Brain clearance of protein aggregates: a close-up on astrocytes

Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types...

Full description

Saved in:
Bibliographic Details
Published inMolecular neurodegeneration Vol. 19; no. 1; pp. 5 - 18
Main Authors Giusti, Veronica, Kaur, Gurkirat, Giusto, Elena, Civiero, Laura
Format Journal Article
LanguageEnglish
Published London BioMed Central 16.01.2024
BioMed Central Ltd
BMC
Subjects
alpha-Synuclein - metabolism
Alzheimer's disease
Amyloid
Amyloid proteins
Astrocytes
Astrocytes - metabolism
Autophagy
Biomedical and Life Sciences
Biomedicine
Brain
Brain - metabolism
Clearance
Dementia
Enzymes
Fibrils
Glycoproteins
Humans
Kinases
Microglia
Microglia - metabolism
Molecular Medicine
Molecular modelling
Nervous system diseases
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neurology
Neurosciences
Pathology
Protein Aggregates
Protein folding
Proteins
Review
Synuclein
Tau
Tau protein
Toxicity
α-Synuclein
α-Synuclein
Tau
Clearance
Astrocytes
Amyloid proteins
Online AccessGet full text
ISSN1750-1326
1750-1326
DOI10.1186/s13024-024-00703-1

Cover

Abstract Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts. Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown. Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to α-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation.
AbstractList Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts.Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown.Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to α-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation.Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts.Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown.Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to α-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation.
Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts. Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown. Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to α-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation.
Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts.Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown.Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to α-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation.
Abstract Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts. Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown. Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to α-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation.
Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts. Although microglia perform a predominant role in the removal of extracellular aggregated proteins, mounting evidence suggests that astrocytes actively contribute to the clearing process. However, the molecular mechanisms used by astrocytes to remove misfolded proteins are still largely unknown. Here we first provide a brief overview of the progressive transition from soluble monomers to insoluble fibrils that characterizes amyloid proteins, referring to [alpha]-Synuclein and Tau as archetypical examples. We then highlight the mechanisms at the basis of astrocyte-mediated clearance with a focus on their potential ability to recognize, collect, internalize and digest extracellular protein aggregates. Finally, we explore the potential of targeting astrocyte-mediated clearance as a future therapeutic approach for the treatment of neurodegenerative disorders characterized by protein misfolding and accumulation. Keywords: Amyloid proteins, Astrocytes, Clearance, [alpha]-Synuclein, Tau
Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates can enter the extracellular space and be subsequently transferred among different cell types, thus spreading between connected brain districts.
ArticleNumber 5
Audience Academic
Author Giusto, Elena
Civiero, Laura
Kaur, Gurkirat
Giusti, Veronica
Author_xml – sequence: 1
  givenname: Veronica
  surname: Giusti
  fullname: Giusti, Veronica
  organization: IRCCS San Camillo Hospital
– sequence: 2
  givenname: Gurkirat
  surname: Kaur
  fullname: Kaur, Gurkirat
  organization: Department of Biology, University of Padova
– sequence: 3
  givenname: Elena
  surname: Giusto
  fullname: Giusto, Elena
  email: elena.giusto@hsancamillo.it
  organization: IRCCS San Camillo Hospital
– sequence: 4
  givenname: Laura
  orcidid: 0000-0002-5334-155X
  surname: Civiero
  fullname: Civiero, Laura
  email: laura.civiero@unipd.it, laura.civiero@hsancamillo.it
  organization: IRCCS San Camillo Hospital, Department of Biology, University of Padova
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38229094$$D View this record in MEDLINE/PubMed
BookMark eNp9kk9r3DAQxU1Jaf60X6CHstBLL05Hkm1JvYQ0tEkg0Et7FmN55GrxWlvJG8i3r3adJtlQghE2M7_3xBvPcXEwhpGK4j2DU8ZU8zkxAbwqdwckiJK9Ko6YrKFkgjcHT74Pi-OUlgCVBKjfFIdCca5BV0fF2deIflzYgTDiaGkR3GIdw0S5iH0fqceJ0pcFZiQkKjfrRcidNMVg73LnbfHa4ZDo3f37pPj1_dvPi6vy5sfl9cX5TWkbUFNpQUsugVmseaed7ITDRijUKFjdWiVF3bZdo5i2tSNoG6pahxwVKFFXmsRJcT37dgGXZh39CuOdCejNrhBibzBOPucwrXbWMseAI694WynbAbbACTjjJGz2Opu91pt2RZ2lcYo47Jnud0b_2_Th1jCQGoRi2eHTvUMMfzaUJrPyydIw4EhhkwzXrNYaZFVl9OMzdBk2ccyzyhSvmzweLR-pHnMCP7qQL7ZbU3MuFWe6mr1O_0Plp6OVt3k5nM_1PcGHp0kfIv77_xngM2BjSCmSe0AYmO2SmXnJzO5sl8xs06tnIusnnHzYTssPL0vFLE35nrGn-DiNF1R_AWyg4ws
CitedBy_id crossref_primary_10_1186_s12974_025_03410_w
crossref_primary_10_3390_jcm14020386
crossref_primary_10_3389_fnmol_2024_1431079
crossref_primary_10_3390_ijms252211941
crossref_primary_10_1016_j_mocell_2024_100089
crossref_primary_10_1080_07391102_2025_2468296
crossref_primary_10_4103_REGENMED_REGENMED_D_24_00005
crossref_primary_10_3390_ijms251910797
crossref_primary_10_3389_frdem_2024_1404841
crossref_primary_10_3389_fnagi_2024_1378576
crossref_primary_10_1016_j_pneurobio_2025_102744
crossref_primary_10_1016_j_colsurfa_2024_136024
crossref_primary_10_1007_s00401_024_02790_2
crossref_primary_10_3390_ph17040530
crossref_primary_10_1016_j_mcn_2024_103975
Cites_doi 10.1074/jbc.274.14.9843
10.1186/s13024-016-0143-y
10.1096/fj.04-2751com
10.1038/s41418-022-01028-6
10.1089/ars.2013.5371
10.1186/1750-1326-7-42
10.1097/00001756-200107030-00028
10.1172/JCI124853
10.1172/JCI43366
