Role of miR-181 family in regulating vascular inflammation and immunity

• Published in: Trends in cardiovascular medicine Vol. 24; no. 3; pp. 105 - 112
• Main Authors: Sun, Xinghui, Sit, Alan, Feinberg, Mark W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2014; Elsevier Limited
• Subjects: Atherosclerosis; Biology; Cardiovascular; Chromosomes; Cytokines; Diabetes; Disease; Endothelium; Fibroblasts - physiology; Gene expression; Genomes; Humans; Immune system; Inflammatory diseases; Leukemia; MicroRNAs - physiology; Muscle, Smooth, Vascular - pathology; Myocytes, Cardiac - physiology; Myocytes, Smooth Muscle - physiology; NF-kappa B - physiology; Pathogenesis; Phosphatase; Physiology; Proteins; Rheumatoid arthritis; Signal Transduction - physiology; T cell receptors; Vascular Diseases - etiology; Vascular Diseases - pathology
• ISSN: 1050-1738; 1873-2615; 1873-2615
• DOI: 10.1016/j.tcm.2013.09.002

The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-κB signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli.