Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature

Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the associ...

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Published inCritical care (London, England) Vol. 25; no. 1; pp. 368 - 10
Main Authors Thomas-Rüddel, Daniel O., Hoffmann, Peter, Schwarzkopf, Daniel, Scheer, Christian, Bach, Friedhelm, Komann, Marcus, Gerlach, Herwig, Weiss, Manfred, Lindner, Matthias, Rüddel, Hendrik, Simon, Philipp, Kuhn, Sven-Olaf, Wetzker, Reinhard, Bauer, Michael, Reinhart, Konrad, Bloos, Frank
Format Journal Article
LanguageEnglish
Published London BioMed Central 21.10.2021
BioMed Central Ltd
BMC
Subjects
Body temperature
Critical care
Critical Care Medicine
Data collection
Datasets
Diagnosis
Emergency Medicine
Environmental aspects
Fever
Fever - complications
Humans
Hyperthermia
Hypothermia
Hypothermia - complications
Infections
Intensive
Medical prognosis
Medicine
Medicine & Public Health
Mortality
Outcome
Pathogens
Patient outcomes
Patients
PCT
Prognosis
Regression analysis
Risk factors
Sepsis
Sepsis - therapy
Temperature
Weather
Germany
PCT
Prognosis
Lactate
Outcome
Mortality
Body temperature
Sepsis
Fever
Blood cultures
Online AccessGet full text
ISSN1364-8535
1466-609X
1364-8535
1466-609X
1366-609X
DOI10.1186/s13054-021-03776-2

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Abstract Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia. Results With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever. Conclusions Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
AbstractList Abstract Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia. Results With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever. Conclusions Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia. With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever. Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia. Results With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever. Conclusions Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011. Keywords: Fever, Sepsis, Outcome, Mortality, Body temperature, PCT, Lactate, Blood cultures, Prognosis
Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia. Results With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever. Conclusions Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia. Results With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever. Conclusions Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.BACKGROUNDFever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia.METHODSWe did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia.With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever.RESULTSWith 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever.Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.CONCLUSIONSSeptic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia. With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever. Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question.
ArticleNumber 368
Audience Academic
Author Scheer, Christian
Weiss, Manfred
Hoffmann, Peter
Bloos, Frank
Bach, Friedhelm
Kuhn, Sven-Olaf
Thomas-Rüddel, Daniel O.
Simon, Philipp
Reinhart, Konrad
Lindner, Matthias
Schwarzkopf, Daniel
Komann, Marcus
Gerlach, Herwig
Bauer, Michael
Wetzker, Reinhard
Rüddel, Hendrik
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34674733$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1186/s13054-016-1375-5