10.1016/j.ceb.2020.05.011
10.1038/s41467-018-05971-2
10.1126/science.adc9020
10.1146/annurev-bioeng-062117-121224
10.3390/cells11091429
10.1126/science.1195227
10.1038/ncomms2534
10.1002/trc2.12090
10.1186/s40478-018-0552-y
10.1111/nan.12811
10.1038/s41467-020-16386-3
10.15252/emmm.202012025
10.1523/JNEUROSCI.0984-06.2006
10.1007/s00401-017-1746-2
10.1016/j.neuron.2017.06.029
10.1186/s40478-017-0488-7
10.2183/pjab.85.12
10.1111/j.1471-4159.2005.03247.x
10.1523/JNEUROSCI.4178-07.2008
10.1080/15384047.2020.1838034
10.1038/s41593-018-0235-9
10.1073/pnas.0908005106
10.1074/jbc.M111.277061
10.1186/s40478-023-01589-8
10.1007/s00401-017-1709-7
10.1016/j.neulet.2019.134316
10.1007/s00401-023-02604-x
10.1016/j.celrep.2021.108895
10.1146/annurev-neuro-070918-050443
10.1186/s40478-022-01468-8
10.1002/(SICI)1097-4547(20000501)60:3<401::AID-JNR15>3.0.CO;2-L
10.1038/ng.859
10.1523/JNEUROSCI.1881-21.2022
10.1007/s00401-016-1648-8
10.1186/s13024-016-0098-z
10.1038/ncb1841
10.1159/000318845
10.3389/fnins.2021.643115
10.1002/ana.20268
10.3389/fneur.2021.737195
10.1007/BF00304137
10.1038/s41467-020-17207-3
10.1007/s12031-021-01943-2
10.1016/j.stemcr.2018.12.011
10.1074/jbc.M115.709485
10.1038/3311
10.3389/fimmu.2020.01097
10.1186/s13024-022-00560-w
10.1016/j.isci.2019.05.039
10.3389/fnmol.2020.569818
10.1038/s41467-021-26433-2
10.1084/jem.20190783
10.1074/jbc.RA117.000378
10.1021/bi027363r
10.1016/j.celrep.2018.08.028
10.1038/s41467-020-20322-w
10.1038/s41374-019-0197-x
10.1038/s41467-020-15701-2
10.1093/brain/awx353
10.1073/pnas.132197599
10.1523/JNEUROSCI.1860-14.2014
10.1038/s41586-020-2156-5
10.1093/brain/awv346
10.1016/j.tins.2010.04.003
10.1016/j.tcb.2016.11.007
10.1016/j.neuron.2022.10.021
10.1093/brain/awac068
10.1038/s41586-020-1984-7
10.1074/jbc.M109.081125
10.1007/s00441-004-0956-9
10.1007/s12035-021-02327-8
10.1038/s41598-020-71329-8
10.1016/j.febslet.2007.03.071
10.1101/2021.07.18.452825
10.1371/journal.pone.0100760
10.1101/2022.08.05.502843
10.1074/jbc.M117.815357
10.1021/bi3010818
10.1038/nrn.2015.1
10.1084/jem.20172158
10.1038/s41392-022-00966-4
10.1126/scirobotics.aah6094
10.1101/cshperspect.a024091
10.1016/j.mcn.2017.04.009
10.1186/s40478-023-01655-1
10.1002/mds.27390
10.1038/nature15368
10.1073/pnas.1301440110
10.1186/1756-6606-3-12
10.1038/nature12776
10.3389/fnins.2017.00217
10.1093/emboj/cdg321
10.1523/JNEUROSCI.3956-16.2017
10.1186/1750-1326-9-43
10.1186/s12974-020-01776-7
10.1186/s12974-022-02486-y
10.1016/j.dib.2016.02.018
10.1007/s00401-022-02437-0
10.15252/embj.2020104464
10.3389/fnagi.2021.690293
10.1038/s41598-017-08720-5
10.1002/glia.22437
10.1038/s41591-022-01926-9
10.1038/ncb1552
10.1186/1750-1326-3-8
10.1038/s43587-022-00281-1
10.1186/s40478-017-0469-x
10.3390/biomedicines10081769
10.1038/s41594-019-0322-y
10.1038/s41586-018-0454-y
10.1523/JNEUROSCI.5699-09.2010
10.3389/fnagi.2019.00231
10.1074/jbc.M808759200
10.1002/glia.22873
10.1186/s13024-019-0314-8
10.1002/glia.23163
10.1016/j.immuni.2005.08.009
10.1016/j.neuron.2015.11.013
10.3389/fnins.2019.00442
10.1042/BCJ20200917
10.15252/embj.201593411
10.1002/ana.410440324
10.1038/s41467-017-00037-1
10.1038/srep42984
10.1038/ncomms9045
10.1073/pnas.1006785107
10.1186/s40478-016-0386-4
10.1016/0006-8993(95)01177-3
10.1523/JNEUROSCI.3981-16.2017
10.1093/brain/awab011
10.1016/j.neuron.2014.04.047
10.1073/pnas.2110746119
10.1186/2047-9158-2-20
10.1016/j.euroneuro.2013.03.007
10.1186/s40478-017-0478-9
10.7150/jca.55173
10.1074/jbc.RA117.000490
10.1038/ncb1901
10.1126/science.1093133
10.3233/JPD-191790
10.1016/S0165-5728(02)00462-9
10.1523/JNEUROSCI.0983-17.2017
10.1016/j.toxlet.2003.09.009
10.1016/j.celrep.2019.10.089
10.1093/braincomms/fcac235
10.1002/glia.24145
10.1038/s41374-021-00644-z
10.1002/glia.23920
10.1016/j.molmed.2005.01.001
10.1007/s00401-020-02254-3
10.1038/nm1747
10.1002/alz.12453
10.15252/embj.201591397
10.1186/s13024-018-0276-2
10.3389/fneur.2020.595532
10.1523/JNEUROSCI.5491-10.2011
10.1126/science.aan6160
10.1002/med.21553
10.1523/JNEUROSCI.0234-12.2012
10.1186/s13024-022-00533-z
10.1523/JNEUROSCI.0954-20.2020
10.1080/19336896.2016.1223003
10.1038/s41586-021-03911-7
10.1038/s41594-020-0384-x
ContentType Journal Article
Copyright The Author(s) 2024
2024. The Author(s).
COPYRIGHT 2024 BioMed Central Ltd.
2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2024
– notice: 2024. The Author(s).
– notice: COPYRIGHT 2024 BioMed Central Ltd.
– notice: 2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7TK
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
7X8
5PM
DOA
DOI 10.1186/s13024-024-00703-1
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Neurosciences Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Open Access Full Text
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE




Publicly Available Content Database
CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1750-1326
EndPage 18
ExternalDocumentID oai_doaj_org_article_b9fcc1f102a242b48cd0ab02e0212e3c
PMC10790381
A782194744
38229094
10_1186_s13024_024_00703_1
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: Università degli Studi di Padova
– fundername: Dipartimento di Biologia, Università degli Studi di Padova
  grantid: STARs 2019: Supporting TAlents in ReSearch
  funderid: http://dx.doi.org/10.13039/501100024032
– fundername: Ministero della Salute
  grantid: GR-2016-02363461
  funderid: http://dx.doi.org/10.13039/501100003196
– fundername: Dipartimento di Biologia, Università degli Studi di Padova
  grantid: STARs 2019: Supporting TAlents in ReSearch
– fundername: Ministero della Salute
  grantid: GR-2016-02363461
GroupedDBID ---
0R~
123
29M
2WC
53G
5VS
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AASML
ABDBF
ABIVO
ABUWG
ACGFO
ACGFS
ACIHN
ACMJI
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DU5
E3Z
EBD
EBLON
EBS
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HH5
HMCUK
HYE
IAO
IHR
INH
INR
IPY
ITC
KQ8
LGEZI
LOTEE
M1P
M48
M~E
NADUK
NXXTH
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
PUEGO
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
TR2
TUS
UKHRP
WOQ
WOW
~8M
AAYXX
ALIPV
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
3V.
7TK
7XB
8FK
AZQEC
DWQXO
K9.
