Early-phase administration of human amnion-derived stem cells ameliorates neurobehavioral deficits of intracerebral hemorrhage by suppressing local inflammation and apoptosis - Kuramoto, Yoji; Fujita, Mitsugu; Takagi, Toshinori; Takeda, Yuki; Doe, Nobutaka; Yamahara, Kenichi; Yoshimura, Shinichi (Journal of neuroinflammation, 2022)
Keywords: Abdominal surgery; Amnion; Amnion - metabolism; Amnion - pathology; Amniotic sac; Animals; Apoptosis; Biomedical and Life Sciences; Biomedicine; Bone marrow; CD11b antigen; CD45 antigen; Cell death; Cell number; Cerebral Hemorrhage - metabolism; Cesarean Section; Clinical trials; Complications and side effects; Cytokines; Experiments; Female; Flow cytometry; Graft versus host disease; Health aspects; Hemorrhage; Human amnion-derived stem cell; Humans; Immunology; Inflammation; Inflammation - metabolism; Inflammation - therapy; Intracerebral hemorrhage; Intravenous administration; Lesions; Macrophage; Macrophages; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells - metabolism; Mesenchyme; Mice; Microglia; Neurobiology; Neurology; Neurosciences; Nitric-oxide synthase; Pregnancy; Prevention; Splenocytes; Stem cell transplantation; Stem cells; Tumor necrosis factor-α; Western blotting; Japan; Inflammation; Human amnion-derived stem cell; Intracerebral hemorrhage; Macrophage; Microglia; Apoptosis