The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study

• Published in: BMC musculoskeletal disorders Vol. 22; no. 1; pp. 438 - 9
• Main Authors: Montazeri-Najafabady, Nima, Dabbaghmanesh, Mohammad Hossein, Nasimi, Nasrin, Sohrabi, Zahra, Chatrabnous, Nazanin
• Format: Journal Article
• Language: English
• Published: London BioMed Central 13.05.2021; BioMed Central Ltd; BMC
• Subjects: Aged; Aging; Alleles; Body Composition; Body fat; Body mass index; Cancer; Case-Control Studies; Epidemiology; Fasting; Gait; Gene expression; Gene frequency; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Hand Strength; Health aspects; Homeostasis; Humans; Internal Medicine; Iran - epidemiology; Low density lipoprotein; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolism; Muscle function; Muscle strength; Musculoskeletal diseases; Musculoskeletal system; Obesity; Obesity - diagnosis; Obesity - epidemiology; Obesity - genetics; Older people; Orthopedics; p53; Physical activity; Polymorphism; Public health; Rehabilitation; Rheumatology; Risk factors; Sarcopenia; Sarcopenia - diagnosis; Sarcopenia - epidemiology; Sarcopenia - genetics; Skeletal muscle; Sports Medicine; Tumor Suppressor Protein p53; Iran; Sarcopenia; Obesity; Body mass index; p53; Polymorphism
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-021-04314-5

Background Aging and obesity are the two major global health concerns. Sarcopenia, an age-linked disease, wherein a progressive loss of muscle volume, muscle strength, and physical activity occurs. In this study we evaluated the association of TP53 rs1625895 polymorphism with the susceptibility to sarcopenic obesity in Iranian old-age subjects. Methods Total of 176 old individuals (45 sarcopenic and 131 healthy) were recruited in this research and genotyped by PCR–RFLP. BMI, Skeletal Muscle Mass Index, body composition, Handgrip Strength, Gait Speed (GS), and biochemical parameters were measured. Chi-square test was done for genotypes and alleles frequency. Linear regression was applied to find the correlation between TP53 rs1625895 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 rs1625895 and the risk of sarcopenia and sarcopenic obesity was investigated by logistic regression. Results G allele was significantly higher in sarcopenic obesity group [ P  = 0.037, OR (CI 95%) = 1.9 (1.03–3.5)] compared to A allele. BMI ( P  = 0.049) and LDL (P = 0.04) were significantly differed between genotypes when GG was compared to AA/AG genotype. The results revealed when GG genotype compared to AA/AG genotype in adjusted model for age, the risk of sarcopenic obesity [ P value = 0.011, OR (CI 95%); 2.72 (1.25–5.91)] increased. Similarly, GG/AG genotype increased the risk of sarcopenic obesity [ P value = 0.028, OR (CI 95%); 2.43 (1.10–5.36)] in adjusted model for age compared to AA genotype. Conclusions We suggested that TP53 rs1625895 polymorphism may increase the risk of sarcopenic obesity in Iranian population.