PKEHL
PQEST
PQUKI
7X8
5PM
ID FETCH-LOGICAL-c608t-c0972701ca52d9f7d3fa638a9a315bc8735bbd6819c5fe0b6e4bfa2a8083549e3
IEDL.DBID M48
ISSN 1750-1326
IngestDate Wed Aug 27 01:07:37 EDT 2025
Thu Aug 21 18:35:49 EDT 2025
Fri Sep 05 06:41:37 EDT 2025
Sat Jul 26 00:11:39 EDT 2025
Tue Jun 17 22:25:34 EDT 2025
Tue Jun 10 21:13:53 EDT 2025
Thu Apr 03 07:06:55 EDT 2025
Thu Apr 24 23:01:00 EDT 2025
Tue Jul 01 01:59:06 EDT 2025
Sat Sep 06 07:29:28 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords α-Synuclein
Tau
Clearance
Astrocytes
Amyloid proteins
Language English
License 2024. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c608t-c0972701ca52d9f7d3fa638a9a315bc8735bbd6819c5fe0b6e4bfa2a8083549e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-5334-155X
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1186/s13024-024-00703-1
PMID 38229094
PQID 2925660897
PQPubID 55149
PageCount 18
ParticipantIDs doaj_primary_oai_doaj_org_article_b9fcc1f102a242b48cd0ab02e0212e3c
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10790381
proquest_miscellaneous_2915990744
proquest_journals_2925660897
gale_infotracmisc_A782194744
gale_infotracacademiconefile_A782194744
pubmed_primary_38229094
crossref_primary_10_1186_s13024_024_00703_1
crossref_citationtrail_10_1186_s13024_024_00703_1
springer_journals_10_1186_s13024_024_00703_1
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-01-16
PublicationDateYYYYMMDD 2024-01-16
PublicationDate_xml – month: 01
  year: 2024
  text: 2024-01-16
  day: 16
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Molecular neurodegeneration
PublicationTitleAbbrev Mol Neurodegeneration
PublicationTitleAlternate Mol Neurodegener
PublicationYear 2024
Publisher BioMed Central
BioMed Central Ltd
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: BMC
References C Alquezar (703_CR29) 2020; 11
L Song (703_CR126) 2022; 72
E Zeinstra (703_CR148) 2003; 135
J Hu (703_CR137) 2023; 111
JC Polanco (703_CR88) 2021; 141
L Fellner (703_CR111) 2013; 61
H Jantti (703_CR138) 2022; 19
B Li (703_CR47) 2018; 9
BS Khakh (703_CR171) 2019; 42
KH Strang (703_CR45) 2018; 293
MP Marzolo (703_CR113) 2000; 60
K Zhao (703_CR38) 2020; 11
KL Fiock (703_CR80) 2023; 11
JOS Onyeisi (703_CR163) 2020; 21
M Tardivel (703_CR105) 2016; 4
L Zhao (703_CR22) 2022; 7
A Tripathi (703_CR67) 2022; 42
Z Li (703_CR167) 2021; 12
P Wang (703_CR131) 2021; 12
H Chai (703_CR173) 2017; 95
TA Bayer (703_CR5) 2015; 25
Y Zhang (703_CR76) 2016; 89
XL Gu (703_CR155) 2010; 3
W Zhang (703_CR15) 2005; 19
HH Gerdes (703_CR98) 2007; 581
H Konishi (703_CR132) 2022; 70
S Weninger (703_CR160) 2020; 6
M Shahnawaz (703_CR52) 2020; 578
DW Sanders (703_CR48) 2014; 82
C Kim (703_CR109) 2018; 13
D Ganesan (703_CR25) 2021; 478
P Cisternas (703_CR78) 2022; 4
R Piacentini (703_CR156) 2017; 65
L Abjean (703_CR168) 2023; 146
TM Sonninen (703_CR71) 2020; 10
SC Watkins (703_CR97) 2005; 23
PM Keeney (703_CR142) 2006; 26
C Soto (703_CR1) 2018; 21
JW Vogel (703_CR63) 2020; 11
A Rustom (703_CR95) 2004; 303
Y Zhang (703_CR11) 2022; 17
AN Shrivastava (703_CR159) 2015; 34
703_CR4
JH Kordower (703_CR59) 2008; 14
F Endo (703_CR174) 2022; 378
Y Sun (703_CR39) 2021; 12
X Wang (703_CR96) 2010; 107
M Gold (703_CR164) 2010; 30
703_CR42
A Chiarini (703_CR169) 2017; 11
KR Parzych (703_CR24) 2014; 20
S Saman (703_CR91) 2012; 287
K Moreau (703_CR165) 2015; 6
GU Hoglinger (703_CR31) 2011; 43
T Mothes (703_CR102) 2023; 11
S Dujardin (703_CR86) 2014; 9
B Dejanovic (703_CR120) 2022; 2
M Tachibana (703_CR130) 2019; 129
P Chastagner (703_CR107) 2020; 12
D Vorselen (703_CR134) 2020; 66
E Emmanouilidou (703_CR87) 2010; 30
K Chen (703_CR112) 2022; 17
B Falcon (703_CR51) 2018; 561
N Dzamko (703_CR108) 2017; 133
A Gauthier-Kemper (703_CR119) 2018; 293
C Kim (703_CR110) 2013; 4
YM Morizawa (703_CR20) 2017; 8
L Streubel-Gallasch (703_CR117) 2021; 58
PI Castagnet (703_CR66) 2005; 94
HJ Lee (703_CR73) 2010; 285
Y Wang (703_CR93) 2017; 12
J Satoh (703_CR149) 1995; 704
L Morel (703_CR172) 2017; 37
EP De Mattos (703_CR21) 2020; 10
J Burre (703_CR64) 2010; 329
ME Tremblay (703_CR14) 2019; 14
L Luo (703_CR114) 2018; 24
CPA Doherty (703_CR41) 2020; 27
T Tsunemi (703_CR72) 2020; 40
T Kimura (703_CR28) 2017; 5
JD Cahoy (703_CR18) 2008; 28
V Brezovakova (703_CR152) 2022; 11
AN Shrivastava (703_CR121) 2016; 7
F Clavaguera (703_CR58) 2009; 11
BE Stopschinski (703_CR127) 2018; 293
703_CR94
MJ Diogenes (703_CR13) 2012; 32
S Schuerle (703_CR136) 2017; 2
Y Shi (703_CR50) 2021; 598
N Jain (703_CR133) 2019; 21
S Sollvander (703_CR143) 2016; 11
N Braidy (703_CR141) 2013; 2
JN Rauch (703_CR128) 2020; 580
JC Polanco (703_CR92) 2016; 291
S Abounit (703_CR101) 2016; 35
C Rabouille (703_CR83) 2017; 27
E Miyoshi (703_CR85) 2021; 101
KA Conway (703_CR34) 1998; 4
H Braak (703_CR60) 2004; 318
TL Spires-Jones (703_CR3) 2017; 134
MK Lee (703_CR36) 2002; 99
V Jaumouille (703_CR135) 2020; 11
S Bachmann (703_CR10) 2021; 15
A di Domenico (703_CR70) 2019; 12
MCL Phillips (703_CR166) 2018; 33
M Merezhko (703_CR84) 2020; 13
A Stuendl (703_CR90) 2016; 139
K Zhang (703_CR106) 2021; 13
N Louros (703_CR2) 2020; 11
N Mayran (703_CR118) 2003; 22
F Liu (703_CR9) 2008; 3
K Mittal (703_CR151) 2019; 16
MX Henderson (703_CR7) 2019; 709
703_CR82
BV Dieriks (703_CR103) 2017; 7
K Gousset (703_CR99) 2009; 11
MC Hoenig (703_CR62) 2018; 141
M Goedert (703_CR61) 2010; 33
DD Li Puma (703_CR157) 2022; 48
JL Eriksen (703_CR33) 2005; 11
A Tan (703_CR153) 2022; 29
A Mudher (703_CR54) 2017; 5
T Kanekiyo (703_CR129) 2011; 31
DR Boyer (703_CR37) 2019; 26
JA Rodriguez (703_CR6) 2015; 525
F Loria (703_CR139) 2017; 134
V Lindstrom (703_CR140) 2017; 82
S Abounit (703_CR100) 2016; 10
L Narhi (703_CR35) 1999; 274
M Sidoryk-Wegrzynowicz (703_CR154) 2017; 5
GG Kovacs (703_CR81) 2018; 6
E Ihse (703_CR122) 2017; 7
K Tanaka (703_CR23) 2009; 85
SY Cheng (703_CR69) 2004; 146
B Combs (703_CR46) 2012; 51
K Malfertheiner (703_CR49) 2021; 12
SL Forrest (703_CR79) 2023; 146
Y Zhang (703_CR116) 2014; 34
KC Luk (703_CR56) 2009; 106
A Filippini (703_CR115) 2021; 69
PH Tu (703_CR8) 1998; 44
Y Yang (703_CR170) 2022; 119
M Kiechle (703_CR27) 2019; 29
BB Holmes (703_CR123) 2013; 110
JR Perea (703_CR125) 2019; 13
L Iovino (703_CR158) 2022; 144
IV Murray (703_CR40) 2003; 42
KH Strang (703_CR44) 2019; 99
BP Imbimbo (703_CR12) 2022; 18
B Frost (703_CR57) 2009; 284
J Rostami (703_CR104) 2017; 37
M Miyazono (703_CR74) 1993; 86
J Rostami (703_CR146) 2020; 17
S Moussaud (703_CR53) 2014; 9
H Konishi (703_CR16) 2020; 39
P Szpakowski (703_CR150) 2022; 10
MF Altay (703_CR43) 2022; 10
M Bellesi (703_CR19) 2017; 37
G Fusco (703_CR26) 2017; 358
NO Manzanza (703_CR30) 2021; 13
WS Chung (703_CR17) 2013; 504
P Pals (703_CR32) 2004; 56
H Jung (703_CR161) 2022; 28
C Hansen (703_CR55) 2011; 121
H Martini-Stoica (703_CR124) 2018; 215
A Mate de Gerando (703_CR77) 2021; 144
C Loov (703_CR144) 2015; 63
R Gargini (703_CR75) 2019; 11
Y Wang (703_CR65) 2016; 17
K Tanji (703_CR68) 2001; 12
C Jancic (703_CR145) 2007; 9
KM Danzer (703_CR89) 2012; 7
K Russ (703_CR147) 2021; 34
MA Anwar (703_CR162) 2019; 39
References_xml – volume: 274
  start-page: 9843
  issue: 14
  year: 1999
  ident: 703_CR35
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.14.9843
– volume: 12
  start-page: 5
  issue: 1
  year: 2017
  ident: 703_CR93
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-016-0143-y
– volume: 19
  start-page: 533
  issue: 6
  year: 2005
  ident: 703_CR15
  publication-title: FASEB J
  doi: 10.1096/fj.04-2751com
– volume: 29
  start-page: 1433
  issue: 8
  year: 2022
  ident: 703_CR153
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-022-01028-6
– volume: 20
  start-page: 460
  issue: 3
  year: 2014
  ident: 703_CR24
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5371
– volume: 7
  start-page: 42
  year: 2012
  ident: 703_CR89
  publication-title: Mol Neurodegener
  doi: 10.1186/1750-1326-7-42
– volume: 12
  start-page: 1909
  issue: 9
  year: 2001
  ident: 703_CR68
  publication-title: Neuroreport.
  doi: 10.1097/00001756-200107030-00028
– volume: 129
  start-page: 1272
  issue: 3
  year: 2019
  ident: 703_CR130
  publication-title: J Clin Invest
  doi: 10.1172/JCI124853
– volume: 121
  start-page: 715
  issue: 2
  year: 2011
  ident: 703_CR55
  publication-title: J Clin Invest
  doi: 10.1172/JCI43366
– volume: 66
  start-page: 112
  year: 2020
  ident: 703_CR134
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/j.ceb.2020.05.011
– volume: 9
  start-page: 3609
  issue: 1
  year: 2018
  ident: 703_CR47
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-05971-2
– volume: 378
  start-page: eadc9020
  issue: 6619
  year: 2022
  ident: 703_CR174
  publication-title: Science
  doi: 10.1126/science.adc9020
– volume: 21
  start-page: 267
  year: 2019
  ident: 703_CR133
  publication-title: Annu Rev Biomed Eng
  doi: 10.1146/annurev-bioeng-062117-121224
– volume: 11
  start-page: 1429
  issue: 9
  year: 2022
  ident: 703_CR152
  publication-title: Cells
  doi: 10.3390/cells11091429
– volume: 329
  start-page: 1663
  issue: 5999
  year: 2010
  ident: 703_CR64
  publication-title: Science.
  doi: 10.1126/science.1195227
– volume: 4
  start-page: 1562
  year: 2013
  ident: 703_CR110
  publication-title: Nat Commun
  doi: 10.1038/ncomms2534
– volume: 6
  start-page: e12090
  issue: 1
  year: 2020
  ident: 703_CR160
  publication-title: Alzheimers Dement (N Y)
  doi: 10.1002/trc2.12090
– volume: 6
  start-page: 50
  issue: 1
  year: 2018
  ident: 703_CR81
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-018-0552-y
– volume: 48
  start-page: e12811
  issue: 5
  year: 2022
  ident: 703_CR157
  publication-title: Neuropathol Appl Neurobiol
  doi: 10.1111/nan.12811
– volume: 11
  start-page: 2643
  issue: 1
  year: 2020
  ident: 703_CR38
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-16386-3
– volume: 12
  start-page: e12025
  issue: 12
  year: 2020
  ident: 703_CR107
  publication-title: EMBO Mol Med
  doi: 10.15252/emmm.202012025
– volume: 26
  start-page: 5256
  issue: 19
  year: 2006
  ident: 703_CR142
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0984-06.2006
– volume: 134
  start-page: 789
  issue: 5
  year: 2017
  ident: 703_CR139
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-017-1746-2
– volume: 95
  start-page: 531
  issue: 3
  year: 2017
  ident: 703_CR173
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2017.06.029
– volume: 5
  start-page: 99
  issue: 1
  year: 2017
  ident: 703_CR54
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-017-0488-7
– volume: 85
  start-page: 12
  issue: 1
  year: 2009
  ident: 703_CR23
  publication-title: Proc Jpn Acad Ser B Phys Biol Sci
  doi: 10.2183/pjab.85.12
– volume: 94
  start-page: 839
  issue: 3
  year: 2005
  ident: 703_CR66
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2005.03247.x
– volume: 28
  start-page: 264
  issue: 1
  year: 2008
  ident: 703_CR18
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4178-07.2008
– volume: 21
  start-page: 1087
  issue: 12
  year: 2020
  ident: 703_CR163
  publication-title: Cancer Biol Ther
  doi: 10.1080/15384047.2020.1838034
– volume: 21
  start-page: 1332
  issue: 10
  year: 2018
  ident: 703_CR1
  publication-title: Nat Neurosci
  doi: 10.1038/s41593-018-0235-9
– volume: 106
  start-page: 20051
  issue: 47
  year: 2009
  ident: 703_CR56
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0908005106
– volume: 287
  start-page: 3842
  issue: 6
  year: 2012
  ident: 703_CR91
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.277061
– volume: 11
  start-page: 97
  issue: 1
  year: 2023
  ident: 703_CR102
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-023-01589-8
– volume: 134
  start-page: 187
  issue: 2
  year: 2017
  ident: 703_CR3
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-017-1709-7
– volume: 709
  start-page: 134316
  year: 2019
  ident: 703_CR7
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2019.134316
– volume: 146
  start-page: 395
  issue: 3
  year: 2023
  ident: 703_CR79
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-023-02604-x
– volume: 34
  start-page: 108895
  issue: 12
  year: 2021
  ident: 703_CR147
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2021.108895
– volume: 42
  start-page: 187
  year: 2019
  ident: 703_CR171
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev-neuro-070918-050443
– volume: 10
  start-page: 163
  issue: 1
  year: 2022
  ident: 703_CR43
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-022-01468-8
– volume: 60
  start-page: 401
  issue: 3
  year: 2000
  ident: 703_CR113
  publication-title: J Neurosci Res
  doi: 10.1002/(SICI)1097-4547(20000501)60:3<401::AID-JNR15>3.0.CO;2-L
– volume: 43
  start-page: 699
  issue: 7
  year: 2011
  ident: 703_CR31
  publication-title: Nat Genet
  doi: 10.1038/ng.859
– volume: 42
  start-page: 2116
  issue: 10
  year: 2022
  ident: 703_CR67
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1881-21.2022
– volume: 133
  start-page: 303
  issue: 2
  year: 2017
  ident: 703_CR108
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-016-1648-8
– volume: 11
  start-page: 38
  issue: 1
  year: 2016
  ident: 703_CR143
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-016-0098-z
– volume: 11
  start-page: 328
  issue: 3
  year: 2009
  ident: 703_CR99
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1841
– volume: 30
  start-page: 131
  issue: 2
  year: 2010
  ident: 703_CR164
  publication-title: Dement Geriatr Cogn Disord
  doi: 10.1159/000318845
– volume: 15
  start-page: 643115
  year: 2021
  ident: 703_CR10
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2021.643115
– volume: 56
  start-page: 591
  issue: 4
  year: 2004
  ident: 703_CR32
  publication-title: Ann Neurol
  doi: 10.1002/ana.20268
– volume: 12
  start-page: 737195
  year: 2021
  ident: 703_CR49
  publication-title: Front Neurol
  doi: 10.3389/fneur.2021.737195
– volume: 86
  start-page: 236
  issue: 3
  year: 1993
  ident: 703_CR74
  publication-title: Acta Neuropathol
  doi: 10.1007/BF00304137