10.1055/s-2007-1024630
10.1097/CCM.0000000000002249
10.7326/0003-4819-56-2-207
10.1016/j.coi.2017.12.003
10.1186/s13054-016-1584-y
10.1097/CCM.0000000000002285
10.1186/s40635-017-0151-4
10.1016/j.cell.2019.03.022
10.1038/nri2432
10.1097/CCM.0000000000003688
10.1001/jama.1896.02430730001001
10.1016/j.tem.2019.08.012
10.1007/s00134-019-05553-w
10.1002/jhm.2541
10.1016/S2213-2600(18)30004-3
10.1371/journal.pone.0170152
10.1097/CCM.0000000000004610
10.1164/rccm.201806-1197OC
10.1038/nri3843
10.1097/CCM.0b013e31825f78aa
10.1007/s00134-019-05813-9
10.1002/sim.3148
10.1016/S0306-9877(98)90022-6
10.1186/cc13755
10.1186/s13054-016-1510-3
10.1016/j.cell.2019.01.050
10.1172/JCI104899
10.1128/mBio.00212-10
10.5194/asr-15-107-2018
10.1097/00005792-196907000-00003
10.1007/s001340051237
10.1378/chest.101.6.1644
10.1177/1751143715601124
10.1093/ofid/ofz032
10.1016/j.ijid.2018.07.020
10.1007/s00134-017-4782-4
10.1186/s13054-016-1467-2
10.2741/1381
10.1097/00003246-199210000-00006
ContentType Journal Article
Contributor Lange, Martina
Schreiber, Torsten
Thomas-Rüddel, Daniel
Teichert, Andrea
Rosenberger, Peter
Clausen, Tobias
Riessen, Reimer
Henn, Philipp
Textor, Zoran
Diers, Anja
Christink, Susann
Matthäus-Krämer, Claudia
Lemke, Thees
Eiserloh, Christel
Meier-Hellmann, Andreas
Rüddel, Hendrik
Schädler, Dirk
Guderian, Liane
Eiche, Jürgen
Fischer, Annemarie
Fleischhacker, Christoph
Klaproth, Marion
Knebel, Frieder
Meinhardt, Alexander
Fuchs, Christina
Lucht, Alexander
Fahrenholz, Meike
Voswinckel, Robert
Scheer, Christian
Häberle, Helene
Bloos, Frank
Bach, Friedhelm
Gerber, Manuela
Kuhn, Sven-Olaf
Seibel, Armin
Simon, Philipp
Bachmann-Holdau, Ulrike
Sternkopf, Michael
Schulz-Ruhtenberg, Nina
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Mezger, Friederike
Jensen, Nicole
Brederlau, Jörg
Jelschen, Florian
Lehmann, Gunther
Toussaint, Susanne
Kaisers, Udo
Koch, Mathias
Barz, Robert
Hoeschen, J
Michaelsen, Birgit
Volkmer, Christel
Vedder, Ina
Redlich, Ulrike
Rücker, Marcus
Dey, K
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Issue 1
Keywords PCT
Prognosis
Lactate
Outcome
Mortality
Body temperature
Sepsis
Fever
Blood cultures
Language English
License 2021. The Author(s).
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References WR Webb (3776_CR7) 1962; 52
Z Rumbus (3776_CR11) 2017; 12
JL McCarville (3776_CR12) 2018; 50
J Dallimore (3776_CR35) 2018; 20
MA Wiewel (3776_CR25) 2016; 20
W Sauerbrei (3776_CR21) 2007; 26
SS Evans (3776_CR22) 2015; 15
3776_CR44
P Hoffmann (3776_CR19) 2018; 15
3776_CR43
F Bloos (3776_CR16) 2017; 43
3776_CR23
A Wang (3776_CR15) 2019; 177
J Sunden-Cullberg (3776_CR39) 2017; 45
RC Bone (3776_CR6) 1992; 101
PE Marik (3776_CR24) 2000; 26
SV Bhavani (3776_CR26) 2020; 48
AM Drewry (3776_CR34) 2017; 45
M Meisner (3776_CR28) 1999; 23
3776_CR40
DS Schneider (3776_CR13) 2008; 8
K Linsenmeyer (3776_CR41) 2016; 11
J Bittel (3776_CR29) 1992; 13
W Osler (3776_CR1) 1896; XXVI
II Geneva (3776_CR20) 2019; 6
LR Leon (3776_CR27) 2004; 9
G Stanzani (3776_CR30) 2020; 46
A Beverly (3776_CR38) 2016; 17
BA Cunha (3776_CR32) 2012; 40
AA Steiner (3776_CR31) 2017; 21
HL DuPont (3776_CR4) 1969; 48
TS Itenov (3776_CR36) 2018; 6
3776_CR18
T Taniguchi (3776_CR42) 2018; 76
MC Mchenry (3776_CR5) 1962; 56
TP Clemmer (3776_CR3) 1992; 20
3776_CR33
RP Atwood (3776_CR8) 1964; 43
AA Romanovsky (3776_CR9) 1998; 50
K Ganeshan (3776_CR10) 2019; 177
3776_CR37
F Bloos (3776_CR17) 2014; 18
AA Steiner (3776_CR14) 2019; 30
EJ Walter (3776_CR2) 2016; 20
References_xml – volume: 20
  start-page: 200
  issue: 1
  year: 2016
  ident: 3776_CR2
  publication-title: Crit Care
  doi: 10.1186/s13054-016-1375-5
– volume: 13
  start-page: S172
  issue: Suppl 1
  year: 1992
  ident: 3776_CR29
  publication-title: Int J Sports Med
  doi: 10.1055/s-2007-1024630
– volume: 45
  start-page: 591
  issue: 4
  year: 2017
  ident: 3776_CR39
  publication-title: Crit Care Med
  doi: 10.1097/CCM.0000000000002249
– volume: 56
  start-page: 207
  issue: 2
  year: 1962
  ident: 3776_CR5
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-56-2-207
– volume: 50
  start-page: 88
  year: 2018
  ident: 3776_CR12
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2017.12.003
– volume: 21
  start-page: 8
  issue: 1
  year: 2017
  ident: 3776_CR31
  publication-title: Crit Care (London, England)
  doi: 10.1186/s13054-016-1584-y
– volume: 45
  start-page: 806
  issue: 5
  year: 2017
  ident: 3776_CR34
  publication-title: Crit Care Med
  doi: 10.1097/CCM.0000000000002285
– ident: 3776_CR44
  doi: 10.1186/s40635-017-0151-4
– volume: 177
  start-page: 223
  issue: 2
  year: 2019
  ident: 3776_CR15
  publication-title: Cell
  doi: 10.1016/j.cell.2019.03.022
– volume: 8
  start-page: 889
  issue: 11
  year: 2008
  ident: 3776_CR13
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2432
– ident: 3776_CR40
  doi: 10.1097/CCM.0000000000003688
– volume: XXVI
  start-page: 999
  issue: 21
  year: 1896
  ident: 3776_CR1
  publication-title: J Am Med Assoc
  doi: 10.1001/jama.1896.02430730001001
– volume: 30
  start-page: 875
  issue: 12
  year: 2019
  ident: 3776_CR14
  publication-title: Trends Endocrinol Metab
  doi: 10.1016/j.tem.2019.08.012
– ident: 3776_CR37
  doi: 10.1007/s00134-019-05553-w
– volume: 11
  start-page: 336
  issue: 5
  year: 2016
  ident: 3776_CR41
  publication-title: J Hosp Med
  doi: 10.1002/jhm.2541
– volume: 6
  start-page: 183
  issue: 3
  year: 2018
  ident: 3776_CR36
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(18)30004-3
– volume: 12
  start-page: e0170152
  issue: 1
  year: 2017
  ident: 3776_CR11
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0170152
– volume: 48
  start-page: 1645
  issue: 11
  year: 2020
  ident: 3776_CR26
  publication-title: Crit Care Med
  doi: 10.1097/CCM.0000000000004610
– ident: 3776_CR43
  doi: 10.1164/rccm.201806-1197OC
– volume: 15
  start-page: 335
  issue: 6
  year: 2015
  ident: 3776_CR22
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3843
– volume: 40
  start-page: 2926
  issue: 10
  year: 2012
  ident: 3776_CR32
  publication-title: Critical Care Med
  doi: 10.1097/CCM.0b013e31825f78aa
– volume: 46
  start-page: 495
  issue: 3
  year: 2020
  ident: 3776_CR30
  publication-title: Intensive Care Med
  doi: 10.1007/s00134-019-05813-9
– volume: 26
  start-page: 5512
  issue: 30
  year: 2007
  ident: 3776_CR21
  publication-title: Stat Med
  doi: 10.1002/sim.3148
– volume: 50
  start-page: 219
  issue: 3
  year: 1998
  ident: 3776_CR9
  publication-title: Med Hypotheses
  doi: 10.1016/S0306-9877(98)90022-6
– volume: 18
  start-page: R42
  issue: 2
  year: 2014
  ident: 3776_CR17
  publication-title: Crit Care
  doi: 10.1186/cc13755
– volume: 20
  start-page: 328
  issue: 1
  year: 2016
  ident: 3776_CR25
  publication-title: Crit Care
  doi: 10.1186/s13054-016-1510-3
– volume: 177
  start-page: 399
  issue: 2
  year: 2019
