Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 - Gong, Bei; Shin, Minsang; Sun, Jiali; Jung, Che-Hun; Bolt, Edward L.; van der Oost, John; Kim, Jeong-Sun (Proceedings of the National Academy of Sciences - PNAS, 2014)
Keywords: Active sites; adaptive immunity; Adenosine triphosphatase; Adenosine triphosphatases; Adenosine Triphosphate - metabolism; Amino Acid Motifs; Amino Acid Sequence; antiviral defense; ATP; bacteria; Bacteria - enzymology; Bacteria - genetics; Bacteria - immunology; bacterial immune-system; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Binding sites; Biochemistry; Biological Sciences; cascade; Clustered Regularly Interspaced Short Palindromic Repeats - physiology; complex; CRISPR-Associated Proteins - chemistry; CRISPR-Associated Proteins - genetics; CRISPR-Associated Proteins - metabolism; CRISPR-Cas Systems - physiology; Crystal structure; Crystallography, X-Ray; Deoxyribonucleases - chemistry; Deoxyribonucleases - genetics; Deoxyribonucleases - metabolism; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA fragmentation; DNA Helicases - chemistry; DNA Helicases - genetics; DNA Helicases - metabolism; DNA, Bacterial - metabolism; DNA, Single-Stranded - metabolism; escherichia-coli; genome; Host-Pathogen Interactions; in-vitro reconstitution; Interspersed Repetitive Sequences; loci; Magnesium - metabolism; Manganese - metabolism; Metal ions; Models, Molecular; Molecular Sequence Data; Molecular structure; Molecules; Mutagenesis, Site-Directed; Neutralization; Nucleic acids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - metabolism; RNA; RNA, Bacterial - metabolism; Sequence Alignment; Sequence Homology, Amino Acid; structural basis; transcription (genetics); Translocation; Tunnels; CRISPR; Cas3; Cas proteins; bacterial immunity; Cascade