– volume: 13
  start-page: 12509
  issue: 11
  year: 2021
  ident: 703_CR106
  publication-title: Am J Transl Res
– volume: 11
  start-page: 3314
  issue: 1
  year: 2020
  ident: 703_CR2
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-17207-3
– volume: 72
  start-page: 772
  issue: 4
  year: 2022
  ident: 703_CR126
  publication-title: J Mol Neurosci
  doi: 10.1007/s12031-021-01943-2
– volume: 12
  start-page: 213
  issue: 2
  year: 2019
  ident: 703_CR70
  publication-title: Stem Cell Rep
  doi: 10.1016/j.stemcr.2018.12.011
– volume: 291
  start-page: 12445
  issue: 24
  year: 2016
  ident: 703_CR92
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M115.709485
– volume: 4
  start-page: 1318
  issue: 11
  year: 1998
  ident: 703_CR34
  publication-title: Nat Med
  doi: 10.1038/3311
– volume: 11
  start-page: 1097
  year: 2020
  ident: 703_CR135
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.01097
– volume: 17
  start-page: 57
  issue: 1
  year: 2022
  ident: 703_CR112
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-022-00560-w
– volume: 16
  start-page: 298
  year: 2019
  ident: 703_CR151
  publication-title: iScience
  doi: 10.1016/j.isci.2019.05.039
– volume: 13
  start-page: 569818
  year: 2020
  ident: 703_CR84
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2020.569818
– volume: 12
  start-page: 6252
  issue: 1
  year: 2021
  ident: 703_CR39
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-26433-2
– ident: 703_CR82
  doi: 10.1084/jem.20190783
– volume: 293
  start-page: 10826
  issue: 27
  year: 2018
  ident: 703_CR127
  publication-title: J Biol Chem
  doi: 10.1074/jbc.RA117.000378
– volume: 42
  start-page: 8530
  issue: 28
  year: 2003
  ident: 703_CR40
  publication-title: Biochemistry.
  doi: 10.1021/bi027363r
– volume: 24
  start-page: 3033
  issue: 11
  year: 2018
  ident: 703_CR114
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.08.028
– volume: 12
  start-page: 95
  issue: 1
  year: 2021
  ident: 703_CR131
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-20322-w
– volume: 99
  start-page: 912
  issue: 7
  year: 2019
  ident: 703_CR44
  publication-title: Lab Investig
  doi: 10.1038/s41374-019-0197-x
– volume: 11
  start-page: 2612
  issue: 1
  year: 2020
  ident: 703_CR63
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-15701-2
– volume: 141
  start-page: 568
  issue: 2
  year: 2018
  ident: 703_CR62
  publication-title: Brain.
  doi: 10.1093/brain/awx353
– volume: 99
  start-page: 8968
  issue: 13
  year: 2002
  ident: 703_CR36
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.132197599
– volume: 34
  start-page: 11929
  issue: 36
  year: 2014
  ident: 703_CR116
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1860-14.2014
– volume: 580
  start-page: 381
  issue: 7803
  year: 2020
  ident: 703_CR128
  publication-title: Nature.
  doi: 10.1038/s41586-020-2156-5
– volume: 139
  start-page: 481
  issue: Pt 2
  year: 2016
  ident: 703_CR90
  publication-title: Brain.
  doi: 10.1093/brain/awv346
– volume: 33
  start-page: 317
  issue: 7
  year: 2010
  ident: 703_CR61
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2010.04.003
– volume: 27
  start-page: 230
  issue: 3
  year: 2017
  ident: 703_CR83
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2016.11.007
– volume: 111
  start-page: 15
  issue: 1
  year: 2023
  ident: 703_CR137
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2022.10.021
– volume: 146
  start-page: 149
  issue: 1
  year: 2023
  ident: 703_CR168
  publication-title: Brain
  doi: 10.1093/brain/awac068
– volume: 578
  start-page: 273
  issue: 7794
  year: 2020
  ident: 703_CR52
  publication-title: Nature.
  doi: 10.1038/s41586-020-1984-7
– volume: 285
  start-page: 9262
  issue: 12
  year: 2010
  ident: 703_CR73
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.081125
– volume: 318
  start-page: 121
  issue: 1
  year: 2004
  ident: 703_CR60
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-004-0956-9
– volume: 58
  start-page: 3119
  issue: 7
  year: 2021
  ident: 703_CR117
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-021-02327-8
– volume: 10
  start-page: 14474
  issue: 1
  year: 2020
  ident: 703_CR71
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-71329-8
– volume: 581
  start-page: 2194
  issue: 11
  year: 2007
  ident: 703_CR98
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2007.03.071
– ident: 703_CR4
  doi: 10.1101/2021.07.18.452825
– volume: 9
  start-page: e100760
  issue: 6
  year: 2014
  ident: 703_CR86
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0100760
– ident: 703_CR94
  doi: 10.1101/2022.08.05.502843
– volume: 293
  start-page: 2408
  issue: 7
  year: 2018
  ident: 703_CR45
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M117.815357
– volume: 51
  start-page: 8597
  issue: 43
  year: 2012
  ident: 703_CR46
  publication-title: Biochemistry.
  doi: 10.1021/bi3010818
– volume: 17
  start-page: 5
  issue: 1
  year: 2016
  ident: 703_CR65
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn.2015.1
– volume: 215
  start-page: 2355
  issue: 9
  year: 2018
  ident: 703_CR124
  publication-title: J Exp Med
  doi: 10.1084/jem.20172158
– volume: 7
  start-page: 113
  issue: 1
  year: 2022
  ident: 703_CR22
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-022-00966-4
– volume: 2
  start-page: eaah6094
  issue: 2
  year: 2017
  ident: 703_CR136
  publication-title: Sci Robot
  doi: 10.1126/scirobotics.aah6094
– ident: 703_CR42
  doi: 10.1101/cshperspect.a024091
– volume: 82
  start-page: 143
  year: 2017
  ident: 703_CR140
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2017.04.009
– volume: 11
  start-page: 161
  issue: 1
  year: 2023
  ident: 703_CR80
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-023-01655-1
– volume: 33
  start-page: 1306
  issue: 8
  year: 2018
  ident: 703_CR166
  publication-title: Mov Disord
  doi: 10.1002/mds.27390
– volume: 525
  start-page: 486
  issue: 7570
  year: 2015
  ident: 703_CR6
  publication-title: Nature.