  ident: 3776_CR10
  publication-title: Cell
  doi: 10.1016/j.cell.2019.01.050
– volume: 43
  start-page: 151
  year: 1964
  ident: 3776_CR8
  publication-title: J Clin Invest
  doi: 10.1172/JCI104899
– ident: 3776_CR18
– ident: 3776_CR23
  doi: 10.1128/mBio.00212-10
– volume: 15
  start-page: 107
  year: 2018
  ident: 3776_CR19
  publication-title: Adv Sci Res
  doi: 10.5194/asr-15-107-2018
– volume: 48
  start-page: 307
  issue: 4
  year: 1969
  ident: 3776_CR4
  publication-title: Medicine (Baltimore)
  doi: 10.1097/00005792-196907000-00003
– volume: 26
  start-page: 716
  issue: 6
  year: 2000
  ident: 3776_CR24
  publication-title: Intens Care Med
  doi: 10.1007/s001340051237
– volume: 23
  start-page: 63
  year: 1999
  ident: 3776_CR28
  publication-title: LaboratoriumsMedizin J Lab Med
– volume: 101
  start-page: 1644
  issue: 6
  year: 1992
  ident: 3776_CR6
  publication-title: Chest
  doi: 10.1378/chest.101.6.1644
– volume: 20
  start-page: 150
  issue: 2
  year: 2018
  ident: 3776_CR35
  publication-title: Crit Care Resusc
– volume: 17
  start-page: 88
  issue: 1
  year: 2016
  ident: 3776_CR38
  publication-title: J Intensive Care Soc
  doi: 10.1177/1751143715601124
– volume: 6
  start-page: ofz032
  issue: 4
  year: 2019
  ident: 3776_CR20
  publication-title: Open Forum Infect Dis
  doi: 10.1093/ofid/ofz032
– volume: 76
  start-page: 23
  year: 2018
  ident: 3776_CR42
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2018.07.020
– volume: 43
  start-page: 1602
  issue: 11
  year: 2017
  ident: 3776_CR16
  publication-title: Intensive Care Med
  doi: 10.1007/s00134-017-4782-4
– ident: 3776_CR33
  doi: 10.1186/s13054-016-1467-2
– volume: 9
  start-page: 1877
  year: 2004
  ident: 3776_CR27
  publication-title: Front Biosci
  doi: 10.2741/1381
– volume: 20
  start-page: 1395
  issue: 10
  year: 1992
  ident: 3776_CR3
  publication-title: Critical Care Med
  doi: 10.1097/00003246-199210000-00006
– volume: 52
  start-page: 643
  year: 1962
  ident: 3776_CR7
  publication-title: Surgery
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Snippet Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary...
Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. We did a secondary analysis of a large...
Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary...
Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. We did a secondary analysis of a large...
Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.BACKGROUNDFever and hypothermia have...
Abstract Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a...
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StartPage 368
SubjectTerms Body temperature
Critical care
Critical Care Medicine
Data collection
Datasets
Diagnosis
Emergency Medicine
Environmental aspects
Fever
Fever - complications
Humans
Hyperthermia
Hypothermia
Hypothermia - complications
Infections
Intensive
Medical prognosis
Medicine
Medicine & Public Health
Mortality
Outcome
Pathogens
Patient outcomes
Patients
PCT
Prognosis
Regression analysis
Risk factors
Sepsis
Sepsis - therapy
Temperature
Weather
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Title Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature
URI https://link.springer.com/article/10.1186/s13054-021-03776-2
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https://doaj.org/article/bc346b4a29bd4202a8d44d449958ae3d
Volume 25
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