Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? - Quak, Jacqueline; Doornbos, Bennard; Roest, Annelieke M.; Duivis, Hester E.; Vogelzangs, Nicole; Nolen, Willem A.; Penninx, Brenda W.J.H.; Kema, Ido P.; de Jonge, Peter (Psychoneuroendocrinology, 2014)
Keywords: Adolescent; Adult; Adult and adolescent clinical studies; Aged; Behavioral psychophysiology; Biological and medical sciences; Case-Control Studies; Depression; Depression - immunology; Depression - metabolism; Depressive Disorder, Major - immunology; Depressive Disorder, Major - metabolism; Depressive symptoms; Endocrinology & Metabolism; Female; Fundamental and applied biological sciences. Psychology; Hormones and behavior; Humans; Immune System - metabolism; Indoleamine 2,3-dioxygenase; Inflammation; Inflammation - immunology; Inflammation - metabolism; Inflammation Mediators - metabolism; Kynurenine; Kynurenine - metabolism; Male; Medical sciences; Metabolic Networks and Pathways; Middle Aged; Miscellaneous; Mood disorders; Netherlands; Proteolysis; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Tryptophan; Tryptophan - metabolism; Young Adult; Netherlands; Tryptophan; Kynurenine; Indoleamine 2,3-dioxygenase; Depressive symptoms; Depression; Inflammation; Mood disorder; Enzyme; Activity; Symptomatology; Aminoacid; Indoleamine-pyrrole 2,3-dioxygenase; Oxidoreductases