  doi: 10.1038/nature15368
– volume: 110
  start-page: E3138
  issue: 33
  year: 2013
  ident: 703_CR123
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1301440110
– volume: 3
  start-page: 12
  year: 2010
  ident: 703_CR155
  publication-title: Mol Brain
  doi: 10.1186/1756-6606-3-12
– volume: 504
  start-page: 394
  issue: 7480
  year: 2013
  ident: 703_CR17
  publication-title: Nature
  doi: 10.1038/nature12776
– volume: 11
  start-page: 217
  year: 2017
  ident: 703_CR169
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2017.00217
– volume: 22
  start-page: 3242
  issue: 13
  year: 2003
  ident: 703_CR118
  publication-title: EMBO J
  doi: 10.1093/emboj/cdg321
– volume: 37
  start-page: 8706
  issue: 36
  year: 2017
  ident: 703_CR172
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3956-16.2017
– volume: 9
  start-page: 43
  year: 2014
  ident: 703_CR53
  publication-title: Mol Neurodegener
  doi: 10.1186/1750-1326-9-43
– volume: 17
  start-page: 119
  issue: 1
  year: 2020
  ident: 703_CR146
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-020-01776-7
– volume: 19
  start-page: 147
  issue: 1
  year: 2022
  ident: 703_CR138
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-022-02486-y
– volume: 7
  start-page: 221
  year: 2016
  ident: 703_CR121
  publication-title: Data Brief
  doi: 10.1016/j.dib.2016.02.018
– volume: 144
  start-page: 81
  issue: 1
  year: 2022
  ident: 703_CR158
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-022-02437-0
– volume: 39
  start-page: e104464
  issue: 22
  year: 2020
  ident: 703_CR16
  publication-title: EMBO J
  doi: 10.15252/embj.2020104464
– volume: 13
  start-page: 690293
  year: 2021
  ident: 703_CR30
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2021.690293
– volume: 7
  start-page: 9008
  issue: 1
  year: 2017
  ident: 703_CR122
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-08720-5
– volume: 61
  start-page: 349
  issue: 3
  year: 2013
  ident: 703_CR111
  publication-title: Glia.
  doi: 10.1002/glia.22437
– volume: 28
  start-page: 1802
  issue: 9
  year: 2022
  ident: 703_CR161
  publication-title: Nat Med
  doi: 10.1038/s41591-022-01926-9
– volume: 9
  start-page: 367
  issue: 4
  year: 2007
  ident: 703_CR145
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1552
– volume: 3
  start-page: 8
  year: 2008
  ident: 703_CR9
  publication-title: Mol Neurodegener
  doi: 10.1186/1750-1326-3-8
– volume: 2
  start-page: 837
  issue: 9
  year: 2022
  ident: 703_CR120
  publication-title: Nat Aging
  doi: 10.1038/s43587-022-00281-1
– volume: 5
  start-page: 67
  issue: 1
  year: 2017
  ident: 703_CR28
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-017-0469-x
– volume: 10
  start-page: 1769
  issue: 8
  year: 2022
  ident: 703_CR150
  publication-title: Biomedicines
  doi: 10.3390/biomedicines10081769
– volume: 26
  start-page: 1044
  issue: 11
  year: 2019
  ident: 703_CR37
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/s41594-019-0322-y
– volume: 561
  start-page: 137
  issue: 7721
  year: 2018
  ident: 703_CR51
  publication-title: Nature.
  doi: 10.1038/s41586-018-0454-y
– volume: 30
  start-page: 6838
  issue: 20
  year: 2010
  ident: 703_CR87
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5699-09.2010
– volume: 11
  start-page: 231
  year: 2019
  ident: 703_CR75
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2019.00231
– volume: 284
  start-page: 12845
  issue: 19
  year: 2009
  ident: 703_CR57
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M808759200
– volume: 63
  start-page: 1997
  issue: 11
  year: 2015
  ident: 703_CR144
  publication-title: Glia
  doi: 10.1002/glia.22873
– volume: 14
  start-page: 16
  issue: 1
  year: 2019
  ident: 703_CR14
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-019-0314-8
– volume: 65
  start-page: 1302
  issue: 8
  year: 2017
  ident: 703_CR156
  publication-title: Glia
  doi: 10.1002/glia.23163
– volume: 23
  start-page: 309
  issue: 3
  year: 2005
  ident: 703_CR97
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2005.08.009
– volume: 89
  start-page: 37
  issue: 1
  year: 2016
  ident: 703_CR76
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2015.11.013
– volume: 13
  start-page: 442
  year: 2019
  ident: 703_CR125
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2019.00442
– volume: 478
  start-page: 1959
  issue: 10
  year: 2021
  ident: 703_CR25
  publication-title: Biochem J
  doi: 10.1042/BCJ20200917
– volume: 35
  start-page: 2120
  issue: 19
  year: 2016
  ident: 703_CR101
  publication-title: EMBO J
  doi: 10.15252/embj.201593411
– volume: 44
  start-page: 415
  issue: 3
  year: 1998
  ident: 703_CR8
  publication-title: Ann Neurol
  doi: 10.1002/ana.410440324
– volume: 8
  start-page: 28
  issue: 1
  year: 2017
  ident: 703_CR20
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-00037-1
– volume: 7
  start-page: 42984
  year: 2017
  ident: 703_CR103
  publication-title: Sci Rep
  doi: 10.1038/srep42984
– volume: 6
  start-page: 8045
  year: 2015
  ident: 703_CR165
  publication-title: Nat Commun
  doi: 10.1038/ncomms9045
– volume: 107
  start-page: 17194
  issue: 40
  year: 2010
  ident: 703_CR96
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1006785107
– volume: 4
  start-page: 117
  issue: 1
  year: 2016
  ident: 703_CR105
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-016-0386-4
– volume: 704
  start-page: 92
  issue: 1
  year: 1995
  ident: 703_CR149
  publication-title: Brain Res
  doi: 10.1016/0006-8993(95)01177-3
– volume: 37
  start-page: 5263
  issue: 21
  year: 2017
  ident: 703_CR19
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3981-16.2017
– volume: 144
  start-page: 1167
  issue: 4
  year: 2021
  ident: 703_CR77
  publication-title: Brain.
  doi: 10.1093/brain/awab011
– volume: 82
  start-page: 1271
  issue: 6
  year: 2014
  ident: 703_CR48
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2014.04.047
– volume: 119
  start-page: e2110746119
  issue: 29
  year: 2022
  ident: 703_CR170
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2110746119
– volume: 2
  start-page: 20
  issue: 1
  year: 2013
  ident: 703_CR141
  publication-title: Transl Neurodegener
  doi: 10.1186/2047-9158-2-20
– volume: 25
  start-page: 713
  issue: 5
  year: 2015
  ident: 703_CR5
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2013.03.007
– volume: 5
  start-page: 89
  issue: 1
  year: 2017
  ident: 703_CR154
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/s40478-017-0478-9
– volume: 12
  start-page: 3587
  issue: 12
  year: 2021
  ident: 703_CR167
  publication-title: J Cancer
  doi: 10.7150/jca.55173
– volume: 293
  start-page: 8065
  issue: 21
  year: 2018
  ident: 703_CR119
  publication-title: J Biol Chem
  doi: 10.1074/jbc.RA117.000490
– volume: 11
  start-page: 909
  issue: 7
  year: 2009
  ident: 703_CR58
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1901
– volume: 303
  start-page: 1007
  issue: 5660
  year: 2004
  ident: 703_CR95
  publication-title: Science.
  doi: 10.1126/science.1093133
– volume: 10
  start-page: 369
  issue: 2
  year: 2020
  ident: 703_CR21
  publication-title: J Parkinsons Dis
  doi: 10.3233/JPD-191790
– volume: 135
  start-page: 166
  issue: 1–2
  year: 2003
  ident: 703_CR148
  publication-title: J Neuroimmunol
  doi: 10.1016/S0165-5728(02)00462-9
– volume: 37
  start-page: 11835
  issue: 49
  year: 2017
  ident: 703_CR104
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0983-17.2017
– volume: 146
  start-page: 139
  issue: 2
  year: 2004
  ident: 703_CR69
  publication-title: Toxicol Lett
  doi: 10.1016/j.toxlet.2003.09.009
– volume: 29
  start-page: 2862
  issue: 9
  year: 2019
  ident: 703_CR27
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2019.10.089
– volume: 4
  start-page: fcac235
  issue: 5
  year: 2022
  ident: 703_CR78
  publication-title: Brain Commun
  doi: 10.1093/braincomms/fcac235
– volume: 70
  start-page: 1009
  issue: 6
  year: 2022
  ident: 703_CR132
  publication-title: Glia.
