节细胞胶质瘤：以伸长细胞型室管膜瘤为胶质成分的病理特点
目的探讨以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤的组织病理学特点。方法对1例节细胞胶质瘤患者的肿瘤组织标本进行常规石蜡切片、HE染色、免疫组织化学染色，以及光学显微镜观察。结果临床主要表现为间断性肢体抽搐、头晕。MRI检查显示右侧顶叶占位性病变。术中可见肿瘤位于右侧顶叶，大小4．50cm×4．00cm×4．00cm，质地柔韧，血运一般，大部分肿瘤组织边界清楚，呈灰红色，分块切除肿瘤后可见术腔与侧脑室相通。HE染色，肿瘤组织由肿瘤性胶质成分和散在其中的神经细胞构成，胶质成分为伸长细胞型室管膜瘤，呈伸展形束状排列，可见血管周围假“菊形团”结构；神经细胞分布疏密不均匀，多分化良好。免疫组织化学染...
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| Published in | 中国现代神经疾病杂志 Vol. 11; no. 3; pp. 349 - 352 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
河南省人民医院病理科,郑州,450003
2011
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-6731 |
| DOI | 10.3969/j.issn.1672-6731.2011.03.018 |
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| Abstract | 目的探讨以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤的组织病理学特点。方法对1例节细胞胶质瘤患者的肿瘤组织标本进行常规石蜡切片、HE染色、免疫组织化学染色，以及光学显微镜观察。结果临床主要表现为间断性肢体抽搐、头晕。MRI检查显示右侧顶叶占位性病变。术中可见肿瘤位于右侧顶叶，大小4．50cm×4．00cm×4．00cm，质地柔韧，血运一般，大部分肿瘤组织边界清楚，呈灰红色，分块切除肿瘤后可见术腔与侧脑室相通。HE染色，肿瘤组织由肿瘤性胶质成分和散在其中的神经细胞构成，胶质成分为伸长细胞型室管膜瘤，呈伸展形束状排列，可见血管周围假“菊形团”结构；神经细胞分布疏密不均匀，多分化良好。免疫组织化学染色，伸长细胞型室管膜瘤成分胶质纤维酸性蛋白、波形蛋白和上皮膜抗原表达阳性；而神经细胞则表达神经元核抗原和神经微丝蛋白。结论节细胞胶质瘤为分化良好、生长缓慢的临床罕见神经上皮来源肿瘤，由肿瘤性成熟节细胞和肿瘤性胶质细胞混合构成。大多数肿瘤性胶质成分为星形细胞，以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤十分罕见。掌握其组织病理学特点，对诊断和治疗具有指导作用。 |
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| AbstractList | 目的探讨以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤的组织病理学特点。方法对1例节细胞胶质瘤患者的肿瘤组织标本进行常规石蜡切片、HE染色、免疫组织化学染色，以及光学显微镜观察。结果临床主要表现为间断性肢体抽搐、头晕。MRI检查显示右侧顶叶占位性病变。术中可见肿瘤位于右侧顶叶，大小4．50cm×4．00cm×4．00cm，质地柔韧，血运一般，大部分肿瘤组织边界清楚，呈灰红色，分块切除肿瘤后可见术腔与侧脑室相通。HE染色，肿瘤组织由肿瘤性胶质成分和散在其中的神经细胞构成，胶质成分为伸长细胞型室管膜瘤，呈伸展形束状排列，可见血管周围假“菊形团”结构；神经细胞分布疏密不均匀，多分化良好。免疫组织化学染色，伸长细胞型室管膜瘤成分胶质纤维酸性蛋白、波形蛋白和上皮膜抗原表达阳性；而神经细胞则表达神经元核抗原和神经微丝蛋白。结论节细胞胶质瘤为分化良好、生长缓慢的临床罕见神经上皮来源肿瘤，由肿瘤性成熟节细胞和肿瘤性胶质细胞混合构成。大多数肿瘤性胶质成分为星形细胞，以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤十分罕见。掌握其组织病理学特点，对诊断和治疗具有指导作用。 R285.5; 目的 探讨以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤的组织病理学特点.方法 对1例节细胞胶质瘤患者的肿瘤组织标本进行常规石蜡切片、HE染色、免疫组织化学染色,以及光学显微镜观察.结果 临床主要表现为间断性肢体抽搐、头晕.MRI检查显示右侧顶叶占位性病变.术中可见肿瘤位于右侧顶叶,大小4.50 cm×4.00 cm×4.00 cm,质地柔韧,血运一般,大部分肿瘤组织边界清楚,呈灰红色,分块切除肿瘤后可见术腔与侧脑室相通.HE染色,肿瘤组织由肿瘤性胶质成分和散在其中的神经细胞构成,胶质成分为伸长细胞型室管膜瘤,呈伸展形束状排列,可见血管周围假"菊形团"结构;神经细胞分布疏密不均匀,多分化良好.免疫组织化学染色,伸长细胞型室管膜瘤成分胶质纤维酸性蛋白、波形蛋白和上皮膜抗原表达阳性;而神经细胞则表达神经元核抗原和神经微丝蛋白.结论 节细胞胶质瘤为分化良好、生长缓慢的临床罕见神经上皮来源肿瘤,由肿瘤性成熟节细胞和肿瘤性胶质细胞混合构成.大多数肿瘤性胶质成分为星形细胞,以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤十分罕见.掌握其组织病理学特点,对诊断和治疗具有指导作用. |
| Author | 许梅 孔令非 |
