神经酰胺在非酒精性脂肪性肝病发生发展中的作用

非酒精性脂肪性肝病（NAFLD）是除外酒精和其他明确的肝损害因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征。＂二次打击＂学说可以部分解释NAFLD的发病机制。神经酰胺是NAFLD发生发展中关键的分子信使,而且其作为一种鞘脂与＂二次打击学说＂密切相关。对神经酰胺在NAFLD中的作用进行了综述。...

Full description

Saved in:
Bibliographic Details
Published in临床肝胆病杂志 Vol. 33; no. 8; pp. 1584 - 1588
Main Author 韩海静 齐雪 牛春燕
Format Journal Article
LanguageChinese
Published 西安医学院,西安,710021%西安医学院第一附属医院,西安,710077 2017
Subjects
神经酰胺类
综述
脂肪肝
脂肪肝
fatty liver
综述
review
ceramides
神经酰胺类
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2017.08.038

Cover

More Information
Summary:非酒精性脂肪性肝病（NAFLD）是除外酒精和其他明确的肝损害因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征。＂二次打击＂学说可以部分解释NAFLD的发病机制。神经酰胺是NAFLD发生发展中关键的分子信使,而且其作为一种鞘脂与＂二次打击学说＂密切相关。对神经酰胺在NAFLD中的作用进行了综述。
Bibliography:fatty liver; ceramides; review
Nonalcoholic fatty liver disease（ NAFLD） is a clinicopathological syndrome caused by liver damage factors except alcohol and has the major feature of diffuse macrovesicular hepatocyte steatosis. The ＂ two-hit ＂ hypothesis can partly explain the pathogenesis of NAFLD. Recent studies have found that ceramide is a key molecular messenger involved in the development and progression of NAFLD,and as a sphingolipid,it is closely associated with the ＂ two-hit＂ hypothesis. This article reviews the role of ceramide in NAFLD.
HAN Haijing, QI Xue, NIU Chunyan. （Xi＇an Medical University, Xi＇an 710021, China）
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2017.08.038