  doi: 10.1002/glia.24145
– volume: 101
  start-page: 1605
  issue: 12
  year: 2021
  ident: 703_CR85
  publication-title: Lab Investig
  doi: 10.1038/s41374-021-00644-z
– volume: 69
  start-page: 681
  issue: 3
  year: 2021
  ident: 703_CR115
  publication-title: Glia.
  doi: 10.1002/glia.23920
– volume: 11
  start-page: 91
  issue: 3
  year: 2005
  ident: 703_CR33
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2005.01.001
– volume: 141
  start-page: 235
  issue: 2
  year: 2021
  ident: 703_CR88
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-020-02254-3
– volume: 14
  start-page: 504
  issue: 5
  year: 2008
  ident: 703_CR59
  publication-title: Nat Med
  doi: 10.1038/nm1747
– volume: 18
  start-page: 1008
  issue: 5
  year: 2022
  ident: 703_CR12
  publication-title: Alzheimers Dement
  doi: 10.1002/alz.12453
– volume: 34
  start-page: 2408
  issue: 19
  year: 2015
  ident: 703_CR159
  publication-title: EMBO J
  doi: 10.15252/embj.201591397
– volume: 13
  start-page: 43
  issue: 1
  year: 2018
  ident: 703_CR109
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-018-0276-2
– volume: 11
  start-page: 595532
  year: 2020
  ident: 703_CR29
  publication-title: Front Neurol
  doi: 10.3389/fneur.2020.595532
– volume: 31
  start-page: 1644
  issue: 5
  year: 2011
  ident: 703_CR129
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5491-10.2011
– volume: 358
  start-page: 1440
  issue: 6369
  year: 2017
  ident: 703_CR26
  publication-title: Science
  doi: 10.1126/science.aan6160
– volume: 39
  start-page: 1053
  issue: 3
  year: 2019
  ident: 703_CR162
  publication-title: Med Res Rev
  doi: 10.1002/med.21553
– volume: 32
  start-page: 11750
  issue: 34
  year: 2012
  ident: 703_CR13
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0234-12.2012
– volume: 17
  start-page: 28
  issue: 1
  year: 2022
  ident: 703_CR11
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-022-00533-z
– volume: 40
  start-page: 8618
  issue: 45
  year: 2020
  ident: 703_CR72
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0954-20.2020
– volume: 10
  start-page: 344
  issue: 5
  year: 2016
  ident: 703_CR100
  publication-title: Prion.
  doi: 10.1080/19336896.2016.1223003
– volume: 598
  start-page: 359
  issue: 7880
  year: 2021
  ident: 703_CR50
  publication-title: Nature.
  doi: 10.1038/s41586-021-03911-7
– volume: 27
  start-page: 249
  issue: 3
  year: 2020
  ident: 703_CR41
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/s41594-020-0384-x
SSID ssj0047005
Score 2.4757009
SecondaryResourceType review_article
Snippet Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and...
Abstract Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 5
SubjectTerms alpha-Synuclein - metabolism
Alzheimer's disease
Amyloid
Amyloid proteins
Astrocytes
Astrocytes - metabolism
Autophagy
Biomedical and Life Sciences
Biomedicine
Brain
Brain - metabolism
Clearance
Dementia
Enzymes
Fibrils
Glycoproteins
Humans
Kinases
Microglia
Microglia - metabolism
Molecular Medicine
Molecular modelling
Nervous system diseases
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neurology
Neurosciences
Pathology
Protein Aggregates
Protein folding
Proteins
Review
Synuclein
Tau
Tau protein
Toxicity
α-Synuclein
SummonAdditionalLinks – databaseName: DOAJ Open Access Full Text
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9UwDI_QTlwmYB-UDZRJ0ziwaE2btgkX9IY2TZPgxKTdonwCEmun9b3D_nvstH2sQ8CFQy-1UyWOHdtJ-jMhhxARxFgWgUnODRPeOyaDUcwXJq98DQFKOsH_9Lm-uBKX19X1g1JfeCdsgAceBHdiVXSOR_CDBryJFdL53Ni8CIhNHkqHqy98b0qmhjVYNKBc0y8ysj7p8XhOsPSgjjM-c0MJrf_3NfmBU3p8YfLRqWlyRufPyOYYRdLF0Pvn5EloX5CtRQsZ9M09PaLpXmfaMN8iH06xCgR1WB8Cp5h2kSZ0BnhpvkK6jRtp_XtqgKXrA1vd0g4o_RJc2z1QtsnV-dmXjxdsLJvAXJ3LJXOIyNPk3Jmq8Co2vowGrMwoU_LKOtmUlbW-hlAAb5rltg7CRlMYidGYUKHcIRtt14aXhPpgBLfcQgvwYiJK1wTObci9qEVUMiN8kqJ2I6Y4lrb4oVNuIWs9SF6nByWveUberdvcDogaf-U-xclZcyIadnoBOqJHHdH_0pGMvMWp1Wiz0D1nxl8PYJCIfqUXECZxBQMUGdmfcYKtuTl5Ug492nqvCwVhI0heNRk5WJOxJd5fa0O3Qh4IG3EfAj6xO-jSekhlwtxXQJEzLZuNeU5pv39LSOCQuys86s3I8aSQv_r1Z6G--h9C3SNPi2RQWGh8n2ws71bhNQRoS_sm2eJPS7U0TQ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9UwDI9gXLggYHwUBioSggNEa9q0TbhMbxPThAQnJr1blM-BxNq39b3D_nvsvLSjQ9uhlzqp6sSOf44Tm5D3gAhCqEpPBWOacucsFV5L6kpd1K4BgBIj-N9_NCen_NuyXqYNtyEdqxzXxLhQu97iHvl-KcE4N4WQ7cHqgmLVKIyuphIa98kDBkgESze0y8nh4i2I2HhRRjT7AwbpOI0PSjplM2MUc_b_vzL_Y5puHpu8ETuNJun4MXmUsGS-2E7-E3LPd0_J7qIDP_r8Kv-Qx9Odcdt8lxwcYi2I3GKVCJzovA95zNEAL_UZON24nTZ8yTU06QdPN6u8B8qwBgN3BZRn5PT468-jE5qKJ1ALo7SmFvPytAWzui6dDK2rggZd01JXrDZWtFVtjGsAEOB5s8I0npugSy0Qk3Hpq-dkp-s7_5LkzmvODDPQA2wZD8K2njHjC8cbHqTICBtHUdmUWRwLXPxR0cMQjdqOvIoPjrxiGfk09Vlt82rc2foQJ2dqiTmx44v-8kwlFVNGBmtZAMSkAXcYLqwrtClKj1nsfWUz8hGnVqHmwu9ZnS4gAJOYA0stACwxCQzyjOzNWoLG2Tl5FA6VNH5Q1_KZkXcTGXviKbbO9xtsA-ARdyPgEy-2sjSxVMXM-xIoYiZlM57nlO73r5gPHDx4iQHfjHweBfL6v24f1Fd3s_GaPCyjqmAh8T2ys77c-DcAwNbmbdSyv2bdK1k
