region: a large population-based study publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2011.05.004 – volume: 54 start-page: 93 year: 2013 ident: 10.1016/j.diabres.2014.12.007_bib0170 article-title: Trends in antidiabetic prescription patterns in Japan from 2005 to 2011 publication-title: Int Heart J doi: 10.1536/ihj.54.93 – volume: 18 start-page: 973 year: 2009 ident: 10.1016/j.diabres.2014.12.007_bib0210 article-title: Trends in the prescription of anti-diabetic medications in the United Kingdom: a population-based analysis publication-title: Pharmacoepidemiol Drug Saf doi: 10.1002/pds.1802 – volume: 37 start-page: S14 issue: Suppl. 1 year: 2014 ident: 10.1016/j.diabres.2014.12.007_bib0150 article-title: Standards of medical care in diabetes – 2014 publication-title: Diabetes Care doi: 10.2337/dc14-S014 – volume: 28 start-page: 2948 year: 2005 ident: 10.1016/j.diabres.2014.12.007_bib0245 article-title: Hypoglycemia in type 2 diabetes publication-title: Diabetes Care doi: 10.2337/diacare.28.12.2948 – volume: 49 start-page: 2024 year: 2006 ident: 10.1016/j.diabres.2014.12.007_bib0200 article-title: Utilisation of antihyperglycaemic drugs in ten European countries: different developments and different levels publication-title: Diabetologia doi: 10.1007/s00125-006-0331-3 – volume: 57 start-page: 2011 year: 2009 ident: 10.1016/j.diabres.2014.12.007_bib0250 article-title: Alogliptin use in elderly people: a pooled analysis from phase 2 and 3 studies publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2009.02484.x – volume: 103 start-page: 137 issue: 2 year: 2014 ident: 10.1016/j.diabres.2014.12.007_bib0130 article-title: Global estimates of diabetes prevalence in adults for 2013 and projections for 2035 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2013.11.002 – volume: 62 start-page: 660 year: 2006 ident: 10.1016/j.diabres.2014.12.007_bib0205 article-title: The impact of new insights and revised practice guidelines on prescribing drugs in the treatment of Type 2 diabetes mellitus publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.2006.02711.x – volume: 35 start-page: 2698 year: 2012 ident: 10.1016/j.diabres.2014.12.007_bib0160 article-title: Basal supplementation of insulin lispro protamine suspension versus insulin glargine and detemir for type 2 diabetes: meta-analysis of randomized controlled trials publication-title: Diabetes Care doi: 10.2337/dc12-0698 – ident: 10.1016/j.diabres.2014.12.007_bib0140 – year: 2011 ident: 10.1016/j.diabres.2014.12.007_bib0135 – volume: 26 start-page: 1847 year: 2003 ident: 10.1016/j.diabres.2014.12.007_bib0175 article-title: Recent antihyperglycemic prescribing trends for US privately insured patients with type 2 diabetes publication-title: Diabetes Care doi: 10.2337/diacare.26.6.1847 – volume: 168 start-page: 2088 year: 2008 ident: 10.1016/j.diabres.2014.12.007_bib0185 article-title: National trends in treatment of type 2 diabetes mellitus, 1994–2007 publication-title: Arch Intern Med doi: 10.1001/archinte.168.19.2088 – volume: 57 start-page: 358 year: 2008 ident: 10.1016/j.diabres.2014.12.007_bib0215 article-title: Prevalence and antihyperglycemic prescribing trends for patients with type 2 diabetes in Italy: a 4-year retrospective study from national primary care data publication-title: Pharmacol Res doi: 10.1016/j.phrs.2008.03.009 – year: 1999 ident: 10.1016/j.diabres.2014.12.007_bib0145 – volume: 31 start-page: 1927 year: 2008 ident: 10.1016/j.diabres.2014.12.007_bib0240 article-title: Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy publication-title: Diabetes Care doi: 10.2337/dc08-0075 – volume: 26 start-page: 1852 issue: 6 year: 2003 ident: 10.1016/j.diabres.2014.12.007_bib0180 article-title: Rapid increase in the use of oral antidiabetic drugs in the United States, 1990–2001 publication-title: Diabetes Care doi: 10.2337/diacare.26.6.1852
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Snippet	To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on behaviour prescribing... Abstract Objective To assess the prescribing pattern of antidiabetic drugs (AD) in a general practice of Southern Italy from 2009 to 2012, with focus on...
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SubjectTerms	Adolescent Adult Aged Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - epidemiology Drug Prescriptions - statistics & numerical data Drug Utilization - trends Endocrinology & Metabolism Female General Practice Humans Hypoglycemic Agents - therapeutic use Italy - epidemiology Male Medical therapy Middle Aged Population Surveillance Prescribing patterns Prevalence Retrospective Studies Young Adult
Title	Trends in the prescription of antidiabetic medications from 2009 to 2012 in a general practice of Southern Italy: A population-based study
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