Hedgehog-Gli通路在胰腺癌上皮间质转化中的作用研究进展
胰腺癌是严重危害人类健康的恶性肿瘤之一,其早期转移与上皮间质转化（EMT）的发生有关,Hedgehog（Hh）通路参与其中。胶质瘤相关癌基因同源蛋白（Gli）家族是Hh信号通路的终末转录因子,发挥核心调控作用。胰腺癌中Hh-Gli通路及EMT相关性的充分研究,对于胰腺癌发生发展及诊治预后的认识具有重要意义。...
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| Published in | 山东医药 Vol. 58; no. 2; pp. 108 - 110 |
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| Main Author | |
| Format | Magazine Article |
| Language | Chinese |
| Published |
武警后勤学院附属医院,天津,300162
2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1002-266X |
| DOI | 10.3969/j.issn.1002-266X.2018.02.037 |
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| Abstract | 胰腺癌是严重危害人类健康的恶性肿瘤之一,其早期转移与上皮间质转化（EMT）的发生有关,Hedgehog（Hh）通路参与其中。胶质瘤相关癌基因同源蛋白（Gli）家族是Hh信号通路的终末转录因子,发挥核心调控作用。胰腺癌中Hh-Gli通路及EMT相关性的充分研究,对于胰腺癌发生发展及诊治预后的认识具有重要意义。 |
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| AbstractList | 胰腺癌是严重危害人类健康的恶性肿瘤之一,其早期转移与上皮间质转化（EMT）的发生有关,Hedgehog（Hh）通路参与其中。胶质瘤相关癌基因同源蛋白（Gli）家族是Hh信号通路的终末转录因子,发挥核心调控作用。胰腺癌中Hh-Gli通路及EMT相关性的充分研究,对于胰腺癌发生发展及诊治预后的认识具有重要意义。 R735.9; 胰腺癌是严重危害人类健康的恶性肿瘤之一,其早期转移与上皮间质转化(EMT)的发生有关,Hedgehog(Hh)通路参与其中.胶质瘤相关癌基因同源蛋白(Gli)家族是Hh信号通路的终末转录因子,发挥核心调控作用.胰腺癌中Hh-Gli通路及EMT相关性的充分研究,对于胰腺癌发生发展及诊治预后的认识具有重要意义. |
| Author | 张斌;李如月;向晓辉;许威;夏时海 |
| AuthorAffiliation | 武警后勤学院附属医院,天津300162 |
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| Snippet | 胰腺癌是严重危害人类健康的恶性肿瘤之一,其早期转移与上皮间质转化（EMT）的发生有关,Hedgehog（Hh）通路参与其中。胶质瘤相关癌基因同源蛋白（Gli）家族是Hh信号通路的终末转录因子,发挥核心调控作用。胰腺癌中Hh-Gli通路及EMT相关性的充分研究,对于胰腺癌发生发展及诊治预后的认识具有重要意义。 R735.9;... |
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| Title | Hedgehog-Gli通路在胰腺癌上皮间质转化中的作用研究进展 |
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