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Nb9UwDI_QuHBBwPgobCiTEBwgomnTNOGC3p42TUhwYtJuUT4BCdqJvnfYfz87r32sY0zi0EvsVE1i13ac_EzIK_AIUqqryBTnlokQPFPRahYqWzZBgoOSM_ifv8iTU_HprDkbYXLwLszV_D1X8v2AiTXB8oPSySDSudtAI0rzUi6nv65oQZymSzE39psZnozP__df-IoZun5E8lqeNJuf4wfk_ug30sVmoR-SO7F7RHYXHcTMvy7oa5pPcuYt8l3y8RDrPlCPFSFwUWmfaMZjgEb7DQJs3DobPlALLP0Q2fqc9kAZVmDMLoDymJweH31dnrCxUALzslQr5hGDpy25t00VdGpDnSzoldW25o3zqq0b54IE449ny0ono3DJVlah_yV0rJ-Qna7v4jNCQ7SCO-6gB9gtkZRvI-culkFIkbQqCJ9m0fgRRRyLWfw0OZpQ0mxm3uQHZ97wgrzd9jnfYGjcyn2Ii7PlRPzr3ABiYUZ1Mk4n73kC78iCj-GE8qG0rqwiItbH2hfkDS6tQS2Fz_N2vGwAg0S8K7MAx4hrGKAoyN6ME7TLz8mTcJhRuwdTaXAUYeZ1W5CDLRl74om1LvZr5AFHEXce4BVPN7K0HVKdUfY1UNRMymZjnlO6H98z9jdE6xqTuwV5Nwnkn-_696Q-_z_2F-RelVUHi4jvkZ3V73XcB-dr5V5mrbsEd50j-g
  priority: 102
  providerName: Springer Nature
Title Brain clearance of protein aggregates: a close-up on astrocytes
URI https://link.springer.com/article/10.1186/s13024-024-00703-1
https://www.ncbi.nlm.nih.gov/pubmed/38229094
https://www.proquest.com/docview/2925660897
https://www.proquest.com/docview/2915990744
https://pubmed.ncbi.nlm.nih.gov/PMC10790381
https://doaj.org/article/b9fcc1f102a242b48cd0ab02e0212e3c
Volume 19
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9QwDI_G9sILYoyPsnEqEoIHKDRt2iZIaOqdNk0nMSHgpHuLkjQZSKMd9yFx_z12ri10DJ54qCrFTtU4dvNznNqEPANE4Fya2IhTqiJWVSbiVomoSlScVTkAFB_Bf3-en83YdJ7Nd0hX7qgV4PJG1w7rSc0Wl69_fN8cg8G_8wbP8zdLDL6xyF-owRF4Q3s-XoRH-VgfVWAFqFz348yN_QaLk8_h_-eX-rel6voxymuxVL9End4ld1psGZZbZdgnO7a-Rw7KGvzqb5vweehPe_pt9ANyPMbaEKHBqhE48WHjQp-zARrVBTjhuL22fBsqYGmWNlpfhQ1QlitY8DZAuU9mpyefJ2dRW0whMnnMV5HBPD1FTI3Kkkq4okqdAttTQqU004YXaaZ1lQNAwPNnsc4t004liiNGY8KmD8hu3dT2EQkrqxjVVEMPWNuY46awlGobVyxnTvCA0E6K0rSZxrHgxaX0HgfP5Vby0l8oeUkD8rLvc7XNs_FP7jFOTs-JObJ9Q7O4kK3JSS2cMdQBglKAQzTjpoqVjhOLWe1tagLyAqdWom7B6xnV_pAAg8ScWLIE8EQFDJAF5GjACRZohuROOWSnwDIRACZB8qIIyNOejD3xVFttmzXyAJjE3Ql4xMOtLvVDSn0mfgEUPtCywZiHlPrrF58fHDx6gQHggLzqFPLXe_1dqI__h1APye3EGxSWHz8iu6vF2j4B2LbSI3KrmBcjsleW009TuI9Pzj98hNZJPhn5rZCRt9afyHFBfw
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbK9gAXBJRHoECQeBzAapx4kxipqnah1Za2K4RaqTfXr7SVIFmaXaH9c_w2ZrzJlhTRWw-5eMZWxp7xjF_fEPIaIoKiSGJHc8YU5dYamjslqI1V1LcpBCj-BP9gnI6O-Jfj_vEK-d2-hcFrle2c6CdqWxncI9-IBTjnNMpFtjX5STFrFJ6utik0VJNawW56iLHmYceem_-CJVy9ufsZxvtNHO9sH34a0SbLADXQ3JQaBLDJImZUP7aiyGxSKFBKJVTC-trkWdLX2qbgOfFiVqRTx3WhYpVj8MKFS6DdW2SV4wZKj6wOt8dfv7W-gGeg5O1TnTzdqPGYkFP_oa1R1nGHPmvAv77hL-d49eLmldNb7xR37pG7TTQbDhbqd5-suPIBWRuUsJL_MQ_fhv5-qd-4XyNbQ8xGERrMU4GqFlZF6FEioFCdwrIfN_Tqj6EClqp2dDYJK6DUU3Cxc6A8JEc30rGPSK-sSveEhNYpzjTTUAO8KS9ykznGtIssT3kh8oCwthelabDNMcXGd-nXOHkqFz0v_Yc9L1lA3i_rTBbIHtdyD3FwlpyIyu0LqotT2Ri51KIwhhUQsymIfDTPjY2UjmKHOPouMQF5h0Mrce6A3zOqeQIBQiIKlxxAuMYECMgDst7hBJs3XXKrHLKZc2p5aSEBebUkY028R1e6aoY8EL7ifgg08XihS0uREo_9L4CSd7SsI3OXUp6feURyFmUCj5wD8qFVyMv_-n-nPr1ejJfk9ujwYF_u7473npE7sTcbTGu-TnrTi5l7DuHgVL9obC4kJzdt5n8AajBvCw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZQKyEuCCiPQIEgIThA1DhxEpsLSoFVWaBCgkq9WX62SJCsmuyh_54ZJ1ma8pA45OIZR7E9E3_jsT8T8hQQgfd55hJOqUqYtSbhTonEZiotbAkAJWTwPx2WB0dseVwcXzjFH3a7TynJ4UwDsjQ1_d7K-sHFebnXYbqNJeFBm00g_tnmhRAQfm3X9fLLcvobswrMbDos88easwkp8Pb__ne-MD1d3jp5KX8apqXFDXJ9xJNxPRjATXLFNbfITt1ALP3jPH4Whx2eYel8h7zex_sgYoM3ReBgx62PA08DFKoTCLxxSa17FStQaTuXrFdxC5Kuh0nuHCS3ydHi3dc3B8l4gUJiypT3iUFuniqlRhWZFb6yuVfgb0qonBba8CovtLYlgALcc5bq0jHtVaY44jImXH6HbDVt4-6R2DrFqKYaasB8xjw3laNUu9SyknnBI0KnXpRmZBfHSy6-yxBl8FIOPS_Dgz0vaURebOqsBm6Nf2rv4-BsNJEXOxS0ZydydDOphTeGekBNCrCHZtzYVOk0c8hk73ITkec4tBK9Fz7PqPEQAjQSebBkDYCJCmggi8juTBO8zszFk3HI0es7mQkAkNDzoorIk40Ya-JOtsa1a9QBAIkrEvCKu4MtbZqUB_Z9ARI-s7JZm-eS5ttp4ASHKF5g0jciLyeD_PVdf-_U-_-n_phc_fx2IT--P_zwgFzLghfhPeO7ZKs_W7uHgM96_Wh0wZ8wVDCn
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Brain+clearance+of+protein+aggregates%3A+a+close-up+on+astrocytes&rft.jtitle=Molecular+neurodegeneration&rft.au=Veronica+Giusti&rft.au=Gurkirat+Kaur&rft.au=Elena+Giusto&rft.au=Laura+Civiero&rft.date=2024-01-16&rft.pub=BMC&rft.eissn=1750-1326&rft.volume=19&rft.issue=1&rft.spage=1&rft.epage=18&rft_id=info:doi/10.1186%2Fs13024-024-00703-1&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_b9fcc1f102a242b48cd0ab02e0212e3c
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1750-1326&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1750-1326&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1750-1326&client=summon