| AuthorAffiliation | 河南省人民医院病理科,郑州450003 |
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| Author_FL | KONG Lingfei XU Mei |
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| Author_xml | – sequence: 1 fullname: 许梅 孔令非 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DocumentTitleAlternate | The pathological features of ganglioglioma with tanycytic ependymoma as the glial component |
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| EndPage | 352 |
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| Keywords | 神经胶质瘤 脑肿瘤 免疫组织化学 室管膜瘤 病理学 |
| Language | Chinese |
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| Notes | Glioma; Brain neoplasms; Ependymoma; Pathology; Immunohistoehemistry Objective To explore the pathological features of ganglioglioma with tanycytic ependymoma as the glial component. Methods One case of ganglioglioma was studied by paraffin slices, HE staining, immunohistochemistry markers and observed under microscopy. Results A 21-year-old woman mainly presented with intermittent physical convulsion and dizziness. Magnetic resonance imaging （MRI） demonstrated an occupying lesion in right parietal lobe. It was seen in the operation that the tumor was located in right parietal lobe. The tumor measuring about 4.50 cmx 4.00 cm x 4,00 cm was tenacious and grey-red in color. The blood supply was general. Most parts of the tumor boundary were clear. After removing the tumor, it was found that the operated cavity was communicated with lateral ventricle. Under microscope it was seen that the tumor was composed of tumorous glial cells and gangliocytes. The glial components were tanycytie ependymoma cells and glial cel |
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| PublicationTitle | 中国现代神经疾病杂志 |
| PublicationTitleAlternate | Chinese Journal of Contemporary Neurology and Neurosurgery |
| PublicationTitle_FL | CHINESE JOURNAL OF CONTEMPORARY NEUROLOGY AND NEUROSURGERY |
| PublicationYear | 2011 |
| Publisher | 河南省人民医院病理科,郑州,450003 |
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| Snippet | 目的探讨以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤的组织病理学特点。方法对1例节细胞胶质瘤患者的肿瘤组织标本进行常规石蜡切片、HE染色、免疫组织化学染色，以及光学... R285.5; 目的 探讨以伸长细胞型室管膜瘤为胶质成分的节细胞胶质瘤的组织病理学特点.方法 对1例节细胞胶质瘤患者的肿瘤组织标本进行常规石蜡切片、HE染色、免疫组织化学染色,... |
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| StartPage | 349 |
| SubjectTerms | 免疫组织化学 室管膜瘤 病理学 神经胶质瘤 脑肿瘤 |
| Title | 节细胞胶质瘤：以伸长细胞型室管膜瘤为胶质成分的病理特点 |
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